DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment zip and Myh2

DIOPT Version :9

Sequence 1:NP_523860.2 Gene:zip / 38001 FlyBaseID:FBgn0265434 Length:2056 Species:Drosophila melanogaster
Sequence 2:NP_001034634.2 Gene:Myh2 / 17882 MGIID:1339710 Length:1942 Species:Mus musculus


Alignment Length:1981 Identity:773/1981 - (39%)
Similarity:1203/1981 - (60%) Gaps:86/1981 - (4%)


- Green bases have known domain annotations that are detailed below.


  Fly    55 PELKYLSVERNQFNDPATQAEWTQKRLVWVPHENQGFVAASIKREHGDEVEVELAETGKRVMILR 119
            |.|:....||.:    |....:..|..|:|....:.||..:|:.:...:|.|: .|.|..:.:..
Mouse    15 PYLRKSEKERIE----AQNRPFDAKTSVFVAEPKESFVKGTIQSKDAGKVTVK-TEAGATLTVKE 74

  Fly   120 DDIQKMNPPKFDKVEDMAELTCLNEASVLHNIKDRYYSGLIYTYSGLFCVVVNPYKKLPIYTEKI 184
            |.|..|||||:||:||||.:|.|:|.:||:|:|:||.:.:||||||||||.|||||.||:|..::
Mouse    75 DQIFPMNPPKYDKIEDMAMMTHLHEPAVLYNLKERYAAWMIYTYSGLFCVTVNPYKWLPVYNPEV 139

  Fly   185 MERYKGIKRHEVPPHVFAITDSAYRNMLGDREDQSILCTGESGAGKTENTKKVIQFLAYVAASKP 249
            :..|:|.||.|.|||:|:|:|:||:.||.|||:||||.|||||||||.|||:|||:.|       
Mouse   140 VAAYRGKKRQEAPPHIFSISDNAYQFMLTDRENQSILITGESGAGKTVNTKRVIQYFA------- 197

  Fly   250 KGSGAVPHPAVLINFSVNTNKYIKVKIMAQNQNQTIEVVNGLKMVEVNSNCQEGELEQQLLQANP 314
                                              ||.|....|..|..|...:|.||.|::.|||
Mouse   198 ----------------------------------TIAVTGDKKKEEATSGKMQGTLEDQIISANP 228

  Fly   315 ILEAFGNAKTVKNDNSSRFGKFIRINFDASGFISGANIETYLLEKSRAIRQAKDERTFHIFYQLL 379
            :||||||||||:|||||||||||||:|..:|.::.|:||||||||||...|.|.||::|||||:.
Mouse   229 LLEAFGNAKTVRNDNSSRFGKFIRIHFGTTGKLASADIETYLLEKSRVTFQLKAERSYHIFYQIT 293

  Fly   380 AGATPEQREKFIL-DDVKSYAFLSNGSLPVPGVDDYAEFQATVKSMNIMGMTSEDFNSIFRIVSA 443
            :...||..|..:: .:...|.|:|.|.:.|..:||..|..||..:::|:|.|:::..||:::..|
Mouse   294 SNKKPELIEMLLITTNPYDYPFVSQGEISVASIDDQEELMATDSAIDILGFTNDEKVSIYKLTGA 358

  Fly   444 VLLFGSMKFRQERNNDQATLPDNT-VAQKIAHLLGLSVTDMTRAFLTPRIKVGRDFVTKAQTKEQ 507
            |:.:|:|||:|::..:||. ||.| ||.|.|:|.||:..|:.:|...||:|||.::|||.||.||
Mouse   359 VMHYGNMKFKQKQREEQAE-PDGTEVADKAAYLQGLNSADLLKALCYPRVKVGNEYVTKGQTVEQ 422

  Fly   508 VEFAVEAIAKACYERMFKWLVNRINRSLDRTKRQGASFIGILDMAGFEIFELNSFEQLCINYTNE 572
            |..||.|:|||.||:||.|:|.|||:.|| ||:....|||:||:||||||:.||.||||||:|||
Mouse   423 VTNAVGALAKAMYEKMFLWMVTRINQQLD-TKQPRQYFIGVLDIAGFEIFDFNSLEQLCINFTNE 486

