Protein Alignment pain and trpa-2

DIOPT Version :10

• Sequence 1: NP_611979.1
• Gene: pain / 37985
• FlyBaseID: FBgn0060296
• Length: 913
• Species: Drosophila melanogaster
• Sequence 2: NP_492031.1
• Gene: trpa-2 / 3565192
• WormBaseID: WBGene00010873
• Length: 481
• Species: Caenorhabditis elegans
• Alignment Length: 527
• Identity: 105/527 - (19%)
• Similarity: 185/527 - (35%)
• Gaps: 176/527 - (33%)

  Fly   426 GERPGDQNFEIIIDYKNLMRQERDSGLNQLQDEMAPIAFIAES--------KEMRHL-------- 474
            |.|....|.||.||:.|    ||........::.....|..|:        ||:|.|
 Worm    12 GHRNEKINDEISIDFCN----ERSRIRRNKAEDSTTFIFNYENGSGETLNWKELRKLKSGKKWGV 72

  Fly   475 LQHPLISS-----------------------FLFLKWHRLSVIFYLNFLIYSLFTASIITYTLLK 516
            ::||.|.:                       ||.|.||..|...:.:||| ::||.....:.:||
 Worm    73 IRHPYILNYVNQKLIDCAFFYSLHILAFLVFFLLLAWHVFSRNLFKDFLI-TIFTGIFFMFLVLK 136

  Fly   517 FHESDQRALTAFFGLLSWLGISYLILREC--IQWIMSPVRYFWSITNIMEVALITLSIFTCMESS 579
              .:.:..:|.  .:.:|..:::     |  |...|:.:.|.|..|           :|.  ...
 Worm   137 --GTIKARITK--SVSTWFIVAF-----CFNIFTYMATLAYVWLPT-----------VFG--YDD 179

  Fly   580 FDKETQRVLAVFTILLVSMEFCLLVGSLPVLSI----------------STHMLMLREVSNSFLK 628
            :..|.::::..|               ||:::|                ..::.|:..:..||..
 Worm   180 YHLEVKKIVTWF---------------LPIIAIISAWANLLYIMRKSPFGIYIFMMTRILRSFAH 229

  Fly   629 SFTLYSIFVLTFSLCFYILFGKSVEEDQSKSATPCPPLGKKEGKDEEQGFN-----TFTKPIEAV 688
            ..|::...::.||..|.::.       :.....|.|.:       ::|..|     |....::||
 Worm   230 IATIWIPTLIAFSFAFLLIM-------RDTGVKPWPLI-------DQQTENMTMVQTMLVILQAV 280

  Fly   689 IKTIVMLTGEFDAGSIQFTSIY-TYLIFLLFVIFMTIVLFNLLNGLAVSDTQVIKAQAE------ 746
            .||..|:.||.||..|..|:.: ..::.|:|.|...|:|.||:..|||.|...:...|:
 Worm   281 TKTSTMMIGEVDANDILDTNQWIPSILVLVFEIITVILLMNLMVSLAVGDVTYLNNTAQDKLLKI 345

  Fly   747 -LNGAICRTNVLSRYEQVLTGHGRAGFLLGNHLFRSICQRLMNIYPNYLSLRQISVLPNDGNKVL 810
             :|..|....:..:::              |.:||...::.    ||.|      |:.:||..:
 Worm   346 KVNFVIEALQISEQFQ--------------NEMFRLHTKKT----PNVL------VINSDGTYI- 385

  Fly   811 IPMSDPFEMRTLKKASFQQLPLSAAVP------QKKLLDPPLRLLPCCCSLLTGKCSQMSGRVVK 869
                          :.|...|.||:|.      :...::..:||     .:.|.|....:..|.|
 Worm   386 --------------SEFDVFPHSASVAISDEAFKISFMETGMRL-----RIKTSKGRVKTATVSK 431

  Fly   870 RALEVID 876
            ..:|.|:
 Worm   432 CDIECIE 438

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
pain	NP_611979.1	ANKYR	2..>182	CDD:440430
		ANK repeat	82..111	CDD:293786
		ANK repeat	113..152	CDD:293786
		ANKYR	<243..>406	CDD:440430
		ANK repeat	324..366	CDD:293786
		ANK repeat	368..393	CDD:293786
		Ion_trans	495..746	CDD:459842	55/274 (20%)
trpa-2	NP_492031.1	TRPV	<190..326	CDD:454755	34/164 (21%)