DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment KIF5C and kif5c

DIOPT Version :9

Sequence 1:	NP_004513.1	Gene:	KIF5C / 3800	HGNCID:	6325	Length:	957	Species:	Homo sapiens
Sequence 2:	XP_002935337.3	Gene:	kif5c / 100493873	XenbaseID:	XB-GENE-977474	Length:	959	Species:	Xenopus tropicalis

Alignment Length:	959	Identity:	850/959 - (88%)
Similarity:	914/959 - (95%)	Gaps:	2/959 - (0%)

- Green bases have known domain annotations that are detailed below.

Human     1 MADPAECSIKVMCRFRPLNEAEILRGDKFIPKFKGDETVVIGQGKPYVFDRVLPPNTTQEQVYNA 65
            |||||||||||||||||||:|||.|||||||.|||::|||:|..||||||:|.|.|||||.||:|
Frog     1 MADPAECSIKVMCRFRPLNKAEIQRGDKFIPVFKGEDTVVVGPSKPYVFDKVFPSNTTQEHVYSA 65

Human    66 CAKQIVKDVLEGYNGTIFAYGQTSSGKTHTMEGKLHDPQLMGIIPRIAHDIFDHIYSMDENLEFH 130
            ||||||||||:||||||||||||||||||||||||||.|:|||||||||||||||||||||||||
Frog    66 CAKQIVKDVLDGYNGTIFAYGQTSSGKTHTMEGKLHDHQMMGIIPRIAHDIFDHIYSMDENLEFH 130

Human   131 IKVSYFEIYLDKIRDLLDVSKTNLAVHEDKNRVPYVKGCTERFVSSPEEVMDVIDEGKANRHVAV 195
            ||||||||||||||||||||||||||||||||||:||||||||||||||||||||||||||||||
Frog   131 IKVSYFEIYLDKIRDLLDVSKTNLAVHEDKNRVPFVKGCTERFVSSPEEVMDVIDEGKANRHVAV 195

Human   196 TNMNEHSSRSHSIFLINIKQENVETEKKLSGKLYLVDLAGSEKVSKTGAEGAVLDEAKNINKSLS 260
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Frog   196 TNMNEHSSRSHSIFLINIKQENVETEKKLSGKLYLVDLAGSEKVSKTGAEGAVLDEAKNINKSLS 260

Human   261 ALGNVISALAEGTKTHVPYRDSKMTRILQDSLGGNCRTTIVICCSPSVFNEAETKSTLMFGQRAK 325
            ||||||||||||||||||||||||||||||||||||||||:||||||:|||||||||||||||||
Frog   261 ALGNVISALAEGTKTHVPYRDSKMTRILQDSLGGNCRTTIIICCSPSIFNEAETKSTLMFGQRAK 325

Human   326 TIKNTVSVNLELTAEEWKKKYEKEKEKNKTLKNVIQHLEMELNRWRNGEAVPEDEQISAKDQKNL 390
            |||||||||||||||||||||||||:|.|:|||:||||||||||||.|||||.|||.||||||.|
Frog   326 TIKNTVSVNLELTAEEWKKKYEKEKDKTKSLKNIIQHLEMELNRWRRGEAVPVDEQTSAKDQKTL 390

Human   391 EPCDNTPIIDNIAPVVAGISTEEKEKYDEEISSLYRQLDDKDDEINQQSQLAEKLKQQMLDQDEL 455
            |||||||:|||.......||:|||:||||:|:|||.|||||||||||||||.||||||||||:||
Frog   391 EPCDNTPVIDNGLVGATNISSEEKKKYDEDIASLYGQLDDKDDEINQQSQLIEKLKQQMLDQEEL 455

Human   456 LASTRRDYEKIQEELTRLQIENEAAKDEVKEVLQALEELAVNYDQKSQEVEDKTRANEQLTDELA 520
            ||||||||||||||||||||||:|||||||||||||||||||||||||||||||:.||||::||.
Frog   456 LASTRRDYEKIQEELTRLQIENDAAKDEVKEVLQALEELAVNYDQKSQEVEDKTKLNEQLSEELT 520

