Protein Alignment KIF5C and Khc

DIOPT Version :10

• Sequence 1: NP_004513.1
• Gene: KIF5C / 3800
• HGNCID: 6325
• Length: 957
• Species: Homo sapiens
• Sequence 2: NP_476590.1
• Gene: Khc / 36810
• FlyBaseID: FBgn0001308
• Length: 975
• Species: Drosophila melanogaster
• Alignment Length: 971
• Identity: 597/971 - (61%)
• Similarity: 748/971 - (77%)
• Gaps: 47/971 - (4%)

Human     4 PAECSIKVMCRFRPLNEAEILRGDKFIPKFKG--DETVVIGQGKPYVFDRVLPPNTTQEQVYNAC 66
            |||.||||:|||||||::|...|.||:.||..  :|..:...||.|:||:|..||.:||:|||..
  Fly     8 PAEDSIKVVCRFRPLNDSEEKAGSKFVVKFPNNVEENCISIAGKVYLFDKVFKPNASQEKVYNEA 72

Human    67 AKQIVKDVLEGYNGTIFAYGQTSSGKTHTMEGKLHDPQLMGIIPRIAHDIFDHIYSMDENLEFHI 131
            ||.||.|||.||||||||||||||||||||||.:.|....||||||.:|||:|||:|:.||||||
  Fly    73 AKSIVTDVLAGYNGTIFAYGQTSSGKTHTMEGVIGDSVKQGIIPRIVNDIFNHIYAMEVNLEFHI 137

Human   132 KVSYFEIYLDKIRDLLDVSKTNLAVHEDKNRVPYVKGCTERFVSSPEEVMDVIDEGKANRHVAVT 196
            ||||:|||:|||||||||||.||:|||||||||||||.|||||||||:|.:||:|||:|||:|||
  Fly   138 KVSYYEIYMDKIRDLLDVSKVNLSVHEDKNRVPYVKGATERFVSSPEDVFEVIEEGKSNRHIAVT 202

Human   197 NMNEHSSRSHSIFLINIKQENVETEKKLSGKLYLVDLAGSEKVSKTGAEGAVLDEAKNINKSLSA 261
            |||||||||||:||||:||||:|.:|||||||||||||||||||||||||.||||||||||||||
  Fly   203 NMNEHSSRSHSVFLINVKQENLENQKKLSGKLYLVDLAGSEKVSKTGAEGTVLDEAKNINKSLSA 267

Human   262 LGNVISALAEGTKTHVPYRDSKMTRILQDSLGGNCRTTIVICCSPSVFNEAETKSTLMFGQRAKT 326
            |||||||||:|.|||:||||||:|||||:|||||.||||||||||:.|||:||||||.||:||||
  Fly   268 LGNVISALADGNKTHIPYRDSKLTRILQESLGGNARTTIVICCSPASFNESETKSTLDFGRRAKT 332

Human   327 IKNTVSVNLELTAEEWKKKYEKEKEKNKTLKNVIQHLEMELNRWRNGEAVPEDEQISAKDQKNLE 391
            :||.|.||.||||||||::||||||||..||..::.||:||.|||.||.|..:|||:.:|....
  Fly   333 VKNVVCVNEELTAEEWKRRYEKEKEKNARLKGKVEKLEIELARWRAGETVKAEEQINMEDLMEA- 396

Human   392 PCDNTPIID------------------NIAPVVAGISTEEKEKYDEEISSLYRQLDDKDDEINQQ 438
               :||.::                  .:|.:.|.::..|:.:...|...||:||||||:|||||
  Fly   397 ---STPNLEVEAAQTAAAEAALAAQRTALANMSASVAVNEQARLATECERLYQQLDDKDEEINQQ 458

Human   439 SQLAEKLKQQMLDQDELLASTRRDYEKIQEELTRLQIENEAAKDEVKEVLQALEELAVNYDQKSQ 503
            ||.||:||:|:::|:||:|:.||:||.:|.|:.|:|.|||:||:|||||||||||||||||||||
  Fly   459 SQYAEQLKEQVMEQEELIANARREYETLQSEMARIQQENESAKEEVKEVLQALEELAVNYDQKSQ 523

