DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment zip and Myh4

DIOPT Version :9

Sequence 1:NP_523860.2 Gene:zip / 38001 FlyBaseID:FBgn0265434 Length:2056 Species:Drosophila melanogaster
Sequence 2:NP_034985.2 Gene:Myh4 / 17884 MGIID:1339713 Length:1939 Species:Mus musculus


Alignment Length:1977 Identity:752/1977 - (38%)
Similarity:1199/1977 - (60%) Gaps:81/1977 - (4%)


- Green bases have known domain annotations that are detailed below.


  Fly    55 PELKYLSVERNQFNDPATQAEWTQKRLVWVPHENQGFVAASIKREHGDEVEVELAETGKRVMILR 119
            |.|:....||.:    |....:..|..|:|....:.:|.|:::...|.:|..: .|.|..|.:..
Mouse    15 PYLRKSEKERIE----AQNKPFDAKSSVFVVDAKESYVKATVQSREGGKVTAK-TEGGATVTVKD 74

  Fly   120 DDIQKMNPPKFDKVEDMAELTCLNEASVLHNIKDRYYSGLIYTYSGLFCVVVNPYKKLPIYTEKI 184
            |.:..|||||:||:||||.:|.|:|.:||:|:|:||.:.:||||||||||.|||||.||:|..::
Mouse    75 DQVFSMNPPKYDKIEDMAMMTHLHEPAVLYNLKERYAAWMIYTYSGLFCVTVNPYKWLPVYNPEV 139

  Fly   185 MERYKGIKRHEVPPHVFAITDSAYRNMLGDREDQSILCTGESGAGKTENTKKVIQFLAYVAASKP 249
            :..|:|.||.|.|||:|:|:|:||:.||.|||:||||.|||||||||.|||:|||:.|       
Mouse   140 VAAYRGKKRQEAPPHIFSISDNAYQFMLTDRENQSILITGESGAGKTVNTKRVIQYFA------- 197

  Fly   250 KGSGAVPHPAVLINFSVNTNKYIKVKIMAQNQNQTIEVVNGLKMVEVNSNCQEGELEQQLLQANP 314
                                              ||.|....|..|..|...:|.||.|::.|||
Mouse   198 ----------------------------------TIAVTGDKKKEEATSGKMQGTLEDQIISANP 228

  Fly   315 ILEAFGNAKTVKNDNSSRFGKFIRINFDASGFISGANIETYLLEKSRAIRQAKDERTFHIFYQLL 379
            :||||||||||:|||||||||||||:|.|:|.::.|:||||||||||...|.|.||::|||||::
Mouse   229 LLEAFGNAKTVRNDNSSRFGKFIRIHFGATGKLASADIETYLLEKSRVTFQLKAERSYHIFYQIM 293

  Fly   380 AGATPEQREKFIL-DDVKSYAFLSNGSLPVPGVDDYAEFQATVKSMNIMGMTSEDFNSIFRIVSA 443
            :...||..|..:: .:...:|::|.|.:.||.:||..|..||..:::|:|.::::..:|:::..|
Mouse   294 SNKKPELIEMLLITTNPYDFAYVSQGEITVPSIDDQEELMATDTAVDILGFSADEKVAIYKLTGA 358

  Fly   444 VLLFGSMKFRQERNNDQATLPDNT-VAQKIAHLLGLSVTDMTRAFLTPRIKVGRDFVTKAQTKEQ 507
            |:.:|:|||:|::..:||. ||.| ||.|.|:|..|:..|:.:|...||:|||.::|||.||.:|
Mouse   359 VMHYGNMKFKQKQREEQAE-PDGTEVADKAAYLTSLNSADLLKALCYPRVKVGNEYVTKGQTVQQ 422

  Fly   508 VEFAVEAIAKACYERMFKWLVNRINRSLDRTKRQGASFIGILDMAGFEIFELNSFEQLCINYTNE 572
            |..:|.|:||:.||:||.|:|.|||:.|| ||:....|||:||:||||||:.|:.||||||:|||
Mouse   423 VYNSVGALAKSMYEKMFLWMVTRINQQLD-TKQPRQYFIGVLDIAGFEIFDFNTLEQLCINFTNE 486

