DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment zip and Myh7

DIOPT Version :9

Sequence 1:NP_523860.2 Gene:zip / 38001 FlyBaseID:FBgn0265434 Length:2056 Species:Drosophila melanogaster
Sequence 2:NP_001348536.1 Gene:Myh7 / 140781 MGIID:2155600 Length:1935 Species:Mus musculus


Alignment Length:1965 Identity:782/1965 - (39%)
Similarity:1192/1965 - (60%) Gaps:88/1965 - (4%)


- Green bases have known domain annotations that are detailed below.


  Fly    79 KRLVWVPHENQGFVAASIKREHGDEVEVELAETGKRVMILRDDIQKMNPPKFDKVEDMAELTCLN 143
            |:.|:||.:.:.||.|.|....|.:|..| .|.||.|.:..|.:.:.|||||||:||||.||.|:
Mouse    34 KKDVFVPDDKEEFVKAKIVSREGGKVTAE-TENGKTVTVKEDQVMQQNPPKFDKIEDMAMLTFLH 97

  Fly   144 EASVLHNIKDRYYSGLIYTYSGLFCVVVNPYKKLPIYTEKIMERYKGIKRHEVPPHVFAITDSAY 208
            |.:||:|:|:||.|.:||||||||||.|||||.||:|..:::..|:|.||.|.|||:|:|:|:||
Mouse    98 EPAVLYNLKERYASWMIYTYSGLFCVTVNPYKWLPVYNAEVVAAYRGKKRSEAPPHIFSISDNAY 162

  Fly   209 RNMLGDREDQSILCTGESGAGKTENTKKVIQFLAYVAASKPKGSGAVPHPAVLINFSVNTNKYIK 273
            :.||.|||:||||.|||||||||.|||:|||:.|.:||...:                       
Mouse   163 QYMLTDRENQSILITGESGAGKTVNTKRVIQYFAVIAAIGDR----------------------- 204

  Fly   274 VKIMAQNQNQTIEVVNGLKMVEVNSNCQEGELEQQLLQANPILEAFGNAKTVKNDNSSRFGKFIR 338
                 ..::||               ..:|.||.|::||||.||||||||||:||||||||||||
Mouse   205 -----SKKDQT---------------PGKGTLEDQIIQANPALEAFGNAKTVRNDNSSRFGKFIR 249

  Fly   339 INFDASGFISGANIETYLLEKSRAIRQAKDERTFHIFYQLLAGATPEQREKFIL-DDVKSYAFLS 402
            |:|.|:|.::.|:||||||||||.|.|.|.||.:|||||:|:...||..:..:: ::...|||:|
Mouse   250 IHFGATGKLASADIETYLLEKSRVIFQLKAERDYHIFYQILSNKKPELLDMLLITNNPYDYAFIS 314

  Fly   403 NGSLPVPGVDDYAEFQATVKSMNIMGMTSEDFNSIFRIVSAVLLFGSMKFRQERNNDQATLPDNT 467
            .|...|..:||..|..||..:.:::|.|.|:.|||:::..|::.||:|||:|::..:||. ||.|
Mouse   315 QGETTVASIDDSEELMATDSAFDVLGFTPEEKNSIYKLTGAIMHFGNMKFKQKQREEQAE-PDGT 378

  Fly   468 -VAQKIAHLLGLSVTDMTRAFLTPRIKVGRDFVTKAQTKEQVEFAVEAIAKACYERMFKWLVNRI 531
             .|.|.|:|:||:..|:.:....||:|||.::|||.|..:||.:|:.|:||:.||:||.|:|.||
Mouse   379 EEADKSAYLMGLNSADLLKGLCHPRVKVGNEYVTKGQNVQQVSYAIGALAKSVYEKMFNWMVTRI 443

