DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment emp and Cd36

DIOPT Version :9

Sequence 1:	NP_726504.2	Gene:	emp / 37999	FlyBaseID:	FBgn0010435	Length:	551	Species:	Drosophila melanogaster
Sequence 2:	NP_001153027.1	Gene:	Cd36 / 12491	MGIID:	107899	Length:	472	Species:	Mus musculus

Alignment Length:	468	Identity:	142/468 - (30%)
Similarity:	234/468 - (50%)	Gaps:	29/468 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly    55 IVVAAALIIGGIVVACEFTVLIDAVVDRMVALRPGAKTFGWWAKPPVEPRISLYIYNVTNADDFL 119
            ::.|...:.|||::... .:||:..:.|.|.|..|...|..|.|.........:|::|.|.||..
Mouse    14 VIGAVLAVFGGILMPVG-DMLIEKTIKREVVLEEGTTAFKNWVKTGTTVYRQFWIFDVQNPDDVA 77

  Fly   120 SNGSKAIVDEVGPYVYSETW-EKVNIVEN-DNGTLSYNLRKIYSFREDLSVGPEDDVVIVPNIPM 182
            .|.||..|.:.|||.|...: .|.||.:: ::.|:|:.......|...||||.|||...|.|:.:
Mouse    78 KNSSKIKVKQRGPYTYRVRYLAKENITQDPEDHTVSFVQPNGAIFEPSLSVGTEDDNFTVLNLAV 142

  Fly   183 LSATSQSKHAARFLRLAMASIMDILKIKPFVQVSVGQLLWGYEDPLLKLAKDVVPKEQKLPY--- 244
            .:|....:::  |:::.:.|::...|...|...|:.:|||||:||.|.|          :||
Mouse   143 AAAPHIYQNS--FVQVVLNSLIKKSKSSMFQTRSLKELLWGYKDPFLSL----------VPYPIS 195

  Fly   245 EEFGLLYGKNGTSSDRVTVNTGVDDIRRYGIIDNFNGRTHLPHWTTDACNTLAGTDGSIFPPHID 309
            ...|:.|..|.|......|..|.|:|.:..||:::.|:.:|.:|.: .|:.:.|||.:.|||.::
Mouse   196 TTVGVFYPYNDTVDGVYKVFNGKDNISKVAIIESYKGKRNLSYWPS-YCDMINGTDAASFPPFVE 259

  Fly   310 HDRILHVYDKDLCRLLPLVFEKEVMTSNEVPGYRFTPPEWVFADVDSHPDNMCFCPAG--KPSCS 372
            ..|.|..:..|:||.:..||..|:.... :|.|||..|...||....:|||.|||...  ..:|:
Mouse   260 KSRTLRFFSSDICRSIYAVFGSEIDLKG-IPVYRFVLPANAFASPLQNPDNHCFCTEKVISNNCT 323

  Fly   373 PNGLFNVSLCQYDSPIMLSFPHFYLADESLRTQVEGISPPMKEKHQFFFDVQPKMGTTLRVRARI 437
            ..|:.::..|:...|:.:|.|||..|...:...:||:. |.:::|:.:.||:|..|.||:...|:
Mouse   324 SYGVLDIGKCKEGKPVYISLPHFLHASPDVSEPIEGLH-PNEDEHRTYLDVEPITGFTLQFAKRL 387

  Fly   438 QINLAVSQVFDIKQVANF--PDIIFPILWFEEGIDNLPDEVTDLMRFAEQVPPKIRVALIVGLCA 500
            |:|:.|.....|:.:.|.  |.|: ||||..| ...:.||..::  |..||..||::..:|.:..
Mouse   388 QVNILVKPARKIEALKNLKRPYIV-PILWLNE-TGTIGDEKAEM--FKTQVTGKIKLLGMVEMAL 448

  Fly   501 LGVILLLLSTFCL 513
            ||:.:::...|.:
Mouse   449 LGIGVVMFVAFMI 461

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
emp	NP_726504.2	CD36	58..511	CDD:279474	141/461 (31%)
Cd36	NP_001153027.1	CD36	16..463	CDD:366481	142/466 (30%)
		Required for interaction with thrombospondins, THBS1 and THBS2. /evidence=ECO:0000269\|PubMed:15748999	93..120		6/26 (23%)
		Interaction with PTK2, PXN and LYN. /evidence=ECO:0000250\|UniProtKB:P16671	460..472		0/2 (0%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3776
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000618
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X155
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.810