  Fly   573 KLQQLFNHTMFILEQEEYQREGIEWKFIDFGLDLQPTIDLIDKPGGIMALLDEECWFPKATDKTF 637
            ||||.|||.||:||||||::|||:|:|||||:||...|:||:||.||.::|:|||.||||||.:|
Mouse   487 KLQQFFNHHMFVLEQEEYKKEGIDWEFIDFGMDLAACIELIEKPMGIFSILEEECMFPKATDTSF 551

  Fly   638 VDKLVSAH------SMHPKFMKTDFRGVADFAIVHYAGRVDYSAAKWLMKNMDPLNENIVSLLQG 696
            .:||...|      ...||..|.  :..|.|::|||||.|||:...||.||.|||||.:|.|.|.
Mouse   552 KNKLYEQHLGKSNNFQKPKPAKG--KAEAHFSLVHYAGTVDYNIIGWLDKNKDPLNETVVGLYQK 614

  Fly   697 S---QDPFVVNIWKDAEIVGMAQQALTDTQFGARTRKGMFRTVSHLYKEQLAKLMDTLRNTNPNF 758
            |   ...|:.:..:.||..|...:.      |.:.:...|:|||.|::|.|.|||..|::|:|:|
Mouse   615 SGLKTLAFLFSGGQAAEAEGGGGKK------GGKKKGSSFQTVSALFRENLNKLMTNLKSTHPHF 673

  Fly   759 VRCIIPNHEKRAGKIDAPLVLDQLRCNGVLEGIRICRQGFPNRIPFQEFRQRYELLTPNVIPKG- 822
            |||:|||..|..|.::..|||.|||||||||||||||:|||:||.:.:|:|||::|..:.||:| 
Mouse   674 VRCLIPNETKTPGAMEHELVLHQLRCNGVLEGIRICRKGFPSRILYADFKQRYKVLNASAIPEGQ 738

  Fly   823 FMDGKKACEKMIQALELDSNLYRVGQSKIFFRAGVLAHLEEERDFKISDLIVNFQAFCRGFLARR 887
            |:|.|||.||::.::::|...|:.|.:|:||:||:|..|||.||.|::.||...||.|||:|.|.
Mouse   739 FIDSKKASEKLLGSIDIDHTQYKFGHTKVFFKAGLLGTLEEMRDEKLAQLITRTQAVCRGYLMRV 803

  Fly   888 NYQKRLQQLNAIRIIQRNCAAYLKLRNWQWWRLYTKVKPLLEVTKQEEKLVQKEDELKQVREKLD 952
            .::|.:::..:|..||.|..|::.:::|.|.:||.|:||||:..:.|:::...:::.::.:|.|.
Mouse   804 EFKKMMERRESIFCIQYNVRAFMNVKHWPWMKLYFKIKPLLKSAETEKEMANMKEDFEKAKEDLA 868

  Fly   953 TLAKNTQEYERKYQQALVEKTTLAEQLQAEIELCAEAEESRSRLMARKQELEDMMQELETRIEEE 1017
            ......:|.|.|....:.||..|..|:|||.:..|:|||...:|:..|.:||..::||..|.|:|
Mouse   869 KSEAKRKELEEKMVALMQEKNDLQLQVQAEADGLADAEERCDQLIKTKIQLEAKIKELTERAEDE 933

  Fly  1018 EERVLALGGEKKKLELNIQDLEEQLEEEEAARQKLQLEKVQLDAKIKKYEEDLALTDDQNQKLLK 1082
            ||....|..:|:|||....:|::.:::.|....|::.||...:.|:|...|::|..|:...||.|
Mouse   934 EEINAELTAKKRKLEDECSELKKDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDENIAKLTK 998

