DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment pain and trpa1a

DIOPT Version :9

Sequence 1:	NP_611979.1	Gene:	pain / 37985	FlyBaseID:	FBgn0060296	Length:	913	Species:	Drosophila melanogaster
Sequence 2:	NP_001007066.1	Gene:	trpa1a / 474351	ZFINID:	ZDB-GENE-050105-6	Length:	1115	Species:	Danio rerio

Alignment Length:	1038	Identity:	215/1038 - (20%)
Similarity:	359/1038 - (34%)	Gaps:	300/1038 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 NNCG-FIDPQAQLAGALAKQDIRQFVAALDSGALADLQDDRHTSIYEKALSTP-------GCRDF 60
            ||.| |....|..:||....::     .|..|..|.|..|.|.:..:|:.|:|       |..|.
Zfish   193 NNLGHFPIHAAAFSGAKKSMEV-----ILLKGEEAGLSIDAHINYVDKSCSSPLHLAVRGGNLDI 252

  Fly    61 IEACIDHGSQVNYINKKLDKAAISYAADSRDPGNLAALLKYRPGNKVQVDRKYGQLTPLNSLAK- 124
            |:.||.:|::::  .::.||:...:.|.|:....:..::                   |:|..|
Zfish   253 IKLCIGYGAKID--QQQCDKSTALHFACSQGATEVVKVM-------------------LSSYPKV 296

  Fly   125 ----NLTD--ENAP-------DVYSCMQLLLDYGASPNIVDQGEFTPLHHVLRKSKVKAGKKELI 176
                |:||  ...|       |.:...:.|:..||:.:.||....:||  :|..|   .|....:
Zfish   297 CDLINITDGANQTPLHKAVIFDHFELSEYLMSQGANIDFVDCKGHSPL--LLATS---CGAWRTV 356

  Fly   177 QLFLDH-------------------------PELDIDSYRNGEVRRLLQAQFPE----------L 206
            .|.|.|                         ..|..:..::..||.||..:..|          |
Zfish   357 NLLLSHGADLTKKDKSGCNFLHLAILQPRGLKNLPTEVLQHESVRELLNDEDIEGCTPLHYACRL 421

  Fly   207 KLPEERHTGPEIDIQTLQRTLRDGDETLFEQQFAEY---LQNLKGGADNQ-LNAHQEEYFGLLQE 267
            .:|:.......:::...|::........|..:|...   .:.|:...|.: ||...|:....|..
Zfish   422 GIPDSVKNMLGLEVSLDQKSKEKKSALHFAAEFGRINTCHRLLEMVTDTRLLNEGDEKGLTPLHL 486

  Fly   268 SIKRGRQRAFDVILSTGMDINSRPGRANEANLVETAVIYGNWQALERLLKE-----PNLRLTPDS 327
            :.:.|..:..:::|..|...:|.               |..|..|.....|     .:..||.:.
Zfish   487 ASREGHVKVVELLLRKGALFHSD---------------YRGWSGLHHAASEGYTQTMDTLLTSNI 536

  Fly   328 KLLNAVIGRLDEPPYDGSS---------HQRCFELLI-NSDRVDINEADSG----------RLVP 372
            ||||...|       ||::         |.....||: ...::.:|:.|:.          |.|.
Zfish   537 KLLNKTDG-------DGNTALHLAARAGHVAAVRLLLYRGAKIILNKNDASFLHEAVHNARREVT 594

  Fly   373 LFFAVKYRNTSAMQKLLKNGAYIGSKSAFGTLPIKDMPPEVLEEHFDSCITTNGERPGDQNFEII 437
            .......|...||.....|     |......:.:.:..||..:...|:||..:.|.....|:.|.
Zfish   595 NMVIESDRCEEAMTTYKPN-----STKRCIVMDMIEFLPESFKHLLDTCIRESEEDVNCTNYYIE 654

  Fly   438 IDYK-------NLMR--QERDSGLNQLQDEMAPIAFIAESKEMRHLLQHPLISSFLFLKW----- 488
            .:::       ||.:  .|:|.....|....|.:.|     ...:||.||:...:|.:||
Zfish   655 YNFRWLQHPLQNLKKTGMEKDMAYKPLSALNAMVNF-----NRVNLLTHPVCKKYLEMKWSAYGI 714

  Fly   489 --HRLSV------IFYLNFLIYSL----------FTASIITYTLLKFHESDQRALTAFFGLLSWL 535
              |.|::      :|.|.:||.:|          .:.:::..:|.|     |..||....||...
Zfish   715 KAHLLNMTVYALGVFPLTYLIVNLKPTLVTSRNVTSVNMVCTSLYK-----QSYLTTSSMLLVLA 774

