DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG15861 and MEGF6

DIOPT Version :9

Sequence 1:	NP_001286863.1	Gene:	CG15861 / 37990	FlyBaseID:	FBgn0035084	Length:	205	Species:	Drosophila melanogaster
Sequence 2:	XP_011539187.1	Gene:	MEGF6 / 1953	HGNCID:	3232	Length:	1603	Species:	Homo sapiens

Alignment Length:	191	Identity:	48/191 - (25%)
Similarity:	64/191 - (33%)	Gaps:	43/191 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    47 RQCVRRCNIVCLNGVCFED-------GSCPCADQYMAGNPDGLVC---------AAECLPGCVAA 95
            |.||||......||.|...       ..|.|...|... .||..|         .|:|..||:..
Human   302 RHCVRRSPCANRNGSCMHRCQVVRGLARCECHVGYQLA-ADGKACEDVDECAAGLAQCAHGCLNT 365

  Fly    96 GGYCAAPDLCVCREDRHYYFDPLSQKCRHRAPRLLDPC---LGRCTHG--NCSSDGRCICAQGYE 155
            .|...    |||...  |......::|......:::.|   .|.|:||  :.|:...|.|.:|||
Human   366 QGSFK----CVCHAG--YELGADGRQCYRIEMEIVNSCEANNGGCSHGCSHTSAGPLCTCPRGYE 424

  Fly   156 LR---------DSLLHGQQCMPICDHN-----CGPRA-YCFAPNLCACRHKQHHYAHNGIC 201
            |.         |.......|..:|.:|     ||..| |..:.:.|.|.......:..|.|
Human   425 LDTDQRTCIDVDDCADSPCCQQVCTNNPGGYECGCYAGYRLSADGCGCEDVDECASSRGGC 485

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG15861	NP_001286863.1	None
MEGF6	XP_011539187.1	EMI	108..176	CDD:284877
		vWFA	<215..261	CDD:294047
		FXa_inhibition	268..304	CDD:291342	1/1 (100%)
		vWFA	<342..384	CDD:294047	11/47 (23%)
		FXa_inhibition	397..432	CDD:291342	12/34 (35%)
		vWFA	<432..469	CDD:294047	8/36 (22%)
		vWFA	<472..511	CDD:294047	3/14 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1218
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900