Protein Alignment zip and spe-15

DIOPT Version :10

• Sequence 1: NP_523860.2
• Gene: zip / 38001
• FlyBaseID: FBgn0287873
• Length: 2056
• Species: Drosophila melanogaster
• Sequence 2: NP_490856.1
• Gene: spe-15 / 171712
• WormBaseID: WBGene00004969
• Length: 1219
• Species: Caenorhabditis elegans
• Alignment Length: 1252
• Identity: 353/1252 - (28%)
• Similarity: 567/1252 - (45%)
• Gaps: 296/1252 - (23%)

  Fly    69 DPATQAEWTQKRLVWVPHENQGFVAASIK--REHGDEVEVE-LAETGKR----VMILRDDIQKMN 126
            |.:|.:.....||||:..|.:|||||.|.  .|:|..:..| .:||..|    .....:|.||
 Worm     2 DSSTHSTADFGRLVWISDEAEGFVAARITDIAENGFTLATEKTSETVNRRYEDTWACEEDPQK-- 64

  Fly   127 PPKFDKVEDMAELTCLNEASVLHNIKDRYYSGLIYTYSGLFCVVVNPYKKLP-IYTEKIMERYKG 190
                 .|||...|..||||::|:|.:.||.:|.||||.....:.:|||:.:. :|:.:.::.|:|
 Worm    65 -----SVEDNCALVHLNEATLLNNCRLRYANGKIYTYVANILISINPYQLIDGLYSPETIKEYRG 124

  Fly   191 IKRHEVPPHVFAITDSAYRNMLGDREDQSILCTGESGAGKTENTKKVIQFLAYVAASKPKGSGAV 255
            ....::.||:|||.|.|||.|...:..|||:.:|||||||||:.|.|:::|.
 Worm   125 KSLGQMEPHIFAIADKAYREMRRIKTSQSIIVSGESGAGKTESQKAVLKYLC------------- 176

  Fly   256 PHPAVLINFSVNTNKYIKVKIMAQNQNQTIEVVNGLKMVEVNSNCQEGELEQQLLQANPILEAFG 320
                                                    .|.....|.::|:||:.||||||||
 Worm   177 ----------------------------------------ENWGTDAGPIQQRLLETNPILEAFG 201

  Fly   321 NAKTVKNDNSSRFGKFIRINFDASGFISGANIETYLLEKSRAIRQAKDERTFHIFYQLLAGATPE 385
            ||||::|:||||||||::|:|..:|.::|..:..||||.||..|||..||.:||||||:||::|:
 Worm   202 NAKTLRNNNSSRFGKFVQIHFSDNGTVAGGFVSHYLLETSRVCRQAAGERNYHIFYQLIAGSSPD 266

  Fly   386 QREKFILDDVKSYAFLSNG----------SLP-----------------VPGVDDYAEFQATVKS 423
            ..:|..|....|:.:|.:|          ||.                 :..:||:|:.:   ::
 Worm   267 LYKKLRLAPASSFNYLKHGATLFFVNSKSSLKTDASRFSETNSSVSDSIISDIDDFAKLE---RA 328

  Fly   424 MNIMGMTSEDFNSIFRIVSAVLLFGSMKFRQERNNDQA----TLPDNTVAQKIAHLLGLSVTDM- 483
            :.:.|::.::...|:..|:.:|..|:::|.:..::.:.    |..........|.||||...:|
 Worm   329 LALSGVSDDEKMFIWSTVAGILHLGNIEFEENASDSRGGCMITSGTENSLMAAAELLGLEPEEMK 393

  Fly   484 ----TRAFLTPRIKVGRDFVTKAQTKEQVEFAVEAIAKACYERMFKWLVNRINRSLDRTKRQGAS 544
                .|...|.:..|....:.......:.....:|:|||.|.::|.|||.:||:|:...|..|
 Worm   394 LGLCARIMQTTKGGVKGTLIRVPLKAHEASAGRDALAKAIYSKLFDWLVAQINKSIPFEKSTG-- 456

  Fly   545 FIGILDMAGFEIFELNSFEQLCINYTNEKLQQLFNHTMFILEQEEYQREGIEWKFIDFGLDLQPT 609
            :||:||:||||.|.:|||||.|||:.|||||..||..:...|||.|:.||:..:.|:| .|....
 Worm   457 YIGVLDVAGFEYFAVNSFEQFCINFCNEKLQHFFNERILKQEQEMYEAEGLNIQKIEF-TDNLDC 520

  Fly   610 IDLID-KPGGIMALLDEECWFPKATDKTFVDKLVSAHSMH-----PKFMKT----DFRGVADFAI 664
            |:|.: |..|:..|||||...|:||.:.|..:...::..|     |:..|.    :.|......|
 Worm   521 IELFEKKASGLFDLLDEEAKLPRATFQHFTQRAHESNKNHFRLDAPRKSKVKSHREMRDDEGLLI 585