  Fly  1083 EKKLLEERANDLSQTLAEEEEKAKHLAKLKAKHEATISELEERLHKDQQQRQESDRSKRKIETEV 1147
            |||.|:|........|..||:|...|.|.|.|.|..:.:||..|.::::.|.:.:|:|||:|.::
Mouse   999 EKKALQEAHQQTLDDLQAEEDKVNTLTKAKTKLEQQVDDLEGSLEQEKKLRMDLERAKRKLEGDL 1063

  Fly  1148 ADLKE---QLNERRVQVDEMQAQLAKREEELTQTLLRIDEESATKATAQKAQRELESQLAEIQED 1209
            ...:|   .:...:.|:||   :|.|:|.|::....:|::|.|.....||..:||::::.|::|:
Mouse  1064 KLAQESTMDIENDKQQLDE---KLKKKEFEMSNLQSKIEDEQALGMQLQKKIKELQARIEELEEE 1125

  Fly  1210 LEAEKAARAKAEKVRRDLSEELEALKNELLDSLDTTAAQQELRSKREQELATLKKSLEEETVNHE 1274
            :|||:|:||||||.|.|||.|||.:...|.::...|:||.|:..|||.|...:::.|||.|:.||
Mouse  1126 IEAERASRAKAEKQRSDLSRELEEISERLEEAGGATSAQIEMNKKREAEFQKMRRDLEEATLQHE 1190

  Fly  1275 GVLADMRHKHSQELNSINDQLENLRKAKTVLEKAKGTLEAENADLATELRSVNSSRQENDRRRKQ 1339
            ...|.:|.||:..:..:.:|::||::.|..|||.|..|:.|..|||:.:.:|:.::...::..:.
Mouse  1191 ATAAALRKKHADSVAELGEQIDNLQRVKQKLEKEKSELKMEIDDLASNMETVSKAKGNLEKMCRT 1255

  Fly  1340 AESQIAELQVKLAEIERARSELQEKCTKLQQEAENITNQLEEAELKASAAVKSASNMESQLTEAQ 1404
            .|.|::|::.|..|.:|..:||..:..:|..|:...:.||:|.:...|...:.......|:.|.:
Mouse  1256 LEDQLSEVKTKEEEQQRLINELSTQKARLHTESGEFSRQLDEKDAMVSQLSRGKQAFTQQIEELK 1320

  Fly  1405 QLLEEETRQKLGLSSKLRQIESEKEALQEQLEEDDEAKRNYERKLAEVTTQMQEIKKKAEEDA-D 1468
            :.||||::.|..|:..|:....:.:.|:||.||:.|||...:|.:::..:::.:.:.|.|.|| .
Mouse  1321 RQLEEESKAKNALAHALQSARHDCDLLREQYEEEQEAKAELQRAMSKANSEVAQWRTKYETDAIQ 1385

  Fly  1469 LAKELEEGKKRLNKDIEALERQVKELIAQNDRLDKSKKKIQSELEDATIELEAQRTKVLELEKKQ 1533
            ..:||||.||:|.:.::..|..|:.:.::...|:|:|:::|:|:||..|::|........|:|||
Mouse  1386 RTEELEEAKKKLAQRLQDAEEHVEAVNSKCASLEKTKQRLQNEVEDLMIDVERSNAACAALDKKQ 1450

  Fly  1534 KNFDKILAEEKAISEQIAQERDTAEREAREKETKVLSVSRELDEAFDKIEDLENKRKTLQNELDD 1598
            :||||:|||.|...|:...|.:.:::|:|...|::..|....:|:.|::|.|:.:.|.||.|:.|
Mouse  1451 RNFDKVLAEWKQKYEETQAELEASQKESRSLSTELFKVKNAYEESLDQLETLKRENKNLQQEISD 1515

  Fly  1599 LANTQGTADKNVHELEKAKRALESQLAELKAQNEELEDDLQLTEDAKLRLEVNMQALRSQFERDL 1663
            |........|::|||||.|:.::.:.:||:|..||.|..|:..|...||:::.:..::|:.:|.:
Mouse  1516 LTEQIAEGGKHIHELEKIKKQIDQEKSELQASLEEAEASLEHEEGKILRIQLELNQVKSEIDRKI 1580

