DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment zip and Myh1

DIOPT Version :9

Sequence 1:NP_523860.2 Gene:zip / 38001 FlyBaseID:FBgn0265434 Length:2056 Species:Drosophila melanogaster
Sequence 2:NP_109604.1 Gene:Myh1 / 17879 MGIID:1339711 Length:1942 Species:Mus musculus


Alignment Length:1974 Identity:773/1974 - (39%)
Similarity:1197/1974 - (60%) Gaps:72/1974 - (3%)


- Green bases have known domain annotations that are detailed below.


  Fly    55 PELKYLSVERNQFNDPATQAEWTQKRLVWVPHENQGFVAASIKREHGDEVEVELAETGKRVMILR 119
            |.|:....||.:    |....:..|..|:|....:.||.|:::...|.:|..: .|.|..|.:..
Mouse    15 PYLRKSEKERIE----AQNKPFDAKSSVFVVDAKESFVKATVQSREGGKVTAK-TEGGTTVTVKD 74

  Fly   120 DDIQKMNPPKFDKVEDMAELTCLNEASVLHNIKDRYYSGLIYTYSGLFCVVVNPYKKLPIYTEKI 184
            |.:..|||||:||:||||.:|.|:|.:||:|:|:||.:.:||||||||||.|||||.||:|..::
Mouse    75 DQVYPMNPPKYDKIEDMAMMTHLHEPAVLYNLKERYAAWMIYTYSGLFCVTVNPYKWLPVYNAEV 139

  Fly   185 MERYKGIKRHEVPPHVFAITDSAYRNMLGDREDQSILCTGESGAGKTENTKKVIQFLAYVAASKP 249
            :..|:|.||.|.|||:|:|:|:||:.||.|||:||||.|||||||||.|||:|||:.|       
Mouse   140 VAAYRGKKRQEAPPHIFSISDNAYQFMLTDRENQSILITGESGAGKTVNTKRVIQYFA------- 197

  Fly   250 KGSGAVPHPAVLINFSVNTNKYIKVKIMAQNQNQTIEVVNGLKMVEVNSNCQEGELEQQLLQANP 314
                                              ||.|....|..|..|...:|.||.|::.|||
Mouse   198 ----------------------------------TIAVTGEKKKEEATSGKMQGTLEDQIISANP 228

  Fly   315 ILEAFGNAKTVKNDNSSRFGKFIRINFDASGFISGANIETYLLEKSRAIRQAKDERTFHIFYQLL 379
            :||||||||||:|||||||||||||:|..:|.::.|:||||||||||...|.|.||::|||||::
Mouse   229 LLEAFGNAKTVRNDNSSRFGKFIRIHFGTTGKLASADIETYLLEKSRVTFQLKAERSYHIFYQIM 293

  Fly   380 AGATPEQREKFIL-DDVKSYAFLSNGSLPVPGVDDYAEFQATVKSMNIMGMTSEDFNSIFRIVSA 443
            :...|:..|..:: .:...|||:|.|.:.||.:||..|..||..:::|:|.||::..||:::..|
Mouse   294 SNKKPDLIEMLLITTNPYDYAFVSQGEITVPSIDDQEELMATDSAIDILGFTSDERVSIYKLTGA 358

  Fly   444 VLLFGSMKFRQERNNDQATLPDNT-VAQKIAHLLGLSVTDMTRAFLTPRIKVGRDFVTKAQTKEQ 507
            |:.:|:|||:|::..:||. ||.| ||.|.|:|..|:..|:.:|...||:|||.::|||.||.:|
Mouse   359 VMHYGNMKFKQKQREEQAE-PDGTEVADKAAYLQNLNSADLLKALCYPRVKVGNEYVTKGQTVQQ 422

  Fly   508 VEFAVEAIAKACYERMFKWLVNRINRSLDRTKRQGASFIGILDMAGFEIFELNSFEQLCINYTNE 572
            |..:|.|:|||.||:||.|:|.|||:.|| ||:....|||:||:||||||:.||.||||||:|||
Mouse   423 VYNSVGALAKAVYEKMFLWMVTRINQQLD-TKQPRQYFIGVLDIAGFEIFDFNSLEQLCINFTNE 486

