DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment pain and trpa-1

DIOPT Version :9

Sequence 1:NP_611979.1 Gene:pain / 37985 FlyBaseID:FBgn0060296 Length:913 Species:Drosophila melanogaster
Sequence 2:NP_502249.3 Gene:trpa-1 / 178118 WormBaseID:WBGene00007801 Length:1211 Species:Caenorhabditis elegans


Alignment Length:919 Identity:195/919 - (21%)
Similarity:340/919 - (36%) Gaps:282/919 - (30%)


- Green bases have known domain annotations that are detailed below.


  Fly     4 NNCGFIDPQAQLAGALAKQDIRQFVAAL-DSGA---------------------------LADLQ 40
            |:|.::|.:.:|....|::...:.:.|| ::|.                           |.:.:
 Worm   304 NSCKWMDREKELIHFAAEKGFLEVLKALVEAGGNKNELNEVKAVPLHVAAQMNQLEVVSYLIEEE 368

  Fly    41 DDRHTSIYEKALSTPGCRDFIEACIDHGSQ--VNYINKKLDKAAISYA-ADSRDPGNLAALLKYR 102
            .|....:.|:.| ||     :...:.|.|:  |.|:..|  ||.::.. .|.|.|          
 Worm   369 KDNIDVVDEQGL-TP-----LMMAVTHDSKKCVEYLIAK--KANLTITDKDERTP---------- 415

  Fly   103 PGNKVQVDRKYGQLTPLNSLAKNLTDENAPDVYSCMQLLLDYGASP-----------------NI 150
                |.:..|:..|:.:..:..:|..:|.....|.::       ||                 |:
 Worm   416 ----VFIGAKFNALSSVEYILDHLRKKNKETERSALK-------SPTRNTLRIVSEDVRRTMVNM 469

  Fly   151 VDQGEFTPLHHVLRKSKVKAGKKELIQLFLDH----PELDIDSY----------RNGEVRRLLQA 201
            ||:.:.||:|.|     ...|..|::||...|    .:::.|..          :.|.||:||:.
 Worm   470 VDRDQNTPMHIV-----ASNGYLEMMQLLQKHGASITQVNEDEETALHRAAIGGQTGAVRQLLEW 529

  Fly   202 QFPELKLPEERHTGPEIDIQTLQRTLRDGDETLFEQQFAEYLQNLKGGADNQL-NAHQEEYFGLL 265
            ....|.:.:      |:....|....|.|.:       |.....|..|||.:. |::|:.   .|
 Worm   530 DIRLLLMKD------EMGNSALHLAARSGHD-------ATTKVLLDNGADKEAKNSYQKT---PL 578

  Fly   266 QESIKRGRQRAFDVILSTGMDINSRPGRANEANLVETAVIYGNWQALERLLKEPNLRLTPDSKLL 330
            |.::..|:......:::.|..|.|   .::...::.||..|||...:...:.|            
 Worm   579 QVAVDSGKLETCQRLVAKGAQIES---SSDTKTVLHTAAFYGNESIVRYFIAE------------ 628

  Fly   331 NAVIGRLDEPPYDGSSHQRCFELLINSDRVDIN----EADSGR-------LVPLFFAVKYRNTSA 384
            ...|.|.||   :|.:   .|::...:|..|:.    |.|..:       ::||   .|:||...
 Worm   629 GVTIDRRDE---EGKT---AFDIACENDHKDVARAFLETDQWKNLMIPCDVIPL---DKHRNPVN 684

  Fly   385 MQKLLKNGAYIGSKSAFGTLPIKDMPPEVLEEHFDSCITTNGERPGD-----QNFEIIIDYKNLM 444
            |::          ::.|.||..|.  ||:.....|:||..:.|....     .||| .:|...:|
 Worm   685 MKR----------RTPFRTLLTKF--PELASFVMDNCIEKSKEETDSTQSVAYNFE-FLDDTYMM 736

  Fly   445 RQERDSGLNQ-------LQDE--------------------MAPIAFIAESKEMRHLLQHPLISS 482
            |...|.|..:       ..||                    ..|:..:|::::: |||.|||..:
 Worm   737 RCVSDDGTGEQLIGCKSAYDEDFKLEKDAQSYASNYDRVYKYHPLKLMADAEKL-HLLNHPLSKA 800

