DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment zip and Myh3

DIOPT Version :9

Sequence 1:NP_523860.2 Gene:zip / 38001 FlyBaseID:FBgn0265434 Length:2056 Species:Drosophila melanogaster
Sequence 2:NP_001093105.1 Gene:Myh3 / 17883 MGIID:1339709 Length:1940 Species:Mus musculus


Alignment Length:1998 Identity:780/1998 - (39%)
Similarity:1198/1998 - (59%) Gaps:107/1998 - (5%)


- Green bases have known domain annotations that are detailed below.


  Fly    55 PELKYLSVERNQFNDPATQAEWTQKRLVWVPHENQGFVAASIKREHGDEVEVELAETGKRVMILR 119
            |.|:....||.:    |....:..|...:|....:.:|...||.....:|.|| .|..:.:::..
Mouse    15 PFLRKSEKERIE----AQNQPFDAKTYCFVVDSKEEYVKGKIKSSQDGKVTVE-TEDSRTLVVKP 74

  Fly   120 DDIQKMNPPKFDKVEDMAELTCLNEASVLHNIKDRYYSGLIYTYSGLFCVVVNPYKKLPIYTEKI 184
            :|:..||||||||:||||.||.|||.:||:|:||||.|.:||||||||||.|||||.||:|..::
Mouse    75 EDVYAMNPPKFDKIEDMAMLTHLNEPAVLYNLKDRYTSWMIYTYSGLFCVTVNPYKWLPVYNPEV 139

  Fly   185 MERYKGIKRHEVPPHVFAITDSAYRNMLGDREDQSILCTGESGAGKTENTKKVIQFLAYVAA--- 246
            ::.|:|.||.|.|||:|:|:|:||:.||.|||:||||.|||||||||.|||:|||:.|.:||   
Mouse   140 VDGYRGKKRQEAPPHIFSISDNAYQFMLTDRENQSILITGESGAGKTVNTKRVIQYFATIAATGD 204

  Fly   247 -SKPKGSGAVPHPAVLINFSVNTNKYIKVKIMAQNQNQTIEVVNGLKMVEVNSNCQEGELEQQLL 310
             :|.|.|                                       ||        :|.||.|::
Mouse   205 LAKKKDS---------------------------------------KM--------KGTLEDQII 222

  Fly   311 QANPILEAFGNAKTVKNDNSSRFGKFIRINFDASGFISGANIETYLLEKSRAIRQAKDERTFHIF 375
            .|||:||||||||||:|||||||||||||:|..:|.::.|:||||||||||...|.|.||::|||
Mouse   223 SANPLLEAFGNAKTVRNDNSSRFGKFIRIHFGTTGKLASADIETYLLEKSRVTFQLKAERSYHIF 287

  Fly   376 YQLLAGATPEQREKFIL-DDVKSYAFLSNGSLPVPGVDDYAEFQATVKSMNIMGMTSEDFNSIFR 439
            ||:|:...||..|..:: .:...|.|:|.|.:.|..:||..|..||..:::|:|.|.|:.:.:::
Mouse   288 YQILSNKKPELIELLLITTNPYDYPFISQGEILVASIDDAEELLATDSAIDILGFTPEEKSGLYK 352

  Fly   440 IVSAVLLFGSMKFRQERNNDQATLPDNT-VAQKIAHLLGLSVTDMTRAFLTPRIKVGRDFVTKAQ 503
            :..||:.:|:|||:|::..:||. ||.| ||.|.|:|:||:.:|:.:|...||:|||.::|||.|
Mouse   353 LTGAVMHYGNMKFKQKQREEQAE-PDGTEVADKTAYLMGLNSSDLLKALCFPRVKVGNEYVTKGQ 416

  Fly   504 TKEQVEFAVEAIAKACYERMFKWLVNRINRSLDRTKRQGASFIGILDMAGFEIFELNSFEQLCIN 568
            |.:||..||.|::|:.||::|.|:|.|||:.|| ||.....|||:||:|||||||.||.||||||
Mouse   417 TVDQVHHAVNALSKSVYEKLFLWMVTRINQQLD-TKLPRQHFIGVLDIAGFEIFEYNSLEQLCIN 480

