DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG3770 and Lhfpl2

DIOPT Version :9

Sequence 1:	NP_001286864.1	Gene:	CG3770 / 37991	FlyBaseID:	FBgn0035085	Length:	219	Species:	Drosophila melanogaster
Sequence 2:	NP_766177.1	Gene:	Lhfpl2 / 218454	MGIID:	2145236	Length:	222	Species:	Mus musculus

Alignment Length:	226	Identity:	76/226 - (33%)
Similarity:	114/226 - (50%)	Gaps:	13/226 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MCYVIITIASLVWFLCSLVADMLFAVALVTPRWLVGPAQ-----GTDSTASSHHQSSVGIY-TRC 59
            ||:||:|..|::|.|.|:|......||.::..||:|.|:     |.:....:.....:||. .|.
Mouse     1 MCHVIVTCRSMLWTLLSIVVAFAELVAFMSADWLIGKAKTRSGSGDEQAGMNSEPHYLGILCIRT 65

  Fly    60 KVMQEGGFQCGRFDLDGLATDS--SVYPNEWKAAMFFVMLGFSLLSVTVILTLITCCRQSACGKS 122
            ..||    |..|..|.|....|  .:....|:|...|:.:|..:|.|..::::.|.|.||...||
Mouse    66 PAMQ----QVSRDTLCGTYAKSFGEIASGFWQATAIFLAVGIFILCVVALVSVFTMCVQSIMRKS 126

  Fly   123 IHNMTACAQVVAGICMMLGLFLHPMGWRANRIQRLCGMDAEPFYPADCSIGVSFYCGIIGVLLTF 187
            |.|:....|.:||:.::|||.|:|.||...:... ||..|.|:.|.|||:|.:||....|.:|||
Mouse   127 IFNVCGLLQGIAGLFLILGLILYPAGWGCQKAID-CGRYASPYKPGDCSLGWAFYTATGGTVLTF 190

  Fly   188 TAAGISLKAESSNMRTRVRRRVEAGSKLVCI 218
            ..|..|.:||.:....:|:..:|.|..|||:
Mouse   191 ICAVFSAQAEIATSSDKVQEEIEEGKNLVCL 221

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG3770	NP_001286864.1	L_HGMIC_fpl	10..195	CDD:287244	63/192 (33%)
Lhfpl2	NP_766177.1	PMP22_Claudin	9..198	CDD:419754	63/193 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167838323
Domainoid	1	1.000	96	1.000	Domainoid score	I7338
eggNOG	1	0.900	-	-		E1_KOG4026
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	124	1.000	Inparanoid score	I4694
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG49708
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0006026
OrthoInspector	1	1.000	-	-		oto93422
orthoMCL	1	0.900	-	-		OOG6_109429
Panther	1	1.100	-	-	LDO	PTHR12489
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5780
SonicParanoid	1	1.000	-	-		X4322
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	14	13.790