DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment zip and Myh8

DIOPT Version :9

Sequence 1:NP_523860.2 Gene:zip / 38001 FlyBaseID:FBgn0265434 Length:2056 Species:Drosophila melanogaster
Sequence 2:XP_036012291.1 Gene:Myh8 / 17885 MGIID:1339712 Length:1966 Species:Mus musculus


Alignment Length:2004 Identity:769/2004 - (38%)
Similarity:1200/2004 - (59%) Gaps:109/2004 - (5%)


- Green bases have known domain annotations that are detailed below.


  Fly    55 PELKYLSVERNQFNDPATQAEWTQKRLVWVPHENQGFVAASIKREHGDEVEVELAETGKRVMILR 119
            |.|:....||.:    |....:..|..|:|....:.:|.:.|:.:.|.:|.|: .|:|..:.:..
Mouse    17 PYLRKSEKERIE----AQNKPFDAKTSVFVAEPKESYVKSVIQSKDGGKVTVK-TESGATLTVKE 76

  Fly   120 DDIQKMNPPKFDKVEDMAELTCLNEASVLHNIKDRYYSGLIYTYSGLFCVVVNPYKKLPIYTEKI 184
            |.:..|||||:||:||||.:|.|:|..||:|:|:||.:.:||||||||||.|||||.||:|..::
Mouse    77 DQVFPMNPPKYDKIEDMAMMTHLHEPGVLYNLKERYAAWMIYTYSGLFCVTVNPYKWLPVYNPEV 141

  Fly   185 MERYKGIKRHEVPPHVFAITDSAYRNMLGDREDQSILCTGESGAGKTENTKKVIQFLAYVAASKP 249
            :..|:|.||.|.|||:|:|:|:||:.||.|||:||||.|||||||||.|||:|||:.|.:|    
Mouse   142 VAAYRGKKRQEAPPHIFSISDNAYQFMLTDRENQSILITGESGAGKTVNTKRVIQYFATIA---- 202

  Fly   250 KGSGAVPHPAVLINFSVNTNKYIKVKIMAQNQNQTIEVVNGLKMVEVNSNCQEGELEQQLLQANP 314
                                                  |.|.|..| .|...:|.||.|::.|||
Mouse   203 --------------------------------------VTGDKKKE-ESGKMQGTLEDQIISANP 228

  Fly   315 ILEAFGNAKTVKNDNSSRFGKFIRINFDASGFISGANIETYLLEKSRAIRQAKDERTFHIFYQLL 379
            :||||||||||:|||||||||||||:|..:|.::.|:||||||||||...|.|.||::|||||:.
Mouse   229 LLEAFGNAKTVRNDNSSRFGKFIRIHFGTTGKLASADIETYLLEKSRVTFQLKAERSYHIFYQIT 293

  Fly   380 AGATPEQREKFIL-DDVKSYAFLSNGSLPVPGVDDYAEFQATVKSMNIMGMTSEDFNSIFRIVSA 443
            :...||..|..:: .:...|||:|.|.:.||.:||..|..||..:::|:|.:.|:..||:::..|
Mouse   294 SNKKPELIEMLLITTNPYDYAFVSQGEITVPSIDDQEELMATDSAIDILGFSPEEKVSIYKLTGA 358

  Fly   444 VLLFGSMKFRQERNNDQATLPDNT-VAQKIAHLLGLSVTDMTRAFLTPRIKVGRDFVTKAQTKEQ 507
            |:.:|:|||:|::..:||. ||.| ||.|.|:|..|:..|:.:|...||:|||.::|||.||.:|
Mouse   359 VMHYGNMKFKQKQREEQAE-PDGTEVADKAAYLQCLNSADLLKALCYPRVKVGNEYVTKGQTVQQ 422

