Protein Alignment KIF5B and cmet

DIOPT Version :9

• Sequence 1: NP_004512.1
• Gene: KIF5B / 3799
• HGNCID: 6324
• Length: 963
• Species: Homo sapiens
• Sequence 2: NP_524993.3
• Gene: cmet / 53561
• FlyBaseID: FBgn0040232
• Length: 2189
• Species: Drosophila melanogaster
• Alignment Length: 1140
• Identity: 290/1140 - (25%)
• Similarity: 470/1140 - (41%)
• Gaps: 306/1140 - (26%)

Human    43 SKPYAFDRVFQSSTSQEQVYNDCAKKIVKDVLEGYNGTIFAYGQTSSGKTHTMEGKLHDPEGMGI 107
            ::||.||.||....|.::|::..||.||...::|:|||||||||||||||:||.|   |.:..|:
  Fly    41 AEPYVFDYVFDEGASNQEVFDRMAKHIVHACMQGFNGTIFAYGQTSSGKTYTMMG---DEQNPGV 102

Human   108 IPRIVQDIFNYIYSMDENLEFHIKVSYFEIYLDKIRDLLDVSKTNLSVHEDKNRVPYVKGCTERF 172
            :....::||..|.|..|. :|.::|.|.|||.:||.|||:....:|.:||..|.:..| .|.|..
  Fly   103 MVLAAKEIFQQISSETER-DFLLRVGYIEIYNEKIYDLLNKKNQDLKIHESGNGIVNV-NCEECI 165

Human   173 VCSPDEVMDTIDEGKSNRHVAVTNMNEHSSRSHSIFLINV---KQENTQTEQKLSGKLYLVDLAG 234
            :.|..:::..:..|...|.|..|||||.|||||:||.|.:   |.:::..:..:...|.||||||
  Fly   166 ITSEVDLLRLLCLGNKERTVGETNMNERSSRSHAIFKIIIESRKSDHSDDDAVIQSVLNLVDLAG 230

Human   235 SEKVSKTGAEGAVLDEAKNINKSLSALGNVISALAEG--STYVPYRDSKMTRILQDSLGGNCRTT 297
            ||:..:|||.||.|.|..:|||||..|.|||.:|:|.  :.:..|||||:|||||.|||||..|:
  Fly   231 SERADQTGARGARLKEGGHINKSLLFLSNVIKSLSENADNRFTNYRDSKLTRILQASLGGNAFTS 295

Human   298 IVICCSPSSYNESETKSTLLFGQRAKTIKNTVCVNVELTAEQWKKKYEK----------EKEKNK 352
            |:....||...||:  |||.|..|||.|:....||..::.....|:.|:          |:|:..
  Fly   296 IICTIKPSIMEESQ--STLSFATRAKKIRIKPQVNEMVSDATMMKRLEREIKVLKDKLAEEERKN 358

Human   353 ILRNTIQWLENEL---------------------------------------------------- 365
            ..:..::.||.::
  Fly   359 ENQQKVEHLERQIKHDMHKIICGHSLSDKGQQKRRRTWCPTASGSHLELAETGTTEDRIDQFPKV 423

Human   366 ---------------NRWRN--------------GETVPIDEQFDKEKANLEAFTVD-----KDI 396
                           .||.|              .|:..|.|:|      |.|..:|     .|:
  Fly   424 SHLPKPVFFHTSNAGKRWDNIPKTINILGSLDIGTESNSISEEF------LPAECIDFGSPRPDV 482

Human   397 -------------------TLTNDKPATAIGVIGNFTDAERR---KCEEEIAKLYKQLDDKDEEI 439
                               .||.||....|..:..||..|:.   :|||     .:.|.:|..|:
  Fly   483 LKPMLTIRQLPDLPLTPKGPLTTDKIKKEIQDLQMFTSLEKHFEVECEE-----VQGLKEKLAEV 542

Human   440 NQQSQLVEKLKTQMLDQEELLASTRRDQDNMQAELNRLQAENDASKEEVKEVLQALEELAVNYDQ 504
            ..|...:|         :|.||...| .|.::.|:..|:|:|:|:..::.|:.:.|..|  ....
  Fly   543 TAQRDNLE---------QESLAEKER-YDALEKEVTSLRADNEAANSKISELEEKLSTL--KQTM 595

