DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment zip and Myh6

DIOPT Version :9

Sequence 1:	NP_523860.2	Gene:	zip / 38001	FlyBaseID:	FBgn0265434	Length:	2056	Species:	Drosophila melanogaster
Sequence 2:	XP_006518740.1	Gene:	Myh6 / 17888	MGIID:	97255	Length:	1939	Species:	Mus musculus

Alignment Length:	1951	Identity:	760/1951 - (38%)
Similarity:	1181/1951 - (60%)	Gaps:	76/1951 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly    83 WVPHENQGFVAASIKREHGDEVEVELAETGKRVMILRDDIQKMNPPKFDKVEDMAELTCLNEASV 147
            :||.:.:.:|.|.:....|.:|..| .|.||.|.|..|.:.:.|||||||:||||.||.|:|.:|
Mouse    38 FVPDDKEEYVKAKVVSREGGKVTAE-TENGKTVTIKEDQVMQQNPPKFDKIEDMAMLTFLHEPAV 101

  Fly   148 LHNIKDRYYSGLIYTYSGLFCVVVNPYKKLPIYTEKIMERYKGIKRHEVPPHVFAITDSAYRNML 212
            |:|:|:||.:.:||||||||||.|||||.||:|..:::..|:|.||.|.|||:|:|:|:||:.||
Mouse   102 LYNLKERYAAWMIYTYSGLFCVTVNPYKWLPVYNAEVVAAYRGKKRSEAPPHIFSISDNAYQYML 166

  Fly   213 GDREDQSILCTGESGAGKTENTKKVIQFLAYVAASKPKGSGAVPHPAVLINFSVNTNKYIKVKIM 277
            .|||:||||.|||||||||.|||:|||:.|.:||.
Mouse   167 TDRENQSILITGESGAGKTVNTKRVIQYFASIAAI------------------------------ 201

  Fly   278 AQNQNQTIEVVNGLKMVEVNSNCQEGELEQQLLQANPILEAFGNAKTVKNDNSSRFGKFIRINFD 342
                        |.:..:.|.|..:|.||.|::||||.||||||||||:|||||||||||||:|.
Mouse   202 ------------GDRSKKENPNANKGTLEDQIIQANPALEAFGNAKTVRNDNSSRFGKFIRIHFG 254

  Fly   343 ASGFISGANIETYLLEKSRAIRQAKDERTFHIFYQLLAGATPEQREKFIL-DDVKSYAFLSNGSL 406
            |:|.::.|:||||||||||.|.|.|.||.:|||||:|:...||..:..:: ::...|||:|.|.:
Mouse   255 ATGKLASADIETYLLEKSRVIFQLKAERNYHIFYQILSNKKPELLDMLLVTNNPYDYAFVSQGEV 319

  Fly   407 PVPGVDDYAEFQATVKSMNIMGMTSEDFNSIFRIVSAVLLFGSMKFRQERNNDQATLPDNTV-AQ 470
            .|..:||..|..||..:.:::..|:|:...::::..|::.:|:|||:|::..:||. ||.|. |.
Mouse   320 SVASIDDSEELLATDSAFDVLSFTAEEKAGVYKLTGAIMHYGNMKFKQKQREEQAE-PDGTEDAD 383

  Fly   471 KIAHLLGLSVTDMTRAFLTPRIKVGRDFVTKAQTKEQVEFAVEAIAKACYERMFKWLVNRINRSL 535
            |.|:|:||:..|:.:....||:|||.::|||.|:.:||.:::.|:||:.||:||.|:|.|||.:|
Mouse   384 KSAYLMGLNSADLLKGLCHPRVKVGNEYVTKGQSVQQVYYSIGALAKSVYEKMFNWMVTRINATL 448

  Fly   536 DRTKRQGASFIGILDMAGFEIFELNSFEQLCINYTNEKLQQLFNHTMFILEQEEYQREGIEWKFI 600
            : ||:....|||:||:||||||:.|||||||||:|||||||.|||.||:||||||::|||||:||
Mouse   449 E-TKQPRQYFIGVLDIAGFEIFDFNSFEQLCINFTNEKLQQFFNHHMFVLEQEEYKKEGIEWEFI 512

  Fly   601 DFGLDLQPTIDLIDKPGGIMALLDEECWFPKATDKTFVDKLVSAH-SMHPKFMKTDFRGV----- 659
            |||:|||..||||:||.|||::|:|||.||||:|.||..||...| .....|.|.  |.|
Mouse   513 DFGMDLQACIDLIEKPMGIMSILEEECMFPKASDMTFKAKLYDNHLGKSNNFQKP--RNVKGKQE 575

  Fly   660 ADFAIVHYAGRVDYSAAKWLMKNMDPLNENIVSLLQGSQDPFVVNIWKDAEIVGMAQQALTDT-- 722
            |.|::|||||.|||:...||.||.|||||.:|.|.|.|....:..::        :..|..||
Mouse   576 AHFSLVHYAGTVDYNIMGWLEKNKDPLNETVVGLYQKSSLKLMATLF--------STYASADTGD 632

