DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG3770 and lhfpl2a

DIOPT Version :9

Sequence 1:	NP_001286864.1	Gene:	CG3770 / 37991	FlyBaseID:	FBgn0035085	Length:	219	Species:	Drosophila melanogaster
Sequence 2:	NP_991226.1	Gene:	lhfpl2a / 402962	ZFINID:	ZDB-GENE-040426-1839	Length:	225	Species:	Danio rerio

Alignment Length:	233	Identity:	73/233 - (31%)
Similarity:	119/233 - (51%)	Gaps:	24/233 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MCYVIITIASLVWFLCSLVADMLFAVALVTPRWLVGPAQGTD--------STASSHHQSSVGIYT 57
            ||:||:|..|::|.|.|:||.....:|.::..||||..:..|        :.|...::.::|||.
Zfish     1 MCHVIVTCRSMLWTLLSIVAAFSELIAFLSTDWLVGFPRAPDAGFSPLGATAAGEAYRPTLGIYG 65

  Fly    58 RC-KVMQ-EGGFQCGRFDLDGLATDSSVYPNE-----WKAAMFFVMLGFSLLSVTVILTLITCCR 115
            || :|.. ..|..||.:         :|:..|     |:|...|:..|..||.....:::.|.|.
Zfish    66 RCIRVPHYRRGVLCGPY---------AVHFGEIASGFWQATAIFLAAGILLLCAVAFISIFTMCF 121

  Fly   116 QSACGKSIHNMTACAQVVAGICMMLGLFLHPMGWRANRIQRLCGMDAEPFYPADCSIGVSFYCGI 180
            ||...|||.|:....|.:||:.:::||.|:|.||.:.::|..||.|:.|:....||.|.:||..:
Zfish   122 QSIMKKSIFNVCGLLQAIAGLFLIVGLVLYPAGWGSQKVQLYCGPDSSPYRLGLCSAGWAFYTAL 186

  Fly   181 IGVLLTFTAAGISLKAESSNMRTRVRRRVEAGSKLVCI 218
            .|.:|.|..|..|.:||.:....:|:..::.|..|:|:
Zfish   187 AGTVLCFLCAVFSAQAEIATSSDKVQEEIQEGKSLICL 224

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG3770	NP_001286864.1	L_HGMIC_fpl	10..195	CDD:287244	62/199 (31%)
lhfpl2a	NP_991226.1	L_HMGIC_fpl	9..201	CDD:287244	62/200 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170582159
Domainoid	1	1.000	123	1.000	Domainoid score	I5530
eggNOG	1	0.900	-	-		E1_KOG4026
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	151	1.000	Inparanoid score	I4330
OMA	1	1.010	-	-		QHG49708
OrthoDB	1	1.010	-	-		D1431349at2759
OrthoFinder	1	1.000	-	-		FOG0006026
OrthoInspector	1	1.000	-	-		otm26549
orthoMCL	1	0.900	-	-		OOG6_109429
Panther	1	1.100	-	-	LDO	PTHR12489
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5780
SonicParanoid	1	1.000	-	-		X4322
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	15	14.800