Human   505 KSQEVEDKTK---EYELLSDELNQKSATLASIDAELQKL--KEMTNHQKKRAAE-MMASLLKDLA 563
            :..|||::..   |:|.   |.::||:.| .:|..|..|  ||.|....:::.: :...:|::..
  Fly   596 RIMEVENQVAVGLEFEF---EAHKKSSKL-RVDDLLSALLEKESTIESLQKSLDNLTRDVLRNSK 656

Human   564 E---IGIAVGNNDVKQPEGTGMIDE-EFTVARLYISKMKSEVKTMVKRCKQLESTQTESNKKMEE 624
            |   :.||....|:.........:| |..:|.|...|...|       |.||.........|:|.
  Fly   657 EGHMLSIAPEQEDIAGDSICNKCEELEKLIADLESKKNSCE-------CDQLRLEIVSVRDKLES 714

Human   625 NEKELAACQLRISQHEAKIKSLTEYLQNVEQKKRQLEESVDALSEELVQLRA------------Q 677
            .|.........|.|.....:.|::.|...:....||:|..|||.::....:|            |
  Fly   715 VESAFNLASSEIIQKATDCERLSKELSTSQNAFGQLQERYDALDQQWQAQQAGITTLHEKHEHVQ 779

Human   678 EKVHEMEKEHLNKVQTANEVKQAVEQQIQSHRETHQKQISSLRDEVEAKAKLITDLQDQNQKMML 742
            ||..::::|:......|.....|..|::|:.....|..|:||.:.:|....::|::|:....:
  Fly   780 EKYQKLQEEYEQLESRARSASSAEFQRLQNDNTKFQADIASLNERLEEAQNMLTEVQNSESTV-- 842

Human   743 EQERLRVEHEKLKATDQEKSRKLHEL---------TVMQDRRE---------------------- 776
              |:||:::.:|.|..:|......|:         .:|:..:|
  Fly   843 --EKLRIQNHELTAKIKELETNFEEMQREYDCLSNQLMESVQENDALREEIKQRPTSHVEESMRS 905

Human   777 --------QARQDLK------GLEETVAK-ELQTLHNLRKLFVQDLATRVK------------KS 814
                    :.:||:.      .|.|:|.: |||....:.:||   .|.::|            :|
  Fly   906 SGISSDFDEQKQDINLLHQFVQLSESVQQIELQHHSGISRLF---RANQMKLDQSEPGLKLCLES 967

Human   815 AE-IDSDDTGGSAAQKQKI-SFLENNLEQLTKVHKQLVRDNADLRCE------LPKLEKRLRATA 871
            || |:.|:....|.:...: .||:.:..|:    |:|.:::.|:..|      :.:||:.:...:
  Fly   968 AEYIEEDNRQSDATEPICLKGFLKRHRFQI----KRLSQEHVDMGEEKRLLDIISQLEQEIEEKS 1028

Human   872 ERVKALESALKEAKE----------------NASRDRKR---------------YQQEVDRI-KE 904
            ..::|.|:.:.|.:|                |...|.:|               |::..||: :|
  Fly  1029 ALMEATEATINEMREQMTNLESALLEKSVIINKVEDYQRQIESLEKQNAEMTMVYEELQDRVTRE 1093

Human   905 AVRSKNMARRGHSAQIAKPIRPGQHP-AASPTHPS 938
            :..|:::.|          :.|.:.. ...||.||
  Fly  1094 SSMSESLLR----------VPPDEDTLPGCPTSPS 1118

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
KIF5B	NP_004512.1	KISc_KHC_KIF5	6..325	CDD:276820	129/286 (45%)
		KISc	8..332	CDD:214526	130/293 (44%)
		DUF4337	<462..>538	CDD:290935	20/78 (26%)
		TACC	467..662	CDD:282818	47/204 (23%)
		TMPIT	598..>686	CDD:285135	21/99 (21%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	908..963		7/32 (22%)
		Globular	915..963		5/25 (20%)
cmet	NP_524993.3	KISc	8..328	CDD:214526	130/293 (44%)
		Motor_domain	8..321	CDD:277568	129/286 (45%)
		Smc	<680..1449	CDD:224117	92/467 (20%)
		TMPIT	779..>867	CDD:285135	22/91 (24%)
		Smc	1042..1910	CDD:224117	15/87 (17%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000669
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.910