DRSC/TRiP Functional Genomics Resources

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Protein Alignment pain and trpa1b

DIOPT Version :10

Sequence 1:NP_611979.1 Gene:pain / 37985 FlyBaseID:FBgn0060296 Length:913 Species:Drosophila melanogaster
Sequence 2:NP_001007067.1 Gene:trpa1b / 474353 ZFINID:ZDB-GENE-050106-1 Length:1120 Species:Danio rerio


Alignment Length:1142 Identity:224/1142 - (19%)
Similarity:379/1142 - (33%) Gaps:382/1142 - (33%)


- Green bases have known domain annotations that are detailed below.


  Fly    16 AGALAKQDIRQFVAALDSGALADLQDDRHTSIYEKALSTPGCRDFIEAC---IDHGSQVNYINKK 77
            |.|....||.:.:.::....:.::||::..:....|:.    :|..::|   :|.|:..|.:|..
Zfish    66 ASAGGNLDIIRLIVSIVGPEVLNVQDEQGRTPLHWAVE----QDQQQSCAVLLDLGADPNILNNA 126

  Fly    78 L-------------DKAAISYAADSR------DPGNLAALLK------------YRPGNKVQVDR 111
            |             ..|.:..:.|..      |.||...:|.            .:.|.|:.:..
Zfish   127 LMGPLHLAVTKQYNHLAEVLLSCDKTNSNLEGDLGNTPVMLACSNNNCQALQILIKRGAKMCIQN 191

  Fly   112 KYGQLTPLNSLAKNLTDENAPDVYSCMQLLL----DYGASP----NIVDQGEFTPLHHVLRKSKV 168
            |.|.. |::::|.....|       .|:::|    :.|.|.    |.:|:.:.||||     ..|
Zfish   192 KLGHY-PIHTVAFAGAKE-------AMEMVLKIGEELGVSSTLHINYLDKSKSTPLH-----LAV 243

  Fly   169 KAGKKELIQLFLDHPELDIDSYRNGEVRRL----LQAQFPELKLPEERHTGPEIDIQTLQRTLRD 229
            :.|..|:|:|.: .....::.:::|:...|    .|.....:|:....:...| ||.    .:||
Zfish   244 RGGNIEVIKLCI-LKGAKVEQHQSGKCTALHFACSQGSLEAVKIMLSSYNRTE-DIV----NIRD 302

  Fly   230 GDE-------TLFEQ-QFAEYLQNL------------KGGADNQLNAHQEEYFG----LLQESIK 270
            |..       |||:. :.||||.:.            ||...:.::..     |    ||..|..
Zfish   303 GANRTPLHRATLFDHVELAEYLISKPNTLSLDLICLGKGAEIDSIDCK-----GLSPLLLASSCS 362

  Fly   271 RGRQRAFDVILSTGMD--INSRPGR----------ANEANLVET--------------------- 302
            ..:..|:  :||.|.|  |..:.||          ....||.||                     
Zfish   363 AWKTVAY--LLSIGADFKIKEKTGRNFLHFVILQPKGLKNLPETVLQSTAVKEMLSDEDVEGCTP 425

  Fly   303 ------------------------------------AVIYGNWQALERLLKEPNLRLTPDSKLLN 331
                                                |..||......|||:    .|| |||:||
Zfish   426 LHYACKLGIHDSVKNMLGLNICLGQKSREKKSALHFAAEYGRINTCHRLLE----TLT-DSKMLN 485

  Fly   332 -------------------AVI------GRLDEPPYDG---------SSHQRCFELLINSDRVDI 362
                               .|:      |.|.:..|.|         ..:.:..::|:.::...:
Zfish   486 DWDEKGLTPLHLASRAGHAQVVDLLLRKGALFQSDYKGWTCLHHAAAEGYTQTMKILLAANVKLL 550

  Fly   363 NEADSGRLVPLFFAVKYRNTSAMQKLLKNGAYIG------------------------------- 396
            :|.:......|..|.:..:.||:..||..||.|.                               
Zfish   551 DEKNEDGNTALHIAAQAGHVSAVLLLLDRGAEIALNDADNSFLHEAVRNERREVVNATIEHERCD 615

  Fly   397 -------SKSAFGTLPIKDMPPEVLEEHFDSCITTNGERPGDQNFEIIIDYK------NLMRQER 448
                   :||....|.|.:..||..:...|.|||.:......|::.|:.:::      .|.:..:
Zfish   616 ESMTSFKAKSRCVVLDIIEFLPESFQHLLDQCITESDHDANSQDYHIMYNFQWLQAPIQLKKYAK 680

