Protein Alignment zip and Myh4

DIOPT Version :10

• Sequence 1: NP_523860.2
• Gene: zip / 38001
• FlyBaseID: FBgn0287873
• Length: 2056
• Species: Drosophila melanogaster
• Sequence 2: NP_034985.2
• Gene: Myh4 / 17884
• MGIID: 1339713
• Length: 1939
• Species: Mus musculus
• Alignment Length: 1977
• Identity: 752/1977 - (38%)
• Similarity: 1199/1977 - (60%)
• Gaps: 81/1977 - (4%)

  Fly    55 PELKYLSVERNQFNDPATQAEWTQKRLVWVPHENQGFVAASIKREHGDEVEVELAETGKRVMILR 119
            |.|:....||.:    |....:..|..|:|....:.:|.|:::...|.:|..: .|.|..|.:..
Mouse    15 PYLRKSEKERIE----AQNKPFDAKSSVFVVDAKESYVKATVQSREGGKVTAK-TEGGATVTVKD 74

  Fly   120 DDIQKMNPPKFDKVEDMAELTCLNEASVLHNIKDRYYSGLIYTYSGLFCVVVNPYKKLPIYTEKI 184
            |.:..|||||:||:||||.:|.|:|.:||:|:|:||.:.:||||||||||.|||||.||:|..::
Mouse    75 DQVFSMNPPKYDKIEDMAMMTHLHEPAVLYNLKERYAAWMIYTYSGLFCVTVNPYKWLPVYNPEV 139

  Fly   185 MERYKGIKRHEVPPHVFAITDSAYRNMLGDREDQSILCTGESGAGKTENTKKVIQFLAYVAASKP 249
            :..|:|.||.|.|||:|:|:|:||:.||.|||:||||.|||||||||.|||:|||:.|
Mouse   140 VAAYRGKKRQEAPPHIFSISDNAYQFMLTDRENQSILITGESGAGKTVNTKRVIQYFA------- 197

  Fly   250 KGSGAVPHPAVLINFSVNTNKYIKVKIMAQNQNQTIEVVNGLKMVEVNSNCQEGELEQQLLQANP 314
                                              ||.|....|..|..|...:|.||.|::.|||
Mouse   198 ----------------------------------TIAVTGDKKKEEATSGKMQGTLEDQIISANP 228

  Fly   315 ILEAFGNAKTVKNDNSSRFGKFIRINFDASGFISGANIETYLLEKSRAIRQAKDERTFHIFYQLL 379
            :||||||||||:|||||||||||||:|.|:|.::.|:||||||||||...|.|.||::|||||::
Mouse   229 LLEAFGNAKTVRNDNSSRFGKFIRIHFGATGKLASADIETYLLEKSRVTFQLKAERSYHIFYQIM 293

  Fly   380 AGATPEQREKFIL-DDVKSYAFLSNGSLPVPGVDDYAEFQATVKSMNIMGMTSEDFNSIFRIVSA 443
            :...||..|..:: .:...:|::|.|.:.||.:||..|..||..:::|:|.::::..:|:::..|
Mouse   294 SNKKPELIEMLLITTNPYDFAYVSQGEITVPSIDDQEELMATDTAVDILGFSADEKVAIYKLTGA 358

  Fly   444 VLLFGSMKFRQERNNDQATLPDNT-VAQKIAHLLGLSVTDMTRAFLTPRIKVGRDFVTKAQTKEQ 507
            |:.:|:|||:|::..:||. ||.| ||.|.|:|..|:..|:.:|...||:|||.::|||.||.:|
Mouse   359 VMHYGNMKFKQKQREEQAE-PDGTEVADKAAYLTSLNSADLLKALCYPRVKVGNEYVTKGQTVQQ 422

