DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment emp and Cd36

DIOPT Version :9

Sequence 1:	NP_726504.2	Gene:	emp / 37999	FlyBaseID:	FBgn0010435	Length:	551	Species:	Drosophila melanogaster
Sequence 2:	NP_113749.2	Gene:	Cd36 / 29184	RGDID:	2301	Length:	472	Species:	Rattus norvegicus

Alignment Length:	477	Identity:	143/477 - (29%)
Similarity:	233/477 - (48%)	Gaps:	33/477 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly    55 IVVAAALIIGGIVVACEFTVLIDAVVDRMVALRPGAKTFGWWAKPPVEPRISLYIYNVTNADDFL 119
            ::.|...:.|||::... .:||:..:.|.|.|..|...|..|.|.........:|::|.|.::..
  Rat    14 VIGAVLAVFGGILMPVG-DLLIEKTIKREVVLEEGTIAFKNWVKTGTTVYRQFWIFDVQNPEEVA 77

  Fly   120 SNGSKAIVDEVGPYVYSETW-EKVNIVEN-DNGTLSYNLRKIYSFREDLSVGPEDDVVIVPNIPM 182
            .|.||..|.:.|||.|...: .|.||.:: .:.|:|:.......|...||||.|:|...|.|:.:
  Rat    78 KNSSKIKVKQRGPYTYRVRYLAKENITQDPKDSTVSFVQPNGAIFEPSLSVGTENDNFTVLNLAV 142

  Fly   183 LSATSQSKHAARFLRLAMASIMDILKIKPFVQVSVGQLLWGYEDPLLKLAKDVVPKEQKLPY--- 244
              |.:...:...|::..:.|::...|...|...|:.:|||||:||.|.|          :||
  Rat   143 --AAAPHIYTNSFVQGVLNSLIKKSKSSMFQTRSLKELLWGYKDPFLSL----------VPYPIS 195

  Fly   245 EEFGLLYGKNGTSSDRVTVNTGVDDIRRYGIIDNFNGRTHLPHWTTDACNTLAGTDGSIFPPHID 309
            ...|:.|..|.|......|..|.|:|.:..|||.:.|:.:|.:|.: .|:.:.|||.:.|||.::
  Rat   196 TTVGVFYPYNNTVDGVYKVFNGKDNISKVAIIDTYKGKRNLSYWES-YCDMINGTDAASFPPFVE 259

  Fly   310 HDRILHVYDKDLCRLLPLVFEKEVMTSNEVPGYRFTPPEWVFADVDSHPDNMCFCPAG--KPSCS 372
            ..|.|..:..|:||.:..||..||.... :|.|||..|...||....:|||.|||...  ..:|:
  Rat   260 KSRTLRFFSSDICRSIYAVFGSEVNLKG-IPVYRFVLPANAFASPLQNPDNHCFCTEKVISNNCT 323

  Fly   373 PNGLFNVSLCQYDSPIMLSFPHFYLADESLRTQVEGISPPMKEKHQFFFDVQPKMGTTLRVRARI 437
            ..|:.::..|:...|:.:|.|||..|...:...:||:: |.:::|:.:.||:|..|.||:...|:
  Rat   324 SYGVLDIGKCKEGKPVYISLPHFLHASPDVSEPIEGLN-PNEDEHRTYLDVEPITGFTLQFAKRL 387

  Fly   438 QINLAVSQVFDIKQVANF--PDIIFPILWFEEGIDNLPDEVTDLMRFAEQVPPKIRVALIVGLCA 500
            |:|:.|.....|:.:.|.  |.|: ||||..| ...:.||..::  |..||..||::..:|.:..
  Rat   388 QVNILVKPARKIEALKNLKRPYIV-PILWLNE-TGTIGDEKAEM--FRNQVTGKIKLLGLVEMVL 448

  Fly   501 LGV----ILLLLSTFCLIRNSH 518
            |||    .:..:.::|..|:.:
  Rat   449 LGVGVVMFVAFMISYCACRSKN 470

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
emp	NP_726504.2	CD36	58..511	CDD:279474	141/465 (30%)
Cd36	NP_113749.2	CD36	14..463	CDD:395898	141/468 (30%)
		Required for interaction with thrombospondins, THBS1 and THBS2. /evidence=ECO:0000250	93..120		6/26 (23%)
		Interaction with PTK2, PXN and LYN. /evidence=ECO:0000250\|UniProtKB:P16671	460..472		2/11 (18%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1106566at2759
OrthoFinder	1	1.000	-	-		FOG0000618
OrthoInspector	1	1.000	-	-		mtm9056
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X155
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	5.920