Protein Alignment zip and myo-6

DIOPT Version :10

• Sequence 1: NP_523860.2
• Gene: zip / 38001
• FlyBaseID: FBgn0287873
• Length: 2056
• Species: Drosophila melanogaster
• Sequence 2: NP_001022590.1
• Gene: myo-6 / 176764
• WormBaseID: WBGene00009730
• Length: 1235
• Species: Caenorhabditis elegans
• Alignment Length: 1327
• Identity: 505/1327 - (38%)
• Similarity: 768/1327 - (57%)
• Gaps: 137/1327 - (10%)

  Fly    54 DPELKYLSVERNQFNDPATQAEWTQKRLVWVPHENQGFVAASIKREHGDEVEVELAETGKRVMIL 118
            ||..|||...:::.........:..|...|||...:|||.|::..:.||.:...:.: |....:.
 Worm     9 DPGWKYLRQAQDEALKEQAARRFDNKTHAWVPDAAEGFVTAAVAVQEGDNLTFTMPD-GTPKKLT 72

  Fly   119 RDDIQKMNPPKFDKVEDMAELTCLNEASVLHNIKDRYYSGLIYTYSGLFCVVVNPYKKLPIYTEK 183
            |.::|::||.||:|.|||:.||.|||||||||::.||||.:||||||||||.:||||.|||||:.
 Worm    73 RAEVQEINPAKFEKTEDMSNLTFLNEASVLHNLRQRYYSMMIYTYSGLFCVFINPYKMLPIYTDS 137

  Fly   184 IMERYKGIKRHEVPPHVFAITDSAYRNMLGDREDQSILCTGESGAGKTENTKKVIQFLAYVAASK 248
            :...|...:|.|:|||:||::|.|:|||:.|:|:||:|.||||||||||||||||.:.|.:
 Worm   138 VASMYVNKRRAEMPPHLFAVSDEAFRNMMSDKENQSMLITGESGAGKTENTKKVIAYFAMI---- 198

  Fly   249 PKGSGAVPHPAVLINFSVNTNKYIKVKIMAQNQNQTIEVVNGLKMVEVNSNCQEGELEQQLLQAN 313
              |||                          |::|.                .|..||.|::|||
 Worm   199 --GSG--------------------------NKDQK----------------SESSLENQVVQAN 219

  Fly   314 PILEAFGNAKTVKNDNSSRFGKFIRINFDASGFISGANIETYLLEKSRAIRQAKDERTFHIFYQL 378
            |.:|||||..|.:|.||||:||||||:||..|.:.|.:||.|||||||.|:||..||::|||||:
 Worm   220 PAIEAFGNGATTRNYNSSRYGKFIRIHFDRKGKLVGGDIEHYLLEKSRVIKQAPGERSYHIFYQI 284

  Fly   379 LAGATPEQREKF-ILDDVKSYAFLSNGSLPVPGVDDYAEFQATVKSMNIMGMTSEDFNSIFRIVS 442
            :  .....||:: :.|:::.|.|:|...:.|||::|..|:|.|..:.|:||.:..:.:.::::.|
 Worm   285 M--TQKALRERYGLSDNIRDYKFVSQAEITVPGMNDTEEWQITDGAFNVMGFSEREKDDLYKLCS 347

  Fly   443 AVLLFGSMKFRQERNNDQATLPDNTVAQKIAHLLGLSVTDMTRAFLTPRIKVGRDFVTKAQTKEQ 507
            |::..|:..|:|:..::||.:.|.|.......|.|::......|...||||||.::|.|.|..:|
 Worm   348 AIMHIGNSTFKQKPRDEQAEVDDMTSPTAACKLFGINTDQFLNALTRPRIKVGMEWVNKGQNVQQ 412

  Fly   508 VEFAVEAIAKACYERMFKWLVNRINRSLDRTKRQGASFIGILDMAGFEIFELNSFEQLCINYTNE 572
            |::||.|::||.|.|||.||:.|:|::|.....:...:||:||:||||||:.||||||.||:.||
 Worm   413 VDWAVGALSKAIYARMFNWLIKRVNKTLQANSDEMVYYIGVLDIAGFEIFDRNSFEQLWINFVNE 477

  Fly   573 KLQQLFNHTMFILEQEEYQREGIEWKFIDFGLDLQPTIDLIDKPGGIMALLDEECWFPKATDKTF 637
            ||||.|||.||:|||||||||||||.|||||||||..|:||:||.||:::|||||..|||:|.|:
 Worm   478 KLQQFFNHHMFVLEQEEYQREGIEWTFIDFGLDLQSCIELIEKPLGIVSMLDEECIVPKASDMTY 542

  Fly   638 VDKLVSAH-SMHPKFMKT----DFRGVADFAIVHYAGRVDYSAAKWLMKNMDPLNENIVSLLQGS 697
            ||||::.| ..||.|.|.    ..:..|.|:|:||||.|.|:|.:||.||.||||::.|::|:.|
 Worm   543 VDKLLTQHLGKHPNFQKAKPPKGKQAEAHFSIMHYAGTVRYNAEQWLDKNKDPLNDSAVAILKTS 607