  Fly   665 VHYAGRVDYSAAKWLMKNMDPLNENIVSLLQGSQDPFVVNIWKDAEIVGMAQQALTDTQFGARTR 729
            .||||.|.|....::.||.|.|:.::..|::.|..|.||:::             |....||...
 Worm   586 RHYAGTVCYETRYFVEKNNDQLHNSLEMLIEQSSFPLVVSLF-------------TSEATGAVKT 637

  Fly   730 KGMFRTVS--HLYKEQLAKLMDTLRNTNPNFVRCIIPNHEKRAGKIDAPLVLDQLRCNGVLEGIR 792
            .|..:.||  ..:|.||:.|:|.|.||..:||||:.||.:.:|...|...:|.||:|.|:...:|
 Worm   638 GGRLKAVSVGAKFKSQLSSLLDKLNNTGTHFVRCVKPNSQMKAWHFDGSAILGQLQCAGMASVLR 702

  Fly   793 ICRQGFPNRIPFQEFRQRYELLTPNVIPKGFMDGKKACEKMIQALELDSNLYRVGQSKIFFRAGV 857
            :.::|||:|..|.:....||...|..:.:  :|.:...:.:..||.||.|.::.|.:|:||.||.
 Worm   703 LMQEGFPSRTSFADLYAMYEKNLPPSLAR--LDPRLFSKCLFHALGLDQNDFQFGNTKVFFTAGK 765

  Fly   858 LAHLEE----------ERDFKISDLIV-----------------------------NFQAFCRGF 883
            .|..::          |...|::|.:|                             ..||:.||:
 Worm   766 FAEFDQMMKQDPETVMELISKVTDWLVKARWRKVQYGAWSVIKLKNKILYRAEKIKKIQAWIRGY 830

  Fly   884 LARRNYQKRLQQLNAIRIIQRNCAAYLKLRNWQWWRLYTKVKPLLEVTKQEEKLVQKEDELKQVR 948
            |.|:.:.|||      .|.::.||.                                   |:..|
 Worm   831 LVRKRFHKRL------AIFRKACAL-----------------------------------LENSR 854

  Fly   949 EKLDTLAKNTQEYERKYQQALVEKTTLAEQLQAEIELCAEAEESRSRLMARKQELEDMMQELETR 1013
            |..|.||:..:..:.|:::| .:.||            .|.:|     :.:..:.:|:..|::..
 Worm   855 EMTDILARMNESSQDKWREA-ADSTT------------GELDE-----LVKTIKNDDLNTEIDRA 901

  Fly  1014 IEEEEERVLALGGEKKKLELNIQDLEEQLEEEEAARQKLQLEKVQLDAKIKKYEEDLALTDDQNQ 1078
            ::..|:.|       |:::..|.||:.|||.:|.|    ::|:.:.:|:.|:..|
 Worm   902 VKCYEDCV-------KRVDSIIADLKLQLENDELA----EVERARKEAEDKERRE---------- 945

  Fly  1079 KLLKEKKLLEERANDLSQTLAEEEEKAK-----HLAKLKAKHEATISELEERLHKDQQQRQESDR 1138
               .|:|...|:...|.:.:.||.|||:     .|...|.|..|...|..:|.:|:::.|.::..
 Worm   946 ---AEEKAAAEQEKILRRKMEEEREKAQKEYELQLEMQKQKLAAEAEEEVKRRNKEERDRLDAAV 1007

  Fly  1139 SKRKIETE--------------------------VADLKEQLNERRVQVDEMQAQLAKREEELTQ 1177
            |.|...::                          .|||::.:|..    ::|:..:|.:||  ..
 Worm  1008 SSRLASSDGVALVAQEASAAPPKQQSKYDLGNWKYADLRDAINTS----NDMELLVACKEE--FH 1066

  Fly  1178 TLLRIDEESATKATAQK 1194
            ..|||..|..:|.:|.:
 Worm  1067 RRLRIYNEWKSKNSANR 1083

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
zip	NP_523860.2	Myosin_N	79..122	CDD:460670	17/49 (35%)
		MYSc_Myh2_insects_mollusks	145..854	CDD:276876	242/757 (32%)
		Myosin_tail_1	931..2011	CDD:460256	62/295 (21%)
spe-15	NP_490856.1	Myosin_N	10..55	CDD:460670	17/44 (39%)
		MYSc_Myo6	78..761	CDD:276833	241/756 (32%)
		CBD_MYO6-like	773..923	CDD:409646	36/215 (17%)
		MAP7	<924..1000	CDD:461709	23/92 (25%)
		MyUb_Myo6	1033..1073	CDD:439319	11/45 (24%)
		Myosin-VI_CBD	1123..1211	CDD:465157