DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment zip and Myh9

DIOPT Version :9

Sequence 1:	NP_523860.2	Gene:	zip / 38001	FlyBaseID:	FBgn0265434	Length:	2056	Species:	Drosophila melanogaster
Sequence 2:	NP_071855.2	Gene:	Myh9 / 17886	MGIID:	107717	Length:	1960	Species:	Mus musculus

Alignment Length:	2008	Identity:	1203/2008 - (59%)
Similarity:	1548/2008 - (77%)	Gaps:	69/2008 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly    58 KYLSVERNQFNDPATQAEWTQKRLVWVPHENQGFVAASIKREHGDEVEVELAETGKRVMILRDDI 122
            |||.|::|..|:|..||:|..|:|||||....||..||:|.|.|:|..|||.|.||:|.:.:|||
Mouse     8 KYLYVDKNFINNPLAQADWAAKKLVWVPSSKNGFEPASLKEEVGEEAIVELVENGKKVKVNKDDI 72

  Fly   123 QKMNPPKFDKVEDMAELTCLNEASVLHNIKDRYYSGLIYTYSGLFCVVVNPYKKLPIYTEKIMER 187
            ||||||||.|||||||||||||||||||:|:|||||||||||||||||:||||.||||:|:|:|.
Mouse    73 QKMNPPKFSKVEDMAELTCLNEASVLHNLKERYYSGLIYTYSGLFCVVINPYKNLPIYSEEIVEM 137

  Fly   188 YKGIKRHEVPPHVFAITDSAYRNMLGDREDQSILCTGESGAGKTENTKKVIQFLAYVAASKPKGS 252
            |||.||||:|||::||||:|||:|:.||||||||||||||||||||||||||:||:||:|.
Mouse   138 YKGKKRHEMPPHIYAITDTAYRSMMQDREDQSILCTGESGAGKTENTKKVIQYLAHVASSH---- 198

  Fly   253 GAVPHPAVLINFSVNTNKYIKVKIMAQNQNQTIEVVNGLKMVEVNSNCQEGELEQQLLQANPILE 317
                                                        .|...:||||:||||||||||
Mouse   199 --------------------------------------------KSKKDQGELERQLLQANPILE 219

  Fly   318 AFGNAKTVKNDNSSRFGKFIRINFDASGFISGANIETYLLEKSRAIRQAKDERTFHIFYQLLAGA 382
            |||||||||||||||||||||||||.:|:|.|||||||||||||||||||:||||||||.||:||
Mouse   220 AFGNAKTVKNDNSSRFGKFIRINFDVNGYIVGANIETYLLEKSRAIRQAKEERTFHIFYYLLSGA 284

  Fly   383 TPEQREKFILDDVKSYAFLSNGSLPVPGVDDYAEFQATVKSMNIMGMTSEDFNSIFRIVSAVLLF 447
            ....:...:|:....|.|||||.:.:||..|...||.|:::|.|||:..::...:.|::|.||..
Mouse   285 GEHLKTDLLLEPYNKYRFLSNGHVTIPGQQDKDMFQETMEAMRIMGIPEDEQMGLLRVISGVLQL 349

  Fly   448 GSMKFRQERNNDQATLPDNTVAQKIAHLLGLSVTDMTRAFLTPRIKVGRDFVTKAQTKEQVEFAV 512
            |::.|::|||.|||::||||.|||::||||::|||.||..||||||||||:|.|||||||.:||:
Mouse   350 GNIAFKKERNTDQASMPDNTAAQKVSHLLGINVTDFTRGILTPRIKVGRDYVQKAQTKEQADFAI 414

  Fly   513 EAIAKACYERMFKWLVNRINRSLDRTKRQGASFIGILDMAGFEIFELNSFEQLCINYTNEKLQQL 577
            ||:|||.|||||:|||.|||::||:|||||||||||||:||||||:|||||||||||||||||||
Mouse   415 EALAKATYERMFRWLVLRINKALDKTKRQGASFIGILDIAGFEIFDLNSFEQLCINYTNEKLQQL 479

