Protein Alignment CG2736 and Scarb2

DIOPT Version :10

• Sequence 1: NP_611991.1
• Gene: CG2736 / 37998
• FlyBaseID: FBgn0035090
• Length: 507
• Species: Drosophila melanogaster
• Sequence 2: NP_031670.1
• Gene: Scarb2 / 12492
• MGIID: 1196458
• Length: 478
• Species: Mus musculus
• Alignment Length: 460
• Identity: 110/460 - (23%)
• Similarity: 187/460 - (40%)
• Gaps: 83/460 - (18%)

  Fly    11 LCLILACVNVFLFVV---SWGVDYRILVAREHIRFRQEMPTMDSWINSPFG-KLKNYVFNVTNAE 71
            |.|:|...:|.|.|.   ...||..|   .:::..:......:||...|.. .::.|.|||||.|
Mouse    12 LSLLLLVTSVTLLVARVFQKAVDQTI---EKNMVLQNGTKVFNSWEKPPLPVYIQFYFFNVTNPE 73

  Fly    72 EFRSGRDSRLKVKEIGPIVYRIVGFNDILDRNETNVRYRKH-------RYRVVEFLPEESVA-PD 128
            |...|....|  :|:||..||.:       ||:.|:::.::       ..:...|...:||. |:
Mouse    74 EILQGEIPLL--EEVGPYTYREL-------RNKANIQFGENGTTISAVTNKAYVFERNQSVGDPN 129

  Fly   129 VLNWTITSTNNVILGAATKVKHTAPLAAFGFDAAL--MMEDIFVTDSVYYFLWEFTRPLLQTLSR 191
            |   .:..|.|:.|.....:.....|... .:|.|  ..:.:||..:|:..||.:...:|..:..
Mouse   130 V---DLIRTINIPLLTVVDLAQLTLLREL-IEAMLKAYQQKLFVIHTVHELLWGYKDEILSLVHI 190

  Fly   192 IS-NIRPNVAVLY--NALKEKEEVYTVNIGPKRGIENFFRIETLNGEVIIREQLPHTRQYDSNSC 253
            .. ::.||..:.|  |...:.|.|:...   :....||.:|...||:..:       ..:.:::|
Mouse   191 FKPDVSPNFGLFYERNGTNDGEYVFLTG---EDNYLNFSKIVEWNGKTSL-------DWWTTDTC 245

  Fly   254 PFNVSGALDNSLFPPFVQPDTPLSIVAIESCRVLPLTYQRQERYNGLDTFRY----TLLQSHQKP 314
              |:....|...|.|.:..|..|.:...:.||.:.:|:...|...||..|||    .:|.:..:.
Mouse   246 --NMINGTDGDSFHPLISKDEVLYLFPSDLCRSVHITFSSFENVEGLPAFRYKVPAEILANTSEN 308

  Fly   315 PG-------CLDTSYGVKLPDGMFDVSQCVINDAPSAFSMPHFYGSSYNWSQHYEGYTPNAEDHE 372
            .|       |:|:        |:.::|.|. |.||...|.||||.:...:....:|..||.|:||
Mouse   309 AGFCIPEGNCMDS--------GVLNISICK-NGAPIIMSFPHFYQADEKFVSAIKGMHPNKEEHE 364

  Fly   373 PYILLEPVTGIPVTEKYRFQSNIPIPDLRRFSSRLSRFSNMMIPSFWYEFEMGQLPGFVTSLMWI 437
            .::.:.|:|||.:....|||.|..:..|..|                  .|.|.:...|..:|::
Mouse   365 SFVDINPLTGIILRGAKRFQINTYVRKLDDF------------------VETGDIRTMVFPVMYL 411

  Fly   438 NVNIV 442
            |.:::
Mouse   412 NESVL 416

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG2736	NP_611991.1	CD36	10..464	CDD:460076	110/460 (24%)
Scarb2	NP_031670.1	CD36	28..457	CDD:460076	104/444 (23%)
		Important for interaction with GBA1	155..191		8/36 (22%)