Protein Alignment zip and smyhc2

DIOPT Version :10

• Sequence 1: NP_523860.2
• Gene: zip / 38001
• FlyBaseID: FBgn0287873
• Length: 2056
• Species: Drosophila melanogaster
• Sequence 2: NP_001096096.2
• Gene: smyhc2 / 100124599
• ZFINID: ZDB-GENE-070822-12
• Length: 1939
• Species: Danio rerio
• Alignment Length: 1975
• Identity: 761/1975 - (38%)
• Similarity: 1195/1975 - (60%)
• Gaps: 71/1975 - (3%)

  Fly    55 PELKYLSVERNQFNDPATQAEWTQKRLVWVPHENQGFVAASIKREHGDEVEVELAETGKRVMILR 119
            |.|:....||.:    |....:..|:..:||.....:|.||:....||:|.|| .|.||.|.:..
Zfish    14 PFLRKSDKERLE----AQTRPFDMKKECFVPDPEVEYVKASVTSRDGDKVTVE-TEFGKTVTVKE 73

  Fly   120 DDIQKMNPPKFDKVEDMAELTCLNEASVLHNIKDRYYSGLIYTYSGLFCVVVNPYKKLPIYTEKI 184
            .|....|||||||:||||..|.|:|.:||.|:|:||.:.:||||||||||.|||||.||:|.:::
Zfish    74 VDCHPQNPPKFDKIEDMAMFTFLHEPAVLFNLKERYAAWMIYTYSGLFCVTVNPYKWLPVYNQEV 138

  Fly   185 MERYKGIKRHEVPPHVFAITDSAYRNMLGDREDQSILCTGESGAGKTENTKKVIQFLAYVAASKP 249
            :..|:|.||.|.|||:|:|:|:||:.||.|||:||:|.|||||||||.|||:|||:.|.:||:
Zfish   139 VVAYRGKKRTEAPPHIFSISDNAYQYMLSDRENQSVLITGESGAGKTVNTKRVIQYFASIAAA-- 201

  Fly   250 KGSGAVPHPAVLINFSVNTNKYIKVKIMAQNQNQTIEVVNGLKMVEVNSNCQEGELEQQLLQANP 314
              .|....|                                       |..::|.||.|::|.||
Zfish   202 --PGGKKDP---------------------------------------SQEKKGTLEDQIIQCNP 225

  Fly   315 ILEAFGNAKTVKNDNSSRFGKFIRINFDASGFISGANIETYLLEKSRAIRQAKDERTFHIFYQLL 379
            .|||||||||::|||||||||||||:|..||.:|.|:||||||||||...|.|.||.:|||||:|
Zfish   226 ALEAFGNAKTIRNDNSSRFGKFIRIHFGVSGKLSSADIETYLLEKSRVTYQLKAERDYHIFYQIL 290

  Fly   380 AGATPEQREKFIL-DDVKSYAFLSNGSLPVPGVDDYAEFQATVKSMNIMGMTSEDFNSIFRIVSA 443
            :...||..|..:: ::...|:::|.|...|..:||..|..||.::.:::|.|.|:.|||:::..|
Zfish   291 SQRKPELLEMLLITNNPYDYSYISQGETQVASIDDRDELIATDEAFDVLGFTQEEKNSIYKLTGA 355

  Fly   444 VLLFGSMKFRQERNNDQATLPDNTVAQKIAHLLGLSVTDMTRAFLTPRIKVGRDFVTKAQTKEQV 508
            ::.:|:|||:|::..:||.......|.|:|:|:||:..|:.:....||:|||.::|||.|..:||
Zfish   356 IMHYGNMKFKQKQREEQAEADGTEDADKVAYLMGLNSADLIKGLCHPRVKVGNEWVTKGQNVQQV 420

  Fly   509 EFAVEAIAKACYERMFKWLVNRINRSLDRTKRQGASFIGILDMAGFEIFELNSFEQLCINYTNEK 573
            .:::.|:||:.||:||.|:|.|||:||| ||:....|||:||:||||||:.|:|||||||:||||
Zfish   421 YYSIGALAKSVYEKMFLWMVVRINQSLD-TKQPRQYFIGVLDIAGFEIFDFNTFEQLCINFTNEK 484

  Fly   574 LQQLFNHTMFILEQEEYQREGIEWKFIDFGLDLQPTIDLIDKPGGIMALLDEECWFPKATDKTFV 638
            |||.|||.||:||||||::|||||:|||||:|||..|:||:||.|||::|:|||.||||:|.||.
Zfish   485 LQQFFNHHMFVLEQEEYKKEGIEWEFIDFGMDLQACIELIEKPMGIMSILEEECMFPKASDATFK 549

  Fly   639 DKLVSAH-SMHPKFMKTDF---RGVADFAIVHYAGRVDYSAAKWLMKNMDPLNENIVSLLQGSQD 699
            .||...| ..:|.|.|...   |..|.||:|||||.|||:.:.||:||.|||||.:|.|.|.|..
Zfish   550 AKLYDNHLGKNPNFQKPRIVKGRPEAHFALVHYAGTVDYNISNWLVKNKDPLNETVVGLFQKSTL 614

