DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment zip and myh15

DIOPT Version :9

Sequence 1:	NP_523860.2	Gene:	zip / 38001	FlyBaseID:	FBgn0265434	Length:	2056	Species:	Drosophila melanogaster
Sequence 2:	XP_002932332.2	Gene:	myh15 / 100487082	XenbaseID:	XB-GENE-999078	Length:	1937	Species:	Xenopus tropicalis

Alignment Length:	1981	Identity:	772/1981 - (38%)
Similarity:	1191/1981 - (60%)	Gaps:	77/1981 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly    62 VERNQFNDPATQAEWTQKRLV-------------WVPHENQGFVAASIKREHGDEVEVELAETGK 113
            ::.:.|.:.|:....::|.|:             |:|.:.:.::.|.||...|.:|.||:.: ||
Frog     2 MDMSDFGEAASFLRKSEKELMIQQTVAFDGKKKCWIPDDKEAYLEAEIKETGGGKVTVEVGD-GK 65

  Fly   114 RVMILRDDIQKMNPPKFDKVEDMAELTCLNEASVLHNIKDRYYSGLIYTYSGLFCVVVNPYKKLP 178
            .|::...|:|:|||||||.:||||.||.|||||||.|::.||.:.:||||||||||.|||||.||
Frog    66 TVVVKEGDVQQMNPPKFDMMEDMAMLTHLNEASVLFNLRKRYANWMIYTYSGLFCVTVNPYKWLP 130

  Fly   179 IYTEKIMERYKGIKRHEVPPHVFAITDSAYRNMLGDREDQSILCTGESGAGKTENTKKVIQFLAY 243
            :|..:::..|||.:|.|.|||:|:|.|:||.:||.:||:||:|.|||||||||.|||:|||:.|.
Frog   131 VYKTEVVAAYKGKRRSEAPPHIFSIADNAYHDMLRNRENQSMLITGESGAGKTVNTKRVIQYFAT 195

  Fly   244 VAASKPKGSGAVPHPAVLINFSVNTNKYIKVKIMAQNQNQTIEVVNGLKMVEVNSNCQEGELEQQ 308
            |||                         |...:..:||..|   ..|            |.||.|
Frog   196 VAA-------------------------IGDPMSKKNQPAT---KTG------------GTLEDQ 220

  Fly   309 LLQANPILEAFGNAKTVKNDNSSRFGKFIRINFDASGFISGANIETYLLEKSRAIRQAKDERTFH 373
            ::||||.|||||||||::|||||||||||||:|..:|.:|.|:||.|||||||.|.|...||::|
Frog   221 IIQANPALEAFGNAKTLRNDNSSRFGKFIRIHFGTTGKLSSADIEIYLLEKSRVIFQQPGERSYH 285

  Fly   374 IFYQLLAGATPEQREKFILD-DVKSYAFLSNGSLPVPGVDDYAEFQATVKSMNIMGMTSEDFNSI 437
            ||||:|:|...|.::..::. :...:.|.|.|.:.|..:||..|..||.::.:|:|...::....
Frog   286 IFYQILSGKMSELQDMLLVSTNPYDFHFSSQGVVTVDNLDDSEELIATDQAFDILGFIPDEKYGS 350

  Fly   438 FRIVSAVLLFGSMKFRQERNNDQATLPDNTVAQKIAHLLGLSVTDMTRAFLTPRIKVGRDFVTKA 502
            :::..|::.||:|||:|::..:||.........|.|:|:|:|.:|:.:..|.||:|||.::|||.
Frog   351 YKLTGAIMHFGNMKFKQKQREEQAEADGTENTDKAAYLMGISSSDLVKGLLHPRVKVGNEYVTKG 415