  Fly   578 FNHTMFILEQEEYQREGIEWKFIDFGLDLQPTIDLIDKPG---GIMALLDEECWFPKATDKTFVD 639
            ||||||||||||||||||||.||||||||||.||||:||.   ||:|||||||||||||||:||:
Mouse   480 FNHTMFILEQEEYQREGIEWNFIDFGLDLQPCIDLIEKPAGPPGILALLDEECWFPKATDKSFVE 544

  Fly   640 KLVSAHSMHPKFMK-TDFRGVADFAIVHYAGRVDYSAAKWLMKNMDPLNENIVSLLQGSQDPFVV 703
            |:|.....||||.| ...:..|||.|:||||:|||.|.:||||||||||:||.:||..|.|.||.
Mouse   545 KVVQEQGTHPKFQKPKQLKDKADFCIIHYAGKVDYKADEWLMKNMDPLNDNIATLLHQSSDKFVS 609

  Fly   704 NIWKDAE-IVGMAQQA-LTDTQF-GA-RTRKGMFRTVSHLYKEQLAKLMDTLRNTNPNFVRCIIP 764
            .:|||.: |:|:.|.| :::|.. || :|||||||||..||||||||||.|||||||||||||||
Mouse   610 ELWKDVDRIIGLDQVAGMSETALPGAFKTRKGMFRTVGQLYKEQLAKLMATLRNTNPNFVRCIIP 674

  Fly   765 NHEKRAGKIDAPLVLDQLRCNGVLEGIRICRQGFPNRIPFQEFRQRYELLTPNVIPKGFMDGKKA 829
            ||||:|||:|..|||||||||||||||||||||||||:.|||||||||:||||.|||||||||:|
Mouse   675 NHEKKAGKLDPHLVLDQLRCNGVLEGIRICRQGFPNRVVFQEFRQRYEILTPNSIPKGFMDGKQA 739

  Fly   830 CEKMIQALELDSNLYRVGQSKIFFRAGVLAHLEEERDFKISDLIVNFQAFCRGFLARRNYQKRLQ 894
            |..||:||||||||||:||||:|||||||||||||||.||:|:|:.|||.|||:|||:.:.||.|
Mouse   740 CVLMIKALELDSNLYRIGQSKVFFRAGVLAHLEEERDLKITDVIIGFQACCRGYLARKAFAKRQQ 804

  Fly   895 QLNAIRIIQRNCAAYLKLRNWQWWRLYTKVKPLLEVTKQEEKLVQKEDELKQVREKLDTLAKNTQ 959
            ||.|::::||||||||:|||||||||:|||||||...:.|::|:.||.||.:||||.........
Mouse   805 QLTAMKVLQRNCAAYLRLRNWQWWRLFTKVKPLLNSIRHEDELLAKEAELTKVREKHLAAENRLT 869

  Fly   960 EYERKYQQALVEKTTLAEQLQAEIELCAEAEESRSRLMARKQELEDMMQELETRIEEEEERVLAL 1024
            |.|....|.:.||..|.||||||.||||||||.|:||.|:|||||::..:||.|:||||||...|
Mouse   870 EMETMQSQLMAEKLQLQEQLQAETELCAEAEELRARLTAKKQELEEICHDLEARVEEEEERCQYL 934

  Fly  1025 GGEKKKLELNIQDLEEQLEEEEAARQKLQLEKVQLDAKIKKYEEDLALTDDQNQKLLKEKKLLEE 1089
            ..||||::.|||:|||||||||:||||||||||..:||:||.|||..:.:|||.||.|||||||:
Mouse   935 QAEKKKMQQNIQELEEQLEEEESARQKLQLEKVTTEAKLKKLEEDQIIMEDQNCKLAKEKKLLED 999

  Fly  1090 RANDLSQTLAEEEEKAKHLAKLKAKHEATISELEERLHKDQQQRQESDRSKRKIETEVADLKEQL 1154
            |..:.:..|.|||||:|.|||||.||||.|::|||||.::::||||.::::||:|.:..||.:|:
Mouse  1000 RVAEFTTNLMEEEEKSKSLAKLKNKHEAMITDLEERLRREEKQRQELEKTRRKLEGDSTDLSDQI 1064