Human   504 EVEDKTRANEQLTDELAQKTTTLTTTQRELSQLQELSNHQKKRATEILNLLLKDLGEIGGIIGTN 568
            |:::|.:..:.|.:||.||.:.......||.||:::|:|||||.||:|..||:||||:|..|...
  Fly   524 EIDNKNKDIDALNEELQQKQSVFNAASTELQQLKDMSSHQKKRITEMLTNLLRDLGEVGQAIAPG 588

Human   569 D------VKTLADVN-GVIEEEFTMARLYISKMKSEVKSLVNRSKQLESAQMDSNRKMNASEREL 626
            :      :..||..: ..:||:||||||:|||||:|.|::..|...:|:.|.|||:|::..|::|
  Fly   589 ESSIDLKMSALAGTDASKVEEDFTMARLFISKMKTEAKNIAQRCSNMETQQADSNKKISEYEKDL 653

Human   627 AACQLLISQHEAKIKSLTDYMQNMEQKRRQLEESQDSLSEELAKLRAQEKMHEVSFQDKEKEHLT 691
            ...:||||||||::|||.:.|:..|.|:|.|||..|||.||.|||:|.|.:..|:.::|::
  Fly   654 GEYRLLISQHEARMKSLQESMREAENKKRTLEEQIDSLREECAKLKAAEHVSAVNAEEKQR---- 714

Human   692 RLQDAEEMKKALEQQMESHREAHQKQLSRLRDEIEEKQKIIDEIRDLNQKLQLEQEKLSSDYNKL 756
                |||::...:.||:..||||.:|:|.|||||..||..:||::|::|||.|..:::::||.|:
  Fly   715 ----AEELRSMFDSQMDELREAHTRQVSELRDEIAAKQHEMDEMKDVHQKLLLAHQQMTADYEKV 775

Human   757 KIEDQEREMKLEKLLLLNDKREQAREDLKGLEETVSRELQTLHNLRKLFVQDLTTRVKKS-VELD 820
            :.||.|:..:|:.::|.|::|||||:||||||:||::||||||||||||||||..|::|: |..:
  Fly   776 RQEDAEKSSELQNIILTNERREQARKDLKGLEDTVAKELQTLHNLRKLFVQDLQQRIRKNVVNEE 840

Human   821 NDDGGGSAAQKQKISFLENNLEQLTKVHKQLVRDNADLRCELPKLEKRLRATAERVKALESALKE 885
            :::.|||.|||||||||||||:||||||||||||||||||||||||||||.|.|||||||:||||
  Fly   841 SEEDGGSLAQKQKISFLENNLDQLTKVHKQLVRDNADLRCELPKLEKRLRCTMERVKALETALKE 905

Human   886 AKENAMRDRKRYQQEVDRIKEAVRAKNMARRAHSAQIAKPIRPGHYPASSPTAVHAIRGGG 946
            |||.|||||||||.||||||||||.|::.||...||||||||.|.       ...||||||
  Fly   906 AKEGAMRDRKRYQYEVDRIKEAVRQKHLGRRGPQAQIAKPIRSGQ-------GAIAIRGGG 959

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
KIF5C	NP_004513.1	KISc_KHC_KIF5	6..327	CDD:276820	247/322 (77%)
		Microtubule-binding	174..315		119/140 (85%)
		PRK03918	<412..907	CDD:235175	284/502 (57%)
		Khc_CBD_cc	836..905	CDD:467880	62/68 (91%)
		Globular	859..956		64/88 (73%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	911..957		18/36 (50%)
Khc	NP_476590.1	KISc_KHC_KIF5	10..333	CDD:276820	247/322 (77%)
		Smc	<341..>807	CDD:440809	223/477 (47%)
		Khc_CBD_cc	856..925	CDD:467880	62/68 (91%)