  Fly   532 NRSLDRTKRQGASFIGILDMAGFEIFELNSFEQLCINYTNEKLQQLFNHTMFILEQEEYQREGIE 596
            |.:|: ||:....|||:||:||||||:.|||||||||:|||||||.|||.||:||||||::||||
Mouse   444 NATLE-TKQPRQYFIGVLDIAGFEIFDFNSFEQLCINFTNEKLQQFFNHHMFVLEQEEYKKEGIE 507

  Fly   597 WKFIDFGLDLQPTIDLIDKPGGIMALLDEECWFPKATDKTFVDKLVSAH-SMHPKFMKTDFRGV- 659
            |.|||||:|||..||||:||.|||::|:|||.||||||.||..||...| .....|.|.  |.| 
Mouse   508 WTFIDFGMDLQACIDLIEKPMGIMSILEEECMFPKATDMTFKAKLYDNHLGKSNNFQKP--RNVK 570

  Fly   660 ----ADFAIVHYAGRVDYSAAKWLMKNMDPLNENIVSLLQGSQDPFVVNIWKDAEIVGMAQQALT 720
                |.|::|||||.|||:...||.||.|||||.:|.|.|.|....:.|::  |...|  ..|..
Mouse   571 GKQEAHFSLVHYAGTVDYNILGWLQKNKDPLNETVVGLYQKSSLKLLSNLF--ANYAG--ADAPA 631

  Fly   721 DTQFGARTRKGMFRTVSHLYKEQLAKLMDTLRNTNPNFVRCIIPNHEKRAGKIDAPLVLDQLRCN 785
            |...|...:...|:|||.|::|.|.|||..||:|:|:||||||||..|..|.:|.|||:.|||||
Mouse   632 DKGKGKAKKGSSFQTVSALHRENLNKLMTNLRSTHPHFVRCIIPNETKSPGVMDNPLVMHQLRCN 696

  Fly   786 GVLEGIRICRQGFPNRIPFQEFRQRYELLTPNVIPKG-FMDGKKACEKMIQALELDSNLYRVGQS 849
            ||||||||||:||||||.:.:|||||.:|.|..||:| |:|.:|..||::.:|::|.|.|:.|.:
Mouse   697 GVLEGIRICRKGFPNRILYGDFRQRYRILNPAAIPEGQFIDSRKGAEKLLGSLDIDHNQYKFGHT 761

  Fly   850 KIFFRAGVLAHLEEERDFKISDLIVNFQAFCRGFLARRNYQKRLQQLNAIRIIQRNCAAYLKLRN 914
            |:||:||:|..|||.||.::|.:|...||..||.|:|..::|.|::.:::.|||.|..|::.::|
Mouse   762 KVFFKAGLLGLLEEMRDERLSRIITRIQAQSRGVLSRMEFKKLLERRDSLLIIQWNIRAFMGVKN 826

  Fly   915 WQWWRLYTKVKPLLEVTKQEEKLVQKEDELKQVREKLDTLAKNTQEYERKYQQALVEKTTLAEQL 979
            |.|.:||.|:||||:..:.|:::...::|..:|::.|:......:|.|.|....|.||..|..|:
Mouse   827 WPWMKLYFKIKPLLKSAETEKEMATMKEEFGRVKDALEKSEARRKELEEKMVSLLQEKNDLQLQV 891

  Fly   980 QAEIELCAEAEESRSRLMARKQELEDMMQELETRIEEEEERVLALGGEKKKLELNIQDLEEQLEE 1044
            |||.:..|:|||...:|:..|.:||..::|:..|:|:|||....|..:|:|||....:|:..:::
Mouse   892 QAEQDNLADAEERCDQLIKNKIQLEAKVKEMTERLEDEEEMNAELTAKKRKLEDECSELKRDIDD 956

  Fly  1045 EEAARQKLQLEKVQLDAKIKKYEEDLALTDDQNQKLLKEKKLLEERANDLSQTLAEEEEKAKHLA 1109
            .|....|::.||...:.|:|...|::|..|:...||.||||.|:|........|..||:|...|.
Mouse   957 LELTLAKVEKEKHATENKVKNLTEEMAGLDEIIVKLTKEKKALQEAHQQALDDLQAEEDKVNTLT 1021