  Fly   723 ---QFGARTRKGMFRTVSHLYKEQLAKLMDTLRNTNPNFVRCIIPNHEKRAGKIDAPLVLDQLRC 784
               ..|.:.:...|:|||.|::|.|.|||..|:.|:|:||||||||..|..|.:|.|||:.||||
Mouse   633 SGKGKGGKKKGSSFQTVSALHRENLNKLMTNLKTTHPHFVRCIIPNERKAPGVMDNPLVMHQLRC 697

  Fly   785 NGVLEGIRICRQGFPNRIPFQEFRQRYELLTPNVIPKG-FMDGKKACEKMIQALELDSNLYRVGQ 848
            |||||||||||:||||||.:.:|||||.:|.|..||:| |:|.:|..||::.:|::|.|.|:.|.
Mouse   698 NGVLEGIRICRKGFPNRILYGDFRQRYRILNPAAIPEGQFIDSRKGAEKLLGSLDIDHNQYKFGH 762

  Fly   849 SKIFFRAGVLAHLEEERDFKISDLIVNFQAFCRGFLARRNYQKRLQQLNAIRIIQRNCAAYLKLR 913
            :|:||:||:|..|||.||.::|.:|...||..||.|.|..::|.:::.:|:.:||.|..|::.::
Mouse   763 TKVFFKAGLLGLLEEMRDERLSRIITRIQAQARGQLMRIEFKKIVERRDALLVIQWNIRAFMGVK 827

  Fly   914 NWQWWRLYTKVKPLLEVTKQEEKLVQKEDELKQVREKLDTLAKNTQEYERKYQQALVEKTTLAEQ 978
            ||.|.:||.|:||||:..:.|:::...::|..:|::.|:......:|.|.|....|.||..|..|
Mouse   828 NWPWMKLYFKIKPLLKSAETEKEMANMKEEFGRVKDALEKSEARRKELEEKMVSLLQEKNDLQLQ 892

  Fly   979 LQAEIELCAEAEESRSRLMARKQELEDMMQELETRIEEEEERVLALGGEKKKLELNIQDLEEQLE 1043
            :|||.:...:|||...:|:..|.:||..::|:..|:|:|||....|..:|:|||....:|::.::
Mouse   893 VQAEQDNLNDAEERCDQLIKNKIQLEAKVKEMTERLEDEEEMNAELTAKKRKLEDECSELKKDID 957

  Fly  1044 EEEAARQKLQLEKVQLDAKIKKYEEDLALTDDQNQKLLKEKKLLEERANDLSQTLAEEEEKAKHL 1108
            :.|....|::.||...:.|:|...|::|..|:...||.||||.|:|........|..||:|...|
Mouse   958 DLELTLAKVEKEKHATENKVKNLTEEMAGLDEIIAKLTKEKKALQEAHQQALDDLQAEEDKVNTL 1022

  Fly  1109 AKLKAKHEATISELEERLHKDQQQRQESDRSKRKIETEVADLKEQLNERRVQVDEMQAQLAKREE 1173
            .|.|.|.|..:.:||..|.::::.|.:.:|:|||:|.::...:|.:.:......:::.:|.|:|.
Mouse  1023 TKSKVKLEQQVDDLEGSLEQEKKVRMDLERAKRKLEGDLKLTQESIMDLENDKLQLEEKLKKKEF 1087

  Fly  1174 ELTQTLLRIDEESATKATAQKAQRELESQLAEIQEDLEAEKAARAKAEKVRRDLSEELEALKNEL 1238
            :::|...:|::|.|.....||..:|.::::.|::|:||||:.||||.||:|.|||.|||.:...|
Mouse  1088 DISQQNSKIEDEQALALQLQKKLKENQARIEELEEELEAERTARAKVEKLRSDLSRELEEISERL 1152

  Fly  1239 LDSLDTTAAQQELRSKREQELATLKKSLEEETVNHEGVLADMRHKHSQELNSINDQLENLRKAKT 1303
            .::...|:.|.|:..|||.|...:::.|||.|:.||...|.:|.||:..:..:.:|::||::.|.
Mouse  1153 EEAGGATSVQIEMNKKREAEFQKMRRDLEEATLQHEATAAALRKKHADSVAELGEQIDNLQRVKQ 1217

  Fly  1304 VLEKAKGTLEAENADLATELRSVNSSRQENDRRRKQAESQIAELQVKLAEIERARSELQEKCTKL 1368
            .|||.|...:.|..|:.:.:..:..::...::..:..|.|..|.:|||.|.:|:.::...:..||
Mouse  1218 KLEKEKSEFKLELDDVTSNMEQIIKAKANLEKVSRTLEDQANEYRVKLEEAQRSLNDFTTQRAKL 1282

  Fly  1369 QQEAENITNQLEEAELKASAAVKSASNMESQLTEAQQLLEEETRQKLGLSSKLRQIESEKEALQE 1433
            |.|...:..||||.|...|...:...:...|:.:.::.||||.:.|..|:..|:....:.:.|:|
Mouse  1283 QTENGELARQLEEKEALISQLTRGKLSYTQQMEDLKRQLEEEGKAKNALAHALQSSRHDCDLLRE 1347