  Fly  1155 NERRVQVDEMQAQLAKREEELTQTLLRIDEESATKATAQKAQRELESQLAEIQEDLEAEKAARAK 1219
            .|.:.|:.|::.||||:||||...|.|::||:|.|..|.|..||||:|::|:|||||:|:|:|.|
Mouse  1065 AELQAQIAELKMQLAKKEEELQAALARVEEEAAQKNMALKKIRELETQISELQEDLESERASRNK 1129

  Fly  1220 AEKVRRDLSEELEALKNELLDSLDTTAAQQELRSKREQELATLKKSLEEETVNHEGVLADMRHKH 1284
            |||.:|||.|||||||.||.|:||:||||||||||||||::.|||:||:|...||..:.:||.||
Mouse  1130 AEKQKRDLGEELEALKTELEDTLDSTAAQQELRSKREQEVSILKKTLEDEAKTHEAQIQEMRQKH 1194

  Fly  1285 SQELNSINDQLENLRKAKTVLEKAKGTLEAENADLATELRSVNSSRQENDRRRKQAESQIAELQV 1349
            ||.:..:.||||..::.|..|||||.|||.|..:||.|::::...:.:::.:||:.|:|:.||||
Mouse  1195 SQAVEELADQLEQTKRVKATLEKAKQTLENERGELANEVKALLQGKGDSEHKRKKVEAQLQELQV 1259

  Fly  1350 KLAEIERARSELQEKCTKLQQEAENITNQLEEAELKASAAVKSASNMESQLTEAQQLLEEETRQK 1414
            |.:|.||.|:||.:|.||||.|.:::|..|.:::.|:|...|..|.:||||.:.|:||:||.|||
Mouse  1260 KFSEGERVRTELADKVTKLQVELDSVTGLLSQSDSKSSKLTKDFSALESQLQDTQELLQEENRQK 1324

  Fly  1415 LGLSSKLRQIESEKEALQEQLEEDDEAKRNYERKLAEVTTQMQEIKKKAEEDADLAKELEEGKKR 1479
            |.||:||:|:|.||.:.:|||||::|||||.|:::|.:..|:.::|||.|:.....:..||.|:|
Mouse  1325 LSLSTKLKQMEDEKNSFREQLEEEEEAKRNLEKQIATLHAQVTDMKKKMEDGVGCLETAEEAKRR 1389

  Fly  1480 LNKDIEALERQVKELIAQNDRLDKSKKKIQSELEDATIELEAQRTKVLELEKKQKNFDKILAEEK 1544
            |.||:|.|.::::|.:|..|:|:|:|.::|.||:|..::|:.||..|..||||||.||::|||||
Mouse  1390 LQKDLEGLSQRLEEKVAAYDKLEKTKTRLQQELDDLLVDLDHQRQSVSNLEKKQKKFDQLLAEEK 1454

  Fly  1545 AISEQIAQERDTAEREAREKETKVLSVSRELDEAFDKIEDLENKRKTLQNELDDLANTQGTADKN 1609
            .||.:.|:|||.||.||||||||.||::|.|:||.::..:||...|..:.|::||.:::....|:
Mouse  1455 TISAKYAEERDRAEAEAREKETKALSLARALEEAMEQKAELERLNKQFRTEMEDLMSSKDDVGKS 1519

  Fly  1610 VHELEKAKRALESQLAELKAQNEELEDDLQLTEDAKLRLEVNMQALRSQFERDLLAKEEGAEEKR 1674
            ||||||:|||||.|:.|:|.|.|||||:||.|||||||||||:||:::||||||..::|.:|||:
Mouse  1520 VHELEKSKRALEQQVEEMKTQLEELEDELQATEDAKLRLEVNLQAMKAQFERDLQGRDEQSEEKK 1584

  Fly  1675 RGLVKQLRDLETELDEERKQRTAAVASKKKLEGDLKEIETTMEMHNKVKEDALKHAKKLQAQVKD 1739
            :.||:|:|::|.||::|||||:.|:|::||||.|||::|..::..||.:|:|:|..:|||||:||
Mouse  1585 KQLVRQVREMEAELEDERKQRSMAMAARKKLEMDLKDLEAHIDTANKNREEAIKQLRKLQAQMKD 1649