  Fly   508 VEFAVEAIAKACYERMFKWLVNRINRSLDRTKRQGASFIGILDMAGFEIFELNSFEQLCINYTNE 572
            |..:|.|:||:.||:||.|:|.|||:.|| ||:....|||:||:||||||:.|:.||||||:|||
Mouse   423 VYNSVGALAKSMYEKMFLWMVTRINQQLD-TKQPRQYFIGVLDIAGFEIFDFNTLEQLCINFTNE 486

  Fly   573 KLQQLFNHTMFILEQEEYQREGIEWKFIDFGLDLQPTIDLIDKPGGIMALLDEECWFPKATDKTF 637
            ||||.|||.||:||||||::|||:|:|||||:||...|:||:||.||.::|:|||.||||||.:|
Mouse   487 KLQQFFNHHMFVLEQEEYKKEGIDWEFIDFGMDLAACIELIEKPMGIFSILEEECMFPKATDTSF 551

  Fly   638 VDKLVSAH------SMHPKFMKTDFRGVADFAIVHYAGRVDYSAAKWLMKNMDPLNENIVSLLQG 696
            .:||...|      ...||..|.  :..|.|::|||||.|||:...||.||.|||||.:|.|.|.
Mouse   552 KNKLYEQHLGKSNNFQKPKPAKG--KAEAHFSLVHYAGTVDYNIIGWLDKNKDPLNETVVGLYQK 614

  Fly   697 S---QDPFVVNIWKDAEIVGMAQQALTDTQFGARTRKGMFRTVSHLYKEQLAKLMDTLRNTNPNF 758
            |   ...|:.:..:.||..|...:.      |.:.:...|:|||.|::|.|.|||..|::|:|:|
Mouse   615 SGLKTLAFLFSGGQAAEAEGGGGKK------GGKKKGSSFQTVSALFRENLNKLMTNLKSTHPHF 673

  Fly   759 VRCIIPNHEKRAGKIDAPLVLDQLRCNGVLEGIRICRQGFPNRIPFQEFRQRYELLTPNVIPKG- 822
            |||:|||..|..|.::..|||.|||||||||||||||:|||:||.:.:|:|||::|..:.||:|
Mouse   674 VRCLIPNETKTPGAMEHELVLHQLRCNGVLEGIRICRKGFPSRILYADFKQRYKVLNASAIPEGQ 738

  Fly   823 FMDGKKACEKMIQALELDSNLYRVGQSKIFFRAGVLAHLEEERDFKISDLIVNFQAFCRGFLARR 887
            |:|.|||.||::.::::|...|:.|.:|:||:||:|..|||.||.|::.||...||.|||:|.|.
Mouse   739 FIDSKKASEKLLGSIDIDHTQYKFGHTKVFFKAGLLGTLEEMRDEKLAQLITRTQAVCRGYLMRV 803

  Fly   888 NYQKRLQQLNAIRIIQRNCAAYLKLRNWQWWRLYTKVKPLLEVTKQEEKLVQKEDELKQVREKLD 952
            .::|.:::..:|..||.|..|::.:::|.|.:||.|:||||:..:.|:::...:::.::.:|.|.
Mouse   804 EFKKMMERRESIFCIQYNVRAFMNVKHWPWMKLYFKIKPLLKSAETEKEMANMKEDFEKAKEDLA 868

  Fly   953 TLAKNTQEYERKYQQALVEKTTLAEQLQAEIELCAEAEESRSRLMARKQELEDMMQELETRIEEE 1017
            ......:|.|.|....:.||..|..|:|||.:..|:|||...:|:..|.:||..::||..|.|:|
Mouse   869 KSEAKRKELEEKMVALMQEKNDLQLQVQAEADGLADAEERCDQLIKTKIQLEAKIKELTERAEDE 933

  Fly  1018 EERVLALGGEKKKLELNIQDLEEQLEEEEAARQKLQLEKVQLDAKIKKYEEDLALTDDQNQKLLK 1082
            ||....|..:|:|||....:|::.:::.|....|::.||...:.|:|...|::|..|:...||.|
Mouse   934 EEINAELTAKKRKLEDECSELKKDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDENIAKLTK 998