  Fly   503 QTKEQVEFAVEAIAKACYERMFKWLVNRINRSLDRTKRQGASFIGILDMAGFEIFELNSFEQLCI 567
            ||..||.:||.|:||..|:|||||||.|||::|| ||.....|||:||:||||||:.||||||||
Frog   416 QTVAQVVYAVGALAKGIYDRMFKWLVVRINKTLD-TKLPRQFFIGVLDIAGFEIFDFNSFEQLCI 479

  Fly   568 NYTNEKLQQLFNHTMFILEQEEYQREGIEWKFIDFGLDLQPTIDLIDKPGGIMALLDEECWFPKA 632
            |:|||||||.|||.||:||||||::|||:|:|||||||||..||||:||.|||::|:|||.||||
Frog   480 NFTNEKLQQFFNHHMFVLEQEEYKKEGIDWEFIDFGLDLQACIDLIEKPLGIMSILEEECMFPKA 544

  Fly   633 TDKTFVDKLVSAH-SMHPKFMKTDF----RGVADFAIVHYAGRVDYSAAKWLMKNMDPLNENIVS 692
            ||.||..||...| ...|.|.|...    :..|.|.::||||.|.|:...||.||.|||||.:|.
Frog   545 TDMTFKSKLYDNHLGKSPNFQKPRLDKKRKYEAHFELMHYAGVVPYNIMGWLEKNKDPLNETVVG 609

  Fly   693 LLQGSQDPFVVNIWKDAEIVGMAQQALTDTQFGARTRK--GMFRTVSHLYKEQLAKLMDTLRNTN 755
            |.|.|.:..:..::::......|.|.      |.:.||  ..|:|||.|:||.|.|||..||:|:
Frog   610 LFQKSSNKLLGCLFENYVSSDSADQG------GEKKRKKGASFQTVSSLHKENLNKLMTNLRSTS 668

  Fly   756 PNFVRCIIPNHEKRAGKIDAPLVLDQLRCNGVLEGIRICRQGFPNRIPFQEFRQRYELLTPNVIP 820
            |:||||||||..|..|.:|..|||.|||||||||||||||:|||||:.:.:|:|||.:|.|:.||
Frog   669 PHFVRCIIPNETKTPGAMDPFLVLHQLRCNGVLEGIRICRKGFPNRVLYADFKQRYRILNPSAIP 733

  Fly   821 KG-FMDGKKACEKMIQALELDSNLYRVGQSKIFFRAGVLAHLEEERDFKISDLIVNFQAFCRGFL 884
            :. |:|.:||.||::..||:|...||.|.:|:||:||:|.:|||.||.::|.::...||..||.|
Frog   734 EDKFVDSRKASEKLLGTLEIDHTQYRFGHTKVFFKAGLLGNLEEMRDERLSKILTLIQARARGKL 798

  Fly   885 ARRNYQKRLQQLNAIRIIQRNCAAYLKLRNWQWWRLYTKVKPLLEVTKQEEKLVQKEDELKQVRE 949
            .|..:||.|::.:|:.:||.|..|::.::||.|.:|:.|:||||:..:.|:::...::|..:::|
Frog   799 MRIEFQKILERRDALLVIQWNIRAFMTVKNWPWMKLFFKIKPLLKSAETEKEMANMKEEFLKLKE 863

  Fly   950 KLDTLAKNTQEYERKYQQALVEKTTLAEQLQAEIELCAEAEESRSRLMARKQELEDMMQELETRI 1014
            .|:......:|.|.|....:.||..|..|||||.::.|:|||....|:..|.::|..:::|..||
Frog   864 ALEKSEARRKELEEKQVTLVQEKNDLTLQLQAEQDMFADAEERCDLLIKSKIQMESKIKDLTERI 928

  Fly  1015 EEEEERVLALGGEKKKLELNIQDLEEQLEEEEAARQKLQLEKVQLDAKIKKYEEDLALTDDQNQK 1079
            |:|||....|..:|:|||....:|::.:::.|....|.:.||...:.|:|...|::|..||...|
Frog   929 EDEEEMNSELTSKKRKLEDECSELKKDIDDLEITLAKAEKEKHATENKVKNLTEEMASLDDTINK 993