  Fly   698 -QDPFVVNIW---------KDAEIVGMAQQALTDTQFGARTRKGMFRTVSHLYKEQLAKLMDTLR 752
             ::..:..:|         :::|..|.||..       .:.:...|.|||.:|:|.|..||..|.
 Worm   608 DKEGVLYQLWEEYQTDVDREESEKRGKAQAK-------KKGKSASFLTVSTMYRESLTSLMTMLH 665

  Fly   753 NTNPNFVRCIIPNHEKRAGKIDAPLVLDQLRCNGVLEGIRICRQGFPNRIPFQEFRQRYELLTPN 817
            .|:|:|:||||||.:|.:|.|||||||:||.||||||||||||:|||||:.|.:||.||.:|..:
 Worm   666 TTHPHFIRCIIPNEKKTSGLIDAPLVLNQLTCNGVLEGIRICRKGFPNRMMFADFRFRYAILAAD 730

  Fly   818 VIPKGFMDGKKACEKMIQAL----ELDSNLYRVGQSKIFFRAGVLAHLEEERDFKISDLIVNFQA 878
              .....|..||.:.|::.|    :|:.:.::||.:|:|||||:||.|||.||..:|.:|:.||.
 Worm   731 --EASDKDAAKASKAMLRKLSKNNQLNVDTFKVGTTKVFFRAGMLARLEELRDEALSAVILKFQC 793

  Fly   879 FCRGFLARRNYQKRLQQLNAIRIIQRNCAAYLKLRNWQWWRLYTKVKPLLEVTKQEEKLVQKEDE 943
            ..|.:||:..|::||.:.:|..|||.|..|::|||:|.|:||::::||:|:..|...::...|.:
 Worm   794 SLRHYLAQLEYKRRLDREDAYPIIQENIRAWIKLRSWPWYRLFSRLKPMLKGMKSNAEIEALEKK 858

  Fly   944 LKQVREKLDTLAKNTQEYERKYQQALVEKTTLAEQLQAEI----ELCAEAEESRSRLMARKQELE 1004
            .|::.|.    .|..:|..:||          |::|:|:|    |..|..|..|..|..|.:|:|
 Worm   859 CKELEEN----HKREEEARKKY----------ADELRAKIDQYEETKAAHERDRMLLDKRNKEIE 909

  Fly  1005 DMMQELETRIEEEEERV-----LALGGEKKKLELNIQDLEEQLE-EEEAARQKLQLEKVQLDAKI 1063
            ::.:.|:...|...|..     |....||:|.|.:.::...|:| |.||.:.|.|.||  |..:|
 Worm   910 ELNRNLKAESESNYENAKKASELERLREKEKKEWDEKERRMQMEAENEANQHKTQTEK--LKDQI 972

  Fly  1064 KKYEEDLALTDDQNQKLLKEKKLLEERANDLSQTLAEEEEKAKHLAKLKAKHEATISELEERLHK 1128
            ...:.|.       :|:..::|..|:...:|...:|..::||:...:.|.|....:..|:::|..
 Worm   973 STLQTDF-------EKVSAQRKAQEQMNAELVDEVASFKQKAERAEEQKKKLVEDLDSLDDKLAA 1030

  Fly  1129 DQQQRQESDRSKRKIETEVADLKEQLNERRVQVDEMQAQLAKREEELTQTLLRIDEESATKATAQ 1193
            :::...|..:..:|:|.::...:.||.....:..|......:||.|:.:..|:...::...:..|
 Worm  1031 EKRANNEHVKHNKKLEGQLKATQTQLTLALKEKHEFDVDCKRRESEIGELKLKAQGDANLISKLQ 1095

  Fly  1194 KAQRELESQLAEIQEDLEAEKAARAKAEKVRRDLSEELEALKNELLDSLDTTAAQQELRSKREQE 1258
            ...|:..|::.|::|||..|:..|.|||:...:|..|.|.|:.::.::.....|:..:...|.:|
 Worm  1096 AMLRKCISRIEELEEDLLEERKLRMKAERQFNELRSEYEVLQEQMAEASGQLTAEAHINKVRAEE 1160

  Fly  1259 LATLKKSLEEETVNHEGVLADMRHKHSQELNSINDQLENLRKAKTVLEKAKGTLEAENADLATEL 1323
            ::.|::.|::..:|||..::|:.:.....:|       |||.    |.:...|||:|      .|
 Worm  1161 VSNLRRDLQKRNLNHEAYISDLCNMQYATVN-------NLRN----LSQQSATLESE------AL 1208

  Fly  1324 RSVNSSRQENDRRRKQAESQIAELQVK 1350
            |.:       |.||..::..:..:.|:
 Worm  1209 RIL-------DHRRALSKQPLPRVYVE 1228

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
zip	NP_523860.2	Myosin_N	79..122	CDD:460670	12/42 (29%)
		MYSc_Myh2_insects_mollusks	145..854	CDD:276876	336/728 (46%)
		Myosin_tail_1	931..2011	CDD:460256	101/430 (23%)
myo-6	NP_001022590.1	Myosin_N	32..>67	CDD:460670	10/35 (29%)
		MYSc_class_II	99..769	CDD:276951	336/728 (46%)
		Myosin_tail_1	855..>1206	CDD:460256	93/384 (24%)