  Fly   573 KLQQLFNHTMFILEQEEYQREGIEWKFIDFGLDLQPTIDLIDKPGGIMALLDEECWFPKATDKTF 637
            ||||.|||.||:||||||::|||||:|||||:||...|:||:||.||.::|:|||.||||||.:|
Mouse   487 KLQQFFNHHMFVLEQEEYKKEGIEWEFIDFGMDLAACIELIEKPMGIFSILEEECMFPKATDTSF 551

  Fly   638 VDKLVSAH------SMHPKFMKTDFRGVADFAIVHYAGRVDYSAAKWLMKNMDPLNENIVSLLQG 696
            .:||...|      ...||..|....  |.|::|||||.|||:.|.||.||.|||||.:|.|.|.
Mouse   552 KNKLYEQHLGKSNNFQKPKPAKGKVE--AHFSLVHYAGTVDYNIAGWLDKNKDPLNETVVGLYQK 614

  Fly   697 SQDPFVVNIWKDAEIVGMAQQALTDTQFGARTRKGMFRTVSHLYKEQLAKLMDTLRNTNPNFVRC 761
            |....:..::..|.....|:......:.||:.:...|:|||.|::|.|.|||..||:|:|:||||
Mouse   615 SSMKTLAYLFSGAAAAAEAESGGGGGKKGAKKKGSSFQTVSALFRENLNKLMTNLRSTHPHFVRC 679

  Fly   762 IIPNHEKRAGKIDAPLVLDQLRCNGVLEGIRICRQGFPNRIPFQEFRQRYELLTPNVIPKG-FMD 825
            ||||..|..|.::..|||.|||||||||||||||:|||:||.:.:|:|||::|..:.||:| |:|
Mouse   680 IIPNETKTPGAMEHELVLHQLRCNGVLEGIRICRKGFPSRILYADFKQRYKVLNASAIPEGQFID 744

  Fly   826 GKKACEKMIQALELDSNLYRVGQSKIFFRAGVLAHLEEERDFKISDLIVNFQAFCRGFLARRNYQ 890
            .|||.||::.::::|...|:.|.:|:||:||:|..|||.||.|::.||...||.|||:|||..||
Mouse   745 SKKASEKLLGSIDIDHTQYKFGHTKVFFKAGLLGLLEEMRDDKLAQLITRTQAMCRGYLARVEYQ 809

  Fly   891 KRLQQLNAIRIIQRNCAAYLKLRNWQWWRLYTKVKPLLEVTKQEEKLVQKEDELKQVREKLDTLA 955
            |.:::..:|..||.|..|::.:::|.|.:||.|:||||:..:.|:::...::|.::.:|.|....
Mouse   810 KMVERRESIFCIQYNVRAFMNVKHWPWMKLYFKIKPLLKSAETEKEMANMKEEFEKAKENLAKAE 874

  Fly   956 KNTQEYERKYQQALVEKTTLAEQLQAEIELCAEAEESRSRLMARKQELEDMMQELETRIEEEEER 1020
            ...:|.|.|....:.||..|..|:|:|.:..|:|||...:|:..|.:||..::|:..|.|:|||.
Mouse   875 AKRKELEEKMVALMQEKNDLQLQVQSEADSLADAEERCDQLIKTKIQLEAKIKEVTERAEDEEEI 939

  Fly  1021 VLALGGEKKKLELNIQDLEEQLEEEEAARQKLQLEKVQLDAKIKKYEEDLALTDDQNQKLLKEKK 1085
            ...|..:|:|||....:|::.:::.|....|::.||...:.|:|...|::|..|:...||.||||
Mouse   940 NAELTAKKRKLEDECSELKKDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDETIAKLTKEKK 1004

