DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment pain and TRPA1

DIOPT Version :9

Sequence 1:	NP_611979.1	Gene:	pain / 37985	FlyBaseID:	FBgn0060296	Length:	913	Species:	Drosophila melanogaster
Sequence 2:	XP_011515926.1	Gene:	TRPA1 / 8989	HGNCID:	497	Length:	1144	Species:	Homo sapiens

Alignment Length:	1137	Identity:	216/1137 - (18%)
Similarity:	380/1137 - (33%)	Gaps:	373/1137 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly    18 ALAKQDIRQFVAALDSGALADLQDDRHTSIYEKALSTPGCRDFIEACIDHGS-QVNYINKKLDKA 81
            |:.|..|......|..||..:|::....:....|:.... .:.::..::|.: .|| :..:....
Human   130 AVEKNQIESVKFLLSRGANPNLRNFNMMAPLHIAVQGMN-NEVMKVLLEHRTIDVN-LEGENGNT 192

  Fly    82 AISYAADSRDPGNLAALLKYRPGNKVQVDRKYGQLTPLNSLAKNLTDENAPDVYSCMQLLLDYGA 146
            |:..|..:.:...|..|||  .|.|.....|:| ..|::..|.:.:.|       ||:::|.:|.
Human   193 AVIIACTTNNSEALQILLK--KGAKPCKSNKWG-CFPIHQAAFSGSKE-------CMEIILRFGE 247

  Fly   147 SP--------NIVDQGEFTPLHHVLRKSKVKAGKKELIQLFLDHPELDIDSYRNGEVRRL----L 199
            ..        |.::.|:.||||     ..|:.|..|:|::.||: ...||....|....:    .
Human   248 EHGYSRQLHINFMNNGKATPLH-----LAVQNGDLEMIKMCLDN-GAQIDPVEKGRCTAIHFAAT 306

  Fly   200 QAQFPELKLPEERHTGPEIDIQTLQRTLRDG-DETLFEQ-------QFAEYLQNLKGGAD----- 251
            |.....:||....::| .:||.    ...|| .||:..:       :.|:||  :..|||
Human   307 QGATEIVKLMISSYSG-SVDIV----NTTDGCHETMLHRASLFDHHELADYL--ISVGADINKID 364

  Fly   252 -------------------------------------NQLNAHQEEYFGL--------------- 264
                                                 |.|:...::.:||
Human   365 SEGRSPLILATASASWNIVNLLLSKGAQVDIKDNFGRNFLHLTVQQPYGLKNLRPEFMQMQQIKE 429

  Fly   265 ------------LQESIKRGRQRAFDVILSTGMDINSRPGRANEANLVETAVIYGNWQALERLLK 317
                        |..:.::|...:.:.:|...:.|:|:  ..::.:.:..|..||.....:|||:
Human   430 LVMDEDNDGCTPLHYACRQGGPGSVNNLLGFNVSIHSK--SKDKKSPLHFAASYGRINTCQRLLQ 492

  Fly   318 EPNLRLTPDSKLLNAVIGRLDEPPYDG---------SSHQRCFELLIN------SDR-------- 359
            :     ..|::|||       |....|         :.|.:..:||:.      ||.
Human   493 D-----ISDTRLLN-------EGDLHGMTPLHLAAKNGHDKVVQLLLKKGALFLSDHNGWTALHH 545

  Fly   360 -------------VDINEADSGRL-----VPLFFAVKYRNTSAMQKLLKNGAYI---GSKSAFGT 403
                         :|.|...:.||     ..|.||.:..:..|:..||.:.|.|   ..:::|..
Human   546 ASMGGYTQTMKVILDTNLKCTDRLDEDGNTALHFAAREGHAKAVALLLSHNADIVLNKQQASFLH 610

  Fly   404 LPIKDMPPEVL-----EEHFDSCITT-NGERPGD------------QNFEIIIDYKNLMRQERDS 450
            |.:.:...||:     .:.:|.|:.. :...||:            :..::::|:..|...|..|
Human   611 LALHNKRKEVVLTIIRSKRWDECLKIFSHNSPGNKCPITEMIEYLPECMKVLLDFCMLHSTEDKS 675

  Fly   451 --------GLNQLQDEMAPIAFIAES------------------KEMRHLLQHPLISSFLFLKWH 489
                    ....||   .|:.|..::                  .....||.||:...:|.:||
Human   676 CRDYYIEYNFKYLQ---CPLEFTKKTPTQDVIYEPLTALNAMVQNNRIELLNHPVCKEYLLMKW- 736

  Fly   490 RLSVIFYLNFLIYSLFTASIITYTLLKFHESDQRALTAFFGLLSWLGI---------------SY 539
             |:..|..:.:....:...:|..|:|..:.....|..:       .||               ||
Human   737 -LAYGFRAHMMNLGSYCLGLIPMTILVVNIKPGMAFNS-------TGIINETSDHSEILDTTNSY 793