  Fly   569 YTNEKLQQLFNHTMFILEQEEYQREGIEWKFIDFGLDLQPTIDLIDKPGGIMALLDEECWFPKAT 633
            :|||||||.|||.||:||||||::|||||.|||||:||...|:||:||.||.::|:|||.|||||
Mouse   481 FTNEKLQQFFNHHMFVLEQEEYKKEGIEWTFIDFGMDLAACIELIEKPMGIFSILEEECMFPKAT 545

  Fly   634 DKTFVDKLVSAH------SMHPKFMKTDFRGVADFAIVHYAGRVDYSAAKWLMKNMDPLNENIVS 692
            |.:|.:||...|      ...||.:|.  :..|.|::|||||.||||.:.||.||.|||||.:|.
Mouse   546 DTSFKNKLYDQHLGKSNNFQKPKVVKG--KAEAHFSLVHYAGTVDYSVSGWLEKNKDPLNETVVG 608

  Fly   693 LLQGSQDPFVVNIWKDAEIVGMAQQALTDTQFG----ARTRKGMFRTVSHLYKEQLAKLMDTLRN 753
            |.|.|.:..:.:::        |..|.||...|    |:.:...|:|||.|::|.|.|||..||.
Mouse   609 LYQKSSNRLLAHLY--------ATFATTDADGGKKKVAKKKGSSFQTVSALFRENLNKLMSNLRT 665

  Fly   754 TNPNFVRCIIPNHEKRAGKIDAPLVLDQLRCNGVLEGIRICRQGFPNRIPFQEFRQRYELLTPNV 818
            |:|:||||||||..|..|.::..|||.|||||||||||||||:||||||.:.:|:|||.:|..:.
Mouse   666 THPHFVRCIIPNETKTPGAMEHSLVLHQLRCNGVLEGIRICRKGFPNRILYGDFKQRYRVLNASA 730

  Fly   819 IPKG-FMDGKKACEKMIQALELDSNLYRVGQSKIFFRAGVLAHLEEERDFKISDLIVNFQAFCRG 882
            ||:| |:|.||||||::.::::|...|:.|.:|:||:||:|..|||.||.:::.||...||.|||
Mouse   731 IPEGQFIDSKKACEKLLASIDIDHTQYKFGHTKVFFKAGLLGTLEEMRDERLAKLITRTQAVCRG 795

  Fly   883 FLARRNYQKRLQQLNAIRIIQRNCAAYLKLRNWQWWRLYTKVKPLLEVTKQEEKLVQKEDELKQV 947
            ||.|..:||.:|:..:|..||.|..|::.:::|.|.:|:.|:||||:..:.|:::...::|.::.
Mouse   796 FLMRVEFQKMMQRRESIFCIQYNIRAFMNVKHWPWMKLFFKIKPLLKSAETEKEMATMKEEFQKT 860

  Fly   948 REKLDTLAKNTQEYERKYQQALVEKTTLAEQLQAEIELCAEAEESRSRLMARKQELEDMMQELET 1012
            :::|.......:|.|.|....:.||..|..|:|||.|...:|||...:|:..|.:||..::|:..
Mouse   861 KDELAKSEAKRKELEEKLVTLVQEKNDLQLQVQAESENLLDAEERCDQLIKAKFQLEAKIKEVTE 925

  Fly  1013 RIEEEEERVLALGGEKKKLELNIQDLEEQLEEEEAARQKLQLEKVQLDAKIKKYEEDLALTDDQN 1077
            |.|:|||....|..:|:|||....:|::.:::.|....|::.||...:.|:|...|:||..|:..
Mouse   926 RAEDEEEINAELTAKKRKLEDECSELKKDIDDLELTLAKVEKEKHATENKVKNLTEELAGLDETI 990

