Protein Alignment pain and ANKRD31

DIOPT Version :10

• Sequence 1: NP_611979.1
• Gene: pain / 37985
• FlyBaseID: FBgn0060296
• Length: 913
• Species: Drosophila melanogaster
• Sequence 2: XP_011541600.1
• Gene: ANKRD31 / 256006
• HGNCID: 26853
• Length: 1931
• Species: Homo sapiens
• Alignment Length: 1067
• Identity: 197/1067 - (18%)
• Similarity: 339/1067 - (31%)
• Gaps: 398/1067 - (37%)

  Fly    37 ADLQDDRHTSIYEKALSTP------------------------GCRDFIEACIDHGSQVNYIN-- 75
            :|..||...|..|||:::.                        |.:.|: ...||.||.|.:.
Human   899 SDNDDDDDCSTSEKAITSKKVLCSTGGKKHYNFKENLTNKKEMGFQQFL-LSEDHLSQENELKAV 962

  Fly    76 -------------KKLDKAAIS-YAAD--------SRDPGN----------LAALLKYRPG---N 105
                         ...|.|.|| :.|:        |.|..|          :..||.:...   |
Human   963 SLTTLPEQEAVNFSYSDNAVISEHVANYEQCIFGPSFDHSNGNPEQNSLACMRTLLTHEASKLTN 1027

  Fly   106 KVQVDRKYGQLTP--------------LNSLAKNL-TDENAPD-----VYSCMQLLLDYGASPNI 150
            .|::.:|.....|              :..:|||. |:.|..|     :||...|        :|
Human  1028 HVELFKKPQDYIPRAPTFLMNQTDTHIVEKMAKNCDTERNYIDRDQKIIYSNEPL--------SI 1084

  Fly   151 VDQGEFTPLHHVLRKSKVKAGKKELIQLFLDHPELDIDSYRN-------GEVRRLLQAQFPELK- 207
            |...:      |:..:||:..::..::....|   :|||:..       ..:.:|.|.:..|:.
Human  1085 VAHSQ------VIETTKVEKRRQNHLESETIH---NIDSHSTDNMSKELANISKLSQREKKEISH 1140

  Fly   208 LPEERHT----GPEIDIQTLQRTLRDGDETLF----------------EQQFAEYLQNL--KGGA 250
            .|:|..|    |.||.|:..:......:..:.                .|.|.:...||  |.|.
Human  1141 KPDEELTNNISGDEITIRNCEEIKEKTESEIHMPTNSQEHKTVQNFRKRQSFLKTTCNLGMKAGR 1205

  Fly   251 DNQLNAHQEEYFGLLQESIKRGRQRAFDVILSTGMDINSRPGRANEANLVETAVIYGNWQALERL 315
            .|:.||..|....|   :::||.......::.:|.|:          ||.:.|    .|..|...
Human  1206 INKRNARGESQLHL---AVRRGNLPLVKALIESGADV----------NLNDNA----GWTPLHEA 1253

  Fly   316 LKEPNLRLTPDSKLLNAVIGRLDEPPYDGSSHQRCFELLINSDRVDINEADSGRLVPLFFAVKYR 380
            ..|.::.:..:  ||.|           |:.        :|.:.:|       .::||..||...
Human  1254 SNEGSIDIIVE--LLKA-----------GAK--------VNCENID-------GILPLHDAVANN 1290

  Fly   381 NTSAMQKLLKNGAYIGSKS--------------------AFGTLP----------IKDMPPEVLE 415
            :..|.:.||:|||....|.                    ::|.:.          :.:..|.|..
Human  1291 HLKAAEILLQNGANPNQKDQKQKSALDEADDEKMKELLRSYGAIETVNRDESDAIVNEKIPAVRS 1355

  Fly   416 EHFDSCITTNGERPGDQNFEIIIDYKNLMRQERD-SGLNQLQDEMAPIAFIAESKEMRHLLQHPL 479
            :....|...:|:         .||..:|..|||. ..|:..|...|.:..|.|.:|  :||:..:
Human  1356 KRHKQCFCDDGK---------TIDSSSLSHQERSRESLSVHQTLSAILQDIEEKQE--YLLEFEI 1409