  Fly   573 KLQQLFNHTMFILEQEEYQREGIEWKFIDFGLDLQPTIDLIDKPGGIMALLDEECWFPKATDKTF 637
            ||||.|||.||:||||||::|||||.|||||:||...|:||:||.||.::|:|||.||||||.:|
Mouse   487 KLQQFFNHHMFVLEQEEYKKEGIEWTFIDFGMDLAACIELIEKPMGIFSILEEECMFPKATDTSF 551

  Fly   638 VDKLV------SAHSMHPKFMKTDFRGVADFAIVHYAGRVDYSAAKWLMKNMDPLNENIVSLLQG 696
            .:||.      ||:...||.:|.  :..|.|:::||||.|||:...||.||.|||||.:|.|.|.
Mouse   552 KNKLYEQHLGKSANFQKPKVVKG--KAEAHFSLIHYAGTVDYNITGWLDKNKDPLNETVVGLYQK 614

  Fly   697 SQDPFVVNIWKDAEIVGMAQQALTDTQFGARTRKG------MFRTVSHLYKEQLAKLMDTLRNTN 755
            |      ::...|.:...||.|..:...|...:||      .|:|||.|::|.|.|||..||:|:
Mouse   615 S------SVKTLAYLFSGAQTAEAEASSGGAAKKGAKKKGSSFQTVSALFRENLNKLMTNLRSTH 673

  Fly   756 PNFVRCIIPNHEKRAGKIDAPLVLDQLRCNGVLEGIRICRQGFPNRIPFQEFRQRYELLTPNVIP 820
            |:||||||||..|..|.::..|||.|||||||||||||||:|||:||.:.:|:|||::|..:.||
Mouse   674 PHFVRCIIPNETKTPGAMEHELVLHQLRCNGVLEGIRICRKGFPSRILYADFKQRYKVLNASAIP 738

  Fly   821 KG-FMDGKKACEKMIQALELDSNLYRVGQSKIFFRAGVLAHLEEERDFKISDLIVNFQAFCRGFL 884
            :| ::|.|||.||::.::::|...|:.|.:|:||:||:|..|||.||.|::.||...||.|||||
Mouse   739 EGQYIDSKKASEKLLGSIDIDHTQYKFGHTKVFFKAGLLGLLEEMRDDKLAQLITRTQAMCRGFL 803

  Fly   885 ARRNYQKRLQQLNAIRIIQRNCAAYLKLRNWQWWRLYTKVKPLLEVTKQEEKLVQKEDELKQVRE 949
            ||..|||.:::..:|..||.|..|::.:::|.|.:|:.|:||||:..:.|:::...::|.::.::
Mouse   804 ARVEYQKMVERRESIFCIQYNIRAFMNVKHWPWMKLFFKIKPLLKSAETEKEMATMKEEFQKTKD 868

  Fly   950 KLDTLAKNTQEYERKYQQALVEKTTLAEQLQAEIELCAEAEESRSRLMARKQELEDMMQELETRI 1014
            .|.......:|.|.|....|.||..|..|:|||.|..|:|||...:|:..|.:||..::|:..|.
Mouse   869 DLAKSEAKRKELEEKMVSLLKEKNDLQLQVQAEAEGLADAEERCDQLIKTKIQLEAKIKEVTERA 933

  Fly  1015 EEEEERVLALGGEKKKLELNIQDLEEQLEEEEAARQKLQLEKVQLDAKIKKYEEDLALTDDQNQK 1079
            |:|||....|..:|:|||....:|::.:::.|....|::.||...:.|:|...|::|..|:...|
Mouse   934 EDEEEINAELTAKKRKLEDECSELKKDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDETIAK 998