  Fly  1078 QKLLKEKKLLEERANDLSQTLAEEEEKAKHLAKLKAKHEATISELEERLHKDQQQRQESDRSKRK 1142
            .||.:|||.|:|........|..||:|...|:|||:|.|..:.:||..|.::::.|.:.:|:|||
Mouse   991 AKLTREKKALQEAHQQTLDDLQAEEDKVNSLSKLKSKLEQQVDDLESSLEQEKKLRVDLERNKRK 1055

  Fly  1143 IETE-------VADL---KEQLNERRVQVDEMQAQLAKREEELTQTLLRIDEESATKATAQKAQR 1197
            :|.:       :.||   |:||:||          |.|::.|.:|...::::|.......||..:
Mouse  1056 LEGDLKLAQESILDLENDKQQLDER----------LKKKDFEYSQLQSKVEDEQTLSLQLQKKIK 1110

  Fly  1198 ELESQLAEIQEDLEAEKAARAKAEKVRRDLSEELEALKNELLDSLDTTAAQQELRSKREQELATL 1262
            ||::::.|::|::|||:|.|||.||.|.|.:.|||.|...|.::...|:.|.||..|||.|...|
Mouse  1111 ELQARIEELEEEIEAERATRAKTEKQRSDYARELEELSERLEEAGGVTSTQIELNKKREAEFLKL 1175

  Fly  1263 KKSLEEETVNHEGVLADMRHKHSQELNSINDQLENLRKAKTVLEKAKGTLEAENADLATELRSVN 1327
            ::.|||.|:.||..:|.:|.||:.....:.:|::||::.|..|||.|...:.|..||::.:.||:
Mouse  1176 RRDLEEATLQHEATVATLRKKHADSAAELAEQIDNLQRVKQKLEKEKSEFKLEIDDLSSSVESVS 1240

  Fly  1328 SSRQENDRRRKQAESQIAELQVKLAEIERARSELQEKCTKLQQEAENITNQLEEAELKASAAVKS 1392
            .|:...::..:..|.|::|.:.|..|::|:.|||..:.::||.||..::.||||.|...|...:|
Mouse  1241 KSKANLEKICRTLEDQLSEARGKNEEMQRSLSELTTQKSRLQTEAGELSRQLEEKESIVSQLSRS 1305

  Fly  1393 ASNMESQLTEAQQLLEEETRQKLGLSSKLRQIESEKEALQEQLEEDDEAKRNYERKLAEVTTQMQ 1457
            ......|:.|.::.||||.:.|..|:..|:....:.:.|:||.||:.|.|...:|.|::..:::.
Mouse  1306 KQAFTQQIEELKRQLEEENKAKNALAHALQSSRHDCDLLREQYEEEQEGKAELQRALSKANSEVA 1370

  Fly  1458 EIKKKAEEDA-DLAKELEEGKKRLNKDIEALERQVKELIAQNDRLDKSKKKIQSELEDATIELEA 1521
            :.:.|.|.|| ...:||||.||:|.:.::..|.||:.:.|:...|:|:|:::|.|:||..:::|.
Mouse  1371 QWRTKYETDAIQRTEELEEAKKKLAQRLQDSEEQVEAVNAKCASLEKTKQRLQGEVEDLMVDVER 1435

  Fly  1522 QRTKVLELEKKQKNFDKILAEEKAISEQIAQERDTAEREAREKETKVLSVSRELDEAFDKIEDLE 1586
            ..:....|:|||:||||:|||.|...|:...|.:.|.:|:|...|::..:....:||.|::|.::
Mouse  1436 ANSLAAALDKKQRNFDKVLAEWKTKCEESQAELEAALKESRSLSTELFKLKNAYEEALDQLETVK 1500

  Fly  1587 NKRKTLQNELDDLANTQGTADKNVHELEKAKRALESQLAELKAQNEELEDDLQLTEDAKLRLEVN 1651
            .:.|.|:.|:.||........|::|||||:::.:|.:.|:::...||.|..|:..|...||:::.
Mouse  1501 RENKNLEQEIADLTEQIAENGKSIHELEKSRKQMELEKADIQMALEEAEAALEHEEAKILRIQLE 1565

