DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment zip and myh8

DIOPT Version :9

Sequence 1:	NP_523860.2	Gene:	zip / 38001	FlyBaseID:	FBgn0265434	Length:	2056	Species:	Drosophila melanogaster
Sequence 2:	XP_012824466.1	Gene:	myh8 / 100379877	XenbaseID:	XB-GENE-5954541	Length:	1935	Species:	Xenopus tropicalis

Alignment Length:	1952	Identity:	755/1952 - (38%)
Similarity:	1182/1952 - (60%)	Gaps:	69/1952 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly    79 KRLVWVPHENQGFVAASIKREHGDEVEVELAETGKRVMILRDDIQKMNPPKFDKVEDMAELTCLN 143
            |..|:|....:.:|...:......:|.|: .:.|..|.:....|...|||||||:||||.:|.||
Frog    34 KNTVFVDDAKELYVKGMVTARDNGKVTVK-TDDGNTVTVKDTQIYPQNPPKFDKIEDMAMMTHLN 97

  Fly   144 EASVLHNIKDRYYSGLIYTYSGLFCVVVNPYKKLPIYTEKIMERYKGIKRHEVPPHVFAITDSAY 208
            |||||:|:|:||.:.:|||||||||..|||||.||:|..:::..|:|.||.|.|||:|:::|:||
Frog    98 EASVLYNLKERYAAWMIYTYSGLFCATVNPYKWLPVYNPEVVAGYRGKKRVEAPPHIFSLSDNAY 162

  Fly   209 RNMLGDREDQSILCTGESGAGKTENTKKVIQFLAYVAASKPKGSGAVPHPAVLINFSVNTNKYIK 273
            :.||.|||:||:|.|||||||||.|||:|||:.|.:||....|....|
Frog   163 QAMLTDRENQSVLITGESGAGKTVNTKRVIQYFATIAALGDPGKKKEP----------------- 210

  Fly   274 VKIMAQNQNQTIEVVNGLKMVEVNSNCQEGELEQQLLQANPILEAFGNAKTVKNDNSSRFGKFIR 338
                                    ||..:|.||.|::||||:||||||||||:||||||||||||
Frog   211 ------------------------SNSLKGTLEDQIIQANPLLEAFGNAKTVRNDNSSRFGKFIR 251

  Fly   339 INFDASGFISGANIETYLLEKSRAIRQAKDERTFHIFYQLLAGATPEQREK-FILDDVKSYAFLS 402
            |:|..:|.:|.|:||||||||||...|...||::|||||::....||..|. .|..:...|..:|
Frog   252 IHFGTTGKLSSADIETYLLEKSRVTFQLSAERSYHIFYQMMTNKKPEIVEMCLITTNPYDYPSIS 316

  Fly   403 NGSLPVPGVDDYAEFQATVKSMNIMGMTSEDFNSIFRIVSAVLLFGSMKFRQERNNDQATLPDNT 467
            .|.:.|..:||..|..||..:::|:|...::...|:::..||:..|:|||:|::..:||. ||.|
Frog   317 QGEIVVKSIDDEEELMATDSAIDILGFNQDEKVGIYKLTGAVMHHGNMKFKQKQREEQAE-PDGT 380

  Fly   468 V-AQKIAHLLGLSVTDMTRAFLTPRIKVGRDFVTKAQTKEQVEFAVEAIAKACYERMFKWLVNRI 531
            . |.|||:|:||:..|:.:|...||:|||.:||||.||..||..:|.|:.|:.:|::|.|:|.||
Frog   381 EDADKIAYLMGLNSADLLKALCYPRVKVGNEFVTKGQTVPQVNNSVGALCKSVFEKLFLWMVIRI 445

  Fly   532 NRSLDRTKRQGASFIGILDMAGFEIFELNSFEQLCINYTNEKLQQLFNHTMFILEQEEYQREGIE 596
            |:.|| ||:....|||:||:||||||:.||.||||||:|||||||.|||.||:||||||::|||:
Frog   446 NQQLD-TKQPRQFFIGVLDIAGFEIFDFNSLEQLCINFTNEKLQQFFNHHMFVLEQEEYKKEGID 509

  Fly   597 WKFIDFGLDLQPTIDLIDKPGGIMALLDEECWFPKATDKTFVDKLVSAH------SMHPKFMKTD 655
            |:|||||:||...|:||:||.||.::|:|||.||||||.:|.:||...|      ...||..|.
Frog   510 WEFIDFGMDLAACIELIEKPMGIFSILEEECMFPKATDTSFKNKLYEQHLGKCKNFEKPKPGKG- 573

  Fly   656 FRGVADFAIVHYAGRVDYSAAKWLMKNMDPLNENIVSLLQGSQDPFVVNIWKDAEIVGMAQQALT 720
             :..|.|::|||||.|||:.:.||.||.|||||::|.|.|.|....:..::..    ..|.:|
Frog   574 -KAEAHFSLVHYAGTVDYNISGWLDKNKDPLNESVVQLYQKSSVKLLALLFSS----HAASEA-- 631