  Fly   508 VEFAVEAIAKACYERMFKWLVNRINRSLDRTKRQGASFIGILDMAGFEIFELNSFEQLCINYTNE 572
            |..||.|:|||.||:||.|:|.|||:.|| ||:....|||:||:||||||:.||.||||||:|||
Mouse   423 VYNAVGALAKAVYEKMFLWMVTRINQQLD-TKQPRQYFIGVLDIAGFEIFDFNSLEQLCINFTNE 486

  Fly   573 KLQQLFNHTMFILEQEEYQREGIEWKFIDFGLDLQPTIDLIDKPGGIMALLDEECWFPKATDKTF 637
            ||||.|||.||:||||||::|||||.|||||:||...|:||:||.||.::|:|||.||||||.:|
Mouse   487 KLQQFFNHHMFVLEQEEYKKEGIEWTFIDFGMDLAACIELIEKPLGIFSILEEECMFPKATDTSF 551

  Fly   638 VDKLVSAH-SMHPKFMK---TDFRGVADFAIVHYAGRVDYSAAKWLMKNMDPLNENIVSLLQGSQ 698
            .:||...| .....|.|   |..:..|.|::|||||.|||:...||.||.||||:.:|.|.|.|.
Mouse   552 KNKLYDQHLGKSNNFQKPKPTKGKAEAHFSLVHYAGTVDYNITGWLDKNKDPLNDTVVGLYQKSA 616

  Fly   699 DPFVVNI---WKDAEIVGMAQQALTDTQFGARTRKGMFRTVSHLYKEQLAKLMDTLRNTNPNFVR 760
            ...:.::   :..||..|.|::       ||:.:...|:|||.|::|.|.|||..||:|:|:|||
Mouse   617 MKTLASLFSTYASAEADGGAKK-------GAKKKGSSFQTVSALFRENLNKLMTNLRSTHPHFVR 674

  Fly   761 CIIPNHEKRAGKIDAPLVLDQLRCNGVLEGIRICRQGFPNRIPFQEFRQRYELLTPNVIPKG-FM 824
            |||||..|..|.::..|||.|||||||||||||||:|||:||.:.:|:|||::|..:.||:| |:
Mouse   675 CIIPNETKTPGAMEHELVLHQLRCNGVLEGIRICRKGFPSRILYGDFKQRYKVLNASAIPEGQFI 739

  Fly   825 DGKKACEKMIQALELDSNLYRVGQSKIFFRAGVLAHLEEERDFKISDLIVNFQAFCRGFLARRNY 889
            |.|||.||::.::::|...|:.|.:|:||:||:|..|||.||.|::.:|...||.|||:|.|..|
Mouse   740 DSKKASEKLLGSIDIDHTQYKFGHTKVFFKAGLLGLLEEMRDEKLAQIITRTQAVCRGYLMRVEY 804

  Fly   890 QKRLQQLNAIRIIQRNCAAYLKLRNWQWWRLYTKVKPLLEVTKQEEKLVQKEDELKQVREKLDTL 954
            ||.|.:..:|..||.|..|::.:::|.|.:|:.|:||||:..:.|:::...::|.::.:::|...
Mouse   805 QKMLLRRESIFCIQYNVRAFMNVKHWPWMKLFFKIKPLLKSAETEKEMATMKEEFQKTKDELAKS 869

  Fly   955 AKNTQEYERKYQQALVEKTTLAEQLQAEIELCAEAEESRSRLMARKQELEDMMQELETRIEEEEE 1019
            ....:|.|.|....|.||..|..|:|:|.:..|:|||...:|:..|.:||..::|:..|.|:|||
Mouse   870 EAKRKELEEKMVTLLKEKNDLQLQVQSEADSLADAEERCEQLIKNKIQLEAKIKEVTERAEDEEE 934

  Fly  1020 RVLALGGEKKKLELNIQDLEEQLEEEEAARQKLQLEKVQLDAKIKKYEEDLALTDDQNQKLLKEK 1084
            ....|..:|:|||....:|::.:::.|....|::.||...:.|:|...|::|..|:...||.|||
Mouse   935 INAELTAKKRKLEDECSELKKDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDENIAKLTKEK 999

