DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG30427 and CG4770

DIOPT Version :9

Sequence 1:	NP_001246512.1	Gene:	CG30427 / 37986	FlyBaseID:	FBgn0043792	Length:	506	Species:	Drosophila melanogaster
Sequence 2:	NP_650848.1	Gene:	CG4770 / 42375	FlyBaseID:	FBgn0038751	Length:	490	Species:	Drosophila melanogaster

Alignment Length:	473	Identity:	145/473 - (30%)
Similarity:	250/473 - (52%)	Gaps:	37/473 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 DLSPVQ---EYYKDKTIFITGASGFMGKVLLEKLLYSCHSLKEVIIICRPKRGKAPETRLEEMFK 65
            ::|.|:   :.|:|..:|||||:||:||.||||||:|...:|.:.::.|||.|...|.|.....:
  Fly     5 EVSTVEHQTDIYQDAVVFITGATGFVGKSLLEKLLWSFPQIKRIYMLIRPKGGVTVEERFRGFLQ 69

  Fly    66 LPIFQRIKDERPEMLKRVTIYQGDVTFDQLGLSGESLKHVTENTNIVFHMAATLKLEGNLRDAID 130
            .|||:|||.|.|..||::..:.|::..|.|||:......:....||:||.|||::....|:.:..
  Fly    70 NPIFERIKSEHPTQLKKIFHFSGNIEDDNLGLNESDRSVLCAEVNIIFHSAATVRFNECLKVSAR 134

  Fly   131 MNLLGTRRALNVAKEMKQLEAFIHLSTAFCNCDQDVMYEKVYEFPHKPEDLMRLAEWMDVKTLDA 195
            :|...|...|.:.::|..|.:|:::|||:||..:..:.|:||  |..|.     .:|....:...
  Fly   135 VNSQATYNLLELCRQMPYLRSFLYVSTAYCNPGRKYVDEQVY--PTMPP-----VDWRQFLSATQ 192

  Fly   196 ITPD---------LLKPHPNTYTYSKRLAELLVRDHYESMPVIIARPSIVTPAVAEPLPGWVDNM 251
            ..||         :..||.||||::|.:||.:|..:.:.:|::|.||||||.|..||.|||:||:
  Fly   193 KIPDDYLNRLADYIKGPHVNTYTFTKSIAEQIVNAYKDVIPIVIVRPSIVTAAYREPYPGWIDNI 257

  Fly   252 NGPTGVLIGAGKGVIRSMICNGELKSEVIPVDIAINGLILLPYHNSLAEKRPLQIPVYNLTVDDA 316
            ...:|:::..|||.|.|::.|.:|..::||||..:|.:|::     :.:.:...:.:.|.|....
  Fly   258 QAISGIMMEIGKGGISSILGNKDLICDIIPVDFVVNAMIMM-----VGKAKLGSLSICNATSGVT 317

  Fly   317 KKRTWKWIMDVGRDLGIKYPFEVGLWYPDGNMTSSKFYHTICTILFMWLPAYLIDFLLLIFGQRR 381
            ...||:.:.::.......||....:.:|:.....|.|.|.:...:..::||.|:|...|:..|::
  Fly   318 NPITWQHLGELTMKWSRIYPTRRMIMFPNFKYRCSAFNHELAVWVLHFVPALLMDLQTLLLAQKK 382

  Fly   382 FMIRVQTKIAVGLEVL----QFFTTRSWDFKST---HFEQIYKELGSTDRRIFKINTDDVDDYEY 439
               |:.|.||......    .||:...|.||:.   :|:::. |.|:.....:  |.:::|..||
  Fly   383 ---RLVTPIAKKFRQACLAGSFFSLNEWIFKNKSRFYFKEMI-ENGTYPTLYW--NLEEMDYDEY 441

  Fly   440 MKVSILGGRQYVMKEPLT 457
            ::..::|..:|:.:|..|
  Fly   442 VRRHMIGINKYLHREKFT 459

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG30427	NP_001246512.1	FAR-N_SDR_e	15..321	CDD:187547	107/314 (34%)
CG30427	NP_001246512.1	Sterile	364..453	CDD:281068	24/95 (25%)
CG4770	NP_650848.1	WcaG	21..358	CDD:223528	115/348 (33%)
		FAR-N_SDR_e	21..337	CDD:187547	109/327 (33%)
		Sterile	364..455	CDD:281068	24/96 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45466762
Domainoid	1	1.000	159	1.000	Domainoid score	I1277
eggNOG	1	0.900	-	-		E1_COG3320
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	182	1.000	Inparanoid score	I1437
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D221518at33208
OrthoFinder	1	1.000	-	-		FOG0000172
OrthoInspector	1	1.000	-	-		mtm964
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR11011
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X145
	10	9.900