DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment zip and myo5b

DIOPT Version :9

Sequence 1:NP_523860.2 Gene:zip / 38001 FlyBaseID:FBgn0265434 Length:2056 Species:Drosophila melanogaster
Sequence 2:XP_031750785.1 Gene:myo5b / 100379760 XenbaseID:XB-GENE-988439 Length:1835 Species:Xenopus tropicalis


Alignment Length:2046 Identity:545/2046 - (26%)
Similarity:908/2046 - (44%) Gaps:424/2046 - (20%)


- Green bases have known domain annotations that are detailed below.


  Fly    76 WTQKRLVWVPHENQGFVAASIKREH--GDEVEVELAETGKRVMILRDDIQKM----NPPKFDKVE 134
            ::|...||:|.....:.:|.|.:::  ||: .::|....:.|:..|.|...:    ||.......
 Frog     7 YSQYTRVWIPDPEDVWRSAEIIKDYKEGDK-SLQLKLEDESVIQHRVDPNNLPHLRNPDILVGEN 70

  Fly   135 DMAELTCLNEASVLHNIKDRYY-SGLIYTYSGLFCVVVNPYKKLPIYTEKIMERYKGIKRHEVPP 198
            |:..|:.|:|.:||||:|.|:. |..||||.|:..|.:|||::||:|.|.::..|.|....::.|
 Frog    71 DLTALSYLHEPAVLHNLKVRFLESNHIYTYCGIVLVAINPYQQLPVYGEDVIYAYSGQNMGDMDP 135

  Fly   199 HVFAITDSAYRNMLGDREDQSILCTGESGAGKTENTKKVIQFLAYVAASKPKGSGAVPHPAVLIN 263
            |:||:.:.||:.|..|.::|||:.:||||||||.:.|..:::.|.|..|                
 Frog   136 HIFAVAEEAYKQMARDEKNQSIIVSGESGAGKTVSAKYAMRYFATVGGS---------------- 184

  Fly   264 FSVNTNKYIKVKIMAQNQNQTIEVVNGLKMVEVNSNCQEGELEQQLLQANPILEAFGNAKTVKND 328
                                                ..|..:|:::|.::||:||.|||||.:||
 Frog   185 ------------------------------------ASEANVEEKVLASSPIMEAIGNAKTTRND 213

  Fly   329 NSSRFGKFIRINFDASGFISGANIETYLLEKSRAIRQAKDERTFHIFYQLLAGATPEQREKFILD 393
            |||||||:|:|.||....|.|||:.||||||||.:.||..||.:||||||.|.|:..:..:..|.
 Frog   214 NSSRFGKYIQIGFDKRYHIIGANMRTYLLEKSRVVFQADMERNYHIFYQLCASASLPEFSELSLA 278

  Fly   394 DVKSYAFLSNGSLPV-PGVDDYAEFQATVKSMNIMGMTSEDFNSIFRIVSAVLLFGSMKFRQERN 457
            :.:.:.:.:.|..|| .||||..:|:.|.::..::|:.......||:||:::|..|::..:.||.
 Frog   279 EAEEFFYTNQGGDPVIDGVDDAEDFEKTRQAFTLLGVKETHQMGIFKIVASILHLGNVAIQTERE 343

  Fly   458 NDQATLPDNTVAQKIAH---LLGLSVTDMTRAFLTPRIKVGRDFVTKAQTKEQVEFAVEAIAKAC 519
            .:...|....  :.:.|   ||||....|.......::....:...|..:.||...|..|:||..
 Frog   344 GESCNLSKGD--KHLTHFCSLLGLEQDQMQHWLCHRKLVTTSETYVKTMSAEQAVNARNALAKHI 406

  Fly   520 YERMFKWLVNRINRSLDRTKRQGASFIGILDMAGFEIFELNSFEQLCINYTNEKLQQLFNHTMFI 584
            |.::|.|:|..:|::|..|.:| .||||:||:.|||.||:|||||.||||.||||||.||..:|.
 Frog   407 YAQLFNWIVQHVNKALHTTIKQ-HSFIGVLDIYGFETFEINSFEQFCINYANEKLQQQFNSHVFK 470

  Fly   585 LEQEEYQREGIEWKFIDFGLDLQPTIDLIDKPGGIMALLDEECWFPKATDKTFVDKLVSAHSMHP 649
            ||||||.:|.|.|..||| .|.||.||||:...||:.||||||..||.||:.:..||...|....
 Frog   471 LEQEEYMKEQIPWTLIDF-YDNQPCIDLIEAKLGILDLLDEECKVPKGTDQNWAQKLYDRHGSSQ 534

  Fly   650 KFMKTDFRGVADFAIVHYAGRVDYSAAKWLMKNMDPLNENIVSLLQGSQDPFVVNIWKDAE---- 710
            .|.|.....|| |.:||:|.:|:|....:|.||.|.:.|..:::|:.|:.|.|.:::::.:    
 Frog   535 HFKKPRMSNVA-FIVVHFADQVEYQCDGFLEKNRDTVYEEQINILKASKYPLVADLFQNEKDTVP 598

