DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment zip and Myh11

DIOPT Version :9

Sequence 1:	NP_523860.2	Gene:	zip / 38001	FlyBaseID:	FBgn0265434	Length:	2056	Species:	Drosophila melanogaster
Sequence 2:	XP_006521906.1	Gene:	Myh11 / 17880	MGIID:	102643	Length:	1979	Species:	Mus musculus

Alignment Length:	2019	Identity:	1202/2019 - (59%)
Similarity:	1548/2019 - (76%)	Gaps:	59/2019 - (2%)

- Green bases have known domain annotations that are detailed below.

  Fly    46 MSEEVDRNDPELKYLSVERNQFNDPATQAEWTQKRLVWVPHENQGFVAASIKREHGDEVEVELAE 110
            |:::...:|.| |:|.|::|..|.|..||:|..|:|||||.|.|||.|||||.|.||||.|||.|
Mouse     1 MAQKGQLSDDE-KFLFVDKNFMNSPMAQADWVAKKLVWVPSEKQGFEAASIKEEKGDEVVVELVE 64

  Fly   111 TGKRVMILRDDIQKMNPPKFDKVEDMAELTCLNEASVLHNIKDRYYSGLIYTYSGLFCVVVNPYK 175
            .||:|.:.:|||||||||||.|||||||||||||||||||:::||:|||||||||||||||||||
Mouse    65 NGKKVTVGKDDIQKMNPPKFSKVEDMAELTCLNEASVLHNLRERYFSGLIYTYSGLFCVVVNPYK 129

  Fly   176 KLPIYTEKIMERYKGIKRHEVPPHVFAITDSAYRNMLGDREDQSILCTGESGAGKTENTKKVIQF 240
            .||||:|||::.|||.||||:|||::||.|:|||:||.||||||||||||||||||||||||||:
Mouse   130 YLPIYSEKIVDMYKGKKRHEMPPHIYAIADTAYRSMLQDREDQSILCTGESGAGKTENTKKVIQY 194

  Fly   241 LAYVAASK--PKGSGAVPHPAVLINFSVNTNKYIKVKIMAQNQNQTIEVVNGLKMVEVNSNCQEG 303
            ||.||:|.  .|.|.....|:...                                        |
Mouse   195 LAVVASSHKGKKDSSITQGPSFAY----------------------------------------G 219

  Fly   304 ELEQQLLQANPILEAFGNAKTVKNDNSSRFGKFIRINFDASGFISGANIETYLLEKSRAIRQAKD 368
            |||:|||||||||||||||||||||||||||||||||||.:|:|.||||||||||||||||||:|
Mouse   220 ELEKQLLQANPILEAFGNAKTVKNDNSSRFGKFIRINFDVTGYIVGANIETYLLEKSRAIRQARD 284

  Fly   369 ERTFHIFYQLLAGATPEQREKFILDDVKSYAFLSNGSLPVPGVDDYAEFQATVKSMNIMGMTSED 433
            ||||||||.|||||..:.:...:|:...||.|||||.:|:|...|...||.|:::|:|||...|:
Mouse   285 ERTFHIFYYLLAGAKEKMKSDLLLESFNSYTFLSNGFVPIPAAQDDEMFQETLEAMSIMGFNEEE 349

  Fly   434 FNSIFRIVSAVLLFGSMKFRQERNNDQATLPDNTVAQKIAHLLGLSVTDMTRAFLTPRIKVGRDF 498
            ..:|.::||:||..|::.|::|||.|||::||||.|||:.||:|::|||.|||.||||||||||.
Mouse   350 QLAILKVVSSVLQLGNIVFKKERNTDQASMPDNTAAQKVCHLVGINVTDFTRAILTPRIKVGRDV 414