Human   521 QKTTTLTTTQRELSQLQELSNHQKKRATEILNLLLKDLGEIGGIIGTNDVKTLADVNGVIEEEFT 585
            ||||.||.|||||||||||||||:||.|||||||||||||||||:|||||||||:||||||||||
Frog   521 QKTTNLTVTQRELSQLQELSNHQRKRTTEILNLLLKDLGEIGGIVGTNDVKTLAEVNGVIEEEFT 585

Human   586 MARLYISKMKSEVKSLVNRSKQLESAQMDSNRKMNASERELAACQLLISQHEAKIKSLTDYMQNM 650
            |||||||||||||||||||||||||||:::|||:||||:||||||||.|||||||||||||||||
Frog   586 MARLYISKMKSEVKSLVNRSKQLESAQIEANRKINASEKELAACQLLSSQHEAKIKSLTDYMQNM 650

Human   651 EQKRRQLEESQDSLSEELAKLRAQEKMHEVSFQDKEKEHLTRLQDAEEMKKALEQQMESHREAHQ 715
            ||:||||||:||:|:||||:|.||||||:|||||||||||||||||||:||.|||||||||||||
Frog   651 EQRRRQLEEAQDALNEELARLHAQEKMHKVSFQDKEKEHLTRLQDAEEIKKTLEQQMESHREAHQ 715

Human   716 KQLSRLRDEIEEKQKIIDEIRDLNQKLQLEQEKLSSDYNKLKIEDQEREMKLEKLLLLNDKREQA 780
            |||||||||||||||:||:::||||||||:.:||:|||.|||.|:::||..|:||:|||:||||:
Frog   716 KQLSRLRDEIEEKQKMIDDLKDLNQKLQLQLDKLTSDYEKLKTEEEQREEDLQKLVLLNEKREQS 780

Human   781 REDLKGLEETVSRELQTLHNLRKLFVQDLTTRVKKSVELDNDDGGGSAAQKQKISFLENNLEQLT 845
            |||||||||||:|||||||||||||:|||..||:|.||||:|:||||||||||||||||||||||
Frog   781 REDLKGLEETVARELQTLHNLRKLFIQDLALRVQKRVELDSDNGGGSAAQKQKISFLENNLEQLT 845

Human   846 KVHKQLVRDNADLRCELPKLEKRLRATAERVKALESALKEAKENAMRDRKRYQQEVDRIKEAVRA 910
            |||||||||||||||||||||||||||||||||||.|||||||||||||:|||||||||||||||
Frog   846 KVHKQLVRDNADLRCELPKLEKRLRATAERVKALEGALKEAKENAMRDRRRYQQEVDRIKEAVRA 910

Human   911 KNMARRAHSAQIAKPIRPGHYPASSPTAVHAIRGGGGSSSNS--THYQK 957
            ||:||||.||||||||||||||||||||||:|||||||:.:|  .|:.|
Frog   911 KNIARRAPSAQIAKPIRPGHYPASSPTAVHSIRGGGGSTHSSYYHHHSK 959

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
KIF5C	NP_004513.1	KISc_KHC_KIF5	6..327	CDD:276820	301/320 (94%)
		Microtubule-binding	174..315		138/140 (99%)
		Smc	<460..801	CDD:224117	293/340 (86%)
		PRK03918	<715..>916	CDD:235175	170/200 (85%)
		Globular	859..956		87/98 (89%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	911..957		37/47 (79%)
kif5c	XP_002935337.3	KISc_KHC_KIF5	6..327	CDD:276820	301/320 (94%)
		COG4372	469..>673	CDD:226809	180/203 (89%)
		SMC_prok_B	580..>912	CDD:274008	287/331 (87%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	1061	1.000	Domainoid score	I551
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H56234
Inparanoid	1	1.050	1681	1.000	Inparanoid score	I1062
NCBI	1	1.000	-	-
OMA	1	1.010	-	-		QHG52972
OrthoDB	1	1.010	-	-		D1334528at2759
OrthoFinder	1	1.000	-	-		FOG0000669
OrthoInspector	1	1.000	-	-		oto153443
Panther	1	1.100	-	-	LDO	PTHR24115
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X952
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	13	13.080