  Fly   721 DTQFGARTRKG-MFRTVSHLYKEQLAKLMDTLRNTNPNFVRCIIPNHEKRAGKIDAPLVLDQLRC 784
            |:..|.:.:|| .|:|||.|::|.|.|||..|::|:|:||||:|||..|..|.:|..|::.||||
Frog   632 DSGKGGKKKKGSSFQTVSALFRENLNKLMTNLKSTHPHFVRCLIPNETKTPGIMDNHLIIHQLRC 696

  Fly   785 NGVLEGIRICRQGFPNRIPFQEFRQRYELLTPNVIPKG-FMDGKKACEKMIQALELDSNLYRVGQ 848
            |||||||||||:|||:||.:.:|:|||::|..:.||.| |:|.||||||::.::::|...|:.|.
Frog   697 NGVLEGIRICRKGFPSRILYGDFKQRYKVLNASAIPDGQFIDSKKACEKLLGSIDVDHTQYKFGH 761

  Fly   849 SKIFFRAGVLAHLEEERDFKISDLIVNFQAFCRGFLARRNYQKRLQQLNAIRIIQRNCAAYLKLR 913
            :|:||:||:|..|||.||.|::.||...||.|||||.|..::|.:::..||.:||.|..:::.::
Frog   762 TKVFFKAGLLGTLEEMRDEKLAQLITCTQALCRGFLMRVEFKKMMERREAIYVIQYNLRSFMNVK 826

  Fly   914 NWQWWRLYTKVKPLLEVTKQEEKLVQKEDELKQVREKLDTLAKNTQEYERKYQQALVEKTTLAEQ 978
            :|.|.:||.|:||||:..:.|:::...::|.::.:|.|.......::.|.|....|.||..|..|
Frog   827 HWPWMKLYFKIKPLLQSAETEKEMQNMKEEFEKTKEALAKAETKAKDLEGKMVALLHEKNELVLQ 891

  Fly   979 LQAEIELCAEAEESRSRLMARKQELEDMMQELETRIEEEEERVLALGGEKKKLELNIQDLEEQLE 1043
            :|:|.|..|::||....|:..|.::|..::||..|:|:|||....|..:|:|||....:|::.::
Frog   892 VQSESETLADSEERCEGLIKSKIQMESKIKELTERLEDEEESNAELTAKKRKLEDECSELKKDID 956

  Fly  1044 EEEAARQKLQLEKVQLDAKIKKYEEDLALTDDQNQKLLKEKKLLEERANDLSQTLAEEEEKAKHL 1108
            :.|....|::.||...:.|:|...|::|..|:...||.||||.|:|........|..||:|...|
Frog   957 DLELTLAKVEKEKHATENKVKNLTEEMATLDENISKLSKEKKALQEAHQQTLDDLQAEEDKVSSL 1021

  Fly  1109 AKLKAKHEATISELEERLHKDQQQRQESDRSKRKIETEVADLKEQLNERRVQVDEMQAQLAKREE 1173
            .|.|.|.|..:.:||..|.::::.|.:.:|:|||:|.::...:|.:.:...:..:.:.:|.|::.
Frog  1022 TKAKTKLEQQVDDLEGSLEQEKKLRLDLERAKRKLEGDLKLSQETVMDLENEKQQAEEKLKKKDF 1086

  Fly  1174 ELTQTLLRIDEESATKATAQKAQRELESQLAEIQEDLEAEKAARAKAEKVRRDLSEELEALKNEL 1238
            |::|...:|::|.:.....||..:||::::.|::|::|||:|||||.||.|.|||.|||.:...|
Frog  1087 EISQLQGKIEDEQSLGIQLQKKIKELQARIEELEEEIEAERAARAKIEKQRADLSRELEEISERL 1151

  Fly  1239 LDSLDTTAAQQELRSKREQELATLKKSLEEETVNHEGVLADMRHKHSQELNSINDQLENLRKAKT 1303
            .::...|:||.|:..|||.|...|::.|||.|:.||.....:|.||:..:..:.:|::||::.|.
Frog  1152 EEAGGATSAQIEMNKKREAEFQKLRRDLEEATLQHEATAGALRKKHADSVAELGEQIDNLQRVKQ 1216

  Fly  1304 VLEKAKGTLEAENADLATELRSVNSSRQENDRRRKQAESQIAELQVKLAEIERARSELQEKCTKL 1368
            .|||.|..|:.|..|||:.|.:|:.|:...::..:..|.|::|::.|..|.:|..::|..:..:|
Frog  1217 KLEKEKSELKMEIDDLASNLENVSKSKANLEKVNRVVEDQLSEVKAKDDEHQRLLNDLSAQKARL 1281

  Fly  1369 QQEAENITNQLEEAELKASAAVKSASNMESQLTEAQQLLEEETRQKLGLSSKLRQIESEKEALQE 1433
            |.|...::.||||.|...|...:.......|:.|.::.|||||:.|..|:..|:....:.:.|:|
Frog  1282 QTENGELSRQLEEKESLISQLSRGKQGFTQQVEELKRQLEEETKAKNALAHGLQSARHDCDLLRE 1346

