Protein Alignment zip and myo5b

DIOPT Version :10

• Sequence 1: NP_523860.2
• Gene: zip / 38001
• FlyBaseID: FBgn0287873
• Length: 2056
• Species: Drosophila melanogaster
• Sequence 2: XP_031750785.1
• Gene: myo5b / 100379760
• XenbaseID: XB-GENE-988439
• Length: 1835
• Species: Xenopus tropicalis
• Alignment Length: 2046
• Identity: 545/2046 - (26%)
• Similarity: 908/2046 - (44%)
• Gaps: 424/2046 - (20%)

  Fly    76 WTQKRLVWVPHENQGFVAASIKREH--GDEVEVELAETGKRVMILRDDIQKM----NPPKFDKVE 134
            ::|...||:|.....:.:|.|.:::  ||: .::|....:.|:..|.|...:    ||.......
 Frog     7 YSQYTRVWIPDPEDVWRSAEIIKDYKEGDK-SLQLKLEDESVIQHRVDPNNLPHLRNPDILVGEN 70

  Fly   135 DMAELTCLNEASVLHNIKDRYY-SGLIYTYSGLFCVVVNPYKKLPIYTEKIMERYKGIKRHEVPP 198
            |:..|:.|:|.:||||:|.|:. |..||||.|:..|.:|||::||:|.|.::..|.|....::.|
 Frog    71 DLTALSYLHEPAVLHNLKVRFLESNHIYTYCGIVLVAINPYQQLPVYGEDVIYAYSGQNMGDMDP 135

  Fly   199 HVFAITDSAYRNMLGDREDQSILCTGESGAGKTENTKKVIQFLAYVAASKPKGSGAVPHPAVLIN 263
            |:||:.:.||:.|..|.::|||:.:||||||||.:.|..:::.|.|..|
 Frog   136 HIFAVAEEAYKQMARDEKNQSIIVSGESGAGKTVSAKYAMRYFATVGGS---------------- 184

  Fly   264 FSVNTNKYIKVKIMAQNQNQTIEVVNGLKMVEVNSNCQEGELEQQLLQANPILEAFGNAKTVKND 328
                                                ..|..:|:::|.::||:||.|||||.:||
 Frog   185 ------------------------------------ASEANVEEKVLASSPIMEAIGNAKTTRND 213

  Fly   329 NSSRFGKFIRINFDASGFISGANIETYLLEKSRAIRQAKDERTFHIFYQLLAGATPEQREKFILD 393
            |||||||:|:|.||....|.|||:.||||||||.:.||..||.:||||||.|.|:..:..:..|.
 Frog   214 NSSRFGKYIQIGFDKRYHIIGANMRTYLLEKSRVVFQADMERNYHIFYQLCASASLPEFSELSLA 278

  Fly   394 DVKSYAFLSNGSLPV-PGVDDYAEFQATVKSMNIMGMTSEDFNSIFRIVSAVLLFGSMKFRQERN 457
            :.:.:.:.:.|..|| .||||..:|:.|.::..::|:.......||:||:::|..|::..:.||.
 Frog   279 EAEEFFYTNQGGDPVIDGVDDAEDFEKTRQAFTLLGVKETHQMGIFKIVASILHLGNVAIQTERE 343

  Fly   458 NDQATLPDNTVAQKIAH---LLGLSVTDMTRAFLTPRIKVGRDFVTKAQTKEQVEFAVEAIAKAC 519
            .:...|....  :.:.|   ||||....|.......::....:...|..:.||...|..|:||..
 Frog   344 GESCNLSKGD--KHLTHFCSLLGLEQDQMQHWLCHRKLVTTSETYVKTMSAEQAVNARNALAKHI 406

  Fly   520 YERMFKWLVNRINRSLDRTKRQGASFIGILDMAGFEIFELNSFEQLCINYTNEKLQQLFNHTMFI 584
            |.::|.|:|..:|::|..|.:| .||||:||:.|||.||:|||||.||||.||||||.||..:|.
 Frog   407 YAQLFNWIVQHVNKALHTTIKQ-HSFIGVLDIYGFETFEINSFEQFCINYANEKLQQQFNSHVFK 470

  Fly   585 LEQEEYQREGIEWKFIDFGLDLQPTIDLIDKPGGIMALLDEECWFPKATDKTFVDKLVSAHSMHP 649
            ||||||.:|.|.|..||| .|.||.||||:...||:.||||||..||.||:.:..||...|....
 Frog   471 LEQEEYMKEQIPWTLIDF-YDNQPCIDLIEAKLGILDLLDEECKVPKGTDQNWAQKLYDRHGSSQ 534

  Fly   650 KFMKTDFRGVADFAIVHYAGRVDYSAAKWLMKNMDPLNENIVSLLQGSQDPFVVNIWKDAE---- 710
            .|.|.....|| |.:||:|.:|:|....:|.||.|.:.|..:::|:.|:.|.|.:::::.:
 Frog   535 HFKKPRMSNVA-FIVVHFADQVEYQCDGFLEKNRDTVYEEQINILKASKYPLVADLFQNEKDTVP 598