  Fly  1080 LLKEKKLLEERANDLSQTLAEEEEKAKHLAKLKAKHEATISELEERLHKDQQQRQESDRSKRKIE 1144
            |.||||.|:|........|..||:|...|.|:|.|.|..:.:||..|.::::.|.:.:|:|||:|
Frog   994 LTKEKKALQEAHQQTLDDLQAEEDKVNSLTKIKTKLEQQVDDLEGSLEQEKKVRMDLERAKRKLE 1058

  Fly  1145 TEVADLKEQLNERRVQVDEMQAQLAKREEELTQTLLRIDEESATKATAQKAQRELESQLAEIQED 1209
            .::...:|.|.:......:|:.:|.|:|.|::|...:|::|.|.....||..:||::::.|::|:
Frog  1059 GDLKLTQESLMDAENDKQQMEEKLKKKEFEISQMSSKIEDEQAIVMQLQKKIKELQARIEELEEE 1123

  Fly  1210 LEAEKAARAKAEKVRRDLSEELEALKNELLDSLDTTAAQQELRSKREQELATLKKSLEEETVNHE 1274
            ||||:|||||.||.|.||:.|||.|...|.::...:|||.|:..|||.|...:::.|||.|::||
Frog  1124 LEAERAARAKVEKQRSDLARELEELSERLEEAGGASAAQIEMNKKRETEYLKMRRDLEEATLHHE 1188

  Fly  1275 GVLADMRHKHSQELNSINDQLENLRKAKTVLEKAKGTLEAENADLATELRSVNSSRQENDRRRKQ 1339
            ...|.:|.||:..:..:.:|::||::.|..|||.|..|:.|..||::.:..:..::..:::..:.
Frog  1189 ATAASLRKKHADTVAELGEQIDNLQRVKQKLEKEKSELKLEADDLSSSMEQLVKAKGISEKLCRT 1253

  Fly  1340 AESQIAELQVKLAEIERARSELQEKCTKLQQEAENITNQLEEAELKASAAVKSASNMESQLTEAQ 1404
            .|.|:.|.:.||.|:.|..:||..:..:||.|.......|||.|...|...:..|:...|:.:.:
Frog  1254 YEDQLNETKAKLDEMTRQVNELTTQKGRLQTENGEFGRLLEEKESLISQLSRGKSSFTQQIEDLR 1318

  Fly  1405 QLLEEETRQKLGLSSKLRQIESEKEALQEQLEEDDEAKRNYERKLAEVTTQMQEIKKKAEEDA-D 1468
            :.|||||:.|..|:..|:....:.:.|:||.:|:.|||...:|.|::...::...:.|.|.|| .
Frog  1319 KQLEEETKAKNALAHALQSARHDCDLLREQFDEEQEAKAELQRSLSKGNAEVATWRNKYETDAIQ 1383

  Fly  1469 LAKELEEGKKRLNKDIEALERQVKELIAQNDRLDKSKKKIQSELEDATIELEAQRTKVLELEKKQ 1533
            ..:||||.||:|...::..|..|:...|:...|:|:|.::|:||||..|:||........::|||
Frog  1384 RTEELEEAKKKLAARLQEAEEAVEAANAKCASLEKTKHRLQNELEDMMIDLERSNAAAAAMDKKQ 1448

  Fly  1534 KNFDKILAEEKAISEQIAQERDTAEREAREKETKVLSVSRELDEAFDKIEDLENKRKTLQNELDD 1598
            :||||::|:.|...|:...|.:|::::||...|::..:....:|..|.:|.::.:.|.||.|:.|
Frog  1449 RNFDKLIADWKQKYEETQAELETSQKDARGLSTELFKLKNAYEEVLDNLETVKRENKNLQEEISD 1513