  Fly  1086 LLEERANDLSQTLAEEEEKAKHLAKLKAKHEATISELEERLHKDQQQRQESDRSKRKIETEVADL 1150
            .|:|........|..||:|...|.|.|.|.|..:.:||..|.::::.|.:.:|:|||:|   .||
Mouse  1005 ALQEAHQQTLDDLQAEEDKVNTLTKAKIKLEQQVDDLEGSLEQEKKIRMDLERAKRKLE---GDL 1066

  Fly  1151 K-EQLNERRVQVDEMQ--AQLAKREEELTQTLLRIDEESATKATAQKAQRELESQLAEIQEDLEA 1212
            | .|.:...|:.|:.|  .:|.|:|.|::....:|::|.|.....||..:||::::.|::|::||
Mouse  1067 KLAQESTMDVENDKQQLDEKLKKKEFEMSNLQSKIEDEQALGMQLQKKIKELQARIEELEEEIEA 1131

  Fly  1213 EKAARAKAEKVRRDLSEELEALKNELLDSLDTTAAQQELRSKREQELATLKKSLEEETVNHEGVL 1277
            |:|:||||||.|.|||.|||.:...|.::...|:||.|:..|||.|...:::.|||.|:.||...
Mouse  1132 ERASRAKAEKQRSDLSRELEEISERLEEAGGATSAQIEMNKKREAEFQKMRRDLEEATLQHEATA 1196

  Fly  1278 ADMRHKHSQELNSINDQLENLRKAKTVLEKAKGTLEAENADLATELRSVNSSRQENDRRRKQAES 1342
            |.:|.||:..:..:.:|::||::.|..|||.|..::.|..|||:.:..::.|:...::..:..|.
Mouse  1197 ATLRKKHADSVAELGEQIDNLQRVKQKLEKEKSEMKMEIDDLASNMEVISKSKGNLEKMCRTLED 1261

  Fly  1343 QIAELQVKLAEIERARSELQEKCTKLQQEAENITNQLEEAELKASAAVKSASNMESQLTEAQQLL 1407
            |::||:.|..|.:|..:||..:..:||.|:...:.||:|.:...|...:.......|:.|.::.|
Mouse  1262 QVSELKTKEEEQQRLINELTAQRGRLQTESGEYSRQLDEKDSLVSQLSRGKQAFTQQIEELKRQL 1326

  Fly  1408 EEETRQKLGLSSKLRQIESEKEALQEQLEEDDEAKRNYERKLAEVTTQMQEIKKKAEEDA-DLAK 1471
            |||.:.|..|:..|:....:.:.|:||.||:.|||...:|.:::..:::.:.:.|.|.|| ...:
Mouse  1327 EEEIKAKSALAHALQSSRHDCDLLREQYEEEQEAKAELQRAMSKANSEVAQWRTKYETDAIQRTE 1391

  Fly  1472 ELEEGKKRLNKDIEALERQVKELIAQNDRLDKSKKKIQSELEDATIELEAQRTKVLELEKKQKNF 1536
            ||||.||:|.:.::..|..|:.:.|:...|:|:|:::|:|:||..|::|........|:|||:||
Mouse  1392 ELEEAKKKLAQRLQDAEEHVEAVNAKCASLEKTKQRLQNEVEDLMIDVERTNAACAALDKKQRNF 1456

  Fly  1537 DKILAEEKAISEQIAQERDTAEREAREKETKVLSVSRELDEAFDKIEDLENKRKTLQNELDDLAN 1601
            ||||||.|...|:...|.:.:::|:|...|::..:....:|:.|.:|.|:.:.|.||.|:.||..
Mouse  1457 DKILAEWKQKYEETHAELEASQKESRSLSTELFKIKNAYEESLDHLETLKRENKNLQQEISDLTE 1521

