DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment pain and ANKRD36

DIOPT Version :9

Sequence 1:	NP_611979.1	Gene:	pain / 37985	FlyBaseID:	FBgn0060296	Length:	913	Species:	Drosophila melanogaster
Sequence 2:	NP_001341516.1	Gene:	ANKRD36 / 375248	HGNCID:	24079	Length:	1915	Species:	Homo sapiens

Alignment Length:	425	Identity:	96/425 - (22%)
Similarity:	143/425 - (33%)	Gaps:	130/425 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly    73 YINKKLDKAAISYAADSRDPGNLA----ALLKYRPGNKVQVDRK----------YGQLTPLNSLA 123
            |..|::.:|.:.        |||.    .||.|...||  .|||          .||...::.|.
Human    31 YHLKRIHRAVLH--------GNLEKLKYLLLTYYDANK--RDRKERTALHLACATGQPEMVHLLV 85

  Fly   124 K-----NLTD--ENAPDV-------YSCMQLLLDYGASPNIVDQGEFTPLHHVLRKSKVKAGKKE 174
            .     ||.|  :..|.:       .:|..|||..||:|||.|....|.||:.:.....     .
Human    86 SRRCELNLCDREDRTPLIKAVQLRQEACATLLLQNGANPNITDFFGRTALHYAVYNEDT-----S 145

  Fly   175 LIQLFLDHPELDIDSYRNGEVRRLL------QAQFPELKLPEERHTGPEIDIQTLQRTLRDGDET 233
            :|:..|.| ..:|:.....|.:.||      :.:..|..|.::.:...   |..|.|:......|
Human   146 MIEKLLSH-GTNIEECSKCEYQPLLFAVSRRKVKMVEFLLKKKANVNA---IDYLGRSALIHAVT 206

  Fly   234 LFEQQFAEYL--QNL---------KGGADNQLNAHQEEYFGLLQESIKRGRQRAFDVILSTGMDI 287
            |.|:.....|  .|:         |...|..:.|.....|.|:.|   ..|:|..|      :.|
Human   207 LGEKDIVILLLQHNIDVLSRDAFRKIAGDYAIEAKNRVIFDLIYE---YERKRYED------LPI 262

  Fly   288 NSRP-------------GRANEANLVETAVIYGNWQALERLLKEPNLRLTPDSKLLNAVIGRLDE 339
            ||.|             |:.:..:.:.|.:..|.........|:|.|:.|.|.
Human   263 NSNPVSSQKQPALKATSGKEDSISNIATEIKDGQKSGTVSSQKQPALKDTSDK------------ 315

  Fly   340 PPYDGSSHQRCFELLINSDRVDINEADSGRLVPLFFAVK-------YRNTSAMQKLLKN------ 391
               |.|......|:.        :|..||.::|   ||:       ||..:..|.:.:|
Human   316 ---DDSVSNTATEIK--------DEQKSGTVLP---AVEQCLNRSLYRPDAVAQPVTENEFSLES 366

  Fly   392 ----GAYIGSKSAFGTLPIKDMPPEVLEEHFDSCI 422
                ..||..:.......|||:.|.| ||..|.|:
Human   367 EIISKLYIPKRKIISPRSIKDVLPPV-EEAVDRCL 400

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
pain	NP_611979.1	ANK	56..180	CDD:238125	35/134 (26%)
		ANK repeat	82..111	CDD:293786	8/32 (25%)
		ANK repeat	113..152	CDD:293786	16/52 (31%)
		ANK	303..406	CDD:238125	21/119 (18%)
		Ank_2	303..398	CDD:289560	21/111 (19%)
		ANK repeat	324..366	CDD:293786	6/41 (15%)
		ANK repeat	368..393	CDD:293786	8/41 (20%)
		Ion_trans	525..746	CDD:278921
ANKRD36	NP_001341516.1	ANK 1. /evidence=ECO:0000255	31..60		9/36 (25%)
		Ank_2	36..128	CDD:403870	28/101 (28%)
		ANK repeat	36..62	CDD:293786	9/35 (26%)
		ANK 2. /evidence=ECO:0000255	64..93		4/28 (14%)
		ANK repeat	66..95	CDD:293786	5/28 (18%)
		ANK repeat	97..128	CDD:293786	10/30 (33%)
		ANK 3. /evidence=ECO:0000255	97..126		8/28 (29%)
		ANK 4. /evidence=ECO:0000255	130..159		7/34 (21%)
		ANK repeat	130..154	CDD:293786	6/29 (21%)
		Ank_2	135..227	CDD:403870	19/100 (19%)
		ANK repeat	163..194	CDD:293786	5/33 (15%)
		ANK 5. /evidence=ECO:0000255	163..192		5/28 (18%)
		ANK 6. /evidence=ECO:0000255	196..225		7/28 (25%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	261..331		16/92 (17%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	470..619
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	639..663
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	676..1203
		PTZ00121	<682..1153	CDD:173412
		CCDC158	1274..>1904	CDD:318193
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1285..1304
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1489..1508
		CCDC144C	1511..1802	CDD:405585
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165143678
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.930