  Fly  1740 ALRDAEEAKAAKEELQALSKEAERKVKALEAEVLQLTEDLASSERARRAAETERDELAEEIANNA 1804
            .:|:.::.:|::||:.|.:||.|:|:|::|||::||.|:||::|||:|.|:.||||||:||||::
Mouse  1650 CMRELDDTRASREEILAQAKENEKKLKSMEAEMIQLQEELAAAERAKRQAQQERDELADEIANSS 1714

  Fly  1805 NKGSLMIDEKRRLEARIATLEEELEEEQSNSEVLLDRSRKAQLQIEQLTTELANEKSNSQKNENG 1869
            .||:|.::||||||||||.|||||||||.|:|::.||.:||.|||:|:.|:|..|:|::|||||.
Mouse  1715 GKGALALEEKRRLEARIAQLEEELEEEQGNTELINDRLKKANLQIDQINTDLNLERSHAQKNENA 1779

  Fly  1870 RALLERQNKELKAKLAEIETAQRTKVKATIATLEAKIANLEEQLENEGKERLLQQKANRKMDKKI 1934
            |..||||||||||||.|:|:|.::|.||:||.||||||.|||||:||.|||....|..|:.:||:
Mouse  1780 RQQLERQNKELKAKLQEMESAVKSKYKASIAALEAKIAQLEEQLDNETKERQAASKQVRRTEKKL 1844

  Fly  1935 KELTMNIEDERRHVDQHKEQMDKLNSRIKLLKRNLDETEEELQKEKTQKRKYQRECEDMIESQEA 1999
            |::.:.:|||||:.:|.|:|.||.::|:|.|||.|:|.|||.|:....:||.|||.||..|:.:|
Mouse  1845 KDVLLQVEDERRNAEQFKDQADKASTRLKQLKRQLEEAEEEAQRANASRRKLQRELEDATETADA 1909

  Fly  2000 MNREINSLKTKLRRTGGIGLSSSRLTGTPSSKRAGGGGGGDDSSVQDESLDGE-DSAN 2056
            ||||::|||.|||| |.:....:|        |....|.||.|   ||.:||: |.|:
Mouse  1910 MNREVSSLKNKLRR-GDLPFVVTR--------RIVRKGTGDCS---DEEVDGKADGAD 1955

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
zip	NP_523860.2	Myosin_N	80..117	CDD:280832	20/36 (56%)
		Myosin_head	133..854	CDD:278492	500/728 (69%)
		MYSc_Myh2_insects_mollusks	145..854	CDD:276876	488/716 (68%)
		Myosin_tail_1	931..2011	CDD:279860	586/1079 (54%)
		Prefoldin	1431..1515	CDD:298833	35/83 (42%)
		FAM76	<1847..1926	CDD:292665	50/78 (64%)
Myh9	NP_071855.2	Mediates interaction with LIMCH1. /evidence=ECO:0000250\|UniProtKB:P35579	2..838		598/877 (68%)
		Myosin_N	30..68	CDD:280832	20/37 (54%)
		Myosin_head	83..764	CDD:278492	500/728 (69%)
		Motor_domain	95..764	CDD:277568	488/716 (68%)
		Actin-binding	654..676		20/21 (95%)
		Myosin_tail_1	842..1921	CDD:279860	586/1078 (54%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1035..1057		9/21 (43%)
		UBAN	1038..1149	CDD:301588	58/110 (53%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1117..1167		38/49 (78%)
		RRF	<1206..1261	CDD:294170	22/54 (41%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1327..1352		14/24 (58%)
		RILP-like	<1480..1587	CDD:304877	57/106 (54%)
		DUF2390	<1610..1678	CDD:295281	31/67 (46%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1768..1788		12/19 (63%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1877..1908		15/30 (50%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1939..1960		9/20 (45%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	1159	1.000	Domainoid score	I15
eggNOG	1	0.900	-	-		E2759_KOG0161
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	2332	1.000	Inparanoid score	I35
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D40305at33208
OrthoFinder	1	1.000	-	-		FOG0000014
OrthoInspector	1	1.000	-	-		otm44362
orthoMCL	1	0.900	-	-		OOG6_100110
Panther	1	1.100	-	-	LDO	PTHR45615
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R786
SonicParanoid	1	1.000	-	-		X58
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	13	12.860