  Fly  1083 EKKLLEERANDLSQTLAEEEEKAKHLAKLKAKHEATISELEERLHKDQQQRQESDRSKRKIETEV 1147
            |||.|:|........|..||:|...|.|.|.|.|..:.:||..|.::::.|.:.:|:|||:|.::
Mouse   999 EKKALQEAHQQTLDDLQAEEDKVNTLTKAKTKLEQQVDDLEGSLEQEKKLRMDLERAKRKLEGDL 1063

  Fly  1148 ADLKE---QLNERRVQVDEMQAQLAKREEELTQTLLRIDEESATKATAQKAQRELESQLAEIQED 1209
            ...:|   .:...:.|:||   :|.|:|.|::....:|::|.|.....||..:||::::.|::|:
Mouse  1064 KLAQESTMDIENDKQQLDE---KLKKKEFEMSNLQSKIEDEQALGMQLQKKIKELQARIEELEEE 1125

  Fly  1210 LEAEKAARAKAEKVRRDLSEELEALKNELLDSLDTTAAQQELRSKREQELATLKKSLEEETVNHE 1274
            :|||:|:||||||.|.|||.|||.:...|.::...|:||.|:..|||.|...:::.|||.|:.||
Mouse  1126 IEAERASRAKAEKQRSDLSRELEEISERLEEAGGATSAQIEMNKKREAEFQKMRRDLEEATLQHE 1190

  Fly  1275 GVLADMRHKHSQELNSINDQLENLRKAKTVLEKAKGTLEAENADLATELRSVNSSRQENDRRRKQ 1339
            ...|.:|.||:..:..:.:|::||::.|..|||.|..|:.|..|||:.:.:|:.::...::..:.
Mouse  1191 ATAAALRKKHADSVAELGEQIDNLQRVKQKLEKEKSELKMEIDDLASNMETVSKAKGNLEKMCRT 1255

  Fly  1340 AESQIAELQVKLAEIERARSELQEKCTKLQQEAENITNQLEEAELKASAAVKSASNMESQLTEAQ 1404
            .|.|::|::.|..|.:|..:||..:..:|..|:...:.||:|.:...|...:.......|:.|.:
Mouse  1256 LEDQLSEVKTKEEEQQRLINELSTQKARLHTESGEFSRQLDEKDAMVSQLSRGKQAFTQQIEELK 1320

  Fly  1405 QLLEEETRQKLGLSSKLRQIESEKEALQEQLEEDDEAKRNYERKLAEVTTQMQEIKKKAEEDA-D 1468
            :.||||::.|..|:..|:....:.:.|:||.||:.|||...:|.:::..:::.:.:.|.|.|| .
Mouse  1321 RQLEEESKAKNALAHALQSARHDCDLLREQYEEEQEAKAELQRAMSKANSEVAQWRTKYETDAIQ 1385

  Fly  1469 LAKELEEGKKRLNKDIEALERQVKELIAQNDRLDKSKKKIQSELEDATIELEAQRTKVLELEKKQ 1533
            ..:||||.||:|.:.::..|..|:.:.::...|:|:|:::|:|:||..|::|........|:|||
Mouse  1386 RTEELEEAKKKLAQRLQDAEEHVEAVNSKCASLEKTKQRLQNEVEDLMIDVERSNAACAALDKKQ 1450

  Fly  1534 KNFDKILAEEKAISEQIAQERDTAEREAREKETKVLSVSRELDEAFDKIEDLENKRKTLQNELDD 1598
            :||||:|||.|...|:...|.:.:::|:|...|::..|....:|:.|::|.|:.:.|.||.|:.|
Mouse  1451 RNFDKVLAEWKQKYEETQAELEASQKESRSLSTELFKVKNAYEESLDQLETLKRENKNLQQEISD 1515

