DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment zip and myo-6

DIOPT Version :9

Sequence 1:	NP_523860.2	Gene:	zip / 38001	FlyBaseID:	FBgn0265434	Length:	2056	Species:	Drosophila melanogaster
Sequence 2:	NP_001022590.1	Gene:	myo-6 / 176764	WormBaseID:	WBGene00009730	Length:	1235	Species:	Caenorhabditis elegans

Alignment Length:	1327	Identity:	505/1327 - (38%)
Similarity:	768/1327 - (57%)	Gaps:	137/1327 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    54 DPELKYLSVERNQFNDPATQAEWTQKRLVWVPHENQGFVAASIKREHGDEVEVELAETGKRVMIL 118
            ||..|||...:::.........:..|...|||...:|||.|::..:.||.:...:.: |....:.
Worm     9 DPGWKYLRQAQDEALKEQAARRFDNKTHAWVPDAAEGFVTAAVAVQEGDNLTFTMPD-GTPKKLT 72

  Fly   119 RDDIQKMNPPKFDKVEDMAELTCLNEASVLHNIKDRYYSGLIYTYSGLFCVVVNPYKKLPIYTEK 183
            |.::|::||.||:|.|||:.||.|||||||||::.||||.:||||||||||.:||||.|||||:.
Worm    73 RAEVQEINPAKFEKTEDMSNLTFLNEASVLHNLRQRYYSMMIYTYSGLFCVFINPYKMLPIYTDS 137

  Fly   184 IMERYKGIKRHEVPPHVFAITDSAYRNMLGDREDQSILCTGESGAGKTENTKKVIQFLAYVAASK 248
            :...|...:|.|:|||:||::|.|:|||:.|:|:||:|.||||||||||||||||.:.|.:
Worm   138 VASMYVNKRRAEMPPHLFAVSDEAFRNMMSDKENQSMLITGESGAGKTENTKKVIAYFAMI---- 198

  Fly   249 PKGSGAVPHPAVLINFSVNTNKYIKVKIMAQNQNQTIEVVNGLKMVEVNSNCQEGELEQQLLQAN 313
              |||                          |::|.                .|..||.|::|||
Worm   199 --GSG--------------------------NKDQK----------------SESSLENQVVQAN 219

  Fly   314 PILEAFGNAKTVKNDNSSRFGKFIRINFDASGFISGANIETYLLEKSRAIRQAKDERTFHIFYQL 378
            |.:|||||..|.:|.||||:||||||:||..|.:.|.:||.|||||||.|:||..||::|||||:
Worm   220 PAIEAFGNGATTRNYNSSRYGKFIRIHFDRKGKLVGGDIEHYLLEKSRVIKQAPGERSYHIFYQI 284

  Fly   379 LAGATPEQREKF-ILDDVKSYAFLSNGSLPVPGVDDYAEFQATVKSMNIMGMTSEDFNSIFRIVS 442
            :  .....||:: :.|:::.|.|:|...:.|||::|..|:|.|..:.|:||.:..:.:.::::.|
Worm   285 M--TQKALRERYGLSDNIRDYKFVSQAEITVPGMNDTEEWQITDGAFNVMGFSEREKDDLYKLCS 347

  Fly   443 AVLLFGSMKFRQERNNDQATLPDNTVAQKIAHLLGLSVTDMTRAFLTPRIKVGRDFVTKAQTKEQ 507
            |::..|:..|:|:..::||.:.|.|.......|.|::......|...||||||.::|.|.|..:|
Worm   348 AIMHIGNSTFKQKPRDEQAEVDDMTSPTAACKLFGINTDQFLNALTRPRIKVGMEWVNKGQNVQQ 412

  Fly   508 VEFAVEAIAKACYERMFKWLVNRINRSLDRTKRQGASFIGILDMAGFEIFELNSFEQLCINYTNE 572
            |::||.|::||.|.|||.||:.|:|::|.....:...:||:||:||||||:.||||||.||:.||
Worm   413 VDWAVGALSKAIYARMFNWLIKRVNKTLQANSDEMVYYIGVLDIAGFEIFDRNSFEQLWINFVNE 477

  Fly   573 KLQQLFNHTMFILEQEEYQREGIEWKFIDFGLDLQPTIDLIDKPGGIMALLDEECWFPKATDKTF 637
            ||||.|||.||:|||||||||||||.|||||||||..|:||:||.||:::|||||..|||:|.|:
Worm   478 KLQQFFNHHMFVLEQEEYQREGIEWTFIDFGLDLQSCIELIEKPLGIVSMLDEECIVPKASDMTY 542

  Fly   638 VDKLVSAH-SMHPKFMKT----DFRGVADFAIVHYAGRVDYSAAKWLMKNMDPLNENIVSLLQGS 697
            ||||::.| ..||.|.|.    ..:..|.|:|:||||.|.|:|.:||.||.||||::.|::|:.|
Worm   543 VDKLLTQHLGKHPNFQKAKPPKGKQAEAHFSIMHYAGTVRYNAEQWLDKNKDPLNDSAVAILKTS 607

  Fly   698 -QDPFVVNIW---------KDAEIVGMAQQALTDTQFGARTRKGMFRTVSHLYKEQLAKLMDTLR 752
             ::..:..:|         :::|..|.||..       .:.:...|.|||.:|:|.|..||..|.
Worm   608 DKEGVLYQLWEEYQTDVDREESEKRGKAQAK-------KKGKSASFLTVSTMYRESLTSLMTMLH 665