  Fly   499 VTKAQTKEQVEFAVEAIAKACYERMFKWLVNRINRSLDRTKRQGASFIGILDMAGFEIFELNSFE 563
            |.|||||||.:||:||:|||.|||:|:|:::|:|::||:|.||||||:||||:|||||||:||||
Mouse   415 VQKAQTKEQADFAIEALAKATYERLFRWILSRVNKALDKTHRQGASFLGILDIAGFEIFEVNSFE 479

  Fly   564 QLCINYTNEKLQQLFNHTMFILEQEEYQREGIEWKFIDFGLDLQPTIDLIDKPG---GIMALLDE 625
            ||||||||||||||||||||||||||||||||||.||||||||||.|:||::|.   |::|||||
Mouse   480 QLCINYTNEKLQQLFNHTMFILEQEEYQREGIEWNFIDFGLDLQPCIELIERPNNPPGVLALLDE 544

  Fly   626 ECWFPKATDKTFVDKLVSAHSMHPKFMK-TDFRGVADFAIVHYAGRVDYSAAKWLMKNMDPLNEN 689
            ||||||||||:||:||.|....||||.| ...:...:|:|:||||:|||:|:.||.|||||||:|
Mouse   545 ECWFPKATDKSFVEKLCSEQGNHPKFQKPKQLKDKTEFSIIHYAGKVDYNASAWLTKNMDPLNDN 609

  Fly   690 IVSLLQGSQDPFVVNIWKDAE-IVGMAQQA-LTDTQF--GARTRKGMFRTVSHLYKEQLAKLMDT 750
            :.|||..|.|.||.::|||.: |||:.|.| :|::..  .::|:|||||||..||||||.|||.|
Mouse   610 VTSLLNASSDKFVADLWKDVDRIVGLDQMAKMTESSLPSASKTKKGMFRTVGQLYKEQLGKLMTT 674

  Fly   751 LRNTNPNFVRCIIPNHEKRAGKIDAPLVLDQLRCNGVLEGIRICRQGFPNRIPFQEFRQRYELLT 815
            ||||.||||||||||||||:||:||.|||:||||||||||||||||||||||.|||||||||:|.
Mouse   675 LRNTTPNFVRCIIPNHEKRSGKLDAFLVLEQLRCNGVLEGIRICRQGFPNRIVFQEFRQRYEILA 739

  Fly   816 PNVIPKGFMDGKKACEKMIQALELDSNLYRVGQSKIFFRAGVLAHLEEERDFKISDLIVNFQAFC 880
            .|.|||||||||:||..||:|||||.||||:||||||||.|||||||||||.||:|:|:.|||.|
Mouse   740 ANAIPKGFMDGKQACILMIKALELDPNLYRIGQSKIFFRTGVLAHLEEERDLKITDVIMAFQAMC 804

  Fly   881 RGFLARRNYQKRLQQLNAIRIIQRNCAAYLKLRNWQWWRLYTKVKPLLEVTKQEEKLVQKEDELK 945
            ||:|||:.:.||.|||.|:::|||||||||||||||||||:|||||||:||:|||::..||:|::
Mouse   805 RGYLARKAFTKRQQQLTAMKVIQRNCAAYLKLRNWQWWRLFTKVKPLLQVTRQEEEMQAKEEEMQ 869

  Fly   946 QVREKLDTLAKNTQEYERKYQQALVEKTTLAEQLQAEIELCAEAEESRSRLMARKQELEDMMQEL 1010
            :::|:........:|.|:|:.|...|||.|.||||||.||.|||||.|.||.|:|||||:::.|:
Mouse   870 KIKERQQKAETELKELEQKHTQLAEEKTLLQEQLQAETELYAEAEEMRVRLAAKKQELEEILHEM 934

  Fly  1011 ETRIEEEEERVLALGGEKKKLELNIQDLEEQLEEEEAARQKLQLEKVQLDAKIKKYEEDLALTDD 1075
            |.|:||||:|...|..|:||:...:.|||||||||||||||||||||..:|||||.|:|:.:.||
Mouse   935 EARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQKLQLEKVTAEAKIKKLEDDILVMDD 999