  Fly  1110 KLKAKHEATISELEERLHKDQQQRQESDRSKRKIETE-------VADL---KEQLNERRVQVDEM 1164
            |.|.|.|..:.:||..|.::::.|.:.:|:|||:|.:       :.||   |:||:||       
Mouse  1022 KAKVKLEQQVDDLEGSLEQEKKVRMDLERAKRKLEGDLKLTQESIMDLENDKQQLDER------- 1079

  Fly  1165 QAQLAKREEELTQTLLRIDEESATKATAQKAQRELESQLAEIQEDLEAEKAARAKAEKVRRDLSE 1229
               |.|::.||.....||::|.|..:..||..:||::::.|::|:||||:.||||.||:|.|||.
Mouse  1080 ---LKKKDFELNALNARIEDEQALGSQLQKKLKELQARIEELEEELEAERTARAKVEKLRSDLSR 1141

  Fly  1230 ELEALKNELLDSLDTTAAQQELRSKREQELATLKKSLEEETVNHEGVLADMRHKHSQELNSINDQ 1294
            |||.:...|.::...|:.|.|:..|||.|...:::.|||.|:.||...|.:|.||:..:..:.:|
Mouse  1142 ELEEISERLEEAGGATSVQIEMNKKREAEFQKMRRDLEEATLQHEATAAALRKKHADSVAELGEQ 1206

  Fly  1295 LENLRKAKTVLEKAKGTLEAENADLATELRSVNSSRQENDRRRKQAESQIAELQVKLAEIERARS 1359
            ::||::.|..|||.|...:.|..|:.:.:..:..::...::..:..|.|:.|.:.|..|.:|:.:
Mouse  1207 IDNLQRVKQKLEKEKSEFKLELDDVTSNMEQIIKAKANLEKMCRTLEDQMNEHRSKAEETQRSVN 1271

  Fly  1360 ELQEKCTKLQQEAENITNQLEEAELKASAAVKSASNMESQLTEAQQLLEEETRQKLGLSSKLRQI 1424
            :|..:..|||.|...::.||:|.|...|...:.......||.:.::.||||.:.|..|:..|:..
Mouse  1272 DLTSQRAKLQTENGELSRQLDEKEALISQLTRGKLTYTQQLEDLKRQLEEEVKAKNALAHALQSA 1336

  Fly  1425 ESEKEALQEQLEEDDEAKRNYERKLAEVTTQMQEIKKKAEEDA-DLAKELEEGKKRLNKDIEALE 1488
            ..:.:.|:||.||:.|||...:|.|::..:::.:.:.|.|.|| ...:||||.||:|.:.::..|
Mouse  1337 RHDCDLLREQYEEETEAKAELQRVLSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQDAE 1401

  Fly  1489 RQVKELIAQNDRLDKSKKKIQSELEDATIELEAQRTKVLELEKKQKNFDKILAEEKAISEQIAQE 1553
            ..|:.:.|:...|:|:|.::|:|:||..:::|........|:|||:||||||||.|...|:...|
Mouse  1402 EAVEAVNAKCSSLEKTKHRLQNEIEDLMVDVERSNAAAAALDKKQRNFDKILAEWKQKYEESQSE 1466

  Fly  1554 RDTAEREAREKETKVLSVSRELDEAFDKIEDLENKRKTLQNELDDLANTQGTADKNVHELEKAKR 1618
            .:::::|||...|::..:....:|:.:.:|..:.:.|.||.|:.||....|:..|::|||||.::
Mouse  1467 LESSQKEARSLSTELFKLKNAYEESLEHLETFKRENKNLQEEISDLTEQLGSTGKSIHELEKIRK 1531

