DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment emp and Scarb2

DIOPT Version :9

Sequence 1:	NP_726504.2	Gene:	emp / 37999	FlyBaseID:	FBgn0010435	Length:	551	Species:	Drosophila melanogaster
Sequence 2:	NP_031670.1	Gene:	Scarb2 / 12492	MGIID:	1196458	Length:	478	Species:	Mus musculus

Alignment Length:	466	Identity:	160/466 - (34%)
Similarity:	245/466 - (52%)	Gaps:	45/466 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly    66 IVVACEFTVLIDAVVDRMVALRPGAKTFGWWAKPPVEPRISLYIYNVTNADDFLSNGSKAIVDEV 130
            ::||..|...:|..:::.:.|:.|.|.|..|.|||:...|..|.:||||.::.| .|...:::||
Mouse    23 LLVARVFQKAVDQTIEKNMVLQNGTKVFNSWEKPPLPVYIQFYFFNVTNPEEIL-QGEIPLLEEV 86

  Fly   131 GPYVYSETWEKVNIVENDNG-TLSYNLRKIYSFREDLSVG-PEDDVVIVPNIPMLSATSQSKHAA 193
            |||.|.|...|.||...:|| |:|....|.|.|..:.||| |..|::...|||:|:....::  .
Mouse    87 GPYTYRELRNKANIQFGENGTTISAVTNKAYVFERNQSVGDPNVDLIRTINIPLLTVVDLAQ--L 149

  Fly   194 RFLRLAMASIMDILKIKPFVQVSVGQLLWGYEDPLLKLA----KDVVPKEQKLPYEEFGLLYGKN 254
            ..||..:.:::...:.|.||..:|.:|||||:|.:|.|.    .||.|        .|||.|.:|
Mouse   150 TLLRELIEAMLKAYQQKLFVIHTVHELLWGYKDEILSLVHIFKPDVSP--------NFGLFYERN 206

  Fly   255 GTSSDRVTVNTGVDDIRRYGIIDNFNGRTHLPHWTTDACNTLAGTDGSIFPPHIDHDRILHVYDK 319
            ||:.......||.|:...:..|..:||:|.|..||||.||.:.||||..|.|.|..|.:|:::..
Mouse   207 GTNDGEYVFLTGEDNYLNFSKIVEWNGKTSLDWWTTDTCNMINGTDGDSFHPLISKDEVLYLFPS 271

  Fly   320 DLCRLLPLVFEKEVMTSNE----VPGYRFTPPEWVFADVDSHPDNMCFC-PAGKPSCSPNGLFNV 379
            ||||.:.:.|     :|.|    :|.:|:..|..:.|:..   :|..|| |.|  :|..:|:.|:
Mouse   272 DLCRSVHITF-----SSFENVEGLPAFRYKVPAEILANTS---ENAGFCIPEG--NCMDSGVLNI 326

  Fly   380 SLCQYDSPIMLSFPHFYLADESLRTQVEGISPPMKEKHQFFFDVQPKMGTTLRVRARIQINLAVS 444
            |:|:..:||::||||||.|||...:.::|:. |.||:|:.|.|:.|..|..||...|.|||..|.
Mouse   327 SICKNGAPIIMSFPHFYQADEKFVSAIKGMH-PNKEEHESFVDINPLTGIILRGAKRFQINTYVR 390

  Fly   445 QVFDIKQVANFPDIIFPILWFEEGIDNLPDEVTDLMRFAEQVPPKIRVALIVG-----LCALGVI 504
            ::.|..:..:...::||:::..|.:  |.|:.|     |.|:...|...|:|.     :.||||.
Mouse   391 KLDDFVETGDIRTMVFPVMYLNESV--LIDKET-----ANQLKSVINTTLVVTNIPYIIMALGVF 448

  Fly   505 LLLLSTFCLIR 515
            ..|:.|:...|
Mouse   449 FGLVFTWLACR 459

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
emp	NP_726504.2	CD36	58..511	CDD:279474	158/460 (34%)
Scarb2	NP_031670.1	CD36	28..455	CDD:279474	156/455 (34%)
Scarb2	NP_031670.1	Important for interaction with GBA	155..191		12/35 (34%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3776
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H48353
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S5605
OMA	1	1.010	-	-		QHG45589
OrthoDB	1	1.010	-	-		D1106566at2759
OrthoFinder	1	1.000	-	-		FOG0000618
OrthoInspector	1	1.000	-	-		mtm8809
orthoMCL	1	0.900	-	-		OOG6_103616
Panther	1	1.100	-	-	O	PTHR11923
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2956
SonicParanoid	1	1.000	-	-		X155
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	12	11.810