  Fly   711 ---------IVGMAQQALTDTQFGARTRKGMFRTVSHLYKEQLAKLMDTLRNTNPNFVRCIIPNH 766
                     .|..|:.||..      ..|...:||.|.::..|..||:||..|.|::||||.||.
 Frog   599 PTPTGKSKISVRPAKPALKS------ANKEHKKTVGHQFRNSLHLLMETLNATTPHYVRCIKPND 657

  Fly   767 EKRAGKIDAPLVLDQLRCNGVLEGIRICRQGFPNRIPFQEFRQRYE-LLTPNVIPKGFMDGKKAC 830
            .|.:...|....:.|||..||||.|||...|:|:|..:.:|..||. |:....|..|  |.|..|
 Frog   658 YKESFSFDPKRAVQQLRACGVLETIRISAAGYPSRWTYHDFFNRYRVLMKKKDISLG--DKKVIC 720

  Fly   831 EKMIQALELDSNLYRVGQSKIFFRAGVLAHLEEERDFKISDLIVNFQAFCRGFLARRNYQKRLQQ 895
            :.:::.|..|.:.::.|::|||||||.:|:||:.|..|.....:..|...||:|.|..| :|:::
 Frog   721 KNVLENLIKDPDKFQFGRTKIFFRAGQVAYLEKLRADKFRAATIMIQKTVRGWLQRVKY-RRMKK 784

  Fly   896 LNAIRIIQRNCAAYLKLRNWQWWRLYTKVKPLLEVTKQEEKLVQKEDELKQVREKLDTLAKNTQE 960
              |...|||....:|..|    ..|:.::.......:::.::::.....::.|:...|:...|:.
 Frog   785 --AAVTIQRYTRGHLARR----LALHLRMTKAAITFQKQFRMIRVYRGFQKTRKAAVTIQSYTRG 843

  Fly   961 --YERKYQQ-------ALVEK---TTLAEQLQAEIELCAEAEESRSRLMARKQELEDMMQELETR 1013
              ..|.|:|       |:::|   ...|.:|.::....|...:...|.|..::||:.:  ::|.|
 Frog   844 MFVRRAYRQLLEQHKAAIIQKHWRGWRARKLFSKFRSAAVVIQCYFRRMKARRELKQL--KIEAR 906

  Fly  1014 IEEEEERVLALGGEKKKLELNIQDLEEQLEEEEAARQKLQLEKVQLDAKIKKYEEDLALTDDQNQ 1078
            ..|..:: |::|.|.|                          .|||..|:          |:||
 Frog   907 TAEHFKK-LSVGMENK--------------------------VVQLQRKL----------DEQN- 933

  Fly  1079 KLLKEKKLLEERANDLSQTLAEEEEKAKHLAKLKAKHEATISELEERLHKDQQQRQESDRSKRKI 1143
               ||:|.|:|:....:.|.|.|.||                 |::.|.| |:|.|:.:.....:
 Frog   934 ---KEQKDLKEQLVSATSTHAVEVEK-----------------LQKELEK-QRQAQQDENQLTSL 977

  Fly  1144 ETEVADLKEQL----NERRVQVDEMQAQLAKREEELTQTLLRIDEESATKATAQKAQRELESQLA 1204
            :.|:..|:|:|    :|::|..|    .|...:|:|.|.:..::||:.
 Frog   978 QQELEALREELAKAYSEKKVVED----TLMNEKEQLLQRVSELEEENT----------------- 1021

  Fly  1205 EIQEDLEAEKAARAKAEKVRRDLSEELEALKNELLDSLDTTAAQQELRSKREQELATLKKSLEEE 1269
                                 :|.||.|.|.|:::           |||:.|...:|:|::||
 Frog  1022 ---------------------NLKEEKEELSNKII-----------LRSEDEFTQSTIKENLE-- 1052

  Fly  1270 TVNHEGVLADMRHKHSQELNSINDQLENLRKAKTVLEKAKGTLEAENADLATELRSVNSSRQEND 1334
                  :..|:..:.|:.        :||.|..|.||:....|:.|          ||..:|:..
 Frog  1053 ------IKKDLEEERSRH--------QNLVKEYTRLEQRYDNLKEE----------VNIIKQQMP 1093

  Fly  1335 RRRKQAESQIAELQVKLAEIERARSELQEKCTKLQQEAENITNQLEEAELKASAAVKSASNMESQ 1399
            ..|:...:|        :.:| :.|......|....:.|:...::|||.|:.:|       |:..
 Frog  1094 GHRRNPSNQ--------SSLE-SDSNYPSISTSEIGDTEDTIKEVEEAGLEKAA-------MDMS 1142

  Fly  1400 LTEAQQLLEEETRQKLGLSSKLRQIESEKEALQEQLEEDDEAKRNYERKLAEVTTQMQEIKKKAE 1464
            |.             |.|..::|::|.|::.||.||::    |...|.|.::|.....|:  .|:
 Frog  1143 LF-------------LKLQKRVRELELERKKLQSQLDK----KEQQENKKSQVIDTTNEV--IAD 1188