  Fly  1599 LANTQGTADKNVHELEKAKRALESQLAELKAQNEELEDDLQLTEDAKLRLEVNMQALRSQFERDL 1663
            |.:.....:|::||:||.|:.:|.:.:|::...||.|..|:..|...||.::.:..::::|||.|
Frog  1514 LTDQISEGNKSLHEIEKVKKQVEQEKSEVQVALEEAEGALEHEESKTLRFQLELSQIKAEFERKL 1578

  Fly  1664 LAKEEGAEEKRRGLVKQLRDLETELDEERKQRTAAVASKKKLEGDLKEIETTMEMHNKVKEDALK 1728
            ..|:|..|..||.|.:.:..|::.|:.|.|.|..||..|||:||||.|:|..:....:...:|.|
Frog  1579 SEKDEETENIRRNLQRIIESLQSNLESEAKSRNEAVRLKKKMEGDLNEMEIQLSHSIRQATEATK 1643

  Fly  1729 HAKKLQAQVKDALRDAEEAKAAKEELQALSKEAERKVKALEAEVLQLTEDLASSERARRAAETER 1793
            ..:.||||.||.....::.....|:|:..:...||:...|::|:.:|...|..:||||:.:|.|.
Frog  1644 AMRNLQAQYKDLQVQYDDYIHLSEDLKEQAAVIERRNTLLQSELDELRAALDQTERARKLSEQEL 1708

  Fly  1794 DELAEEIANNANKGSLMIDEKRRLEARIATLEEELEE---EQSNSEVLLDRSRKAQLQIEQLTTE 1855
            .|..|.:....::.:.:|::|::||..|:.::.|:||   |..|:|   |:::||......:..|
Frog  1709 LESTERVNLLHSQNTSLINQKKKLETDISHMQNEVEESIQECRNAE---DKAKKAITDAAMMAEE 1770

  Fly  1856 LANEKSNSQKNENGRALLERQNKELKAKLAEIETAQRTKVKATIATLEAKIANLEEQLENEGKER 1920
            |..|:..|...|..:..:|:..|:|:.:|.|.|.......|..|..||:::..||.:||:|.:..
Frog  1771 LKKEQDTSAHLERMKKNMEQTIKDLQKRLDEAEQIAMKGGKKQIQKLESRVRELENELESEQRRN 1835

  Fly  1921 LLQQKANRKMDKKIKELTMNIEDERRHVDQHKEQMDKLNSRIKLLKRNLDETEEELQKEKTQKRK 1985
            ....|..||.:::|||||...|::::::.:.::.:|||..::|..|...:|..|:..:..::.:|
Frog  1836 SESLKGFRKFERRIKELTYQGEEDKKNLIRMQDLIDKLQLKVKSYKHQAEEASEQSNQYLSKYKK 1900

  Fly  1986 YQRECEDMIESQEAMNREINSLKTKLRRTGG 2016
            .|.|.:|..|..:....::|.|::|.|...|
Frog  1901 LQHELDDAQERADIAESQVNKLRSKTRDVAG 1931

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
zip	NP_523860.2	Myosin_N	80..117	CDD:280832	13/49 (27%)
		Myosin_head	133..854	CDD:278492	367/729 (50%)
		MYSc_Myh2_insects_mollusks	145..854	CDD:276876	358/717 (50%)
		Myosin_tail_1	931..2011	CDD:279860	344/1083 (32%)
		Prefoldin	1431..1515	CDD:298833	30/84 (36%)
		FAM76	<1847..1926	CDD:292665	20/78 (26%)
myh15	XP_002932332.2	Myosin_N	32..70	CDD:367160	12/38 (32%)
		Motor_domain	97..768	CDD:354959	358/717 (50%)
		Myosin_tail_1	848..1925	CDD:366712	344/1079 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D47111at2759
OrthoFinder	1	1.000	-	-		FOG0000014
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X58
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	3.010