Protein Alignment pain and wtrw

DIOPT Version :10

• Sequence 1: NP_611979.1
• Gene: pain / 37985
• FlyBaseID: FBgn0060296
• Length: 913
• Species: Drosophila melanogaster
• Sequence 2: NP_731193.1
• Gene: wtrw / 40931
• FlyBaseID: FBgn0260005
• Length: 986
• Species: Drosophila melanogaster
• Alignment Length: 1036
• Identity: 214/1036 - (20%)
• Similarity: 373/1036 - (36%)
• Gaps: 327/1036 - (31%)

  Fly     2 DFNNCG--------------FIDPQAQLAGALAKQDIRQFVAALD-----SGALADLQDDRHTSI 47
            ::..||              |.:|.::|:..:....:|  ::.:|     :|.:...:|...:::
  Fly    71 EYMECGPSPPAESAPSMYDSFEEPTSELSVQICNDTLR--ISLIDQMKSAAGRVKLFEDIEQSNV 133

  Fly    48 YEKALSTPG----------CR---------DFIEACIDHGSQVNYINKKLDKAAISYAADSRDPG 93
            ..:.:.|..          |.         |.||:.::.|:.:::    .|:..||....|...|
  Fly   134 VAEGIRTHFESASKLEKNLCYLWAAYLKRWDLIESLLEAGADLHF----CDQNGISALHLSAFSG 194

  Fly    94 NLAAL-LKYRPGNKVQVDRKYGQLTPLNSLAKNLTDENAPDVYSCMQLLLDYGA-------SPNI 150
            .||.| |....|..|.:..|.  .|||:..|.....|.|       :||::.||       .||.
  Fly   195 CLATLGLLVAKGLNVNLQSKC--YTPLHCAAFGNAAEAA-------KLLINNGADISKDTSKPNC 250

  Fly   151 VDQGEFTPLHHVLRKSKVKAGKKELIQLFLDHPELDIDSYR-NGEVRRLLQAQFPELKLPEERHT 214
                |.:.||..:|.:.:     |.:|:|:.. ..|::|.: ||.....|.|....::..|....
  Fly   251 ----EESLLHCAVRSNAL-----ECLQIFIAE-GADVNSLKPNGTNAIHLAADLGNIQCLEALLN 305

  Fly   215 GPEIDIQTLQRTLRDGDETLFEQQFAEYLQNLKGGADNQLNAHQEEYFGLLQESIKRGRQRAFDV 279
            .|..| ..::..:|:.:.|                              .|..:...|.....|:
  Fly   306 APNAD-ANVRICIREKEST------------------------------ALHLAADEGNVECVDL 339

  Fly   280 ILSTGMDI---NSR-------PGRANEANLVETAVIYGNWQALERLLKEPNLRLTPDSKLLNAVI 334
            :|:.|.|.   |.|       ..|.:..:.||:.:..||..|    ..|.....||    |:|.:
  Fly   340 LLAKGADAKLKNHRGFTPLHLAARTSSLDCVESLLRNGNADA----NAEDFDHRTP----LHAAV 396

  Fly   335 GRLDEPPYDGSSHQRCFELLINSDRVDINEADSGRLVPLFFAVKYRNTSAMQKLLKNGAYIGSKS 399
            |: .|..||      ..|.||... .::|..|......|..|........::.|:.:||.:.:||
  Fly   397 GK-SENAYD------IMETLIQWG-ANVNHKDIYGFTALHLAALDGLVQCVEMLIFHGADVTTKS 453

  Fly   400 AFGTLPI----KDMPPEV--LEEHFDSCITT-NGERPGDQNFEIIIDYKNLMRQ---ERDSGLNQ 454
            ..||..:    :..|..|  :.:..|:.||. :.:.|.::..|:.:|::.|::.   ...|.||.
  Fly   454 KKGTSALNVITRKTPASVAMIRQKLDAAITLHHSQDPVNREVELELDFRQLLQHCHPREISYLNT 518

  Fly   455 LQDEMAPIAFIAESKEMRHLLQHPLISSFLFLKWHRL------SVIFYLNFLIY-SLFTASIITY 512
            ..||           ..:.:|:|||.||||::||.::      .:||..:|::: :|:..:.:.:
  Fly   519 FVDE-----------GQKEILEHPLCSSFLYIKWGKIRKYYIGRLIFCFSFVLFLTLYVLTALAH 572

