DRSC/TRiP Functional Genomics Resources

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Protein Alignment KIF5C and cmet

DIOPT Version :9

Sequence 1:NP_004513.1 Gene:KIF5C / 3800 HGNCID:6325 Length:957 Species:Homo sapiens
Sequence 2:NP_524993.3 Gene:cmet / 53561 FlyBaseID:FBgn0040232 Length:2189 Species:Drosophila melanogaster


Alignment Length:1231 Identity:308/1231 - (25%)
Similarity:495/1231 - (40%) Gaps:377/1231 - (30%)


- Green bases have known domain annotations that are detailed below.


Human     8 SIKVMCRFRPLNEAEILRGDKFIPKFKGDETVVI--GQGKPYVFDRVLPPNTTQEQVYNACAKQI 70
            ||:|..:.||...     |...:.:.|...::.:  ...:|||||.|.....:.::|::..||.|
  Fly     8 SIQVCIKVRPCEP-----GLTSLWQVKERRSIHLADSHAEPYVFDYVFDEGASNQEVFDRMAKHI 67

Human    71 VKDVLEGYNGTIFAYGQTSSGKTHTMEGKLHDPQLMGIIPRIAHDIFDHIYSMDENLEFHIKVSY 135
            |...::|:|||||||||||||||:||.|   |.|..|::...|.:||..|.|..|. :|.::|.|
  Fly    68 VHACMQGFNGTIFAYGQTSSGKTYTMMG---DEQNPGVMVLAAKEIFQQISSETER-DFLLRVGY 128

Human   136 FEIYLDKIRDLLDVSKTNLAVHEDKNRVPYVKGCTERFVSSPEEVMDVIDEGKANRHVAVTNMNE 200
            .|||.:||.|||:....:|.:||..|.:..| .|.|..::|..:::.::..|...|.|..|||||
  Fly   129 IEIYNEKIYDLLNKKNQDLKIHESGNGIVNV-NCEECIITSEVDLLRLLCLGNKERTVGETNMNE 192

Human   201 HSSRSHSIFLINI---KQENVETEKKLSGKLYLVDLAGSEKVSKTGAEGAVLDEAKNINKSLSAL 262
            .|||||:||.|.|   |.::.:.:..:...|.||||||||:..:|||.||.|.|..:|||||..|
  Fly   193 RSSRSHAIFKIIIESRKSDHSDDDAVIQSVLNLVDLAGSERADQTGARGARLKEGGHINKSLLFL 257

Human   263 GNVISALAEGTKTH-VPYRDSKMTRILQDSLGGNCRTTIVICCSPSVFNEAETKSTLMFGQRAKT 326
            .|||.:|:|..... ..|||||:|||||.|||||..|:|:....||:..|::  |||.|..|||.
  Fly   258 SNVIKSLSENADNRFTNYRDSKLTRILQASLGGNAFTSIICTIKPSIMEESQ--STLSFATRAKK 320

Human   327 IKNTVSVN-----------LELTAEEWKKKYEKEKEKNKTLKNVIQHLEMELNR----------- 369
            |:....||           ||...:..|.|..:|:.||:..:.| :|||.::..           
  Fly   321 IRIKPQVNEMVSDATMMKRLEREIKVLKDKLAEEERKNENQQKV-EHLERQIKHDMHKIICGHSL 384

Human   370 -----------W---RNGEAVPEDEQISAKDQKNLEP-------------------CDNTPIIDN 401
                       |   .:|..:...|..:.:|:.:..|                   .||.|...|
  Fly   385 SDKGQQKRRRTWCPTASGSHLELAETGTTEDRIDQFPKVSHLPKPVFFHTSNAGKRWDNIPKTIN 449

Human   402 IAPVVAGISTEEKEKYDEEISS-----------------LYRQLDD---------KDDEINQQSQ 440
            |...: .|.||.....:|.:.:                 ..|||.|         ..|:|.::.|
  Fly   450 ILGSL-DIGTESNSISEEFLPAECIDFGSPRPDVLKPMLTIRQLPDLPLTPKGPLTTDKIKKEIQ 513

Human   441 ---------------------LAEKLKQQMLDQDEL----LASTRRDYEKIQEELTRLQIENEAA 480
                                 |.|||.:....:|.|    ||...| |:.:::|:|.|:.:||||
  Fly   514 DLQMFTSLEKHFEVECEEVQGLKEKLAEVTAQRDNLEQESLAEKER-YDALEKEVTSLRADNEAA 577

