Protein Alignment KIF5C and SMY1

DIOPT Version :10

• Sequence 1: NP_004513.1
• Gene: KIF5C / 3800
• HGNCID: 6325
• Length: 957
• Species: Homo sapiens
• Sequence 2: NP_012844.1
• Gene: SMY1 / 853783
• SGDID: S000001562
• Length: 656
• Species: Saccharomyces cerevisiae
• Alignment Length: 593
• Identity: 168/593 - (28%)
• Similarity: 280/593 - (47%)
• Gaps: 106/593 - (17%)

Human     3 DPAE-CSIKVMCRFRP----LNEAEILRGDKFIPKFKGDETVVIGQGKP-----------YVFDR 51
            |.:| |.|:|:.|..|    .|.....:.|.:      :.||:.....|           :.||:
Yeast    21 DSSEPCHIEVILRAIPEKGLQNNESTFKIDPY------ENTVLFRTNNPLHETTKETHSTFQFDK 79

Human    52 VLPPNTTQEQVYNACAKQIVKDVLEGYNGTIFAYGQTSSGKTHTMEGKLHDPQLMGIIPRIAHDI 116
            |...|.|||.|.......|:.|||.|||||:..||.:.|||::::.|   ..:..||:|.|...:
Yeast    80 VFDANATQEDVQKFLVHPIINDVLNGYNGTVITYGPSFSGKSYSLIG---SKESEGILPNICKTL 141

Human   117 FDHIYSMDENLE-----FHIKVSYFEIYLDKIRDLLD--VSKTNLAVHEDKNRVPY-VKGCTERF 173
            ||   ::::|.|     |.:.|..||||::|..|||.  ..:..|.:|...:::.. :|......
Yeast   142 FD---TLEKNEETKGDSFSVSVLAFEIYMEKTYDLLVPLPERKPLKLHRSSSKMDLEIKDICPAH 203

Human   174 VSSPEEVMDVID--EGKANRHVAVTNMNEHSSRSHSIFLINIKQENVETEKKLSGKLYLVDLAGS 236
            |.|.|::...|.  :...|| :|..:..|. ||||.:|.::::|.|.:.:...:..||||||.|:
Yeast   204 VGSYEDLRSYIQAVQNVGNR-MACGDKTER-SRSHLVFQLHVEQRNRKDDILKNSSLYLVDLHGA 266

Human   237 EKVSKTGAEGAVLDEAKNINKSLSALGNVISAL----------AEGTKTHVPYRDSKMTRILQDS 291
            ||..|........|..|.:|:|:.||.|.:.:|          |:|:.:.. ||:|::|.:|:||
Yeast   267 EKFDKRTESTLSQDALKKLNQSIEALKNTVRSLSMKERDSAYSAKGSHSSA-YRESQLTEVLKDS 330

Human   292 LGGNCRTTIVICCSPSVFNEAETKSTLMFGQRAKTIKNTVSVNLELTAEEWKKKYE------KEK 350
            ||||.:|.:::.|..|  |...|.|||.||...:.|.|.|:.|  .|....|||.:      |.|
Yeast   331 LGGNRKTKVILTCFLS--NVPTTLSTLEFGDSIRQINNKVTDN--TTGLNLKKKMDLFIQDMKIK 391

Human   351 EKNKTLKNVIQHLEMELNRWRNGEAVPEDEQISAKDQKNLEPCDNTPI-----IDNIAPVVAGIS 410
            :.|...:..|...|::..:..:.:::|||:     ::|.||......|     :|:|..:::..:
Yeast   392 DDNYVAQINILKAEIDSLKSLHNKSLPEDD-----EKKMLENTKKENIKLKLQLDSITQLLSSST 451

Human   411 TEE-KEKYDEEISSLYRQLDDKDDEINQQSQLAEKLKQQMLDQDELLASTRRDYEKIQEELTRLQ 474
            .|: ..:.|||:|.:.             ::..|::.|..|..|..:.|.    .|:|:||
Yeast   452 NEDPNNRIDEEVSEIL-------------TKRCEQIAQLELSFDRQMNSN----SKLQQEL---- 495

Human   475 IENEAAKDEVKEVL--QALEELAVNYDQKSQEVEDKTRANEQLTDELAQKTTTLTTTQREL---- 533
             |.:.:|:|..|.:  :.||::.:    :.:|:::....|..|..|| :..|.||.|:.|.
Yeast   496 -EYKKSKEEALESMNVRLLEQIQL----QEREIQELLTTNAILKGEL-ETHTKLTETRSERIKSL 554

Human   534 -SQLQELS 540
             |.::|||
Yeast   555 ESSVKELS 562

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
KIF5C	NP_004513.1	KISc_KHC_KIF5	6..327	CDD:276820	111/356 (31%)
		Microtubule-binding	174..315		50/152 (33%)
		PRK03918	<412..907	CDD:235175	34/137 (25%)
		Khc_CBD_cc	836..905	CDD:467880
		Globular	859..956
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	911..957
SMY1	NP_012844.1	KISc_KHC_KIF5	25..364	CDD:276820	110/355 (31%)
		COG2433	<402..568	CDD:441980	44/193 (23%)