DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG15861 and DKK4

DIOPT Version :9

Sequence 1:	NP_001286863.1	Gene:	CG15861 / 37990	FlyBaseID:	FBgn0035084	Length:	205	Species:	Drosophila melanogaster
Sequence 2:	NP_055235.1	Gene:	DKK4 / 27121	HGNCID:	2894	Length:	224	Species:	Homo sapiens

Alignment Length:	194	Identity:	44/194 - (22%)
Similarity:	55/194 - (28%)	Gaps:	79/194 - (40%)

- Green bases have known domain annotations that are detailed below.

  Fly    33 SQLCSDYEMLVV---NTRQCVRRCNIVCLNGV-----CFEDGSCPCADQYMAGNPDGLVCA---- 85
            |.|||....||:   |.|....      |:|.     |..|..|......:....:...||
Human    10 SWLCSPLGALVLDFNNIRSSAD------LHGARKGSQCLSDTDCNTRKFCLQPRDEKPFCATCRG 68

  Fly    86 --------AECLPGCVAAGGYCAAPDLCVCREDRHYYFDPLSQKCRHRAPRLLDPCLGRCTHGNC 142
                    |.|.||.:...      |:|...||.    .|:.:       |.||...|....|..
Human    69 LRRRCQRDAMCCPGTLCVN------DVCTTMEDA----TPILE-------RQLDEQDGTHAEGTT 116

  Fly   143 ----------------SSDGRCICAQGYELRDSLLHGQQCMPICDHNCGPRAYCFAPNLCACRH 190
                            .|.||    :|.|       |:.|:...|  ||       |.||..||
Human   117 GHPVQENQPKRKPSIKKSQGR----KGQE-------GESCLRTFD--CG-------PGLCCARH 160

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG15861	NP_001286863.1	None
DKK4	NP_055235.1	Dickkopf_N	41..91	CDD:309719	10/55 (18%)
		DKK-type Cys-1	41..90		10/54 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	109..139		5/33 (15%)
		DKK-type Cys-2	145..218		9/25 (36%)
		Prokineticin	<145..202	CDD:148298	9/25 (36%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1218
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900