DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment KIF5C and klp3

DIOPT Version :10

Sequence 1:NP_004513.1 Gene:KIF5C / 3800 HGNCID:6325 Length:957 Species:Homo sapiens
Sequence 2:NP_594686.1 Gene:klp3 / 2542195 PomBaseID:SPAC1834.07 Length:554 Species:Schizosaccharomyces pombe


Alignment Length:589 Identity:218/589 - (37%)
Similarity:318/589 - (53%) Gaps:75/589 - (12%)


- Green bases have known domain annotations that are detailed below.


Human     8 SIKVMCRFRPLNEAEILRGDKFIPKFKGDETVVI---GQGKPYVFDRVLPPNTTQEQVYNACAKQ 69
            ||||:||.||.|:.|...|...:.....|.||.|   .....:|||||..|::||..:::...:.
pombe     3 SIKVVCRIRPTNQLEQDLGGNNVIYPLNDSTVHIETSDYSGNFVFDRVFHPSSTQNDIFSYSIES 67

Human    70 IVKDVLEGYNGTIFAYGQTSSGKTHTMEGKLHDPQLMGIIPRIAHDIFDHIYSMDENLEFHIKVS 134
            .|.|:..|||||:.|||||.||||:||.|..::.:..|:.||:...|||.|.......|:.:|||
pombe    68 TVDDLFLGYNGTVLAYGQTGSGKTYTMMGIENNFEKEGMTPRMLRRIFDKIRDSPSTTEYEVKVS 132

Human   135 YFEIYLDKIRDLLDVSKTNLAVHEDKNRVPYVKGCTERFVSSPEEVMDVIDEGKANRHVAVTNMN 199
            |.|||::||.|||......|.|||||.:..||:|....:|||..|.:|::::|..:|.||.|:||
pombe   133 YMEIYMEKIHDLLSEKNDRLTVHEDKLQGVYVQGLKTIYVSSETEALDILNKGMGSRAVASTSMN 197

Human   200 EHSSRSHSIFLINIKQENVETEKKLSGKLYLVDLAGSEKVSKTGAEGAVLDEAKNINKSLSALGN 264
            ..||||||||::.:.|.:.|:.:...|:|:||||||||.|.|:||.|..|:|||.||:|||.||.
pombe   198 AQSSRSHSIFVLEVVQTDTESGETRRGRLFLVDLAGSESVGKSGAVGQTLEEAKKINRSLSTLGM 262

Human   265 VISALAEGTKTHVPYRDSKMTRILQDSLGGNCRTTIVICCSPSVFNEAETKSTLMFGQRAKTIKN 329
            ||::|.:...:||||||||:||||::|||||.|||::|.|||..:|..||.|||.||.|||:|||
pombe   263 VINSLTDSKLSHVPYRDSKLTRILKESLGGNSRTTLIINCSPDSYNATETLSTLRFGHRAKSIKN 327

Human   330 TVSVNLELTAEEWKKKYEKEKEK------NKTLKNVIQHLEMELNRWRNGEAVPEDEQISAKDQK 388
            ...||.||:.:|.|::....|:.      ...:.|.:.:.....|.| :||.......::.|  .
pombe   328 KAVVNSELSVDEMKRQLYIYKDALSRCVCGARINNNLDYNNCHSNVW-SGEHSLTLSNLAEK--S 389

Human   389 NLEPCDNTPIIDNIAPVVAGISTEEKEKYDEE---ISSLYRQLDDKDDEINQ---QSQLAEKLKQ 447
            ||:.          |.::.|..|.::...|.:   ::|::|...| .|.||:   ::||  :|||
pombe   390 NLKE----------AEIIQGNRTIQESNNDRDESTVASIHRHNFD-SDSINRLYAEAQL--ELKQ 441

Human   448 QMLDQDELLASTRRDYEKIQEELTRLQIENEAAKDEVKEVLQALEELAVNYDQ--KSQEVEDKTR 510
                :|.:|:||                     |.::.:::.||.:....|.:  |:..|.....
pombe   442 ----RDGVLSST---------------------KQQLSDLMTALGDAQERYVELVKNHRVNSNLT 481

Human   511 ANEQLTDE----LAQKTTTLTTTQRELSQLQELS----------NHQKKRATEILNLLLKDLGEI 561
            ||..|.|:    :.||....:......:.||:||          |.|:|.   |..|:.|:..:.
pombe   482 ANNSLNDKPGFTIEQKDKNFSINNERNNFLQKLSTLDSSLAALVNVQRKL---IKALISKERPQN 543

Human   562 GGII 565
            |.:|
pombe   544 GTVI 547

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
KIF5CNP_004513.1 KISc_KHC_KIF5 6..327 CDD:276820 157/321 (49%)
Microtubule-binding 174..315 77/140 (55%)
PRK03918 <412..907 CDD:235175 40/176 (23%)
Khc_CBD_cc 836..905 CDD:467880
Globular 859..956
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 911..957
klp3NP_594686.1 KISc_KHC_KIF5 1..325 CDD:276820 157/321 (49%)
Blue background indicates that the domain is not in the aligned region.

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