  Fly   700 PFVVNIWKDAEIVGMAQQALTDT----QFGARTRKGMFRTVSHLYKEQLAKLMDTLRNTNPNFVR 760
            ..:..::  |...| |:.|  |:    :.||:.:...|:|||.|::|.|.|||..||:|:|:|||
Zfish   615 KLLGTLF--ANYAG-AESA--DSGGKGKGGAKKKGSSFQTVSALHRENLNKLMTNLRSTHPHFVR 674

  Fly   761 CIIPNHEKRAGKIDAPLVLDQLRCNGVLEGIRICRQGFPNRIPFQEFRQRYELLTPNVIPKG-FM 824
            |:|||..|..|.::.|||:.|||||||||||||||:||||||.:.:|:|||.:|.|:.||:| |:
Zfish   675 CLIPNETKTPGAMENPLVMHQLRCNGVLEGIRICRKGFPNRILYGDFKQRYRILNPSAIPEGQFI 739

  Fly   825 DGKKACEKMIQALELDSNLYRVGQSKIFFRAGVLAHLEEERDFKISDLIVNFQAFCRGFLARRNY 889
            |.||..||::.:|::|.|.|::|.:|:||:||:|..|||.||.:::.:|...||..||.|:|..:
Zfish   740 DNKKGAEKLLGSLDIDHNQYKLGHTKVFFKAGLLGTLEEMRDDRLALIITGIQARARGILSRIEF 804

  Fly   890 QKRLQQLNAIRIIQRNCAAYLKLRNWQWWRLYTKVKPLLEVTKQEEKLVQKEDELKQVREKLDTL 954
            ||.:::.:::.:||.|..|::.::||.|.:||.|:||||:..:.|:::...::|..:::|.....
Zfish   805 QKIVERRDSLLVIQWNVRAFMGVKNWPWMKLYFKIKPLLKTAETEKEMANMKEEFTKLKEAYAKS 869

  Fly   955 AKNTQEYERKYQQALVEKTTLAEQLQAEIELCAEAEESRSRLMARKQELEDMMQELETRIEEEEE 1019
            ....:|.|.|....|.||..|...:|:|.:..|:|||....|:..|.:.|..::||..|:|:|||
Zfish   870 EARKKELEEKMVSLLQEKNDLQLAVQSEQDNLADAEERCEGLIKSKIQFEAKVKELTERLEDEEE 934

  Fly  1020 RVLALGGEKKKLELNIQDLEEQLEEEEAARQKLQLEKVQLDAKIKKYEEDLALTDDQNQKLLKEK 1084
            ....|..:|:|||....:|::.:::.|....|::.||...:.|:|...|::|..|:...||.|||
Zfish   935 MNAELVAKKRKLEDECSELKKDIDDLELTLAKVEKEKHATENKVKNLTEEMAALDEIIAKLTKEK 999

  Fly  1085 KLLEERANDLSQTLAEEEEKAKHLAKLKAKHEATISELEERLHKDQQQRQESDRSKRKIETEVAD 1149
            |.|:|........|..||:|...|.|.|||.|..:.:||..|.::::.|.:.:|:|||:|.::..
Zfish  1000 KALQEAHQQTLDDLQSEEDKVNTLTKAKAKLEQQVDDLEGSLEQEKKIRMDLERAKRKLEGDLKL 1064

  Fly  1150 LKEQLNERRVQVDEMQAQLAKREEELTQTLLRIDEESATKATAQKAQRELESQLAEIQEDLEAEK 1214
            .:|.|.:......:|:.:|.|::.|::|...:|::|.|.:|..||..:||::::.|::|:||||:
Zfish  1065 TQENLMDLENDKQQMEERLKKKDFEISQLNSKIEDEQALEAQLQKKLKELQARIEELEEELEAER 1129

  Fly  1215 AARAKAEKVRRDLSEELEALKNELLDSLDTTAAQQELRSKREQELATLKKSLEEETVNHEGVLAD 1279
            |||||.||.|.|||.|||.:...|.::...||||.|:..|||.|...|::.|||.|:.||...:.
Zfish  1130 AARAKVEKQRADLSRELEEISERLEEAGGATAAQIEMNKKREAEFQKLRRDLEEATLQHEATAST 1194

  Fly  1280 MRHKHSQELNSINDQLENLRKAKTVLEKAKGTLEAENADLATELRSVNSSRQENDRRRKQAESQI 1344
            :|.||:..::.:.:|::||::.|..|||.|..|..|..|:.:.:..:..::...::..:..|.|:
Zfish  1195 LRKKHADSVSDLGEQIDNLQRVKQKLEKEKSELRLELDDVVSNMEQIVKAKANLEKMCRTLEDQM 1259

  Fly  1345 AELQVKLAEIERARSELQEKCTKLQQEAENITNQLEEAELKASAAVKSASNMESQLTEAQQLLEE 1409
            :|.:.|..|.:|..::...:..|||.|...::.||||.:...|...:...:...|:.:.::.|||
Zfish  1260 SEYRTKAEEGQRTINDFTMQKAKLQTENGELSRQLEEKDSLVSQLTRGKQSYTQQIEDLKRQLEE 1324

