DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG2790 and DNAJC21

DIOPT Version :9

Sequence 1:	NP_611986.2	Gene:	CG2790 / 37992	FlyBaseID:	FBgn0027599	Length:	540	Species:	Drosophila melanogaster
Sequence 2:	XP_011512267.2	Gene:	DNAJC21 / 134218	HGNCID:	27030	Length:	676	Species:	Homo sapiens

Alignment Length:	604	Identity:	221/604 - (36%)
Similarity:	329/604 - (54%)	Gaps:	79/604 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MRCYYEELELQRNANDGDIKSAYRKMALRWHPDKNPDRLAEAKERFQLIQQAYEVLSDPQERSWY 65
            |:|:||.|.::|:|::.::|.||||:||:||||||.|..|||.|:|:|||.||:||||||||:||
Human    88 MKCHYEALGVRRDASEEELKKAYRKLALKWHPDKNLDNAAEAAEQFKLIQAAYDVLSDPQERAWY 152

  Fly    66 DNHREQILRGK-NSDYAENCLDVFQFFTSSCYKGYGDNEHGFYRVYTDVFVQIASEDLEFM---D 126
            |||||.:|:|. :.:|.::.||:.::||.:||.||||:|.|||.||.:||..||.|:||.:   :
Human   153 DNHREALLKGGFDGEYQDDSLDLLRYFTVTCYSGYGDDEKGFYTVYRNVFEMIAKEELESVLEEE 217

  Fly   127 KDDRLGMAPDFGHSNSSYEDVVGPFYAFWQAYSTRKTYDWLCPYDVREIKERFILRKVEKEMKKI 191
            .||    .|.||.|.|.|:.||.||||:||::.|:|.:.|...||.|:...|:..|.:|||.|||
Human   218 VDD----FPTFGDSQSDYDTVVHPFYAYWQSFCTQKNFAWKEEYDTRQASNRWEKRAMEKENKKI 278

  Fly   192 VQAARKERNEEVRNLVNFVRKRDPRVQAYRRMLEERVEANRLKQEEKRKEQLRKRQEELAAVRKN 256
            ...||||:||.||.||.|:||||.||||:|:::||:......|.||.|::|..|:.:.:...|:.
Human   279 RDKARKEKNELVRQLVAFIRKRDKRVQAHRKLVEEQNAEKARKAEEMRRQQKLKQAKLVEQYREQ 343

  Fly   257 N-VFNEGYEEQLKQLEQQYDSKSEDYTDEDENDDDGEDFDHEGGQEAEEYE-VEYVDDLYCVACN 319
            : :.....|::|:::|.:|:.:..|.:||:|.::. |..|.|.|::::|.| .|..|||||.||:
Human   344 SWMTMANLEKELQEMEARYEKEFGDGSDENEMEEH-ELKDEEDGKDSDEAEDAELYDDLYCPACD 407

  Fly   320 KTFKNAKARANHEESKKHNENVDRLCQEMEEEEDAFHNEPHEDSLMGVQESLEELQVSEDQISFD 384
            |:||..||..|||:||||.|.|..|.|::||||:.| :.|..|.......|.||:   ||
Human   408 KSFKTEKAMKNHEKSKKHREMVALLKQQLEEEEENF-SRPQIDENPLDDNSEEEM---ED----- 463

  Fly   385 GVPSEEESSLAKR-------TKKNKKARKSAVKQAQAEGSDEPDEPIE----KKAIKSESED--- 435
             .|.::...|..|       :||.||.::...:....:.|..|....:    ||.:..|..|
Human   464 -APKQKVKYLTFRFIFALRLSKKQKKKKQKPAQDVPGKDSYLPAAHFQMAWGKKCVLGERRDGES 527

  Fly   436 --------------------------------EDWSKGKKASKKSKSKKTTTRKVKLLEQTVSEP 468
                                            ||.:..:.::|:.:........|..:.:...:|
Human   528 EHKCAKMLLENRQNYDDNFNVNGPGEGVKVDPEDTNLNQDSAKELEDSPQENVSVTEIIKPCDDP 592

  Fly   469 NTKEATVAPKSGDEDLD-------PTKSQH-----TCVTCRLVFDSKNKLFAHLKKTNHGVYIPK 521
            .::..:|....|.:..|       |.:.|.     :|.||...|.|:||||.|||.|.|......
Human   593 KSEAKSVPKPKGKKTKDMKKPVRVPAEPQTMSVLISCTTCHSEFPSRNKLFDHLKATGHARAPSS 657

  Fly   522 AKPNVEGKPPGKAKGKRNK 540
            :..|.......|.:.::|:
Human   658 SSLNSATSSQSKKEKRKNR 676

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG2790	NP_611986.2	DnaJ	3..66	CDD:278647	39/62 (63%)
		ZUO1	19..>252	CDD:227594	123/236 (52%)
		zf-C2H2_jaz	313..337	CDD:288983	15/23 (65%)
		C2H2 Zn finger	315..337	CDD:275371	13/21 (62%)
DNAJC21	XP_011512267.2	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165156730
Domainoid	1	1.000	193	1.000	Domainoid score	I3208
eggNOG	1	0.900	-	-		E1_KOG0717
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H6752
Inparanoid	1	1.050	371	1.000	Inparanoid score	I2135
Isobase	1	0.950	-	0	Normalized mean entropy	S1790
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D407472at33208
OrthoFinder	1	1.000	-	-		FOG0004881
OrthoInspector	1	1.000	-	-		oto90391
orthoMCL	1	0.900	-	-		OOG6_102227
Panther	1	1.100	-	-	LDO	PTHR44029
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R772
SonicParanoid	1	1.000	-	-		X3443
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	16	15.740