  Fly  1599 LANTQGTADKNVHELEKAKRALESQLAELKAQNEELEDDLQLTEDAKLRLEVNMQALRSQFERDL 1663
            |........|::|||||.|:.::.:.:||:|..||.|..|:..|...||:::.:..::|:.:|.:
Mouse  1516 LTEQIAEGGKHIHELEKIKKQIDQEKSELQASLEEAEASLEHEEGKILRIQLELNQVKSEIDRKI 1580

  Fly  1664 LAKEEGAEEKRRGLVKQLRDLETELDEERKQRTAAVASKKKLEGDLKEIETTMEMHNKVKEDALK 1728
            ..|:|..::.:|..::.:..:::.||.|.:.|..|:..|||:||||.|:|..:...|:...:|::
Mouse  1581 AEKDEEIDQLKRNHLRVVESMQSTLDAEIRSRNDALRIKKKMEGDLNEMEIQLNHANRQAAEAIR 1645

  Fly  1729 HAKKLQAQVKDALRDAEEAKAAKEELQALSKEAERKVKALEAEVLQLTEDLASSERARRAAETER 1793
            :.:..|..:||.....::|...:::|:......||:...::||:.:|...|..:||:||.||.|.
Mouse  1646 NLRNTQGMLKDTQLHLDDALRGQDDLKEQLAMVERRANLMQAEIEELRASLEQTERSRRVAEQEL 1710

  Fly  1794 DELAEEIANNANKGSLMIDEKRRLEARIATLEEELE---EEQSNSEVLLDRSRKAQLQIEQLTTE 1855
            .:.:|.:.....:.:.:|:.|::||..|:.::.|:|   :|..|:|   ::::||......:..|
Mouse  1711 LDASERVQLLHTQNTSLINTKKKLETDISQIQGEMEDIVQEARNAE---EKAKKAITDAAMMAEE 1772

  Fly  1856 LANEKSNSQKNENGRALLERQNKELKAKLAEIETAQRTKVKATIATLEAKIANLEEQLENEGKER 1920
            |..|:..|...|..:..:|:..|:|:.:|.|.|.......|..|..|||::..||.::|||.|..
Mouse  1773 LKKEQDTSAHLERMKKNMEQTVKDLQHRLDEAEQLALKGGKKQIQKLEARVRELENEVENEQKRN 1837

  Fly  1921 LLQQKANRKMDKKIKELTMNIEDERRHVDQHKEQMDKLNSRIKLLKRNLDETEEELQKEKTQKRK 1985
            :...|..||.::::||||...|::|::|.:.::.:|||.:::|..||..:|.||:......:.||
Mouse  1838 IEAVKGLRKHERRVKELTYQTEEDRKNVLRLQDLVDKLQTKVKAYKRQAEEAEEQSNVNLAKFRK 1902

  Fly  1986 YQRECEDMIESQEAMNREINSLKTKLR 2012
            .|.|.|:..|..:....::|.|:.|.|
Mouse  1903 IQHELEEAEERADIAESQVNKLRVKSR 1929

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
zip	NP_523860.2	Myosin_N	79..122	CDD:460670	11/42 (26%)
		MYSc_Myh2_insects_mollusks	145..854	CDD:276876	350/720 (49%)
		Myosin_tail_1	931..2011	CDD:460256	336/1086 (31%)
Myh4	NP_034985.2	Myosin_N	33..77	CDD:460670	11/44 (25%)
		MYSc_Myh4	100..770	CDD:276879	350/720 (49%)
		Actin-binding. /evidence=ECO:0000250	659..681		13/21 (62%)
		Actin-binding. /evidence=ECO:0000250	761..775		6/13 (46%)
		Myosin_tail_1	850..1927	CDD:460256	336/1082 (31%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1128..1147		13/18 (72%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1153..1172		6/18 (33%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1276..1299		7/22 (32%)