  Fly   540 LI---------------LRECIQWIMSPVRYFWSITNIMEVALITLSIFTCME--SSFDKETQRV 587
            ||               .:|..|.......||..|:|::|..:.|..|...:.  .......|..
Human   794 LIKTCMILVFLSSIFGYCKEAGQIFQQKRNYFMDISNVLEWIIYTTGIIFVLPLFVEIPAHLQWQ 858

  Fly   588 LAVFTILLVSMEFCLLVGSLPVLSISTHMLMLREVSNSFLKSFTLYSIFVLTFSLCFYILFGKSV 652
            .....:....|.|.|.:.......|  .::||..:..:.|:|..::...:|.|.|.||||....
Human   859 CGAIAVYFYWMNFLLYLQRFENCGI--FIVMLEVILKTLLRSTVVFIFLLLAFGLSFYILLNLQ- 920

  Fly   653 EEDQSKSATPCPPLGKKEGKDEEQGFNTFTKPIEAVIKTIVMLTGEFDAGSIQFTSIY------- 710
                                      :.|:.|:.::|:|..|:.|:.:... .|...|
Human   921 --------------------------DPFSSPLLSIIQTFSMMLGDINYRE-SFLEPYLRNELAH 958

  Fly   711 ---TYLIFLLFVIFMTIVLFNLLNGLAVSDTQVIKAQAELNGAICRTNVLSRYEQVLTGHGRAGF 772
               ::...:.|.||:.|||.|||.||||.|...::..|.|.....:..:.:..|:.|.    ..|
Human   959 PVLSFAQLVSFTIFVPIVLMNLLIGLAVGDIAEVQKHASLKRIAMQVELHTSLEKKLP----LWF 1019

  Fly   773 LLGNHLFRSICQRLMNIYPNYLSLRQISVLPNDGNKVL---------------IPMSD-PFEMRT 821
            |      |.:.|:...:|||         .|..|..:.               ||.:| ..||..
Human  1020 L------RKVDQKSTIVYPN---------KPRSGGMLFHIFCFLFCTGEIRQEIPNADKSLEMEI 1069

  Fly   822 LK-KASFQQLPLSAAVPQKKLLDPPLRLLPCCCSLLTGKCSQMSGRVVKRALEVI------DQKN 879
            || |...:.|..        ||:....|:                :::.:.:|:|      |...
Human  1070 LKQKYRLKDLTF--------LLEKQHELI----------------KLIIQKMEIISETEDDDSHC 1110

  Fly   880 AAEQRRKQEQI--NDSR----LKLIEYKLEQL 905
            :.:.|.|:||:  .:||    |:.::.|...|
Human  1111 SFQDRFKKEQMEQRNSRWNTVLRAVKAKTHHL 1142

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
pain	NP_611979.1	ANK	56..180	CDD:238125	30/132 (23%)
		ANK repeat	82..111	CDD:293786	8/28 (29%)
		ANK repeat	113..152	CDD:293786	9/46 (20%)
		ANK	303..406	CDD:238125	31/146 (21%)
		Ank_2	303..398	CDD:289560	29/138 (21%)
		ANK repeat	324..366	CDD:293786	13/77 (17%)
		ANK repeat	368..393	CDD:293786	8/29 (28%)
		Ion_trans	525..746	CDD:278921	53/262 (20%)
TRPA1	XP_011515926.1	Ank_4	91..143	CDD:290365	3/12 (25%)
		ANK repeat	92..120	CDD:293786
		ANK	120..243	CDD:238125	26/124 (21%)
		ANK repeat	122..153	CDD:293786	7/22 (32%)
		Ank_2	127..220	CDD:289560	19/93 (20%)
		ANK repeat	155..187	CDD:293786	4/33 (12%)
		ANK repeat	189..214	CDD:293786	6/26 (23%)
		ANK repeat	222..261	CDD:293786	9/46 (20%)
		Ank_4	226..282	CDD:290365	17/67 (25%)
		ANK	258..387	CDD:238125	31/141 (22%)
		ANK repeat	266..294	CDD:293786	12/33 (36%)
		Ank_2	268..364	CDD:289560	27/108 (25%)
		ANK repeat	296..364	CDD:293786	17/74 (23%)
		ANK	361..527	CDD:238125	23/179 (13%)
		ANK repeat	366..397	CDD:293786	0/30 (0%)
		ANK repeat	437..468	CDD:293786	5/32 (16%)
		Ank_2	442..531	CDD:289560	20/102 (20%)
		ANK repeat	470..504	CDD:293786	11/45 (24%)
		ANK	501..625	CDD:238125	24/130 (18%)
		ANK repeat	506..536	CDD:293786	4/29 (14%)
		Ank_2	511..602	CDD:289560	17/90 (19%)
		ANK repeat	538..570	CDD:293786	3/31 (10%)
		ANK repeat	572..597	CDD:293786	6/24 (25%)
		Ion_trans	769..997	CDD:278921	54/264 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0510
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810