  Fly  1619 ALESQLAELKAQNEELEDDLQLTEDAKLRLEVNMQALRSQFERDLLAKEEGAEEKRRGLVKQLRD 1683
            .||::..||::..||.|..|:..|...||.::....::::.||.|..|:|..|:.:|..::.:..
Mouse  1532 QLEAEKLELQSALEEAEASLEHEEGKILRAQLEFNQIKAEIERKLAEKDEEMEQAKRNHLRMVDS 1596

  Fly  1684 LETELDEERKQRTAAVASKKKLEGDLKEIETTMEMHNKVKEDALKHAKKLQAQVKDALRDAEEAK 1748
            |:|.||.|.:.|..|:..|||:||||.|:|..:...|::..:|.|..|.||:.:||.....::|.
Mouse  1597 LQTSLDAETRSRNEALRVKKKMEGDLNEMEIQLSHANRMAAEAQKQVKSLQSLLKDTQIQLDDAV 1661

  Fly  1749 AAKEELQALSKEAERKVKALEAEVLQLTEDLASSERARRAAETERDELAEEIANNANKGSLMIDE 1813
            .|.::|:......||:...|:||:.:|...:..:||:|:.||.|..|.:|.:....::.:.:|::
Mouse  1662 RANDDLKENIAIVERRNNLLQAELEELRAVVEQTERSRKLAEQELIETSERVQLLHSQNTSLINQ 1726

  Fly  1814 KRRLEARIATLEEELEE---EQSNSEVLLDRSRKAQLQIEQLTTELANEKSNSQKNENGRALLER 1875
            |::::|.::.|:.|:||   |..|:|   ::::||......:..||..|:..|...|..:..:|:
Mouse  1727 KKKMDADLSQLQTEVEEAVQECRNAE---EKAKKAITDAAMMAEELKKEQDTSAHLERMKKNMEQ 1788

  Fly  1876 QNKELKAKLAEIETAQRTKVKATIATLEAKIANLEEQLENEGKERLLQQKANRKMDKKIKELTMN 1940
            ..|:|:.:|.|.|.......|..:..|||::..||.:||.|.|......|..||.:::|||||..
Mouse  1789 TIKDLQHRLDEAEQIALKGGKKQLQKLEARVRELENELEAEQKRNAESVKGMRKSERRIKELTYQ 1853

  Fly  1941 IEDERRHVDQHKEQMDKLNSRIKLLKRNLDETEEELQKEKTQKRKYQRECEDMIESQEAMNREIN 2005
            .|::|:::.:.::.:|||..::|..||..:|.||:.....::.||.|.|.::..|..:....::|
Mouse  1854 TEEDRKNLLRLQDLVDKLQLKVKAYKRQAEEAEEQANTNLSKFRKVQHELDEAEERADIAESQVN 1918

  Fly  2006 SLKTKLRRTGGIGLS 2020
            .|:.|.|..|..||:
Mouse  1919 KLRAKSRDIGAKGLN 1933

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
zipNP_523860.2 Myosin_N 80..117 CDD:280832 14/36 (39%)
Myosin_head 133..854 CDD:278492 375/729 (51%)
MYSc_Myh2_insects_mollusks 145..854 CDD:276876 367/717 (51%)
Myosin_tail_1 931..2011 CDD:279860 345/1093 (32%)
Prefoldin 1431..1515 CDD:298833 30/84 (36%)
FAM76 <1847..1926 CDD:292665 21/78 (27%)
Myh7NP_001348536.1 COG5022 37..1432 CDD:227355 623/1456 (43%)
MYSc_class_II 99..766 CDD:276951 367/717 (51%)
Actin-binding 655..677 15/21 (71%)
Actin-binding 757..771 6/13 (46%)
SMC_prok_B 1173..1930 CDD:274008 232/759 (31%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1915..1935 7/19 (37%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E2759_KOG0161
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D47111at2759
OrthoFinder 1 1.000 - - FOG0000014
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 1 0.900 - - OOG6_100110
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 1 1.000 - - X58
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
76.720

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