DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG3770 and lhfpl2b

DIOPT Version :9

Sequence 1:	NP_001286864.1	Gene:	CG3770 / 37991	FlyBaseID:	FBgn0035085	Length:	219	Species:	Drosophila melanogaster
Sequence 2:	NP_001017562.1	Gene:	lhfpl2b / 550224	ZFINID:	ZDB-GENE-050417-10	Length:	221	Species:	Danio rerio

Alignment Length:	224	Identity:	83/224 - (37%)
Similarity:	129/224 - (57%)	Gaps:	10/224 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MCYVIITIASLVWFLCSLVADMLFAVALVTPRWLVGPAQGTD---STASSHH--QSSVGIYTRC- 59
            ||:||:|..|::|.|.|:|......||.::..||||.::|::   :..:||.  |.::|||.||
Zfish     1 MCHVIVTCRSMLWTLMSIVVAFAELVAFMSAEWLVGYSEGSELNFTVTASHRSDQRTLGIYNRCL 65

  Fly    60 KVMQEGGFQCGRFDLDGLATDSSVYPNEWKAAMFFVMLGFSLLSVTVILTLITCCRQSACGKSIH 124
            ||.|:...|||.:..|.:...|..    |:|.:.|:::|..||||..||::.:.|.||...|||.
Zfish    66 KVAQQKVVQCGPYATDFMEIASGF----WQATVIFLVIGIFLLSVVGILSVFSMCFQSILKKSIF 126

  Fly   125 NMTACAQVVAGICMMLGLFLHPMGWRANRIQRLCGMDAEPFYPADCSIGVSFYCGIIGVLLTFTA 189
            |:....|.:||:.::|||.|:|.||.:.::...||.||..:....||:|.:||..|.|.:|||..
Zfish   127 NVCGLLQGIAGLFLILGLMLYPAGWGSKKVVDYCGPDASAYKVGLCSLGWAFYTAIGGTVLTFIC 191

  Fly   190 AGISLKAESSNMRTRVRRRVEAGSKLVCI 218
            |..|.:||.:....:|:..:|.|..|:|:
Zfish   192 AMFSAQAEIATSSDKVQDEIEEGRSLICV 220

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG3770	NP_001286864.1	L_HGMIC_fpl	10..195	CDD:287244	71/190 (37%)
lhfpl2b	NP_001017562.1	L_HMGIC_fpl	9..197	CDD:287244	71/191 (37%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170582160
Domainoid	1	1.000	123	1.000	Domainoid score	I5530
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H100779
Inparanoid	1	1.050	151	1.000	Inparanoid score	I4330
OMA	1	1.010	-	-		QHG49708
OrthoDB	1	1.010	-	-		D1431349at2759
OrthoFinder	1	1.000	-	-		FOG0006026
OrthoInspector	1	1.000	-	-		otm26549
orthoMCL	1	0.900	-	-		OOG6_109429
Panther	1	1.100	-	-	O	PTHR12489
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5780
SonicParanoid	1	1.000	-	-		X4322
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	14	13.940