  Fly  1085 KLLEERANDLSQTLAEEEEKAKHLAKLKAKHEATISELEERLHKDQQQRQESDRSKRKIETEVAD 1149
            |.|:|........|..||:|...|.|.|.|.|..:.:||..|.::::.|.:.:|:|||:|.::..
Mouse  1000 KALQEAHQQTLDDLQAEEDKVNTLTKAKTKLEQQVDDLEGSLEQEKKLRMDLERAKRKLEGDLKL 1064

  Fly  1150 LKE---QLNERRVQVDEMQAQLAKREEELTQTLLRIDEESATKATAQKAQRELESQLAEIQEDLE 1211
            .:|   .:...:.|:||   :|.|:|.|::..:.:|::|.|.:...||..:||::::.|::|::|
Mouse  1065 AQESTMDIENDKQQLDE---KLKKKEFEISNLISKIEDEQAVEIQLQKKIKELQARIEELEEEIE 1126

  Fly  1212 AEKAARAKAEKVRRDLSEELEALKNELLDSLDTTAAQQELRSKREQELATLKKSLEEETVNHEGV 1276
            ||:|:||||||.|.|||.|||.:...|.::...|:||.|:..|||.|...|::.|||.|:.||..
Mouse  1127 AERASRAKAEKQRSDLSRELEEISERLEEAGGATSAQVEMNKKRETEFQKLRRDLEEATLQHEAT 1191

  Fly  1277 LADMRHKHSQELNSINDQLENLRKAKTVLEKAKGTLEAENADLATELRSVNSSRQENDRRRKQAE 1341
            .|.:|.||:..:..:.:|::||::.|..|||.|..|:.|..||::...::..::...::..:..|
Mouse  1192 AAALRKKHADSVAELGEQIDNLQRVKQKLEKEKSELKMEIDDLSSNAEAIAKAKGNLEKMCRTLE 1256

  Fly  1342 SQIAELQVKLAEIERARSELQEKCTKLQQEAENITNQLEEAELKASAAVKSASNMESQLTEAQQL 1406
            .|::||:.|..|.:|..:||..:..:||.||...:.||:|.:...|...:|......|:.|.::.
Mouse  1257 DQVSELKSKEEEQQRLINELTAQRARLQTEAGEYSRQLDEKDALVSQLSRSKQASTQQIEELKRQ 1321

  Fly  1407 LEEETRQKLGLSSKLRQIESEKEALQEQLEEDDEAKRNYERKLAEVTTQMQEIKKKAEEDA-DLA 1470
            |||||:.|..|:..|:....:.:.|:||.||:.|.|...:|.|::..:::.:.:.|.|.|| ...
Mouse  1322 LEEETKAKNALAHALQSSRHDCDLLREQYEEEQEGKAELQRALSKANSEVAQWRTKYETDAIQRT 1386

  Fly  1471 KELEEGKKRLNKDIEALERQVKELIAQNDRLDKSKKKIQSELEDATIELEAQRTKVLELEKKQKN 1535
            :||||.||:|.:.::|.|..|:.:.|:...|:|:|:::|:|:||..|::|........|:|||:|
Mouse  1387 EELEEAKKKLAQRLQAAEEHVEAVNAKCASLEKTKQRLQNEVEDLMIDVERTNAACAALDKKQRN 1451

  Fly  1536 FDKILAEEKAISEQIAQERDTAEREAREKETKVLSVSRELDEAFDKIEDLENKRKTLQNELDDLA 1600
            |||:|:|.:...|:...|.::.::|:|...|::..|....:|:.|.:|.|..:.|.||.|:.||.
Mouse  1452 FDKVLSEWRQKYEETQAELESCQKESRTLSTELFKVKNAYEESLDHLETLRRENKNLQQEISDLT 1516