  Fly  1652 MQALRSQFERDLLAKEEGAEEKRRGLVKQLRDLETELDEERKQRTAAVASKKKLEGDLKEIETTM 1716
            :..::|:.:|.:..|:|..|:.:|...:.:..::..||.|.:.|..|:..|||:||||.|||..:
Mouse  1566 LTQVKSEIDRKIAEKDEEIEQLKRNYQRTVETMQGALDAEVRSRNEAIRLKKKMEGDLNEIEIQL 1630

  Fly  1717 EMHNKVKEDALKHAKKLQAQVKDALRDAEEAKAAKEELQALSKEAERKVKALEAEVLQLTEDLAS 1781
            ...|:...:.:||.:.:|.|:||.....::|...:|:|:......||:...|:|||.:|...|..
Mouse  1631 SHANRQAAETIKHLRSVQGQLKDTQLHLDDALRGQEDLKEQLAIVERRANLLQAEVEELRATLEQ 1695

  Fly  1782 SERARRAAETERDELAEEIANNANKGSLMIDEKRRLEARIATLEEELEEEQSNSEVLLDRSRKAQ 1846
            :||||:.||.|..:..|.:.....:.:.:|..|::||..:..|:.|:|:...::....::::||.
Mouse  1696 TERARKLAEQELLDSNERVQLLHTQNTSLIHTKKKLETDLTQLQSEVEDACRDARNAEEKAKKAI 1760

  Fly  1847 LQIEQLTTELANEKSNSQKNENGRALLERQNKELKAKLAEIETAQRTKVKATIATLEAKIANLEE 1911
            .....:..||..|:..|...|..:..||:..|:|:.:|.|.|.......|..|..||.:|..||.
Mouse  1761 TDAAMMAEELKKEQDTSAHLERMKKNLEQTVKDLQHRLDEAEQLALKGGKKQIQKLETRIRELEF 1825

  Fly  1912 QLENEGKERLLQQKANRKMDKKIKELTMNIEDERRHVDQHKEQMDKLNSRIKLLKRNLDETEEEL 1976
            :||.|.|......|..||.::::||||...|::|::|.:.::.:|||..::|..||..:|.:|:.
Mouse  1826 ELEGEQKRNTESVKGLRKYERRVKELTYQSEEDRKNVLRLQDLVDKLQVKVKSYKRQAEEADEQA 1890

  Fly  1977 QKEKTQKRKYQRECEDMIESQEAMNREINSLKTKLRRTGGIGLSSSRL 2024
            ....|:.||.|.|.|:..|..:....::|.|:.|.|     ..:|||:
Mouse  1891 NAHLTKFRKAQHELEEAEERADIAESQVNKLRAKTR-----DFTSSRM 1933

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
zipNP_523860.2 Myosin_N 80..117 CDD:280832 8/36 (22%)
Myosin_head 133..854 CDD:278492 372/737 (50%)
MYSc_Myh2_insects_mollusks 145..854 CDD:276876 363/725 (50%)
Myosin_tail_1 931..2011 CDD:279860 345/1090 (32%)
Prefoldin 1431..1515 CDD:298833 30/84 (36%)
FAM76 <1847..1926 CDD:292665 23/78 (29%)
Myh3NP_001093105.1 Myosin_N 35..73 CDD:367160 9/38 (24%)
MYSc_Myh3 100..767 CDD:276878 363/725 (50%)
Actin-binding. /evidence=ECO:0000250 656..678 15/21 (71%)
Actin-binding. /evidence=ECO:0000250 758..772 6/13 (46%)
Myosin_tail_1 847..1924 CDD:366712 345/1086 (32%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1260..1289 10/28 (36%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E2759_KOG0161
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D47111at2759
OrthoFinder 1 1.000 - - FOG0000014
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 1 0.900 - - OOG6_100110
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 1 1.000 - - X58
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
76.720

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