  Fly  1076 QNQKLLKEKKLLEERANDLSQTLAEEEEKAKHLAKLKAKHEATISELEERLHKDQQQRQESDRSK 1140
            ||.||.||:||||||.:||:..|||||||||:|.|||:|||:.|||||.||.|:::.|||.::.|
Mouse  1000 QNSKLSKERKLLEERVSDLTTNLAEEEEKAKNLTKLKSKHESMISELEVRLKKEEKSRQELEKLK 1064

  Fly  1141 RKIETEVADLKEQLNERRVQVDEMQAQLAKREEELTQTLLRIDEESATKATAQKAQRELESQLAE 1205
            ||:|.:.:|..||:.:.:.|:.|::.||||:||||...|.|:|||.|.|..|.|..||||..:::
Mouse  1065 RKLEGDASDFHEQIADLQAQIAELKMQLAKKEEELQAALARLDEEIAQKNNALKKIRELEGHISD 1129

  Fly  1206 IQEDLEAEKAARAKAEKVRRDLSEELEALKNELLDSLDTTAAQQELRSKREQELATLKKSLEEET 1270
            :||||::|:|||.||||.:|||.|||||||.||.|:||:||.|||||:|||||:..|||:|:|||
Mouse  1130 LQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEET 1194

  Fly  1271 VNHEGVLADMRHKHSQELNSINDQLENLRKAKTVLEKAKGTLEAENADLATELRSVNSSRQENDR 1335
            .:||..:.:||.||:|.:..:.:|||..::||..|:|:|.|||.||||||.|||.:..::||.:.
Mouse  1195 RSHEAQVQEMRQKHTQAVEELTEQLEQFKRAKANLDKSKQTLEKENADLAGELRVLGQAKQEVEH 1259

  Fly  1336 RRKQAESQIAELQVKLAEIERARSELQEKCTKLQQEAENITNQLEEAELKASAAVKSASNMESQL 1400
            ::|:.|.|:.:||.|.::.||||:||.:|..|||.|.|::|..|.|||.||....|..:::.|||
Mouse  1260 KKKKLEVQLQDLQSKCSDGERARAELSDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLGSQL 1324

  Fly  1401 TEAQQLLEEETRQKLGLSSKLRQIESEKEALQEQLEEDDEAKRNYERKLAEVTTQMQEIKKKAEE 1465
            .:.|:||:|||||||.:|:||||:|.|:.:||:||:|:.|||:|.||.::.:..|:.:.|||.::
Mouse  1325 QDTQELLQEETRQKLNVSTKLRQLEDERNSLQDQLDEEMEAKQNLERHVSTLNIQLSDSKKKLQD 1389

  Fly  1466 DADLAKELEEGKKRLNKDIEALERQVKELIAQNDRLDKSKKKIQSELEDATIELEAQRTKVLELE 1530
            .|...:.:|||||||.|::|.|.:|.:|..|..|:|:|:|.::|.||:|..::|:.||..|..||
Mouse  1390 FASTIEVMEEGKKRLQKEMEGLSQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLE 1454

  Fly  1531 KKQKNFDKILAEEKAISEQIAQERDTAEREAREKETKVLSVSRELDEAFDKIEDLENKRKTLQNE 1595
            ||||.||::|||||.||.:.|.|||.||.||||||||.||::|.|:||.:..|:||...|.|:.|
Mouse  1455 KKQKKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEEALEAKEELERTNKMLKAE 1519

  Fly  1596 LDDLANTQGTADKNVHELEKAKRALESQLAELKAQNEELEDDLQLTEDAKLRLEVNMQALRSQFE 1660
            ::||.:::....||||||||:|||||:|:.|:|.|.|||||:||.|||||||||||||||:.|||
Mouse  1520 MEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFE 1584