  Fly  1664 LAKEEGAEEKRRGLVKQLRDLETELDEERKQRTAAVASKKKLEGDLKEIETTMEMHNKVKEDALK 1728
            ..|:|..::.:|..::.:..:::.||.|.:.|..|:..|||:||||.|:|..:...|:...:|::
Mouse  1581 AEKDEEIDQLKRNHLRVVESMQSTLDAEIRSRNDALRIKKKMEGDLNEMEIQLNHANRQAAEAIR 1645

  Fly  1729 HAKKLQAQVKDALRDAEEAKAAKEELQALSKEAERKVKALEAEVLQLTEDLASSERARRAAETER 1793
            :.:..|..:||.....::|...:::|:......||:...::||:.:|...|..:||:||.||.|.
Mouse  1646 NLRNTQGMLKDTQLHLDDALRGQDDLKEQLAMVERRANLMQAEIEELRASLEQTERSRRVAEQEL 1710

  Fly  1794 DELAEEIANNANKGSLMIDEKRRLEARIATLEEELE---EEQSNSEVLLDRSRKAQLQIEQLTTE 1855
            .:.:|.:.....:.:.:|:.|::||..|:.::.|:|   :|..|:|   ::::||......:..|
Mouse  1711 LDASERVQLLHTQNTSLINTKKKLETDISQIQGEMEDIVQEARNAE---EKAKKAITDAAMMAEE 1772

  Fly  1856 LANEKSNSQKNENGRALLERQNKELKAKLAEIETAQRTKVKATIATLEAKIANLEEQLENEGKER 1920
            |..|:..|...|..:..:|:..|:|:.:|.|.|.......|..|..|||::..||.::|||.|..
Mouse  1773 LKKEQDTSAHLERMKKNMEQTVKDLQHRLDEAEQLALKGGKKQIQKLEARVRELENEVENEQKRN 1837

  Fly  1921 LLQQKANRKMDKKIKELTMNIEDERRHVDQHKEQMDKLNSRIKLLKRNLDETEEELQKEKTQKRK 1985
            :...|..||.::::||||...|::|::|.:.::.:|||.:::|..||..:|.||:......:.||
Mouse  1838 IEAVKGLRKHERRVKELTYQTEEDRKNVLRLQDLVDKLQTKVKAYKRQAEEAEEQSNVNLAKFRK 1902

  Fly  1986 YQRECEDMIESQEAMNREINSLKTKLR 2012
            .|.|.|:..|..:....::|.|:.|.|
Mouse  1903 IQHELEEAEERADIAESQVNKLRVKSR 1929

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
zipNP_523860.2 Myosin_N 80..117 CDD:280832 9/36 (25%)
Myosin_head 133..854 CDD:278492 357/732 (49%)
MYSc_Myh2_insects_mollusks 145..854 CDD:276876 350/720 (49%)
Myosin_tail_1 931..2011 CDD:279860 336/1086 (31%)
Prefoldin 1431..1515 CDD:298833 28/84 (33%)
FAM76 <1847..1926 CDD:292665 22/78 (28%)
Myh4NP_034985.2 Myosin_N 35..73 CDD:308391 10/38 (26%)
MYSc_Myh4 100..770 CDD:276879 350/720 (49%)
Actin-binding. /evidence=ECO:0000250 659..681 13/21 (62%)
Actin-binding. /evidence=ECO:0000250 761..775 6/13 (46%)
SMC_N 850..1927 CDD:330553 336/1082 (31%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1128..1147 13/18 (72%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1153..1172 6/18 (33%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1276..1299 7/22 (32%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E2759_KOG0161
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D47111at2759
OrthoFinder 1 1.000 - - FOG0000014
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 1 0.900 - - OOG6_100110
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 1 1.000 - - X58
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
76.720

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