DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG3829 and SCARB1

DIOPT Version :9

Sequence 1:	NP_001286874.1	Gene:	CG3829 / 38000	FlyBaseID:	FBgn0035091	Length:	597	Species:	Drosophila melanogaster
Sequence 2:	NP_001354910.1	Gene:	SCARB1 / 949	HGNCID:	1664	Length:	552	Species:	Homo sapiens

Alignment Length:	471	Identity:	129/471 - (27%)
Similarity:	232/471 - (49%)	Gaps:	23/471 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly    87 LGVMFLLFVISVTGFFVMWFTEYYNNTILENLILAENSDTANSWLN-PDPKYDTLLKAHIFHYPN 150
            |||..||..: :....::.........:|:|:.:..:|.:.|.|.. |.|.|   |..:.|...|
Human    14 LGVAGLLCAV-LGAVMIVMVPSLIKQQVLKNVRIDPSSLSFNMWKEIPIPFY---LSVYFFDVMN 74

  Fly   151 IDDYLAGRADKIKVVDVGPLTYQEHTVKDEVSFNKNFTVSFRDRKSYKFLPEKSSIGEHEVVRVP 215
            ..:.|.|  :|.:|.:.||..|:|...|..::||.|.||||.:.::::|.|.||...|.:.:.:|
Human    75 PSEILKG--EKPQVRERGPYVYREFRHKSNITFNNNDTVSFLEYRTFQFQPSKSHGSESDYIVMP 137

  Fly   216 NVPLISAAGPVKRMKAFERLAVSTWIKQFKEPLFKNLTVSEYLWGYEDSIIKL-----KSLGRGR 275
            |:.::.||..::......:|.::.......|..|.|.||.|.:|||:|.::.|     ..:...:
Human   138 NILVLGAAVMMENKPMTLKLIMTLAFTTLGERAFMNRTVGEIMWGYKDPLVNLINKYFPGMFPFK 202

  Fly   276 RRFGLLMSRNGTSVDSVQLNTGEDDITKFSIITQFNGMPQLDYWEGDECNRIDGSEPSMFSPHLL 340
            .:|||....|.:......:.||..:|::..::.::||:.::|:|..|:||.|:|:...|:.|.:.
Human   203 DKFGLFAELNNSDSGLFTVFTGVQNISRIHLVDKWNGLSKVDFWHSDQCNMINGTSGQMWPPFMT 267

  Fly   341 QDRSTVNVFLQVLCRKVPLHFEKEVTIYNDIDVLRYRTPMDVFSHPSKNPANQCYCQNTELCLPS 405
            .: |::..:....||.:.|.: ||..::..|...|:..|..:|::.|..|.|:.:|.    ||.|
Human   268 PE-SSLEFYSPEACRSMKLMY-KESGVFEGIPTYRFVAPKTLFANGSIYPPNEGFCP----CLES 326

  Fly   406 GVINATKCYGDAPIFPSFPHFFTGDPVLYQDFEGIEPDAAVHQTYADIHPRFGFPISGASRVQIN 470
            |:.|.:.|...||:|.|.|||...||||.:...|:.|:...|..:.||||..|.|::.:.::|::
Human   327 GIQNVSTCRFSAPLFLSHPHFLNADPVLAEAVTGLHPNQEAHSLFLDIHPVTGIPMNCSVKLQLS 391

  Fly   471 IMLDKTPILRNQGDRLKNTTILPLMWIEITSGDFSEEVLHTLYLSTFGLNAIQQTLKYGTLLISV 535
            :.:.....:...|.  ....:|||:|. ..||....|.|||.|.....:..:....:|  :|:::
Human   392 LYMKSVAGIGQTGK--IEPVVLPLLWF-AESGAMEGETLHTFYTQLVLMPKVMHYAQY--VLLAL 451

  Fly   536 TSFSLIVAGVYYLNSR 551
            ....|:|..:..:.|:
Human   452 GCVLLLVPVICQIRSQ 467

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG3829	NP_001286874.1	CD36	91..546	CDD:279474	125/460 (27%)
SCARB1	NP_001354910.1	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165148211
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3776
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG45589
OrthoDB	1	1.010	-	-		D1106566at2759
OrthoFinder	1	1.000	-	-		FOG0000618
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11923
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X155
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	8	7.860