  Fly   480 ---------ISSFLFLKWHRLSVIFYLNFLIYSLFTASIITYTLLKFH-ESDQRALTAFFGLLSW 534
                     |...|.:|                    .|:...|.|.. |.|..|......:.|:
Human  1410 RNPEDAEQYIEKMLKIK--------------------KIMDNVLAKQKAERDDLAKKYRVSIESF 1454

  Fly   535 LGISYLILRECIQWIMSPVRYFWSITNI--MEVALITLSIFTCMESSFDKETQRVLAVFTILLVS 597
               .:..|||             .:.|:  .:.:|:.::          |:.:::       .:.
Human  1455 ---KHGALRE-------------QLANLAARQKSLLVVA----------KKQKKI-------SLK 1486

  Fly   598 MEFCLLVGSLPVLSISTHMLMLREVSNSFLKSFTLYSIFVLTFSLCFYILFGKSVEEDQSKSATP 662
            ::.|..|.|||.||:  ..|..|...:|...|..|.|:              :::|..||.|.:|
Human  1487 IQNCRNVTSLPCLSL--RKLPPRSEISSEKDSQELTSL--------------ENLEHPQSGSLSP 1535

  Fly   663 CPPLGKKEGKDEEQGFN----TFTKPIEAVIKTIVMLTGEF---DAGSIQFTSIYTYLIF----- 715
            .      .|..:|...:    .:::.....:.:..:..|||   |..|.|..|..|...|
Human  1536 V------SGSMQETQLSLETWNYSQNTNICLNSEAVRRGEFSGNDMNSKQNGSDCTLDGFPKSRH 1594

  Fly   716 -------------LLFV---------------------IFMTIVLFNLLNGLAVSDTQVIKAQ-- 744
                         :.|:                     .:::..:...||   :|:|..:.|:
Human  1595 SDGTEKNKLPSQPVAFIGQTEYSQKENDLTEATDKDHEFYVSSPVIGKLN---ISETASVLAENA 1656

  Fly   745 AELNGAICRTNVLSRYE------------------QVLTGHGRAGFLLGNHLFRSICQRLMNIYP 791
            |..:..||..: ||.|:                  :.|...|.|  :||:.....:        .
Human  1657 AHPSNIICDQD-LSNYDPKRGNRKTSSQQSPTGASESLAHQGIA--VLGSDTVHQM--------K 1710

  Fly   792 NYLSLRQISVLPNDGNKVLIPMSDPFEMRTLKKA-SFQQLPLSAAVPQKKL-----LDPPLRLLP 850
            .||. :.:||:|...:..:...|...:..|:||| ::...|....:..|.|     ::|...:|.
Human  1711 PYLK-KSVSVVPCADDSQISSSSGSGQQDTIKKALNYSTAPKKKCIQIKDLILLGRINPGNNILE 1774

  Fly   851 C--------CCSLLTGKCSQMSGRVVK 869
            .        ...||.||....||::.|
Human  1775 FKTQETTHKASILLNGKLKVESGQIYK 1801

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
pain	NP_611979.1	ANKYR	2..>182	CDD:440430	42/225 (19%)
		ANK repeat	82..111	CDD:293786	10/50 (20%)
		ANK repeat	113..152	CDD:293786	11/58 (19%)
		ANKYR	<243..>406	CDD:440430	37/194 (19%)
		ANK repeat	324..366	CDD:293786	6/41 (15%)
		ANK repeat	368..393	CDD:293786	8/24 (33%)
		Ion_trans	495..746	CDD:459842	48/301 (16%)
ANKRD31	XP_011541600.1	ANKYR	<483..612	CDD:440430
		ANK repeat	522..553	CDD:293786
		ANK repeat	555..580	CDD:293786
		ANKYR	<1206..1345	CDD:440430	33/183 (18%)
		ANK repeat	1212..1243	CDD:293786	8/43 (19%)
		ANK repeat	1245..1276	CDD:293786	9/55 (16%)
		ANK repeat	1278..1309	CDD:293786	11/37 (30%)
		RAMA	1739..1839	CDD:465856	16/63 (25%)