Human   481 KDEVKEVLQALEEL---------------AVNYDQKSQEVEDKTRANEQLTDELAQKTTTLTTTQ 530
            ..::.|:.:.|..|               .:.::.::.:...|.|.:: |...|.:|.:|:.:.|
  Fly   578 NSKISELEEKLSTLKQTMRIMEVENQVAVGLEFEFEAHKKSSKLRVDD-LLSALLEKESTIESLQ 641

Human   531 RELSQL--------------------------------QELSN-----HQKKRATEILNLLLK-- 556
            :.|..|                                :||..     ..||.:.|...|.|:  
  Fly   642 KSLDNLTRDVLRNSKEGHMLSIAPEQEDIAGDSICNKCEELEKLIADLESKKNSCECDQLRLEIV 706

Human   557 -------------------------DLGEIGGIIGTND-----------------------VKTL 573
                                     |...:...:.|:.                       :.||
  Fly   707 SVRDKLESVESAFNLASSEIIQKATDCERLSKELSTSQNAFGQLQERYDALDQQWQAQQAGITTL 771

Human   574 ADVNGVIEEEFTMARLYISKMKSEVKSLVNRSKQLESAQ----MDSNRKMNA-----SER----- 624
            .:.:..::|::       .|::.|.:.|.:|::...||:    .:.|.|..|     :||     
  Fly   772 HEKHEHVQEKY-------QKLQEEYEQLESRARSASSAEFQRLQNDNTKFQADIASLNERLEEAQ 829

Human   625 ---------ELAACQLLISQHE--AKIKSLTDYMQNMEQK----RRQLEES---QDSLSEELAK- 670
                     |....:|.|..||  ||||.|....:.|:::    ..||.||   .|:|.||:.: 
  Fly   830 NMLTEVQNSESTVEKLRIQNHELTAKIKELETNFEEMQREYDCLSNQLMESVQENDALREEIKQR 894

Human   671 --LRAQEKM-------------------HEV-----SFQDKEKEH---LTRLQDAEEMK------ 700
              ...:|.|                   |:.     |.|..|.:|   ::||..|.:||      
  Fly   895 PTSHVEESMRSSGISSDFDEQKQDINLLHQFVQLSESVQQIELQHHSGISRLFRANQMKLDQSEP 959

Human   701 ------KALEQQMESHREA--------------HQKQLSRLRDE---IEEKQKIIDEIRDLNQKL 742
                  ::.|...|.:|::              |:.|:.||..|   :.|:::::|.|..|.|  
  Fly   960 GLKLCLESAEYIEEDNRQSDATEPICLKGFLKRHRFQIKRLSQEHVDMGEEKRLLDIISQLEQ-- 1022

Human   743 QLEQEKLSSDYNKLKIEDQEREMK------LEKLLLLNDKREQAREDLKGLEETVSRELQTLHNL 801
            ::|::....:..:..|.:...:|.      |||.:::| |.|..:..::.||:..:........|
  Fly  1023 EIEEKSALMEATEATINEMREQMTNLESALLEKSVIIN-KVEDYQRQIESLEKQNAEMTMVYEEL 1086

Human   802 RKLFVQDLTTRVKKSVEL------DNDDGGG----SAAQKQKISFLENNLEQLTKVHKQLVRDNA 856
                 ||..||.....|.      |.|...|    .:.::|:::.|:.:   :|::..|:    :
  Fly  1087 -----QDRVTRESSMSESLLRVPPDEDTLPGCPTSPSRREQEVATLKTS---ITELQSQV----S 1139

Human   857 DLRCEL--------------PKLEKRLRATAERVKALESALKEAKENAMRDRKRYQQEVDR 903
            ||:.||              .:|:......:||..::|..|.|..|    |.|:.|:.:||
  Fly  1140 DLKAELENHLRQIQLKDGNIARLQTDFEEMSERCLSMEVRLAELDE----DTKQKQELLDR 1196

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
KIF5CNP_004513.1 KISc_KHC_KIF5 6..327 CDD:276820 137/324 (42%)
Microtubule-binding 174..315 66/144 (46%)
Smc <460..801 CDD:224117 99/539 (18%)
PRK03918 <715..>916 CDD:235175 49/222 (22%)
Globular 859..956 14/59 (24%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 911..957
cmetNP_524993.3 KISc 8..328 CDD:214526 138/331 (42%)
Motor_domain 8..321 CDD:277568 137/324 (42%)
Smc <680..1449 CDD:224117 107/543 (20%)
TMPIT 779..>867 CDD:285135 22/94 (23%)
Smc 1042..1910 CDD:224117 38/172 (22%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 1 1.000 - - FOG0000669
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.910

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