  Fly   711 ---------IVGMAQQALTDTQFGARTRKGMFRTVSHLYKEQLAKLMDTLRNTNPNFVRCIIPNH 766
                     .|..|:.||..      ..|...:||.|.::..|..||:||..|.|::||||.||.
 Frog   599 PTPTGKSKISVRPAKPALKS------ANKEHKKTVGHQFRNSLHLLMETLNATTPHYVRCIKPND 657

  Fly   767 EKRAGKIDAPLVLDQLRCNGVLEGIRICRQGFPNRIPFQEFRQRYE-LLTPNVIPKGFMDGKKAC 830
            .|.:...|....:.|||..||||.|||...|:|:|..:.:|..||. |:....|..|  |.|..|
 Frog   658 YKESFSFDPKRAVQQLRACGVLETIRISAAGYPSRWTYHDFFNRYRVLMKKKDISLG--DKKVIC 720

  Fly   831 EKMIQALELDSNLYRVGQSKIFFRAGVLAHLEEERDFKISDLIVNFQAFCRGFLARRNYQKRLQQ 895
            :.:::.|..|.:.::.|::|||||||.:|:||:.|..|.....:..|...||:|.|..| :|:::
 Frog   721 KNVLENLIKDPDKFQFGRTKIFFRAGQVAYLEKLRADKFRAATIMIQKTVRGWLQRVKY-RRMKK 784

  Fly   896 LNAIRIIQRNCAAYLKLRNWQWWRLYTKVKPLLEVTKQEEKLVQKEDELKQVREKLDTLAKNTQE 960
              |...|||....:|..|    ..|:.::.......:::.::::.....::.|:...|:...|:.
 Frog   785 --AAVTIQRYTRGHLARR----LALHLRMTKAAITFQKQFRMIRVYRGFQKTRKAAVTIQSYTRG 843

  Fly   961 --YERKYQQ-------ALVEK---TTLAEQLQAEIELCAEAEESRSRLMARKQELEDMMQELETR 1013
              ..|.|:|       |:::|   ...|.:|.::....|...:...|.|..::||:.:  ::|.|
 Frog   844 MFVRRAYRQLLEQHKAAIIQKHWRGWRARKLFSKFRSAAVVIQCYFRRMKARRELKQL--KIEAR 906

  Fly  1014 IEEEEERVLALGGEKKKLELNIQDLEEQLEEEEAARQKLQLEKVQLDAKIKKYEEDLALTDDQNQ 1078
            ..|..:: |::|.|.|                          .|||..|:          |:|| 
 Frog   907 TAEHFKK-LSVGMENK--------------------------VVQLQRKL----------DEQN- 933

  Fly  1079 KLLKEKKLLEERANDLSQTLAEEEEKAKHLAKLKAKHEATISELEERLHKDQQQRQESDRSKRKI 1143
               ||:|.|:|:....:.|.|.|.||                 |::.|.| |:|.|:.:.....:
 Frog   934 ---KEQKDLKEQLVSATSTHAVEVEK-----------------LQKELEK-QRQAQQDENQLTSL 977

  Fly  1144 ETEVADLKEQL----NERRVQVDEMQAQLAKREEELTQTLLRIDEESATKATAQKAQRELESQLA 1204
            :.|:..|:|:|    :|::|..|    .|...:|:|.|.:..::||:.                 
 Frog   978 QQELEALREELAKAYSEKKVVED----TLMNEKEQLLQRVSELEEENT----------------- 1021

  Fly  1205 EIQEDLEAEKAARAKAEKVRRDLSEELEALKNELLDSLDTTAAQQELRSKREQELATLKKSLEEE 1269
                                 :|.||.|.|.|:::           |||:.|...:|:|::||  
 Frog  1022 ---------------------NLKEEKEELSNKII-----------LRSEDEFTQSTIKENLE-- 1052

  Fly  1270 TVNHEGVLADMRHKHSQELNSINDQLENLRKAKTVLEKAKGTLEAENADLATELRSVNSSRQEND 1334
                  :..|:..:.|:.        :||.|..|.||:....|:.|          ||..:|:..
 Frog  1053 ------IKKDLEEERSRH--------QNLVKEYTRLEQRYDNLKEE----------VNIIKQQMP 1093

  Fly  1335 RRRKQAESQIAELQVKLAEIERARSELQEKCTKLQQEAENITNQLEEAELKASAAVKSASNMESQ 1399
            ..|:...:|        :.:| :.|......|....:.|:...::|||.|:.:|       |:..
 Frog  1094 GHRRNPSNQ--------SSLE-SDSNYPSISTSEIGDTEDTIKEVEEAGLEKAA-------MDMS 1142

  Fly  1400 LTEAQQLLEEETRQKLGLSSKLRQIESEKEALQEQLEEDDEAKRNYERKLAEVTTQMQEIKKKAE 1464
            |.             |.|..::|::|.|::.||.||::    |...|.|.::|.....|:  .|:
 Frog  1143 LF-------------LKLQKRVRELELERKKLQSQLDK----KEQQENKKSQVIDTTNEV--IAD 1188