  Fly  1601 NTQGTADKNVHELEKAKRALESQLAELKAQNEELEDDLQLTEDAKLRLEVNMQALRSQFERDLLA 1665
            .......|::|||||.|:.:|.:..|::|..||.|..|:..|...||:::.:..::|:.:|.:..
Mouse  1517 EQIAEGGKHIHELEKIKKQVEQEKCEIQAALEEAEASLEHEEGKILRIQLELNQVKSEIDRKIAE 1581

  Fly  1666 KEEGAEEKRRGLVKQLRDLETELDEERKQRTAAVASKKKLEGDLKEIETTMEMHNKVKEDALKHA 1730
            |:|..::.:|..|:.:..:::.||.|.:.|..|:..|||:||||.|:|..:...|::..::|::.
Mouse  1582 KDEEIDQLKRNHVRVVETMQSTLDAEIRSRNDALRVKKKMEGDLNEMEIQLNHANRLAAESLRNY 1646

  Fly  1731 KKLQAQVKDALRDAEEAKAAKEELQALSKEAERKVKALEAEVLQLTEDLASSERARRAAETERDE 1795
            :..|..:||.....::|...:|:|:......||:...|:||:.:|...|..:||:|:.||.|..:
Mouse  1647 RNTQGILKDTQLHLDDALRGQEDLKEQLAIVERRANLLQAEIEELRATLEQTERSRKIAEQELLD 1711

  Fly  1796 LAEEIANNANKGSLMIDEKRRLEARIATLEEELEE---EQSNSEVLLDRSRKA------------ 1845
            .:|.:.....:.:.:|:.|::||..::.|:.|:||   |..|:|   ::::||            
Mouse  1712 ASERVQLLHTQNTSLINTKKKLENDVSQLQSEVEEVIQESRNAE---EKAKKAITDVSTTHITLP 1773

  Fly  1846 -----------------QLQIEQLTTELANEKSNSQKNENGRALLERQNKELKAKLAEIETAQRT 1893
                             ..|...:..||..|:..|...|..:..:|:..|:|:.:|.|.|.....
Mouse  1774 TPVLPATTRAYFCLDLFASQAAMMAEELKKEQDTSAHLERMKKNMEQTVKDLQHRLDEAEQLALK 1838

  Fly  1894 KVKATIATLEAKIANLEEQLENEGKERLLQQKANRKMDKKIKELTMNIEDERRHVDQHKEQMDKL 1958
            ..|..|..|||::..||.::|||.|......|..||.::::||||...|::|::|.:.::.:|||
Mouse  1839 GGKKQIQKLEARVRELEGEVENEQKRNAEAVKGLRKHERRVKELTYQTEEDRKNVLRLQDLVDKL 1903

  Fly  1959 NSRIKLLKRNLDETEEELQKEKTQKRKYQRECEDMIESQEAMNREINSLKTKLR 2012
            .:::|..||..:|.||:......:.||.|.|.|:..|..:....::|.|:.|.|
Mouse  1904 QAKVKSYKRQAEEAEEQSNANLAKFRKLQHELEEAEERADIAESQVNKLRVKSR 1957

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
zipNP_523860.2 Myosin_N 80..117 CDD:280832 9/36 (25%)
Myosin_head 133..854 CDD:278492 366/730 (50%)
MYSc_Myh2_insects_mollusks 145..854 CDD:276876 359/718 (50%)
Myosin_tail_1 931..2011 CDD:279860 343/1115 (31%)
Prefoldin 1431..1515 CDD:298833 30/84 (36%)
FAM76 <1847..1926 CDD:292665 23/78 (29%)
Myh8XP_036012291.1 Myosin_N 37..75 CDD:397036 10/38 (26%)
Motor_domain 102..769 CDD:419868 359/718 (50%)
Myosin_tail_1 849..1955 CDD:396244 343/1111 (31%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E2759_KOG0161
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D47111at2759
OrthoFinder 1 1.000 - - FOG0000014
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 1 0.900 - - OOG6_100110
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 1 1.000 - - X58
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
65.720

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