DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment KIF5B and unc-116

DIOPT Version :9

Sequence 1:	NP_004512.1	Gene:	KIF5B / 3799	HGNCID:	6324	Length:	963	Species:	Homo sapiens
Sequence 2:	NP_001370811.1	Gene:	unc-116 / 176179	WormBaseID:	WBGene00006840	Length:	815	Species:	Caenorhabditis elegans

Alignment Length:	957	Identity:	441/957 - (46%)
Similarity:	577/957 - (60%)	Gaps:	167/957 - (17%)

- Green bases have known domain annotations that are detailed below.

Human     3 DLAECNIKVMCRFRPLNESEVNRGDKYIAKFQGEDTVVIASKPYAFDRVFQSSTSQEQVYNDCAK 67
            |.|||.::|.||.||||::|....|:::.||..||::.:..|.|.||:||:.:|:|||||...|.
Worm     6 DGAECGVQVFCRIRPLNKTEEKNADRFLPKFPSEDSISLGGKVYVFDKVFKPNTTQEQVYKGAAY 70

Human    68 KIVKDVLEGYNGTIFAYGQTSSGKTHTMEGKLHDPEGMGIIPRIVQDIFNYIYSMDENLEFHIKV 132
            .||:|||.|||||:||||||||||||||||.:.|....|||||||.||||:||||||||:|||||
Worm    71 HIVQDVLSGYNGTVFAYGQTSSGKTHTMEGVIGDNGLSGIIPRIVADIFNHIYSMDENLQFHIKV 135

Human   133 SYFEIYLDKIRDLLDVSKTNLSVHEDKNRVPYVKGCTERFVCSPDEVMDTIDEGKSNRHVAVTNM 197
            ||:|||.:|||||||..|.|||:||||||||||||.|||||..||||:..|::|||||.||||||
Worm   136 SYYEIYNEKIRDLLDPEKVNLSIHEDKNRVPYVKGATERFVGGPDEVLQAIEDGKSNRMVAVTNM 200

Human   198 NEHSSRSHSIFLINVKQENTQTEQKLSGKLYLVDLAGSEKVSKTGAEGAVLDEAKNINKSLSALG 262
            |||||||||:|||.||||:..|:::|:|||||||||||||||||||:|.||:|||||||||:|||
Worm   201 NEHSSRSHSVFLITVKQEHQTTKKQLTGKLYLVDLAGSEKVSKTGAQGTVLEEAKNINKSLTALG 265

Human   263 NVISALAEGS-TYVPYRDSKMTRILQDSLGGNCRTTIVICCSPSSYNESETKSTLLFGQRAKTIK 326
            .||||||||: ::|||||||:|||||:|||||.|||::||.|||.:||:|||||||||.||||||
Worm   266 IVISALAEGTKSHVPYRDSKLTRILQESLGGNSRTTVIICASPSHFNEAETKSTLLFGARAKTIK 330

Human   327 NTVCVNVELTAEQWKKKYEKEKEKNKILRNTIQWLENELNRWRNGETVPIDEQFD-KEKANLEAF 390
            |.|.:|.|||||:||::||||||||..|...:|....||:|||.||:|...|..: .:.|.:...
Worm   331 NVVQINEELTAEEWKRRYEKEKEKNTRLAALLQAAALELSRWRAGESVSEVEWVNLSDSAQMAVS 395

Human   391 TVDKDITLTNDK-----PATAIGVIGNFTDAERRKCEEEIAKLYKQLDDKDEEINQQSQLVEKLK 450
            .|....|...::     |.......|..||.|::|.|||..|||:|||:||:||.:.||.:|||:
Worm   396 EVSGGSTPLMERSIAPAPPMLTSTTGPITDEEKKKYEEERVKLYQQLDEKDDEIQKVSQELEKLR 460

Human   451 TQMLDQEELLASTRRDQDNMQAELNRLQAENDASKEEVKEVLQALEELAVNYDQKSQEVEDKTKE 515
            .|:|.|||.|.:.|.:::.::.|.||.|.|.:..::|.||::.||||:|||.|.:..|.|...:|
Worm   461 QQVLLQEEALGTMRENEELIREENNRFQKEAEDKQQEGKEMMTALEEIAVNLDVRQAECEKLKRE 525

