DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment KIF5C and unc-116

DIOPT Version :9

Sequence 1:	NP_004513.1	Gene:	KIF5C / 3800	HGNCID:	6325	Length:	957	Species:	Homo sapiens
Sequence 2:	NP_001370811.1	Gene:	unc-116 / 176179	WormBaseID:	WBGene00006840	Length:	815	Species:	Caenorhabditis elegans

Alignment Length:	972	Identity:	453/972 - (46%)
Similarity:	590/972 - (60%)	Gaps:	184/972 - (18%)

- Green bases have known domain annotations that are detailed below.

Human     3 DPAECSIKVMCRFRPLNEAEILRGDKFIPKFKGDETVVIGQGKPYVFDRVLPPNTTQEQVYNACA 67
            |.|||.::|.||.||||:.|....|:|:|||..::::.:| ||.||||:|..|||||||||...|
Worm     6 DGAECGVQVFCRIRPLNKTEEKNADRFLPKFPSEDSISLG-GKVYVFDKVFKPNTTQEQVYKGAA 69

Human    68 KQIVKDVLEGYNGTIFAYGQTSSGKTHTMEGKLHDPQLMGIIPRIAHDIFDHIYSMDENLEFHIK 132
            ..||:|||.|||||:||||||||||||||||.:.|..|.||||||..|||:|||||||||:||||
Worm    70 YHIVQDVLSGYNGTVFAYGQTSSGKTHTMEGVIGDNGLSGIIPRIVADIFNHIYSMDENLQFHIK 134

Human   133 VSYFEIYLDKIRDLLDVSKTNLAVHEDKNRVPYVKGCTERFVSSPEEVMDVIDEGKANRHVAVTN 197
            |||:|||.:|||||||..|.||::||||||||||||.|||||..|:||:..|::||:||.|||||
Worm   135 VSYYEIYNEKIRDLLDPEKVNLSIHEDKNRVPYVKGATERFVGGPDEVLQAIEDGKSNRMVAVTN 199

Human   198 MNEHSSRSHSIFLINIKQENVETEKKLSGKLYLVDLAGSEKVSKTGAEGAVLDEAKNINKSLSAL 262
            ||||||||||:|||.:|||:..|:|:|:|||||||||||||||||||:|.||:|||||||||:||
Worm   200 MNEHSSRSHSVFLITVKQEHQTTKKQLTGKLYLVDLAGSEKVSKTGAQGTVLEEAKNINKSLTAL 264

Human   263 GNVISALAEGTKTHVPYRDSKMTRILQDSLGGNCRTTIVICCSPSVFNEAETKSTLMFGQRAKTI 327
            |.||||||||||:||||||||:|||||:|||||.|||::||.|||.||||||||||:||.|||||
Worm   265 GIVISALAEGTKSHVPYRDSKLTRILQESLGGNSRTTVIICASPSHFNEAETKSTLLFGARAKTI 329

Human   328 KNTVSVNLELTAEEWKKKYEKEKEKNKTLKNVIQHLEMELNRWRNGEAVPEDEQISAKDQKNLEP 392
            ||.|.:|.||||||||::||||||||..|..::|...:||:|||.||:|.|.|.::..|...:..
Worm   330 KNVVQINEELTAEEWKRRYEKEKEKNTRLAALLQAAALELSRWRAGESVSEVEWVNLSDSAQMAV 394

Human   393 CD----NTPIID-NIAP-------VVAGISTEEKEKYDEEISSLYRQLDDKDDEINQQSQLAEKL 445
            .:    :||::: :|||       ....|:.|||:||:||...||:|||:|||||.:.||..|||
Worm   395 SEVSGGSTPLMERSIAPAPPMLTSTTGPITDEEKKKYEEERVKLYQQLDEKDDEIQKVSQELEKL 459

Human   446 KQQMLDQDELLASTRRDYEKIQEELTRLQIENEAAKDEVKEVLQALEELAVNYDQKSQEVEDKTR 510
            :||:|.|:|.|.:.|.:.|.|:||..|.|.|.|..:.|.||::.||||:|||.|.:..|.|...|
Worm   460 RQQVLLQEEALGTMRENEELIREENNRFQKEAEDKQQEGKEMMTALEEIAVNLDVRQAECEKLKR 524