  Fly  1465 EDADLA------KELEEGKKRLNKDIEALERQVKELIAQNDRLDKSKKKIQSELEDATIELEAQR 1523
            .|.|:|      :|||...|:|..|:..:.:.:.:........:.....:.::|:.|..||:.::
 Frog  1189 RDTDIAYNNLKRQELESENKKLKNDLNEMRKTIADGAVDGSSEEARIAMLLNQLKSAHEELDVRK 1253

  Fly  1524 TKVLELE------KKQKNFDKILAEE-------KAISEQIAQE--RDTAEREAREKETKVLSVSR 1573
            .:||.|.      .:||..::|::.|       |.:.|..|.|  ....|...:.::...|:...
 Frog  1254 EEVLMLRTQIVKAAQQKESERIMSSEASWPNSNKEMDEDDAIEAYHGVCETNRKTQDWGYLNEDG 1318

  Fly  1574 ELDEAFDKIEDLENKRKTLQNELDDLANTQGTADKNVHELEKAKRALESQLAELKAQNEELEDDL 1638
            ||..|:   :.|:...:.|:.:|      |..:.::..|:|.....::|...||:.|.:.|...|
 Frog  1319 ELGLAY---QGLKQVARLLEAQL------QAQSRQHDEEVEILTSHIDSLKEELEKQQQVLLQAL 1374

  Fly  1639 QLTEDAKLRLEVNMQALRSQFE----RDLLAKEEGAEEKRRGLVKQLR-------DLETELDEER 1692
            ||:.:|::...:..:..|...|    ::||.|.|..|:|   |.|||:       |.|..:..||
 Frog  1375 QLSPEAQVEFGLQHEITRLTNENLDLKELLEKSEKNEKK---LKKQLKTYMKKGQDSEDVVQTER 1436

  Fly  1693 KQRTAAVASKKKLEGDLKEIETTMEMHNKVKEDALKHAKKLQAQVKDALRDAEEAKAAKEELQAL 1757
            |.......:.:::|   |:.:..:|.:   ||:.....:.|...||            .|::.::
 Frog  1437 KPELTRQVTVQRIE---KDFQGMLEYY---KEEEPLLVRNLIIDVK------------PEQMSSM 1483

  Fly  1758 SKEAERKVKALEAEVLQLTEDLASSERARRAAETERDELAEEIANNANKGSLMIDEKRRLEARIA 1822
                   |..|.|.:|.:.        .|.|.....|:....:..:...|...:.:|...|.:|.
 Frog  1484 -------VPCLPAYILFMC--------IRHADYINDDQKVHSLLTSTINGIKKVLKKHHSEFQIT 1533

  Fly  1823 T------------LEEELEEE---QSNS-----------------EVLLDRSRKAQLQIEQLTTE 1855
            :            |::...:|   .|||                 :||.|.|    :||.|...:
 Frog  1534 SFWLSNSSRLLHCLKQYSGDEGFMTSNSPKQNEHCLRNFDLTEYRQVLSDLS----IQIYQQMIK 1594

  Fly  1856 LANEKSNSQKNENGRALLERQNKELKAKLAEIETAQRTKVKA---TIATLEAKIANL---EEQLE 1914
            :|..........   |:||.::.:..:.:.:....:||...|   ...:|||.|..|   ...:.
 Frog  1595 IAETHMQPMIVS---AMLETESIQGLSGVKQTGYRKRTSSMADGDNSYSLEAVIRQLNTFNSIMC 1656

  Fly  1915 NEGKERLLQQKANRKMDKKIKELTMNIEDERRHVDQHKEQMDKLNSRIKLLKRNLDETEEELQKE 1979
            :.|.:..:.|:..:::...|..:|:|....|:.|......|.        |:.|:.:.||.|:.:
 Frog  1657 DHGLDPEIIQQVFKQLFYMINAVTLNNLLLRKDVCSWSTGMQ--------LRYNISQLEEWLRGK 1713

  Fly  1980 KTQKRKYQRECEDMIESQEAMNREINSLKTK 2010
            ........:..|.:|::.:.:     .||.|
 Frog  1714 NLHPSGAAQTMEPLIQAAQLL-----QLKKK 1739

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
zipNP_523860.2 Myosin_N 80..117 CDD:280832 9/38 (24%)
Myosin_head 133..854 CDD:278492 272/739 (37%)
MYSc_Myh2_insects_mollusks 145..854 CDD:276876 268/727 (37%)
Myosin_tail_1 931..2011 CDD:279860 236/1166 (20%)
Prefoldin 1431..1515 CDD:298833 20/89 (22%)
FAM76 <1847..1926 CDD:292665 17/84 (20%)
myo5bXP_031750785.1 MYSc_Myo5 81..744 CDD:276831 268/727 (37%)
IQ 758..780 CDD:197470 7/22 (32%)
IQ 781..800 CDD:197470 6/20 (30%)
IQ 855..875 CDD:197470 3/19 (16%)
Smc 895..>1217 CDD:224117 109/496 (22%)
Smc 1123..>1458 CDD:224117 86/375 (23%)
Myo5b_CBD 1461..1832 CDD:271261 59/326 (18%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 1 1.000 - - FOG0000014
OrthoInspector 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
11.000

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