  Fly  1410 ETRQKLGLSSKLRQIESEKEALQEQLEEDDEAKRNYERKLAEVTTQMQEIKKKAEEDA-DLAKEL 1473
            |.:.|..|:..::....:.|.|:||.||:.|||...:|.|::..:::.:.:.|.|.|| ...:||
Zfish  1325 EVKAKNALAHAVQSARHDAELLREQYEEEQEAKAELQRSLSKANSEVAQWRTKYETDAIQRTEEL 1389

  Fly  1474 EEGKKRLNKDIEALERQVKELIAQNDRLDKSKKKIQSELEDATIELEAQRTKVLELEKKQKNFDK 1538
            ||.||:|.:.::..|..|:.:.|:...|:|:|.::|:|:||..:::|........|:|||:||||
Zfish  1390 EEAKKKLAQRLQDAEEAVEAVNAKCSSLEKTKHRLQNEIEDLMVDVERSNAAAAALDKKQRNFDK 1454

  Fly  1539 ILAEEKAISEQIAQERDTAEREAREKETKVLSVSRELDEAFDKIEDLENKRKTLQNELDDLANTQ 1603
            :|||.|...|:...|.::|::|:|...|::..:....:|:.|.:|.::.:.|.||.|:.||....
Zfish  1455 VLAEWKQKYEESQTELESAQKESRSLSTELFKLKNSYEESLDHLESMKRENKNLQEEISDLTEQL 1519

  Fly  1604 GTADKNVHELEKAKRALESQLAELKAQNEELEDDLQLTEDAKLRLEVNMQALRSQFERDLLAKEE 1668
            |.:.||:|||||.::.||.:..|::...||.|..|:..|...||.::....:::..||.|..|:|
Zfish  1520 GESGKNIHELEKVRKQLEQEKQEIQTALEEAEGSLEHEEGKILRAQLEFNQVKADIERKLSEKDE 1584

  Fly  1669 GAEEKRRGLVKQLRDLETELDEERKQRTAAVASKKKLEGDLKEIETTMEMHNKVKEDALKHAKKL 1733
            ..|:.:|...:.:..|::.|:.|.:.|..|:..|||:||||.|:|..:...|:...:|.|..|.|
Zfish  1585 EMEQAKRNQQRVVDTLQSSLESETRSRNEALRLKKKMEGDLNEMEIQLSQANRQASEAQKQLKGL 1649

  Fly  1734 QAQVKDALRDAEEAKAAKEELQALSKEAERKVKALEAEVLQLTEDLASSERARRAAETERDELAE 1798
            ...:|||....::|....::|:......||:...|:||:.:|...:..:||.|:.||.|..:::|
Zfish  1650 HGHLKDAQLQLDDALRGNDDLKENIAIVERRNNLLQAELDELRSLVEQTERGRKLAEQELMDVSE 1714

  Fly  1799 EIANNANKGSLMIDEKRRLEARIATLEEELEE---EQSNSEVLLDRSRKAQLQIEQLTTELANEK 1860
            .:....::.:.::::|::||.....|:.|:||   |..|:|   ::::||......:..||..|:
Zfish  1715 RVQLLHSQNTSLLNQKKKLEGDNTQLQTEVEEAVQECRNAE---EKAKKAITDAAMMAEELKKEQ 1776

  Fly  1861 SNSQKNENGRALLERQNKELKAKLAEIETAQRTKVKATIATLEAKIANLEEQLENEGKERLLQQK 1925
            ..|...|..:..:|:..|:|:.:|.|.|.......|..:..||:::..||.::|.|.::.....|
Zfish  1777 DTSAHLERMKKNMEQTIKDLQHRLDEAEQIAMKGGKKQVQKLESRVRELESEVEMEQRKASDSVK 1841

  Fly  1926 ANRKMDKKIKELTMNIEDERRHVDQHKEQMDKLNSRIKLLKRNLDETEEELQKEKTQKRKYQREC 1990
            ..||.:::|||||...|::|:::.:.::.:|||..::|..||..:|.||:......:.||.|.|.
Zfish  1842 GVRKYERRIKELTYQTEEDRKNLARLQDLVDKLQLKVKSYKRTAEEAEEQANSNLGKFRKLQHEL 1906

  Fly  1991 EDMIESQEAMNREINSLKTKLRRTG 2015
            ::..|..:....::|.|:.|.|.:|
Zfish  1907 DEAEERADIAESQVNKLRAKSRDSG 1931

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
zip	NP_523860.2	Myosin_N	79..122	CDD:460670	15/42 (36%)
		MYSc_Myh2_insects_mollusks	145..854	CDD:276876	357/718 (50%)
		Myosin_tail_1	931..2011	CDD:460256	334/1083 (31%)
smyhc2	NP_001096096.2	Myosin_N	32..76	CDD:460670	15/44 (34%)
		MYSc_class_II	99..769	CDD:276951	357/718 (50%)
		Myosin_tail_1	849..1926	CDD:460256	334/1079 (31%)