Protein Alignment CG2736 and SCARB2

DIOPT Version :9

• Sequence 1: NP_611991.1
• Gene: CG2736 / 37998
• FlyBaseID: FBgn0035090
• Length: 507
• Species: Drosophila melanogaster
• Sequence 2: NP_005497.1
• Gene: SCARB2 / 950
• HGNCID: 1665
• Length: 478
• Species: Homo sapiens
• Alignment Length: 511
• Identity: 126/511 - (24%)
• Similarity: 187/511 - (36%)
• Gaps: 121/511 - (23%)

  Fly    11 LCLILACVNVFLFVV---SWGVDYRILVAREHIRFRQEMPTMDSWINSPFGKLKN-YVFNVTNAE 71
            |.|:|...:|.|.|.   ...||..|   .:.|..|......|||...|...... |.|||||.|
Human    12 LSLLLLVTSVTLLVARVFQKAVDQSI---EKKIVLRNGTEAFDSWEKPPLPVYTQFYFFNVTNPE 73

  Fly    72 EFRSGRDSRLKVKEIGPIVYRIVGFNDILDRNETNVRYRKH-------RYRVVEFLPEESVAP-- 127
            |...|...|  |:|:||..||.:       ||:.|:::..:       ..:...|..::||..
Human    74 EILRGETPR--VEEVGPYTYREL-------RNKANIQFGDNGTTISAVSNKAYVFERDQSVGDPK 129

  Fly   128 ------------DVLNWTITSTNNVILGAATKVKHTAPLAAFGFDAALMMEDIFVTDSVYYFLWE 180
                        .|:.|:.......|:.|..|.               ..:.:|||.:|...||.
Human   130 IDLIRTLNIPVLTVIEWSQVHFLREIIEAMLKA---------------YQQKLFVTHTVDELLWG 179

  Fly   181 FTRPLLQTLSRISNIRPNVAVLYNALKEKEEV----YTVNIGPKRGIENFFRIETLNGEVIIREQ 241
            :..   :.||.|...||:::..:....||...    |....|....: ||.:|...||:..:
Human   180 YKD---EILSLIHVFRPDISPYFGLFYEKNGTNDGDYVFLTGEDSYL-NFTKIVEWNGKTSL--- 237

  Fly   242 LPHTRQYDSNSCPFNVSGALDNSLFPPFVQPDTPLSIVAIESCRVLPLTYQRQERYNGLDTFRY- 305
                ..:.::.|  |:....|...|.|.:..|..|.:...:.||.:.:|:...|...||..|||
Human   238 ----DWWITDKC--NMINGTDGDSFHPLITKDEVLYVFPSDFCRSVYITFSDYESVQGLPAFRYK 296

  Fly   306 ----TLLQSHQKPPGCLDTSYGVKLPDGMFDVSQCVINDAPSAFSMPHFYGSSYNWSQHYEGYTP 366
                .|..:......|:..  |..|..|:.:||.|. |.||...|.||||.:...:....||..|
Human   297 VPAEILANTSDNAGFCIPE--GNCLGSGVLNVSICK-NGAPIIMSFPHFYQADERFVSAIEGMHP 358

  Fly   367 NAEDHEPYILLEPVTGIPVTEKYRFQSNIPIPDLRRFSSRLSRFSNMMIPSFWYEFEMGQLPGFV 431
            |.||||.::.:.|:|||.:....|||.||.:..|..|                  .|.|.:...|
Human   359 NQEDHETFVDINPLTGIILKAAKRFQINIYVKKLDDF------------------VETGDIRTMV 405

  Fly   432 TSLMWINVNIVQHIQ--------------------PYCM----VLFLVLALWSVLK 463
            ..:|::|.::  ||.                    ||.:    |.|.::..|...|
Human   406 FPVMYLNESV--HIDKETASRLKSMINTTLIITNIPYIIMALGVFFGLVFTWLACK 459

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG2736	NP_611991.1	CD36	10..462	CDD:279474	125/508 (25%)
SCARB2	NP_005497.1	CD36	28..455	CDD:307331	118/489 (24%)
		Important for interaction with GBA	155..191		12/53 (23%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165148218
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3776
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1106566at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11923
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	6	5.850