DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG3829 and Cd36

DIOPT Version :9

Sequence 1:	NP_001286874.1	Gene:	CG3829 / 38000	FlyBaseID:	FBgn0035091	Length:	597	Species:	Drosophila melanogaster
Sequence 2:	NP_001153027.1	Gene:	Cd36 / 12491	MGIID:	107899	Length:	472	Species:	Mus musculus

Alignment Length:	460	Identity:	133/460 - (28%)
Similarity:	221/460 - (48%)	Gaps:	30/460 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly    95 VISVTGFFVMWFTE-YYNNTILENLILAENSDTANSWLNPDPKYDTLL--KAHIFHYPNIDDYLA 156
            |::|.|..:|...: ....||...::|.|.:....:|:    |..|.:  :..||...|.|| :|
Mouse    18 VLAVFGGILMPVGDMLIEKTIKREVVLEEGTTAFKNWV----KTGTTVYRQFWIFDVQNPDD-VA 77

  Fly   157 GRADKIKVVDVGPLTYQ-EHTVKDEVSFN-KNFTVSFRDRKSYKFLPEKSSIGEHEVVRVPNVPL 219
            ..:.||||...||.||: .:..|:.::.: ::.||||.......|.|..|...|.:...|.|  |
Mouse    78 KNSSKIKVKQRGPYTYRVRYLAKENITQDPEDHTVSFVQPNGAIFEPSLSVGTEDDNFTVLN--L 140

  Fly   220 ISAAGPVKRMKAFERLAVSTWIKQFKEPLFKNLTVSEYLWGYEDSIIKLKSLGRGRRRFGLLMSR 284
            ..||.|.....:|.::.:::.||:.|..:|:..::.|.||||:|..:.|...... ...|:....
Mouse   141 AVAAAPHIYQNSFVQVVLNSLIKKSKSSMFQTRSLKELLWGYKDPFLSLVPYPIS-TTVGVFYPY 204

  Fly   285 NGTSVDSV-QLNTGEDDITKFSIITQFNGMPQLDYWEGDECNRIDGSEPSMFSPHLLQDRSTVNV 348
            |.| ||.| ::..|:|:|:|.:||..:.|...|.||. ..|:.|:|::.:.|.|.:.:.| |:..
Mouse   205 NDT-VDGVYKVFNGKDNISKVAIIESYKGKRNLSYWP-SYCDMINGTDAASFPPFVEKSR-TLRF 266

  Fly   349 FLQVLCRKVPLHFEKEVTIYNDIDVLRYRTPMDVFSHPSKNPANQCYCQNTEL---CLPSGVINA 410
            |...:||.:...|..|:.: ..|.|.|:..|.:.|:.|.:||.|.|:|....:   |...||::.
Mouse   267 FSSDICRSIYAVFGSEIDL-KGIPVYRFVLPANAFASPLQNPDNHCFCTEKVISNNCTSYGVLDI 330

  Fly   411 TKCYGDAPIFPSFPHFFTGDPVLYQDFEGIEPDAAVHQTYADIHPRFGFPISGASRVQINIMLD- 474
            .||....|::.|.|||....|.:.:..||:.|:...|:||.|:.|..||.:..|.|:|:||::.
Mouse   331 GKCKEGKPVYISLPHFLHASPDVSEPIEGLHPNEDEHRTYLDVEPITGFTLQFAKRLQVNILVKP 395

  Fly   475 --KTPILRNQGDRLKNTTILPLMWIEITS--GDFSEEVLHTLYLSTFGLNAIQQTLKYGTLLISV 535
              |...|:|    ||...|:|::|:..|.  ||...|:..|.......|..:.:....|..::..
Mouse   396 ARKIEALKN----LKRPYIVPILWLNETGTIGDEKAEMFKTQVTGKIKLLGMVEMALLGIGVVMF 456

  Fly   536 TSFSL 540
            .:|.:
Mouse   457 VAFMI 461

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG3829	NP_001286874.1	CD36	91..546	CDD:279474	133/460 (29%)
Cd36	NP_001153027.1	CD36	16..463	CDD:366481	133/460 (29%)
		Required for interaction with thrombospondins, THBS1 and THBS2. /evidence=ECO:0000269\|PubMed:15748999	93..120		6/26 (23%)
		Interaction with PTK2, PXN and LYN. /evidence=ECO:0000250\|UniProtKB:P16671	460..472		0/2 (0%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3776
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	1.030639	Normalized mean entropy	S6187
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000618
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X155
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.760