DRSC/TRiP Functional Genomics Resources

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Protein Alignment pain and Trpa1

DIOPT Version :10

Sequence 1:NP_611979.1 Gene:pain / 37985 FlyBaseID:FBgn0060296 Length:913 Species:Drosophila melanogaster
Sequence 2:NP_997491.2 Gene:Trpa1 / 312896 RGDID:1303284 Length:1125 Species:Rattus norvegicus


Alignment Length:1134 Identity:221/1134 - (19%)
Similarity:374/1134 - (32%) Gaps:365/1134 - (32%)


- Green bases have known domain annotations that are detailed below.


  Fly     2 DFNNCGFIDPQAQLAGALAKQDIRQFVAALDSGALADLQDDRHTSIYEKALSTPGC-RDFIEACI 65
            |:.|       ..|..|..|..:......|..||..:|::  ...:....::..|. .:.|:...
  Rat    97 DYGN-------TPLHWAAEKNQVESVKFLLSQGANPNLRN--RNMMAPLHIAVQGMYNEVIKVLT 152

  Fly    66 DH-GSQVNYINKKLDKAAISYAADSRDPGNLAALLKYRPGNKVQVDRKYGQLTPLNSLAKNLTDE 129
            :| .:.:|...:..:.|.:|..|...... |..||:  .|.|:....|:|.. |::..|.:    
  Rat   153 EHKATNINLEGENGNTALMSTCAKDNSEA-LQILLE--KGAKLCKSNKWGDY-PVHQAAFS---- 209

  Fly   130 NAPDVYSCMQLLLDYG--------ASPNIVDQGEFTPLHHVLRKSKVKAGKKELIQLFLD---HP 183
               ....||:|:|.||        |..|.|:..:.:|||     ..|::|..::|::.||   | 
  Rat   210 ---GAKRCMELILAYGEKTGYSREAHINFVNHKKASPLH-----LAVQSGDLDMIKMCLDSGAH- 265

  Fly   184 ELDIDSYRNGEVRRL----LQAQFPELKLPEERHTGPEIDIQTLQRTLRDGDE-------TLFE- 236
               ||...|.:...|    .|.....:||....:||....:..:     ||::       :||: 
  Rat   266 ---IDMMENAKCMALHFAATQGATDIVKLMISSYTGSSDIVNAV-----DGNQETLLHRASLFDH 322

  Fly   237 QQFAEYLQNLKGGADNQLNAHQEEYFGLLQESIKRGRQRAFDVILSTG--MDINSRPGRANEANL 299
            ...|:||  :..|||  :|:...|....|..:.........:::||.|  :||....||    |.
  Rat   323 HDLADYL--ISVGAD--INSTDSEGRSPLILATASASWNIVNLLLSKGAKVDIKDHLGR----NF 379

  Fly   300 VETAV--IYG---------NWQALERL-LKEPNLRLTP--------------------------- 325
            :...|  .||         ..|.::.| :.|.|...||                           
  Rat   380 LHLTVQQPYGLRNLRPEFLQMQHIKELVMDEDNDGCTPLHYACRQGAPVSVNNLLRFNVSVHSKS 444

  Fly   326 -DSKLLNAVIGRLDEPPYDGSSHQR---CFELLIN-SDRVDINEADSGRLVPLFFAVKYRNTSAM 385
             |.|          .|.:..:|:.|   |..||.: ||...:||.|...:.||..|.|..:...:
  Rat   445 KDKK----------SPLHFAASYGRINTCQRLLQDISDTRLLNEGDLHGMTPLHLAAKNGHDKVV 499

  Fly   386 QKLLKNGAY-------------------------------------------------------- 394
            |.|||.||.                                                        
  Rat   500 QLLLKKGALFLSDHNGWTALHHASMGGYTQTMKVILDTNLKCTDRLDEEGNTALHFAAREGHAKA 564

  Fly   395 ------------------------------------IGSK------------SAFGTLPIKDMP- 410
                                                |.||            |.....||.:|. 
  Rat   565 VAMLLSYNADILLNKKQASFLHIALHNKRKEVVLTTIRSKRWDECLQVFTHDSPSNRCPIMEMVE 629

  Fly   411 --PEVLEEHFDSCITTNGERPGDQNFEIIIDYKNL-----MRQERDSGLNQLQD---EMAPIAFI 465
              ||.::...|.|:..:.|....|::.|..::|.|     |.::    :...||   |...|..:
  Rat   630 YLPECMKVLLDFCMIPSTEDKSCQDYHIEYNFKYLQCPLSMTKK----VTPTQDVIYEPLTILNV 690

  Fly   466 AESKEMRHLLQHPLISSFLFLKW-------HRLSVIFY------LNFLIYSL-----FTASIITY 512
            ........||.||:...:|.:||       |.:::..|      :..|:..:     |.::.|..
  Rat   691 MVQHNRIELLNHPVCREYLLMKWCAYGFRAHMMNLGSYCLGLIPMTLLVVKIQPGMAFNSTGIIN 755

  Fly   513 TLLKFHESDQRALTAF----FGLLSWLGISYLILRECIQWIMSPVRYFWSITNIMEVALITLSIF 573
            ..:..||.....|.:|    ..:|.:|...:...:|.:|.......||....|.:|..:.|.|:.
  Rat   756 ETISTHEERINTLNSFPLKICMILVFLSSIFGYCKEVVQIFQQKRNYFLDYNNALEWVIYTTSMI 820