  Fly  1434 QLEEDDEAKRNYERKLAEVTTQMQEIKKKAEEDA-DLAKELEEGKKRLNKDIEALERQVKELIAQ 1497
            |.||:.|||...:|.|::..:::.:.:.|.|.|| ...:||||.||:|.:.::..|..|:.:.|:
Mouse  1348 QYEEEMEAKAELQRVLSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQDAEEAVEAVNAK 1412

  Fly  1498 NDRLDKSKKKIQSELEDATIELEAQRTKVLELEKKQKNFDKILAEEKAISEQIAQERDTAEREAR 1562
            ...|:|:|.::|:|:||..:::|........|:|||:||||||||.|...|:...|.:::::|||
Mouse  1413 CSSLEKTKHRLQNEIEDLMVDVERSNAAAAALDKKQRNFDKILAEWKQKYEESQSELESSQKEAR 1477

  Fly  1563 EKETKVLSVSRELDEAFDKIEDLENKRKTLQNELDDLANTQGTADKNVHELEKAKRALESQLAEL 1627
            ...|::..:....:|:.:.:|..:.:.|.||.|:.||....|...||||||||.::.||.:..||
Mouse  1478 SLSTELFKLKNAYEESLEHLETFKRENKNLQEEISDLTEQLGEGGKNVHELEKIRKQLEVEKLEL 1542

  Fly  1628 KAQNEELEDDLQLTEDAKLRLEVNMQALRSQFERDLLAKEEGAEEKRRGLVKQLRDLETELDEER 1692
            ::..||.|..|:..|...||.::....::::.||.|..|:|..|:.:|..::.:..|:|.||.|.
Mouse  1543 QSALEEAEASLEHEEGKILRAQLEFNQIKAEIERKLAEKDEEMEQAKRNHLRMVDSLQTSLDAET 1607

  Fly  1693 KQRTAAVASKKKLEGDLKEIETTMEMHNKVKEDALKHAKKLQAQVKDALRDAEEAKAAKEELQAL 1757
            :.|..|:..|||:||||.|:|..:...|::..:|.||.|..||.:||.....::|..|.::|:..
Mouse  1608 RSRNEALRVKKKMEGDLNEMEIQLSQANRIASEAQKHLKNSQAHLKDTQLQLDDAVHANDDLKEN 1672

  Fly  1758 SKEAERKVKALEAEVLQLTEDLASSERARRAAETERDELAEEIANNANKGSLMIDEKRRLEARIA 1822
            ....||:...|:||:.:|...:..:||:|:.||.|..|.:|.:....::.:.:|::|:::|:.:.
Mouse  1673 IAIVERRNNLLQAELEELRAVVEQTERSRKLAEQELIETSERVQLLHSQNTSLINQKKKMESDLT 1737

  Fly  1823 TLEEELEE---EQSNSEVLLDRSRKAQLQIEQLTTELANEKSNSQKNENGRALLERQNKELKAKL 1884
            .|:.|:||   |..|:|   ::::||......:..||..|:..|...|..:..:|:..|:|:.:|
Mouse  1738 QLQTEVEEAVQECRNAE---EKAKKAITDAAMMAEELKKEQDTSAHLERMKKNMEQTIKDLQHRL 1799

  Fly  1885 AEIETAQRTKVKATIATLEAKIANLEEQLENEGKERLLQQKANRKMDKKIKELTMNIEDERRHVD 1949
            .|.|.......|..:..|||::..||.:||.|.|......|..||.:::|||||...|::::::.
Mouse  1800 DEAEQIALKGGKKQLQKLEARVRELENELEAEQKRNAESVKGMRKSERRIKELTYQTEEDKKNLM 1864

  Fly  1950 QHKEQMDKLNSRIKLLKRNLDETEEELQKEKTQKRKYQRECEDMIESQEAMNREINSLKTKLRRT 2014
            :.::.:|||..::|..||..:|.||:.....::.||.|.|.::..|..:....::|.|:.|.|..
Mouse  1865 RLQDLVDKLQLKVKAYKRQAEEAEEQANTNLSKFRKVQHELDEAEERADIAESQVNKLRAKSRDI 1929

  Fly  2015 G 2015
            |
Mouse  1930 G 1930

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
zip	NP_523860.2	Myosin_N	80..117	CDD:280832	11/33 (33%)
		Myosin_head	133..854	CDD:278492	365/734 (50%)
		MYSc_Myh2_insects_mollusks	145..854	CDD:276876	357/722 (49%)
		Myosin_tail_1	931..2011	CDD:279860	339/1083 (31%)
		Prefoldin	1431..1515	CDD:298833	30/84 (36%)
		FAM76	<1847..1926	CDD:292665	21/78 (27%)
Myh6	XP_006518740.1	Myosin_N	34..72	CDD:367160	11/34 (32%)
		MYSc_class_II	99..768	CDD:276951	357/722 (49%)
		Myosin_tail_1	848..1925	CDD:366712	339/1079 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0161
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D47111at2759
OrthoFinder	1	1.000	-	-		FOG0000014
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100110
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X58
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	5.720