DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG3770 and LHFPL2

DIOPT Version :9

Sequence 1:	NP_001286864.1	Gene:	CG3770 / 37991	FlyBaseID:	FBgn0035085	Length:	219	Species:	Drosophila melanogaster
Sequence 2:	NP_005770.1	Gene:	LHFPL2 / 10184	HGNCID:	6588	Length:	228	Species:	Homo sapiens

Alignment Length:	233	Identity:	72/233 - (30%)
Similarity:	118/233 - (50%)	Gaps:	21/233 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MCYVIITIASLVWFLCSLVADMLFAVALVTPRWLVGPAQ--------GTDSTASSHHQSSVGIYT 57
            ||:||:|..|::|.|.|:|......:|.::..||:|.|:        |....:...:..::|||.
Human     1 MCHVIVTCRSMLWTLLSIVVAFAELIAFMSADWLIGKARSRGGVEPAGPGGGSPEPYHPTLGIYA 65

  Fly    58 RCKVMQEGGFQ-------CGRFDLDGLATDSSVYPNEWKAAMFFVMLGFSLLSVTVILTLITCCR 115
            ||  ::..|.|       ||.:    ..:...:....|:|...|:.:|..:|.:..::::.|.|.
Human    66 RC--IRNPGVQHFQRDTLCGPY----AESFGEIASGFWQATAIFLAVGIFILCMVALVSVFTMCV 124

  Fly   116 QSACGKSIHNMTACAQVVAGICMMLGLFLHPMGWRANRIQRLCGMDAEPFYPADCSIGVSFYCGI 180
            ||...|||.|:....|.:||:.::|||.|:|.||...:....||..|..:.|.|||:|.:||..|
Human   125 QSIMKKSIFNVCGLLQGIAGLFLILGLILYPAGWGCQKAIDYCGHYASAYKPGDCSLGWAFYTAI 189

  Fly   181 IGVLLTFTAAGISLKAESSNMRTRVRRRVEAGSKLVCI 218
            .|.:|||..|..|.:||.:....:|:..:|.|..|:|:
Human   190 GGTVLTFICAVFSAQAEIATSSDKVQEEIEEGKNLICL 227

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG3770	NP_001286864.1	L_HGMIC_fpl	10..195	CDD:287244	60/199 (30%)
LHFPL2	NP_005770.1	L_HMGIC_fpl	9..204	CDD:287244	60/200 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165148232
Domainoid	1	1.000	103	1.000	Domainoid score	I6803
eggNOG	1	0.900	-	-		E1_KOG4026
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	131	1.000	Inparanoid score	I4645
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG49708
OrthoDB	1	1.010	-	-		D1431349at2759
OrthoFinder	1	1.000	-	-		FOG0006026
OrthoInspector	1	1.000	-	-		oto89848
orthoMCL	1	0.900	-	-		OOG6_109429
Panther	1	1.100	-	-	LDO	PTHR12489
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5780
SonicParanoid	1	1.000	-	-		X4322
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	15	14.800