  Fly  1661 RDLLAKEEGAEEKRRGLVKQLRDLETELDEERKQRTAAVASKKKLEGDLKEIETTMEMHNKVKED 1725
            |||.|::|..|||||.|.:||.:.||||::|||||..|.|:|||||||||::|...:...|.:|:
Mouse  1585 RDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREE 1649

  Fly  1726 ALKHAKKLQAQVKDALRDAEEAKAAKEELQALSKEAERKVKALEAEVLQLTEDLASSERARRAAE 1790
            |:|..:|||||:||..|:.::|:|:::|:.|.|||.|:|.|:|||:::||.||||::||||:.|:
Mouse  1650 AIKQLRKLQAQMKDFQRELDDARASRDEIFATSKENEKKAKSLEADLMQLQEDLAAAERARKQAD 1714

  Fly  1791 TERDELAEEIANNANKGSLMIDEKRRLEARIATLEEELEEEQSNSEVLLDRSRKAQLQIEQLTTE 1855
            .|::|||||:|::.:..:.:.|||||||||||.|||||||||.|.|.:.||.|||.||.|||:.|
Mouse  1715 LEKEELAEELASSLSGRNTLQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATLQAEQLSNE 1779

  Fly  1856 LANEKSNSQKNENGRALLERQNKELKAKLAEIETAQRTKVKATIATLEAKIANLEEQLENEGKER 1920
            ||.|:|.:||||:.|..||||||||::||.|:|.|.:.|:|:|:|.||||||.||||:|.|.:|:
Mouse  1780 LATERSTAQKNESARQQLERQNKELRSKLQEVEGAVKAKLKSTVAALEAKIAQLEEQVEQEAREK 1844

  Fly  1921 LLQQKANRKMDKKIKELTMNIEDERRHVDQHKEQMDKLNSRIKLLKRNLDETEEELQKEKTQKRK 1985
            ....|:.::.|||:||:.:.:||||:..:|:|||.:|.|:::|.|||.|:|.|||.|:....:||
Mouse  1845 QAATKSLKQKDKKLKEVLLQVEDERKMAEQYKEQAEKGNTKVKQLKRQLEEAEEESQRINANRRK 1909

  Fly  1986 YQRECEDMIESQEAMNREINSLKTKLRRTGGIGLSSSRLTGTPSSKRAGGGGGGDDSSVQDESLD 2050
            .|||.::..||.|||.||:|:||:||||    |..:|.:    .|:||||....:::...:|.:|
Mouse  1910 LQRELDEATESNEAMGREVNALKSKLRR----GNEASFV----PSRRAGGRRVIENTDGSEEEMD 1966

  Fly  2051 GEDS 2054
            ..||
Mouse  1967 ARDS 1970

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
zip	NP_523860.2	Myosin_N	80..117	CDD:280832	26/36 (72%)
		Myosin_head	133..854	CDD:278492	489/730 (67%)
		MYSc_Myh2_insects_mollusks	145..854	CDD:276876	477/718 (66%)
		Myosin_tail_1	931..2011	CDD:279860	588/1079 (54%)
		Prefoldin	1431..1515	CDD:298833	36/83 (43%)
		FAM76	<1847..1926	CDD:292665	45/78 (58%)
Myh11	XP_006521906.1	Myosin_N	33..71	CDD:367160	27/37 (73%)
		MYSc_class_II	99..778	CDD:276951	477/718 (66%)
		Myosin_tail_1	855..1935	CDD:366712	588/1079 (54%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	1159	1.000	Domainoid score	I15
eggNOG	1	0.900	-	-		E2759_KOG0161
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	2332	1.000	Inparanoid score	I35
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D40305at33208
OrthoFinder	1	1.000	-	-		FOG0000014
OrthoInspector	1	1.000	-	-		otm44362
orthoMCL	1	0.900	-	-		OOG6_100110
Panther	1	1.100	-	-	O	PTHR45615
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X58
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	13	12.830