Human   511 ANEQLTDELAQKTTTLTTTQRELSQLQELSNHQKKRATEILNLLLKDLGE--------IGGIIGT 567
                          .|...|.:...|::..|    :||.:||..|.:.|.        |..:|..
Worm   525 --------------ELEVVQEDNQSLEDRMN----QATSLLNAHLDECGPKIRHFKEGIYNVIRE 571

Human   568 NDVKTLADVNGVIEEE--FTMARLYISKMKSEVKSLVNRSKQLESAQMDSNRKMNASERELAACQ 630
            .::..:|..|..:.:.  ....|:.:||:.||..:                    |.|...||
Worm   572 FNIADIASQNDQLPDHDLLNHVRIGVSKLFSEYSA--------------------AKESSTAA-- 614

Human   631 LLISQHEAKIKSLTDYMQNMEQKRRQLEESQDSLSEELAKLRAQEKMHEVSFQDKEKEHLTRLQD 695
                :|:|:.|                      |:.::|::.:.                   ||
Worm   615 ----EHDAEAK----------------------LAADVARVESG-------------------QD 634

Human   696 AEEMKKALEQQMESHREAHQKQLSRLRDEIEEKQKIIDEIRDLNQKLQLEQEKLSSDYNKLKIED 760
            |..||:
Worm   635 AGRMKQ----------------------------------------------------------- 640

Human   761 QEREMKLEKLLLLNDKREQAREDLKGLEETVSRELQTLHNLRKLFVQDLTTRVKKSVELDNDDGG 825
                      ||:.|   ||.:::|.|.:.|:.||.||.||:|.|::.|..|.:.:.:.:.:|..
Worm   641 ----------LLVKD---QAAKEIKPLTDRVNMELTTLKNLKKEFMRVLVARCQANQDTEGEDSL 692

Human   826 GSAAQKQKISFLENNLEQLTKVHKQLVRDNADLRCELPKLEKRLRATAERVKALESALKEAKENA 890
            ...||||:|.||||||::||||||||||||||||.||||:|.|||...:|:|.||:||:::|:.:
Worm   693 SGPAQKQRIQFLENNLDKLTKVHKQLVRDNADLRVELPKMEARLRGREDRIKILETALRDSKQRS 757

Human   891 MRDRKRYQQEVDRIKEAVRAKNMARRAHSAQIAKPIRPGHYPASSPTAVHAIRGGGGSSSNS 952
            ..:||:|||||:|||||||.:|| ||.::.||.||||||.. .:||:|  .:..|..:.||:
Worm   758 QAERKKYQQEVERIKEAVRQRNM-RRMNAPQIVKPIRPGQV-YTSPSA--GMSQGAPNGSNA 815

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
KIF5C	NP_004513.1	KISc_KHC_KIF5	6..327	CDD:276820	233/320 (73%)
		Microtubule-binding	174..315		108/140 (77%)
		Smc	<460..801	CDD:224117	68/350 (19%)
		PRK03918	<715..>916	CDD:235175	77/200 (39%)
		Globular	859..956		48/94 (51%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	911..957		18/42 (43%)
unc-116	NP_001370811.1	KISc_KHC_KIF5	9..329	CDD:276820	233/320 (73%)
unc-116	NP_001370811.1	SMC_prok_A	440..>782	CDD:274009	152/499 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	446	1.000	Domainoid score	I285
eggNOG	1	0.900	-	-		E2759_KOG0240
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	663	1.000	Inparanoid score	I438
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG52972
OrthoDB	1	1.010	-	-		D1334528at2759
OrthoFinder	1	1.000	-	-		FOG0000669
OrthoInspector	1	1.000	-	-		otm15040
orthoMCL	1	0.900	-	-		OOG6_100344
Panther	1	1.100	-	-	O	PTHR24115
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2595
SonicParanoid	1	1.000	-	-		X952
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	14	13.870