Protein Alignment ACAT1 and yip2

DIOPT Version :9

• Sequence 1: NP_001373606.1
• Gene: ACAT1 / 38
• HGNCID: 93
• Length: 434
• Species: Homo sapiens
• Sequence 2: NP_523528.1
• Gene: yip2 / 34313
• FlyBaseID: FBgn0040064
• Length: 398
• Species: Drosophila melanogaster
• Alignment Length: 400
• Identity: 149/400 - (37%)
• Similarity: 227/400 - (56%)
• Gaps: 16/400 - (4%)

Human    40 KEVVIVSATRTPIGSFLGSLSLLPATKLGSIAIQGAIEKAGIPKEEVKEAYMGNVLQGG--EGQA 102
            |.:.||:|.||..|:|.|||..:..|:|.:.|.:.|::.||:..|:|....:|||:...  :|..
  Fly     6 KGIYIVAAKRTAFGTFGGSLKGINQTQLQTTAAKAALDAAGLKGEQVDTVIVGNVIASSSTDGIY 70

Human   103 PTRQAVLGAGLPISTPCTTINKVCASGMKAIMMASQSLMCGHQDVMVAGGMESMSNVPYVMNR-- 165
            ..|...|..|:||..|...||::|.||.::|:..:|.::.|...:.:.||:|:||..|::...
  Fly    71 VPRHVGLNCGVPIEKPALGINRLCGSGFQSIVNGAQDILVGGAKIALTGGVENMSQSPFIARNVR 135

Human   166 -GSTPYGGVKLEDLIVKDGLTDVYNKIHMGSCAENTAKKLNIARNEQDAYAINSYTRSKAAWEAG 229
             |:|......|||.:.. ||||.|.|:.|...|||.|.:..|:|...|.:::.|....:...:.|
  Fly   136 FGTTLGASYNLEDALWA-GLTDTYCKLPMALTAENLADQYKISRERVDEFSLLSQKNWEKGQKEG 199

Human   230 KFGNEVIPVTVTVKGQPDVVVKEDEEYKRVDFSKVPKLKTVFQKENGTVTAANASTLNDGAAALV 294
            .|..|:.|:.:.|||:....|.::....:.....:.||.::| |:||.|||..||.:.|||:|::
  Fly   200 AFNAEITPIKLKVKGKEVDFVVDEHPRPKTTIEGLNKLPSLF-KKNGVVTAGTASGICDGASAVI 263

Human   295 LMTADAAKRLNVTPLARIVAFADAAVEPIDFPIAPVYAASMVLKDVGLKKEDIAMWEVNEAFSLV 359
            :.:.:|.|..|:.||||:|||:...|:|....|.||.|...|||..|.|.|||.:.|:||||:..
  Fly   264 VASEEALKEYNLKPLARLVAFSFVGVKPEIMGIGPVPAIQNVLKVSGKKLEDIDLIEINEAFAAQ 328

Human   360 VLANIKMLEIDPQKVNINGGAVSLGHPIGKCFLNFRMSGARIVGHLTHAL--KQGEYGLASICNG 422
            .||....|::|..|:|:||||::||||:|       .||:||.|||.|.|  |:.:||:.|.|.|
  Fly   329 TLACADALKLDTSKLNVNGGAIALGHPLG-------ASGSRITGHLVHELQRKKLKYGIGSACIG 386

Human   423 GGGASAMLIQ 432
            ||...|:|::
  Fly   387 GGQGIALLLE 396

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ACAT1	NP_001373606.1	thiolase	43..433	CDD:238383	148/396 (37%)
		Coenzyme A binding. /evidence=ECO:0000269|PubMed:17371050	258..260		0/1 (0%)
yip2	NP_523528.1	PRK05790	6..398	CDD:180261	149/399 (37%)
		thiolase	9..397	CDD:238383	148/396 (37%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0183
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D321628at33208
OrthoFinder	1	1.000	-	-		FOG0000432
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.820