  Fly   574 TCMESSFD--KETQRVLAVFTILLVSMEFCLLVGSLPVLSISTHMLMLREVSNSFLKSFTLYSIF 636
            ..:....|  ...|.......|....|.|.|.:.......|  .::||..:..:.|:|..::...
  Rat   821 FVLPLFLDIPAYMQWQCGAIAIFFYWMNFLLYLQRFENCGI--FIVMLEVIFKTLLRSTGVFIFL 883

  Fly   637 VLTFSLCFYILFGKSVEEDQSKSATPCPPLGKKEGKDEEQGFNTFTKPIEAVIKTIVMLTGEFDA 701
            :|.|.|.||:|....                           :.|:.|:.::|:|..|:.|:.:.
  Rat   884 LLAFGLSFYVLLNFQ---------------------------DAFSTPLLSLIQTFSMMLGDINY 921

  Fly   702 GSIQFTSI------YTYLIF---LLFVIFMTIVLFNLLNGLAVSDTQVIKAQAELNGAICRTNVL 757
            .......:      |..|.|   :.|.:|:.|||.|||.||||.|...::..|.|.....:..:.
  Rat   922 RDAFLEPLFRNELAYPVLTFGQLIAFTMFVPIVLMNLLIGLAVGDIAEVQKHASLKRIAMQVELH 986

  Fly   758 SRYEQVLTGHGRAGFLLGNHLFRSICQRLMNIYPN-------------YLSLRQI-SVLPNDGNK 808
            :..|:.|.          ....|.:.||...:|||             :||:::. ...||    
  Rat   987 TNLEKKLP----------FWYLRKVDQRSTIVYPNRPRHGRMLRFFHYFLSMQETRQEAPN---- 1037

  Fly   809 VLIPMSDPFEMRTLKKASFQQLPLSAAVPQKKLLDPPLRLLPCCCSLLTGKCSQMSGRVVKRALE 873
                :....||..||: .::...|::      ||:....|:                :::.:.:|
  Rat  1038 ----IDTCLEMEILKQ-KYRLKDLTS------LLEKQHELI----------------KLIIQKME 1075

  Fly   874 VI----DQKN--AAEQRRKQEQINDSRLK 896
            :|    |:.|  :.:.|.|:|::.....|
  Rat  1076 IISETEDEDNHCSFQDRFKKERLEQMHSK 1104

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
painNP_611979.1 ANKYR 2..>182 CDD:440430 42/192 (22%)
ANK repeat 82..111 CDD:293786 7/28 (25%)
ANK repeat 113..152 CDD:293786 11/46 (24%)
ANKYR <243..>406 CDD:440430 51/312 (16%)
ANK repeat 324..366 CDD:293786 14/73 (19%)
ANK repeat 368..393 CDD:293786 8/24 (33%)
Ion_trans 495..746 CDD:459842 57/276 (21%)
Trpa1NP_997491.2 ANKYR 47..337 CDD:440430 62/277 (22%)
ANK 1. /evidence=ECO:0000255 63..94
ANK repeat 98..129 CDD:293786 8/37 (22%)
ANK 2. /evidence=ECO:0000255 98..127 7/35 (20%)
ANK repeat 131..163 CDD:293786 4/31 (13%)
ANK 3. /evidence=ECO:0000255 131..161 3/29 (10%)
ANK 4. /evidence=ECO:0000255 165..194 8/31 (26%)
ANK repeat 165..190 CDD:293786 6/27 (22%)
Ank_4 166..219 CDD:372654 15/63 (24%)
ANK repeat 198..237 CDD:293786 11/46 (24%)
ANK 5. /evidence=ECO:0000255 198..227 9/36 (25%)
ANK repeat 239..268 CDD:293786 10/37 (27%)
ANK 6. /evidence=ECO:0000255 239..268 10/37 (27%)
ANK 7. /evidence=ECO:0000255 272..301 6/28 (21%)
ANK repeat 276..307 CDD:293786 6/35 (17%)
ANKYR 301..582 CDD:440430 53/303 (17%)
ANK repeat 309..340 CDD:293786 9/34 (26%)
ANK 8. /evidence=ECO:0000255 309..338 8/32 (25%)
ANK repeat 342..373 CDD:293786 7/30 (23%)
ANK 9. /evidence=ECO:0000255 342..371 5/28 (18%)
ANK repeat 413..444 CDD:293786 2/30 (7%)
ANK 10. /evidence=ECO:0000255 413..442 2/28 (7%)
ANK repeat 446..480 CDD:293786 12/43 (28%)
ANK 11. /evidence=ECO:0000255 446..475 10/38 (26%)
ANK repeat 482..512 CDD:293786 10/29 (34%)
ANK 12. /evidence=ECO:0000255 482..511 10/28 (36%)
ANK repeat 514..546 CDD:293786 0/31 (0%)
ANK 13. /evidence=ECO:0000255 514..543 0/28 (0%)
ANK 14. /evidence=ECO:0000255 548..577 0/28 (0%)
ANK repeat 548..573 CDD:293786 0/24 (0%)
Ion_trans 775..975 CDD:459842 49/228 (21%)
Blue background indicates that the domain is not in the aligned region.

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