  Fly  1602 TQGTADKNVHELEKAKRALESQLAELKAQNEELEDDLQLTEDAKLRLEVNMQALRSQFERDLLAK 1666
            ......|.:|||||.|:.:|.:.:||:|..||.|..|:..|...||:::.:..::|:.:|.:..|
Mouse  1522 QIAEGGKRIHELEKIKKQIEQEKSELQAALEEAEASLEHEEGKILRIQLELNQVKSEIDRKIAEK 1586

  Fly  1667 EEGAEEKRRGLVKQLRDLETELDEERKQRTAAVASKKKLEGDLKEIETTMEMHNKVKEDALKHAK 1731
            :|..::.:|..::.:..:::.||.|.:.|..|:..|||:||||.|:|..:...|::..:||::.:
Mouse  1587 DEEIDQLKRNHIRVVESMQSTLDAEIRSRNDAIRLKKKMEGDLNEMEIQLNHSNRMAAEALRNYR 1651

  Fly  1732 KLQAQVKDALRDAEEAKAAKEELQALSKEAERKVKALEAEVLQLTEDLASSERARRAAETERDEL 1796
            ..|..:||.....::|...:|:|:......||:...|:||:.:|...|..:||:|:.||.|..:.
Mouse  1652 NTQGILKDTQLHLDDALRGQEDLKEQLAMVERRANLLQAEIEELRATLEQTERSRKIAEQELLDA 1716

  Fly  1797 AEEIANNANKGSLMIDEKRRLEARIATLEEELE---EEQSNSEVLLDRSRKAQLQIEQLTTELAN 1858
            :|.:.....:.:.:|:.|::||..|:.::.|:|   :|..|:|   ::::||......:..||..
Mouse  1717 SERVQLLHTQNTSLINTKKKLETDISQIQGEMEDIVQEARNAE---EKAKKAITDAAMMAEELKK 1778

  Fly  1859 EKSNSQKNENGRALLERQNKELKAKLAEIETAQRTKVKATIATLEAKIANLEEQLENEGKERLLQ 1923
            |:..|...|..:..||:..|:|:.:|.|.|.......|..|..|||::..||.::|||.|..:..
Mouse  1779 EQDTSAHLERMKKNLEQTVKDLQHRLDEAEQLALKGGKKQIQKLEARVRELEGEVENEQKRNVEA 1843

  Fly  1924 QKANRKMDKKIKELTMNIEDERRHVDQHKEQMDKLNSRIKLLKRNLDETEEELQKEKTQKRKYQR 1988
            .|..||.::::||||...|::|::|.:.::.:|||.|::|..||..:|.||:......:.||.|.
Mouse  1844 IKGLRKHERRVKELTYQTEEDRKNVLRLQDLVDKLQSKVKAYKRQAEEAEEQSNVNLAKFRKIQH 1908

  Fly  1989 ECEDMIESQEAMNREINSLKTKLR 2012
            |.|:..|..:....::|.|:.|.|
Mouse  1909 ELEEAEERADIAESQVNKLRVKSR 1932

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
zipNP_523860.2 Myosin_N 80..117 CDD:280832 10/36 (28%)
Myosin_head 133..854 CDD:278492 365/729 (50%)
MYSc_Myh2_insects_mollusks 145..854 CDD:276876 358/717 (50%)
Myosin_tail_1 931..2011 CDD:279860 345/1086 (32%)
Prefoldin 1431..1515 CDD:298833 29/84 (35%)
FAM76 <1847..1926 CDD:292665 23/78 (29%)
Myh1NP_109604.1 Myosin_N 35..73 CDD:367160 11/38 (29%)
MYSc_Myh1_mammals 100..773 CDD:276875 358/717 (50%)
Actin-binding. /evidence=ECO:0000250 662..684 15/21 (71%)
Actin-binding. /evidence=ECO:0000250 764..778 6/13 (46%)
Myosin_tail_1 853..1930 CDD:366712 345/1082 (32%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1156..1175 6/18 (33%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E2759_KOG0161
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D47111at2759
OrthoFinder 1 1.000 - - FOG0000014
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 1 0.900 - - OOG6_100110
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 1 1.000 - - X58
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
65.720

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