  Fly  1080 LLKEKKLLEERANDLSQTLAEEEEKAKHLAKLKAKHEATISELEERLHKDQQQRQESDRSKRKIE 1144
            |.||||.|:|........|..||:|...|.|.|.|.|..:.:||..|.::::.|.:.:|:|||:|
Mouse   999 LTKEKKALQEAHQQTLDDLQAEEDKVNTLTKAKIKLEQQVDDLEGSLEQEKKLRMDLERAKRKLE 1063

  Fly  1145 TEVADLKEQL----NERRVQVDEMQAQLAKREEELTQTLLRIDEESATKATAQKAQRELESQLAE 1205
            .::...:|.:    ||:: |:||   :|.|:|.|::....:|::|.|.....||..:||::::.|
Mouse  1064 GDLKLAQESIMDIENEKQ-QLDE---RLKKKEFEMSNLQSKIEDEQAIGIQLQKKIKELQARIEE 1124

  Fly  1206 IQEDLEAEKAARAKAEKVRRDLSEELEALKNELLDSLDTTAAQQELRSKREQELATLKKSLEEET 1270
            ::|::|||:|:||||||.|.|||.|||.:...|.::...|:||.|:..|||.|...:::.|||.|
Mouse  1125 LEEEIEAERASRAKAEKQRSDLSRELEEISERLEEAGGATSAQIEMNKKREAEFQKMRRDLEEAT 1189

  Fly  1271 VNHEGVLADMRHKHSQELNSINDQLENLRKAKTVLEKAKGTLEAENADLATELRSVNSSRQENDR 1335
            :.||...|.:|.||:..:..:.:|::||::.|..|||.|..::.|..|||:.:.:|:.::...::
Mouse  1190 LQHEATAATLRKKHADSVAELGEQIDNLQRVKQKLEKEKSEMKMEIDDLASNVETVSKAKGNLEK 1254

  Fly  1336 RRKQAESQIAELQVKLAEIERARSELQEKCTKLQQEAENITNQLEEAELKASAAVKSASNMESQL 1400
            ..:..|.|::||:.|..|.:|..::|..:..:||.|:...:.||:|.|...|...:.......|:
Mouse  1255 MCRTLEDQVSELKSKEEEQQRLINDLTTQRGRLQTESGEFSRQLDEKEALVSQLSRGKQAFTQQI 1319

  Fly  1401 TEAQQLLEEETRQKLGLSSKLRQIESEKEALQEQLEEDDEAKRNYERKLAEVTTQMQEIKKKAEE 1465
            .|.::.||||.:.|..|:..|:....:.:.|:||.||:.|:|...:|.|::..:::.:.:.|.|.
Mouse  1320 EELKRQLEEEVKAKNALAHALQSSRHDCDLLREQYEEEQESKAELQRALSKANSEVAQWRTKYET 1384

  Fly  1466 DA-DLAKELEEGKKRLNKDIEALERQVKELIAQNDRLDKSKKKIQSELEDATIELEAQRTKVLEL 1529
            || ...:||||.||:|.:.::|.|..|:.:.|:...|:|:|:::|:|:||..:::|........|
Mouse  1385 DAIQRTEELEEAKKKLAQRLQAAEEHVEAVNAKCASLEKTKQRLQNEVEDLMLDVERTNAACAAL 1449

  Fly  1530 EKKQKNFDKILAEEKAISEQIAQERDTAEREAREKETKVLSVSRELDEAFDKIEDLENKRKTLQN 1594
            :|||:||||||||.|...|:...|.:.:::|||...|::..:....:|:.|::|.|:.:.|.||.
Mouse  1450 DKKQRNFDKILAEWKQKYEETHAELEASQKEARSLGTELFKMKNAYEESLDQLETLKRENKNLQQ 1514

  Fly  1595 ELDDLANTQGTADKNVHELEKAKRALESQLAELKAQNEELEDDLQLTEDAKLRLEVNMQALRSQF 1659
            |:.||........|.:|||||.|:.:|.:..||:|..||.|..|:..|...||:::.:..::|:.
Mouse  1515 EISDLTEQIAEGGKRIHELEKIKKQVEQEKCELQAALEEAEASLEHEEGKILRIQLELNQVKSEI 1579