  Fly   536 GISYLILRECIQWIMSPVRYFWSITNIMEVA------LITLSIFTCMESSFDKETQRVLAV---F 591
            ...|.:.:|.:|.....:.|...::|.|:.|      |..:.:...::||:..:...:.|:   .
Zfish   775 MNMYAVGKEILQMFQQRLNYLRDLSNYMDWAAAICALLFVVPLLMNLKSSWHWQAGALAALTSWL 839

  Fly   592 TILLVSMEFCLLVGSLPVLSISTHMLMLREVSNSFLKSFTLYSIFVLTFSLCFYILFGKSVEEDQ 656
            .:||....|         ..|..:::|.||:|.:.|....|:...:|.|:|.||.|.   :|:..
Zfish   840 NLLLYLQRF---------ERIGIYVVMFREISRTLLSIIVLFFYLILGFALSFYALM---IEQQH 892

  Fly   657 SKSATPCPPLGKKEGKDEEQGFNTFTKPIEAVIKTIVMLTGEFD----------AGSIQFTSIYT 711
                                    |.:...::::|.||:.||.:          .|.:.|..: |
Zfish   893 ------------------------FGRMFLSLLQTFVMMVGEMNYQDNFMKPYLQGDLPFPDL-T 932

  Fly   712 YLIFLLFVIFMTIVLFNLLNGLAVSDTQVIKAQAELNGAICRTNVLSRYEQVLTGHGRAGFLLGN 776
            ..||:.||:.:.|:|.|||.||||.|.      ||:....|    |.|....:..|......|..
Zfish   933 LAIFVWFVLLVPILLMNLLIGLAVGDI------AEVQTNAC----LKRIAMQIELHTNLEERLPY 987

  Fly   777 HLFRSICQRLMNIYPNYLSLRQISVLPNDGNKVLIPMSDPFEMRTLKKASFQQL-PLSAAVPQKK 840
            ...:.:.|..:..|||    |..|     |.|......:..:.||....:|.|| ||     :::
Zfish   988 WFMKRVDQVTIREYPN----RCFS-----GKKRWFFGGNEVKSRTRLGPTFHQLTPL-----ERE 1038

  Fly   841 LLDPPLRLLPCCCSLLTGKCSQMSGRVVKRALEVIDQKNAAEQRRKQEQINDSRLKLIEYKLE 903
            |.....||                             |..:|...||..:    ||||..|:|
Zfish  1039 LTKQKYRL-----------------------------KEISETMEKQHNL----LKLIVQKME 1068

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
pain	NP_611979.1	ANK	56..180	CDD:238125	29/137 (21%)
		ANK repeat	82..111	CDD:293786	2/28 (7%)
		ANK repeat	113..152	CDD:293786	11/52 (21%)
		ANK	303..406	CDD:238125	25/127 (20%)
		Ank_2	303..398	CDD:289560	24/119 (20%)
		ANK repeat	324..366	CDD:293786	12/51 (24%)
		ANK repeat	368..393	CDD:293786	6/34 (18%)
		Ion_trans	525..746	CDD:278921	55/239 (23%)
trpa1a	NP_001007066.1	Ank_2	40..126	CDD:289560
		ANK	55..182	CDD:238125
		ANK repeat	61..93	CDD:293786
		ANK repeat	95..126	CDD:293786
		Ank_2	100..193	CDD:289560	215/1038 (21%)
		ANK repeat	128..160	CDD:293786
		ANK repeat	162..193	CDD:293786	215/1038 (21%)
		ANK repeat	195..234	CDD:293786	11/43 (26%)
		Ank_4	199..255	CDD:290365	15/60 (25%)
		ANK	231..360	CDD:238125	32/154 (21%)
		ANK repeat	236..264	CDD:293786	8/27 (30%)
		Ank_2	241..337	CDD:289560	21/116 (18%)
		ANK repeat	269..304	CDD:293786	8/53 (15%)
		ANK repeat	306..337	CDD:293786	5/30 (17%)
		ANK	334..500	CDD:238125	28/170 (16%)
		ANK repeat	339..370	CDD:293786	8/35 (23%)
		Ank_2	344..440	CDD:289560	15/100 (15%)
		ANK repeat	410..441	CDD:293786	4/30 (13%)
		Ank_2	415..504	CDD:289560	13/88 (15%)
		ANK repeat	443..477	CDD:293786	6/33 (18%)
		ANK	474..598	CDD:238125	27/145 (19%)
		ANK repeat	480..509	CDD:293786	4/28 (14%)
		Ank_2	484..575	CDD:289560	21/112 (19%)
		ANK repeat	511..543	CDD:293786	9/31 (29%)
		ANK repeat	545..570	CDD:293786	5/24 (21%)
		Ion_trans	784..963	CDD:278921	51/221 (23%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0510
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.810