  Fly   753 NTNPNFVRCIIPNHEKRAGKIDAPLVLDQLRCNGVLEGIRICRQGFPNRIPFQEFRQRYELLTPN 817
            .|:|:|:||||||.:|.:|.|||||||:||.||||||||||||:|||||:.|.:||.||.:|..:
Worm   666 TTHPHFIRCIIPNEKKTSGLIDAPLVLNQLTCNGVLEGIRICRKGFPNRMMFADFRFRYAILAAD 730

  Fly   818 VIPKGFMDGKKACEKMIQAL----ELDSNLYRVGQSKIFFRAGVLAHLEEERDFKISDLIVNFQA 878
              .....|..||.:.|::.|    :|:.:.::||.:|:|||||:||.|||.||..:|.:|:.||.
Worm   731 --EASDKDAAKASKAMLRKLSKNNQLNVDTFKVGTTKVFFRAGMLARLEELRDEALSAVILKFQC 793

  Fly   879 FCRGFLARRNYQKRLQQLNAIRIIQRNCAAYLKLRNWQWWRLYTKVKPLLEVTKQEEKLVQKEDE 943
            ..|.:||:..|::||.:.:|..|||.|..|::|||:|.|:||::::||:|:..|...::...|.:
Worm   794 SLRHYLAQLEYKRRLDREDAYPIIQENIRAWIKLRSWPWYRLFSRLKPMLKGMKSNAEIEALEKK 858

  Fly   944 LKQVREKLDTLAKNTQEYERKYQQALVEKTTLAEQLQAEI----ELCAEAEESRSRLMARKQELE 1004
            .|::.|.    .|..:|..:||          |::|:|:|    |..|..|..|..|..|.:|:|
Worm   859 CKELEEN----HKREEEARKKY----------ADELRAKIDQYEETKAAHERDRMLLDKRNKEIE 909

  Fly  1005 DMMQELETRIEEEEERV-----LALGGEKKKLELNIQDLEEQLE-EEEAARQKLQLEKVQLDAKI 1063
            ::.:.|:...|...|..     |....||:|.|.:.::...|:| |.||.:.|.|.||  |..:|
Worm   910 ELNRNLKAESESNYENAKKASELERLREKEKKEWDEKERRMQMEAENEANQHKTQTEK--LKDQI 972

  Fly  1064 KKYEEDLALTDDQNQKLLKEKKLLEERANDLSQTLAEEEEKAKHLAKLKAKHEATISELEERLHK 1128
            ...:.|.       :|:..::|..|:...:|...:|..::||:...:.|.|....:..|:::|..
Worm   973 STLQTDF-------EKVSAQRKAQEQMNAELVDEVASFKQKAERAEEQKKKLVEDLDSLDDKLAA 1030

  Fly  1129 DQQQRQESDRSKRKIETEVADLKEQLNERRVQVDEMQAQLAKREEELTQTLLRIDEESATKATAQ 1193
            :::...|..:..:|:|.::...:.||.....:..|......:||.|:.:..|:...::...:..|
Worm  1031 EKRANNEHVKHNKKLEGQLKATQTQLTLALKEKHEFDVDCKRRESEIGELKLKAQGDANLISKLQ 1095

  Fly  1194 KAQRELESQLAEIQEDLEAEKAARAKAEKVRRDLSEELEALKNELLDSLDTTAAQQELRSKREQE 1258
            ...|:..|::.|::|||..|:..|.|||:...:|..|.|.|:.::.::.....|:..:...|.:|
Worm  1096 AMLRKCISRIEELEEDLLEERKLRMKAERQFNELRSEYEVLQEQMAEASGQLTAEAHINKVRAEE 1160

  Fly  1259 LATLKKSLEEETVNHEGVLADMRHKHSQELNSINDQLENLRKAKTVLEKAKGTLEAENADLATEL 1323
            ::.|::.|::..:|||..::|:.:.....:|       |||.    |.:...|||:|      .|
Worm  1161 VSNLRRDLQKRNLNHEAYISDLCNMQYATVN-------NLRN----LSQQSATLESE------AL 1208

  Fly  1324 RSVNSSRQENDRRRKQAESQIAELQVK 1350
            |.:       |.||..::..:..:.|:
Worm  1209 RIL-------DHRRALSKQPLPRVYVE 1228

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
zip	NP_523860.2	Myosin_N	80..117	CDD:280832	10/36 (28%)
		Myosin_head	133..854	CDD:278492	344/740 (46%)
		MYSc_Myh2_insects_mollusks	145..854	CDD:276876	336/728 (46%)
		Myosin_tail_1	931..2011	CDD:279860	101/430 (23%)
		Prefoldin	1431..1515	CDD:298833
		FAM76	<1847..1926	CDD:292665
myo-6	NP_001022590.1	Myosin_N	34..72	CDD:367160	11/38 (29%)
		MYSc_class_II	99..769	CDD:276951	336/728 (46%)
		SbcC	<774..1178	CDD:223496	117/426 (27%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D47111at2759
OrthoFinder	1	1.000	-	-		FOG0000014
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100110
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X58
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.820