  Fly  1660 ERDLLAKEEGAEEKRRGLVKQLRDLETELDEERKQRTAAVASKKKLEGDLKEIETTMEMHNKVKE 1724
            :|.:..|:|..::.:|..::.:..:::.||.|.:.|..|:..|||:||||.|:|..:...|::..
Mouse  1580 DRKIAEKDEEIDQLKRNHIRVVESMQSTLDAEIRSRNDAIRIKKKMEGDLNEMEIQLNHSNRMAA 1644

  Fly  1725 DALKHAKKLQAQVKDALRDAEEAKAAKEELQALSKEAERKVKALEAEVLQLTEDLASSERARRAA 1789
            :||::.:..|..:||.....::|...:|:|:......||:...|:||:.:|...|..:||:|:.|
Mouse  1645 EALRNYRNTQGILKDTQLHLDDALRGQEDLKEQLAMVERRANLLQAEIEELRATLEQTERSRKIA 1709

  Fly  1790 ETERDELAEEIANNANKGSLMIDEKRRLEARIATLEEELE---EEQSNSEVLLDRSRKAQLQIEQ 1851
            |.|..:.:|.:.....:.:.:|:.|::||..|:.::.|:|   :|..|:|   ::::||......
Mouse  1710 EQELLDASERVQLLHTQNTSLINTKKKLETDISQIQGEMEDIVQEARNAE---EKAKKAITDAAM 1771

  Fly  1852 LTTELANEKSNSQKNENGRALLERQNKELKAKLAEIETAQRTKVKATIATLEAKIANLEEQLENE 1916
            :..||..|:..|...|..:..:|:..|:|:.:|.|.|.......|..|..|||::..||.::|:|
Mouse  1772 MAEELKKEQDTSAHLERMKKNMEQTVKDLQLRLDEAEQLALKGGKKQIQKLEARVRELEGEVESE 1836

  Fly  1917 GKERLLQQKANRKMDKKIKELTMNIEDERRHVDQHKEQMDKLNSRIKLLKRNLDETEEELQKEKT 1981
            .|......|..||.::::||||...|::|:::.:.::.:|||.:::|..||..:|.||:.....:
Mouse  1837 QKRNAEAVKGLRKHERRVKELTYQTEEDRKNILRLQDLVDKLQAKVKSYKRQAEEAEEQSNTNLS 1901

  Fly  1982 QKRKYQRECEDMIESQEAMNREINSLKTKLR 2012
            :.||.|.|.|:..|..:....::|.|:.|.|
Mouse  1902 KFRKIQHELEEAEERADIAESQVNKLRVKSR 1932

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
zipNP_523860.2 Myosin_N 80..117 CDD:280832 9/36 (25%)
Myosin_head 133..854 CDD:278492 367/735 (50%)
MYSc_Myh2_insects_mollusks 145..854 CDD:276876 360/723 (50%)
Myosin_tail_1 931..2011 CDD:279860 343/1087 (32%)
Prefoldin 1431..1515 CDD:298833 30/84 (36%)
FAM76 <1847..1926 CDD:292665 21/78 (27%)
Myh2NP_001034634.2 Myosin_N 36..73 CDD:280832 9/37 (24%)
Myosin_head 88..773 CDD:278492 367/735 (50%)
Motor_domain 100..773 CDD:277568 360/723 (50%)
Myosin_tail_1 853..1930 CDD:279860 343/1083 (32%)
RILP-like 968..1101 CDD:304877 44/136 (32%)
MIT_CorA-like <1302..>1414 CDD:294313 34/111 (31%)
DUF342 <1673..1770 CDD:302792 27/99 (27%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E2759_KOG0161
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D47111at2759
OrthoFinder 1 1.000 - - FOG0000014
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 1 0.900 - - OOG6_100110
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 1 1.000 - - X58
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
65.720

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