Human   516 YEL-------LSDELNQKSATLASIDAELQKLKEMTNHQKKRAAEMMASLLKDLAEIGIAVGNND 573
            .|:       |.|.:||.::.|   :|.|.:......|.|
Worm   526 LEVVQEDNQSLEDRMNQATSLL---NAHLDECGPKIRHFK------------------------- 562

Human   574 VKQPEGTGMIDEEFTVARLYISKMKSEVKTMVKRCKQLESTQTESNKKMEENEKELAACQLRISQ 638
                ||...:..||.:|
Worm   563 ----EGIYNVIREFNIA------------------------------------------------ 575

Human   639 HEAKIKSLTEYLQNVEQKKRQLEESVDALSEELVQLRAQEKVHEMEKEHLNKVQTANEVKQAVEQ 703
                         ::..:..||.:                  |::          .|.|:..|.:
Worm   576 -------------DIASQNDQLPD------------------HDL----------LNHVRIGVSK 599

Human   704 QIQSHRETHQKQISSLRDEVEAKAKLITDLQDQNQKMMLEQERLRVEHEKLKATDQEKSRKLHEL 768
            ....:....:   ||...|.:|:|||..|:             .|||      :.|:..| :.:|
Worm   600 LFSEYSAAKE---SSTAAEHDAEAKLAADV-------------ARVE------SGQDAGR-MKQL 641

Human   769 TVMQDRREQARQDLKGLEETVAKELQTLHNLRKLFVQDLATRVKKSAEIDSDDTGGSAAQKQKIS 833
            .|    ::||.:::|.|.:.|..||.||.||:|.|::.|..|.:.:.:.:.:|:....||||:|.
Worm   642 LV----KDQAAKEIKPLTDRVNMELTTLKNLKKEFMRVLVARCQANQDTEGEDSLSGPAQKQRIQ 702

Human   834 FLENNLEQLTKVHKQLVRDNADLRCELPKLEKRLRATAERVKALESALKEAKENASRDRKRYQQE 898
            ||||||::||||||||||||||||.||||:|.|||...:|:|.||:||:::|:.:..:||:||||
Worm   703 FLENNLDKLTKVHKQLVRDNADLRVELPKMEARLRGREDRIKILETALRDSKQRSQAERKKYQQE 767

Human   899 VDRIKEAVRSKNMARRGHSAQIAKPIRPGQHPAASPTHPSAIRGGGA 945
            |:|||||||.:|| ||.::.||.|||||||    ..|.|||....||
Worm   768 VERIKEAVRQRNM-RRMNAPQIVKPIRPGQ----VYTSPSAGMSQGA 809

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
KIF5B	NP_004512.1	KISc_KHC_KIF5	6..325	CDD:276820	227/319 (71%)
		KISc	8..332	CDD:214526	230/324 (71%)
		DUF4337	<462..>538	CDD:290935	27/82 (33%)
		TACC	467..662	CDD:282818	36/201 (18%)
		TMPIT	598..>686	CDD:285135	3/87 (3%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	908..963		19/38 (50%)
		Globular	915..963		15/31 (48%)
unc-116	NP_001370811.1	KISc_KHC_KIF5	9..329	CDD:276820	227/319 (71%)
unc-116	NP_001370811.1	SMC_prok_A	440..>782	CDD:274009	148/490 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	446	1.000	Domainoid score	I285
eggNOG	1	0.900	-	-		E2759_KOG0240
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H55829
Inparanoid	1	1.050	663	1.000	Inparanoid score	I438
Isobase	1	0.950	-	0	Normalized mean entropy	S1747
OMA	1	1.010	-	-		QHG52972
OrthoDB	1	1.010	-	-		D1334528at2759
OrthoFinder	1	1.000	-	-		FOG0000669
OrthoInspector	1	1.000	-	-		otm15040
orthoMCL	1	0.900	-	-		OOG6_100344
Panther	1	1.100	-	-	LDO	PTHR24115
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2595
SonicParanoid	1	1.000	-	-		X952
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	16	15.820