  Fly   449 DSGLNQLQDEMAPIAFIAESKEMRHLLQHPLISSFLFLKWHRL-SVIFYLNFLIYSLFTASIITY 512
            .......|...|..|.:..::  ..||.|||...:|.:||... |.:.:||..|| |.....:||
Zfish   681 TDKTKAFQPLAALNAMVRYNR--LELLIHPLSRKYLEMKWTAYGSKVHFLNLAIY-LLGLLPLTY 742

  Fly   513 TLLKFHE-------------------SDQRALTAFFGLLSWLGISYLILRECIQWIMSPVRYFWS 558
            .:|....                   |:|:.|.:...::..:...|.|.:|.:|.....|.||..
Zfish   743 LILNLRPSQDFSKGNGTSVIMVPVSFSEQQYLISVCIIMVIVMNVYSICKEVVQLAQQRVNYFTD 807

  Fly   559 ITNIME--VALITLSIFTCMESSFDKETQRVLAVFTILLVSMEFCLLVGSLPVLSISTHMLMLRE 621
            .:|..:  .|:..|.....|..|.:...|.....:.||...:.|.|.......:.|  :::|...
Zfish   808 FSNPADWSAAISALVFVVPMCCSVEATWQWEAGAYAILTSWIGFLLYFQRFERIGI--YVVMFNG 870

  Fly   622 VSNSFLKSFTLYSIFVLTFSLCFYILFGKSVEEDQSKSATPCPPLGKKEGKDEEQGFNTFTKPIE 686
            :..:.:....|:...:|.|.|.||.|.                 |.:.|          |:....
Zfish   871 IVRTLVCIMVLFVFLLLAFGLAFYALM-----------------LHRPE----------FSSISL 908

  Fly   687 AVIKTIVMLTGE----------FDAGSIQFTSIYTYLIFLLFVIFMTIVLFNLLNGLAVSDTQVI 741
            |:.:|.||..||          ::.|.:.|.:| ||.:|:.||:.|.|:|.||:.||||.|...:
Zfish   909 ALAQTFVMTVGELNYQSTFLNSYEEGHMAFPAI-TYFVFVFFVLLMPILLMNLMIGLAVGDIAEV 972

  Fly   742 KAQAELNGAICRTNVLSRYEQVLTGHGRAGFLLGNHLFRSICQRLMNIYPNYLSLRQIS-----V 801
            :..|||.....:.::.:..|:.|.                           |..|:::.     |
Zfish   973 QRNAELKRIAMQIDLHTALEEKLP---------------------------YWFLKRVDKPSTVV 1010

  Fly   802 LPNDGNKVLIPMSDPFEMRTLKKASFQQLPLSAAVPQKKLLDPPLRLLPCCCSLLTGKCSQMSGR 866
            .||...|||:......|::...:.                     ||         ..||:..|.
Zfish  1011 YPNKCKKVLLEALVHGEIQNTVRT---------------------RL---------NLCSRKEGL 1045

  Fly   867 VVKRALEVIDQKNAAEQRRKQEQINDSRLKLIEYKLE 903
            :.:   |:..|||..::.....:...:.||||..|:|
Zfish  1046 LER---ELHKQKNRLKEMSCMLEKQHNLLKLIIQKME 1079

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
painNP_611979.1 ANKYR 2..>182 CDD:440430 42/207 (20%)
ANK repeat 82..111 CDD:293786 7/46 (15%)
ANK repeat 113..152 CDD:293786 9/46 (20%)
ANKYR <243..>406 CDD:440430 51/319 (16%)
ANK repeat 324..366 CDD:293786 13/75 (17%)
ANK repeat 368..393 CDD:293786 6/24 (25%)
Ion_trans 495..746 CDD:459842 64/281 (23%)
trpa1bNP_001007067.1 Ank_2 33..124 CDD:463710 12/61 (20%)
ANK repeat 58..91 CDD:293786 4/24 (17%)
ANK repeat 94..124 CDD:293786 6/33 (18%)
ANKYR 111..394 CDD:440430 64/308 (21%)
ANK repeat 126..158 CDD:293786 3/31 (10%)
ANK repeat 160..191 CDD:293786 5/30 (17%)
ANK repeat 193..232 CDD:293786 9/46 (20%)
ANK repeat 237..265 CDD:293786 9/33 (27%)
ANK repeat 267..302 CDD:293786 7/39 (18%)
ANK repeat 350..375 CDD:293786 7/31 (23%)
ANKYR 370..611 CDD:440430 40/245 (16%)
ANK repeat 421..452 CDD:293786 0/30 (0%)
ANK repeat 457..488 CDD:293786 13/35 (37%)
ANK repeat 491..520 CDD:293786 3/28 (11%)
ANK repeat 522..554 CDD:293786 3/31 (10%)
ANK repeat 556..581 CDD:293786 6/24 (25%)
Ion_trans 759..977 CDD:459842 56/247 (23%)

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