  Fly   483 FLFLKWHRLS-VIFYLNFLIYSLFTASIITY---TLLKFHESDQRAL--TAFFG----------- 530
            .|..||:||. .::|....:|.:|..|:..|   |...::..::.:.  :.:|.           
 Worm   801 LLKYKWNRLGRPMYYFALFMYLVFIVSLTQYVRHTKAPYNVWNEESYYDSEYFDENETCPQINTT 865

  Fly   531 --------LLSWLGISYLILRECIQWIMSPVRYF-----WSITNIMEVALITLSIFT-CMESSFD 581
                    ::..|.:.. ||.||.|.......|.     |....|...||||:..|: |..:|..
 Worm   866 KPDVVWKIIIQTLAVCQ-ILVECFQLFQRKFAYLVNWENWIDCFIYSTALITVYDFSECSATSGV 929

  Fly   582 KET-QRVLAVFTILLVSMEFCLLVGSLPVLSISTHMLMLREVSNSFLKSFTLYSIFVLTFSLCFY 645
            ::. |.:||...|....:....::..:|...|  .::|..::..:|.:.|.::.:|::.||..||
 Worm   930 RQNWQWILAALCIFFGWINLLFMIRKMPRFGI--FVVMFVDIVKTFFRFFPVFVLFIIAFSSSFY 992

  Fly   646 ILFGKSVEEDQSKSATPCPPLGKKEGKDEEQGFNT-FTKPIEAVIKTIVMLTGEFDAGSIQFTSI 709
            ::.....|                        |:| |..|    :||.||:.|||     :||.|
 Worm   993 VILQNRPE------------------------FSTIFMSP----LKTTVMMIGEF-----EFTGI 1024

  Fly   710 Y-------------------TYLIFLLFVIFMTIVLFNLLNGLAVSDTQVIKAQAELNGAICRTN 755
            :                   ...:|..|.|.|||:|.|||.||||.|.:.::.:|||.....:.:
 Worm  1025 FHGDETTHAEKMFGPAHTAVACALFFFFCIIMTILLMNLLVGLAVDDIKGVQEKAELKRLAMQVD 1089

  Fly   756 VLSRYEQVL 764
            ::.:.|..|
 Worm  1090 LVLQIEASL 1098

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
painNP_611979.1 ANK 56..180 CDD:238125 29/143 (20%)
ANK repeat 82..111 CDD:293786 4/29 (14%)
ANK repeat 113..152 CDD:293786 7/55 (13%)
ANK 303..406 CDD:238125 24/113 (21%)
Ank_2 303..398 CDD:289560 21/105 (20%)
ANK repeat 324..366 CDD:293786 9/45 (20%)
ANK repeat 368..393 CDD:293786 6/31 (19%)
Ion_trans 525..746 CDD:278921 61/268 (23%)
trpa-1NP_502249.3 Ank_4 51..104 CDD:290365
ANK repeat 51..81 CDD:293786
ANK 78..227 CDD:238125
ANK repeat 86..114 CDD:293786
Ank_2 88..204 CDD:289560
ANK repeat 116..171 CDD:293786
ANK 168..298 CDD:238125
ANK repeat 173..204 CDD:293786
ANK repeat 206..237 CDD:293786
Ank_4 208..258 CDD:290365
Ank_2 244..342 CDD:289560 8/37 (22%)
ANK repeat 280..310 CDD:293786 2/5 (40%)
Ank_2 316..409 CDD:289560 17/100 (17%)
ANK repeat 316..342 CDD:293786 4/25 (16%)
ANK 339..493 CDD:238125 34/187 (18%)
ANK repeat 344..376 CDD:293786 2/31 (6%)
ANK repeat 378..409 CDD:293786 10/38 (26%)
Ank_2 383..504 CDD:289560 30/148 (20%)
ANK 468..594 CDD:238125 33/146 (23%)
ANK repeat 473..504 CDD:293786 9/35 (26%)
Ank_2 479..571 CDD:289560 23/109 (21%)
ANK repeat 506..538 CDD:293786 7/31 (23%)
ANK 536..659 CDD:238125 31/159 (19%)
ANK repeat 540..571 CDD:293786 8/37 (22%)
Ank_2 545..636 CDD:289560 24/115 (21%)
ANK repeat 573..601 CDD:293786 5/30 (17%)
ANK repeat 605..636 CDD:293786 8/42 (19%)
Ion_trans 857..1080 CDD:278921 60/258 (23%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
21.910

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