  Fly  1465 EDADLA------KELEEGKKRLNKDIEALERQVKELIAQNDRLDKSKKKIQSELEDATIELEAQR 1523
            .|.|:|      :|||...|:|..|:..:.:.:.:........:.....:.::|:.|..||:.::
 Frog  1189 RDTDIAYNNLKRQELESENKKLKNDLNEMRKTIADGAVDGSSEEARIAMLLNQLKSAHEELDVRK 1253

  Fly  1524 TKVLELE------KKQKNFDKILAEE-------KAISEQIAQE--RDTAEREAREKETKVLSVSR 1573
            .:||.|.      .:||..::|::.|       |.:.|..|.|  ....|...:.::...|:...
 Frog  1254 EEVLMLRTQIVKAAQQKESERIMSSEASWPNSNKEMDEDDAIEAYHGVCETNRKTQDWGYLNEDG 1318

  Fly  1574 ELDEAFDKIEDLENKRKTLQNELDDLANTQGTADKNVHELEKAKRALESQLAELKAQNEELEDDL 1638
            ||..|:   :.|:...:.|:.:|      |..:.::..|:|.....::|...||:.|.:.|...|
 Frog  1319 ELGLAY---QGLKQVARLLEAQL------QAQSRQHDEEVEILTSHIDSLKEELEKQQQVLLQAL 1374

  Fly  1639 QLTEDAKLRLEVNMQALRSQFE----RDLLAKEEGAEEKRRGLVKQLR-------DLETELDEER 1692
            ||:.:|::...:..:..|...|    ::||.|.|..|:|   |.|||:       |.|..:..||
 Frog  1375 QLSPEAQVEFGLQHEITRLTNENLDLKELLEKSEKNEKK---LKKQLKTYMKKGQDSEDVVQTER 1436

  Fly  1693 KQRTAAVASKKKLEGDLKEIETTMEMHNKVKEDALKHAKKLQAQVKDALRDAEEAKAAKEELQAL 1757
            |.......:.:::|   |:.:..:|.:   ||:.....:.|...||            .|::.::
 Frog  1437 KPELTRQVTVQRIE---KDFQGMLEYY---KEEEPLLVRNLIIDVK------------PEQMSSM 1483

  Fly  1758 SKEAERKVKALEAEVLQLTEDLASSERARRAAETERDELAEEIANNANKGSLMIDEKRRLEARIA 1822
                   |..|.|.:|.:.        .|.|.....|:....:..:...|...:.:|...|.:|.
 Frog  1484 -------VPCLPAYILFMC--------IRHADYINDDQKVHSLLTSTINGIKKVLKKHHSEFQIT 1533

  Fly  1823 T------------LEEELEEE---QSNS-----------------EVLLDRSRKAQLQIEQLTTE 1855
            :            |::...:|   .|||                 :||.|.|    :||.|...:
 Frog  1534 SFWLSNSSRLLHCLKQYSGDEGFMTSNSPKQNEHCLRNFDLTEYRQVLSDLS----IQIYQQMIK 1594

  Fly  1856 LANEKSNSQKNENGRALLERQNKELKAKLAEIETAQRTKVKA---TIATLEAKIANL---EEQLE 1914
            :|..........   |:||.::.:..:.:.:....:||...|   ...:|||.|..|   ...:.
 Frog  1595 IAETHMQPMIVS---AMLETESIQGLSGVKQTGYRKRTSSMADGDNSYSLEAVIRQLNTFNSIMC 1656

  Fly  1915 NEGKERLLQQKANRKMDKKIKELTMNIEDERRHVDQHKEQMDKLNSRIKLLKRNLDETEEELQKE 1979
            :.|.:..:.|:..:::...|..:|:|....|:.|......|.        |:.|:.:.||.|:.:
 Frog  1657 DHGLDPEIIQQVFKQLFYMINAVTLNNLLLRKDVCSWSTGMQ--------LRYNISQLEEWLRGK 1713

  Fly  1980 KTQKRKYQRECEDMIESQEAMNREINSLKTK 2010
            ........:..|.:|::.:.:     .||.|
 Frog  1714 NLHPSGAAQTMEPLIQAAQLL-----QLKKK 1739

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
zip	NP_523860.2	Myosin_N	79..122	CDD:460670	10/44 (23%)
		MYSc_Myh2_insects_mollusks	145..854	CDD:276876	268/727 (37%)
		Myosin_tail_1	931..2011	CDD:460256	236/1166 (20%)
myo5b	XP_031750785.1	MYSc_Myo5	81..744	CDD:276831	268/727 (37%)
		IQ	758..780	CDD:197470	7/22 (32%)
		IQ	781..800	CDD:197470	6/20 (30%)
		IQCD	851..880	CDD:467745	5/28 (18%)
		Smc	<895..>1465	CDD:440809	166/762 (22%)
		Myo5b_CBD	1461..1832	CDD:271261	59/326 (18%)