  Fly   513 TLLKFHESDQRALTA------------------FFGLLSWLGISYLILRECIQWIMSPV------ 553
            ......::|...:.|                  |...:.|             |::..:
  Fly   573 NCYNGSKNDNTTIPAQELCQKQSILGDMLRNNPFVMEMQW-------------WVLVAITIVEIF 624

  Fly   554 -------------RYFWSITNIMEVALITLSIFTCMESSFDKET---QRVLAVFTILLVSMEFCL 602
                         .|...:.||||..:|| |:|. :...:..:|   |..:..|.:||......|
  Fly   625 RKLYGITGYSSFRHYVTQVENIMEWFVIT-SVFV-ISYIYTNKTYTFQNHIGAFAVLLGWTNLML 687

  Fly   603 LVGSLPVLSISTHMLMLREVSNSFLKSFTLYSIFVLTFSLCFYILFGKSVEEDQSKSATPCPPLG 667
            ::|.|||..:  ::.|...|...|.|.|..||..::.|::.|.::|..|
  Fly   688 MIGQLPVFDV--YVAMYTRVQGEFAKLFMAYSCMLIGFTISFCVIFPSS---------------- 734

  Fly   668 KKEGKDEEQGFNTFTKPIEAVIKTIVMLTGEFDAGSI----------QFTSIYTYLIFLLFVIFM 722
                       ::|..|....|..:||:.||.|...:          ....:...:.|:||::|:
  Fly   735 -----------SSFANPFMGFITVLVMMIGEQDLSLLINDPEGKDPPFLLEVSAQITFVLFLLFV 788

  Fly   723 TIVLFNLLNGLAVSDTQVIKAQAELNGAICRTNVLSRYEQVLTGHGRAGFL---LGNHLFRS--- 781
            ||:|.|||.|:||.|.|.:|..|.|:..:.:|.::|..|..|..    |:|   |.|.|..:
  Fly   789 TIILMNLLVGIAVHDIQGLKKTAGLSKLVRQTKLISYIESALFN----GYLPTWLRNLLHYTALV 849

  Fly   782 --------ICQR-------------LMNIY-------------------PNYLSLRQISVLPNDG 806
                    :|.:             ||..|                   .||||.:. ....|:|
  Fly   850 SPQAYRVVLCVKPLNPSEKRLPREILMKAYEVGKMRKHFGHTISSKNSAENYLSYKN-KYNNNNG 913

  Fly   807 --NKVLIPMSDP-----------------------FEMRTLKKASFQQLPLSAAVPQKKLL 842
              ...::|.|||                       .|::.||:|...|...::.|..|.|:
  Fly   914 ATTGYVLPDSDPDAGQFTTLTTKIDDNADRIEFLTQEIQELKQALISQQQQASKVIDKLLI 974

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
pain	NP_611979.1	ANKYR	2..>182	CDD:440430	46/225 (20%)
		ANK repeat	82..111	CDD:293786	10/29 (34%)
		ANK repeat	113..152	CDD:293786	12/45 (27%)
		ANKYR	<243..>406	CDD:440430	37/172 (22%)
		ANK repeat	324..366	CDD:293786	12/41 (29%)
		ANK repeat	368..393	CDD:293786	3/24 (13%)
		Ion_trans	495..746	CDD:459842	62/301 (21%)
wtrw	NP_731193.1	ANK repeat	182..213	CDD:293786	10/30 (33%)
		ANKYR	196..482	CDD:440430	77/351 (22%)
		ANK repeat	215..242	CDD:293786	10/35 (29%)
		ANK repeat	250..281	CDD:293786	9/40 (23%)
		ANK repeat	283..317	CDD:293786	7/34 (21%)
		ANK repeat	323..351	CDD:293786	7/57 (12%)
		ANK repeat	353..385	CDD:293786	7/35 (20%)
		ANK repeat	387..420	CDD:293786	12/44 (27%)
		ANK repeat	422..452	CDD:293786	5/29 (17%)
		Ion_trans	613..812	CDD:459842	55/229 (24%)