  Fly  1434 QLEEDDEAKRNYERKLAEVTTQMQEIKKKAEEDA-DLAKELEEGKKRLNKDIEALERQVKELIAQ 1497
            |.||:.|||...:|.|::...::.:.:.|.|.|| ...:||||.||:|.:.::..|.||:.:.::
Frog  1347 QFEEEQEAKAELQRSLSKANGEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQDAEEQVEAVNSK 1411

  Fly  1498 NDRLDKSKKKIQSELEDATIELEAQRTKVLELEKKQKNFDKILAEEKAISEQIAQERDTAEREAR 1562
            ...|:|:|:::|||:||..:::|...:....|:|||:||||:|:|.|...|:...|.:.|.:|||
Frog  1412 CASLEKTKQRLQSEVEDLMVDVERANSAAASLDKKQRNFDKVLSEWKQKYEEGQAELEAALKEAR 1476

  Fly  1563 EKETKVLSVSRELDEAFDKIEDLENKRKTLQNELDDLANTQGTADKNVHELEKAKRALESQLAEL 1627
            ...|::..:....:||.:::|.|:.:.|.||.|:.||....|...|:::||||:|:.:|.:..:|
Frog  1477 SLSTEIFKMKNAYEEALEQVETLKRENKNLQQEISDLTEQIGEGSKSINELEKSKKQVEQEKNDL 1541

  Fly  1628 KAQNEELEDDLQLTEDAKLRLEVNMQALRSQFERDLLAKEEGAEEKRRGLVKQLRDLETELDEER 1692
            :|..||.|..|:..|...||:::.:..::|:.:|.:..|:|..|:.:|...:.:..:::.||.|.
Frog  1542 QAALEEAEGSLEHEEAKILRIQLELNQVKSEVDRKIAEKDEEIEQLKRNSQRSIDTMQSTLDSEI 1606

  Fly  1693 KQRTAAVASKKKLEGDLKEIETTMEMHNKVKEDALKHAKKLQAQVKDALRDAEEAKAAKEELQAL 1757
            :.|..|:..|||:||||.|:|..:...|:...:|.|..:.:|||.||.....::|....::|:..
Frog  1607 RSRNDALRLKKKMEGDLNELEIQLSHANRQAGEAQKQLRNVQAQYKDTQLQLDDALRGHDDLKEQ 1671

  Fly  1758 SKEAERKVKALEAEVLQLTEDLASSERARRAAETERDELAEEIANNANKGSLMIDEKRRLEARIA 1822
            ....||:....:||:.:....|..:||:|:.||.|..:.:|.:....::.:.:|:.|::||:.|.
Frog  1672 VAVIERRNNLQQAEIEENRSALEQTERSRKIAEQELLDSSERLQLLHSQNTSLINSKKKLESDIG 1736

  Fly  1823 TLEEELEE---EQSNSEVLLDRSRKAQLQIEQLTTELANEKSNSQKNENGRALLERQNKELKAKL 1884
            .|:.|.||   |..|:|   ::::||......:..||..|:..|...|..:..||:..|:|:.:|
Frog  1737 QLQNEAEEAVQEARNAE---EKAKKAITDAALMAEELKKEQDTSAHLERMKKNLEQTVKDLQNRL 1798

  Fly  1885 AEIETAQRTKVKATIATLEAKIANLEEQLENEGKERLLQQKANRKMDKKIKELTMNIEDERRHVD 1949
            .|.|.......|..:..||:::..||.:|:||.|..:...|..||.::::||||...|::|::|.
Frog  1799 DEAEQLAMKGGKKQLQKLESRVRELENELDNEQKRGVEAVKGVRKYERRVKELTYQTEEDRKNVL 1863

  Fly  1950 QHKEQMDKLNSRIKLLKRNLDETEEELQKEKTQKRKYQRECEDMIESQEAMNREINSLKTKLRRT 2014
            :.::.:|||..::|..||..:|:||:.....::.||.|.|.|:..|..:....::|.|:||.|..
Frog  1864 RLQDLVDKLQLKVKAYKRQAEESEEQANAHLSRFRKVQHELEEAEERADIAESQVNKLRTKSRDI 1928

  Fly  2015 GG 2016
            ||
Frog  1929 GG 1930

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
zip	NP_523860.2	Myosin_N	80..117	CDD:280832	7/36 (19%)
		Myosin_head	133..854	CDD:278492	358/730 (49%)
		MYSc_Myh2_insects_mollusks	145..854	CDD:276876	350/718 (49%)
		Myosin_tail_1	931..2011	CDD:279860	342/1083 (32%)
		Prefoldin	1431..1515	CDD:298833	31/84 (37%)
		FAM76	<1847..1926	CDD:292665	21/78 (27%)
myh8	XP_012824466.1	Myosin_N	34..72	CDD:367160	8/38 (21%)
		MYSc_class_II	99..767	CDD:276951	350/718 (49%)
		Myosin_tail_1	847..1924	CDD:366712	341/1079 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D47111at2759
OrthoFinder	1	1.000	-	-		FOG0000014
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X58
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	4.010