DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG3829 and Scarb2

DIOPT Version :9

Sequence 1:	NP_001286874.1	Gene:	CG3829 / 38000	FlyBaseID:	FBgn0035091	Length:	597	Species:	Drosophila melanogaster
Sequence 2:	NP_446453.1	Gene:	Scarb2 / 117106	RGDID:	621882	Length:	478	Species:	Rattus norvegicus

Alignment Length:	472	Identity:	138/472 - (29%)
Similarity:	233/472 - (49%)	Gaps:	38/472 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly    82 GTLIMLGVMFLLFVISVTGFFVMWFTEYYNNTILENLILAENSDTANSWLNPD-PKYDTLLKAHI 145
            |||.:     ||.|.|||......|.:..:.||.:|::|...:...:||..|. |.|   ::.:.
  Rat    10 GTLSL-----LLLVTSVTLLVARVFQKAVDQTIEKNMVLQNGTKVFDSWEKPPLPVY---IQFYF 66

  Fly   146 FHYPNIDDYLAGRADKIKVVDVGPLTYQEHTVKDEVSFNKN-FTVSFRDRKSYKFLPEKSSIGEH 209
            |:..|.::.|.|....::  :|||.||:|...|..|.|.:| .|:|....|:|.| ....|:|:.
  Rat    67 FNVTNPEEILQGEIPLLE--EVGPYTYRELRNKANVQFGENGTTISAVTNKAYIF-ERNQSVGDP 128

  Fly   210 --EVVRVPNVPLISAAGPVKRMKAFERLAVSTWIKQFKEPLFKNLTVSEYLWGYEDSIIKLKSLG 272
              :::|..|:||::.....:  :.|.|..:...:|.:::.||...||.|.||||:|.::.|..:.
  Rat   129 TVDLIRTINIPLLTVVEMAQ--QPFLREIIEAMLKAYQQTLFVTHTVHELLWGYKDEVLSLVHIF 191

  Fly   273 RG--RRRFGLLMSRNGTSVDSVQLNTGEDDITKFSIITQFNGMPQLDYWEGDECNRIDGSEPSMF 335
            |.  ...|||...||||:.......||||:...|:.|.::||...||:|..|.||.|:|::...|
  Rat   192 RPDVSPNFGLFYERNGTNDGEYVFLTGEDNYLNFTKIVEWNGKTSLDWWTTDTCNMINGTDGDSF 256

  Fly   336 SPHLLQDRSTVNVFLQVLCRKVPLHFEKEVTIYNDIDVLRYRTPMDVFSHPSKNPANQCYCQNTE 400
            .|.:.:| .|:.:|....||.|.:.|.....: ..:...||:.|.::.::.|:|..   :|....
  Rat   257 HPLISKD-ETLYIFPSDFCRSVYITFSSFENV-EGLPAFRYKVPAEILANSSENAG---FCIPEG 316

  Fly   401 LCLPSGVINATKCYGDAPIFPSFPHFFTGDPVLYQDFEGIEPDAAVHQTYADIHPRFGFPISGAS 465
            .|:.:||:|.:.|...|||..|||||:..|.......:|:.|:...|:::.||:|..|..:.||.
  Rat   317 NCMDAGVLNVSICKNGAPIIMSFPHFYQADEKFVSAIKGMRPNKEEHESFVDINPLTGIILRGAK 381

  Fly   466 RVQINIMLDKTPILRNQGDRLKNTTILPLMWIEITSGDFSEEVLHTLYLSTFGLNAIQQTLKYGT 530
            |.|||..:.|.......|:  ..|.:.|:|::       :|.||.....:: .|.::..|    |
  Rat   382 RFQINTYVKKLDDFVETGN--IRTMVFPVMYL-------NESVLIDKETAS-QLKSVINT----T 432

  Fly   531 LLISVTSFSLIVAGVYY 547
            |:::...:.::..||::
  Rat   433 LIVTNIPYIIMALGVFF 449

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG3829	NP_001286874.1	CD36	91..546	CDD:279474	134/460 (29%)
Scarb2	NP_446453.1	CD36	34..457	CDD:395898	128/443 (29%)
Scarb2	NP_446453.1	Important for interaction with GBA. /evidence=ECO:0000250	155..191		12/35 (34%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3776
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG45589
OrthoDB	1	1.010	-	-		D1106566at2759
OrthoFinder	1	1.000	-	-		FOG0000618
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11923
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X155
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	8	7.930