Protein Alignment pain and LOC1279693

DIOPT Version :10

• Sequence 1: NP_611979.1
• Gene: pain / 37985
• FlyBaseID: FBgn0060296
• Length: 913
• Species: Drosophila melanogaster
• Sequence 2: XP_061516912.1
• Gene: LOC1279693 / 1279693
• VectorBaseID: AGAMI1_000842
• Length: 1126
• Species: Anopheles gambiae
• Alignment Length: 893
• Identity: 190/893 - (21%)
• Similarity: 316/893 - (35%)
• Gaps: 277/893 - (31%)

  Fly    53 STPGCRDFIEACIDHGSQVNYINK---KLDKAAISYAADSRDPGNLAALLKYRPGNKVQVDRKYG 114
            |..||.:.....|.||..||...|   .|..||.         ||..|..:....|..::|
Mosquito   301 SFSGCTECCAFLIQHGLDVNMQPKWYTPLHCAAF---------GNSLATAELLIKNGARID---- 352

  Fly   115 QLTPLN------SLAKNLTDENAPDVYSCMQLLLDYGASPNIVDQGEFTPLHHVLRKSKVKAGKK 173
              .|.|      ||.......||.|   |::..:.:|::.|.:::....|:|     .....|..
Mosquito   353 --VPTNKQHCEESLLHCAVRSNAID---CLRFFIAHGSNVNALERNGTNPIH-----LAADLGHT 407

  Fly   174 ELIQLFLDHPELDIDSYRNGEVRRLLQAQFPELKLPEERHTGPEIDIQTLQRTLRDGDETLFEQQ 238
            :.:...|:.|..|                             |.|.||       .||    :|.
Mosquito   408 QCLAALLECPNAD-----------------------------PNIRIQ-------QGD----KQM 432

  Fly   239 FAEYLQNLKGGADNQLNAHQEEYFGLLQESIKRGRQRAFDVILSTGMDINSRPGRANEANLVETA 303
            .|.:|...:|..|                        ....:|:.|.|:.:|..|.  ...:..|
Mosquito   433 TALHLAADEGNLD------------------------CVTQLLARGADVRARNHRG--FTPLHLA 471

  Fly   304 VIYGNWQALERLLK----EPNL----RLTPDSKLLNAVIGRLDEPPYDGSSHQRCFELLINSDRV 360
            ...|:...:|.|||    :||:    :.||    |:|.:.:.|       :.....|.|| :...
Mosquito   472 ARSGSADCVEALLKLGGCDPNMADFDQRTP----LHAAVSKSD-------TAVEMIETLI-AWGA 524

  Fly   361 DINEADSGRLVPLFFAVKYRNTSAMQKLLKNGAYIGSKSAFGTLPI----KDMPPE--VLEEHFD 419
            ::|:.|......|..|........::.||.:||.:..||..||..:    :..|..  |::...|
Mosquito   525 NVNQRDVYGFTALHLAALDALGPCVETLLYHGADVTMKSRKGTSALNIISRKTPASLGVIQCKLD 589

  Fly   420 SCIT-TNGERPGDQNFEIIIDYKNLMRQ---ERDSGLNQLQDEMAPIAFIAESKEMRHLLQHPLI 480
            :.|| |:.:....:..|:.:|::::::.   ...|.||...|:           ..:..|||||.
Mosquito   590 AAITLTHSQDSSSREVELELDFRSILQHCHPREISYLNTFVDD-----------GQKEFLQHPLC 643

  Fly   481 SSFLFLKWHRLSVIFYLNFLIYSLFTASIITYTL-----------------LKFHESDQR----- 523
            |:||::||:::...:....|....|...:..|.|                 ::..|..|:
Mosquito   644 SAFLYIKWNKIRKYYIARLLFCFTFVLFLTLYVLTALAHNCYNGSKDMKETIQEQELCQKQSIFG 708

  Fly   524 ------------------ALTA------FFGLLSWLGISYLILR--ECIQWIMSPVRYFWSITNI 562
                              |:||      .:|:..:..:.:.:.:  ..|:|
Mosquito   709 DMLRNNPFVIEMQWMVLVAITAIEICRKIYGITGYTSLKHYVTQTENAIEW-------------- 759

  Fly   563 MEVALITLSIFTCMESSFDKET---QRVLAVFTILLVSMEFCLLVGSLPVLSISTHMLMLREVSN 624
                .|.||:|. :...:.|.|   |..:..|.:||......|::|.|||  ...::.|..:|..
Mosquito   760 ----FIILSVFV-ISYIYTKRTYTWQNHVGAFAVLLGWTNLMLMIGQLPV--FGAYVAMYTKVQV 817

  Fly   625 SFLKSFTLYSIFVLTFSLCFYILFGKSVEEDQSKSATPCPPLGKKEGKDEEQGFNTFTKPIEAVI 689
            .|.|.|..||..::.|::.|.::|..|                           ::|..|....|
Mosquito   818 EFAKLFMAYSCMLIGFTISFCVIFPSS---------------------------SSFANPFMGFI 855

  Fly   690 KTIVMLTGEFDAGSI----------QFTSIYTYLIFLLFVIFMTIVLFNLLNGLAVSDTQVIKAQ 744
            ..:||:|||.|...:          ....|...:.|:||::|:|::|.|||.|:||.|.|.:|..
Mosquito   856 TVLVMMTGEQDLELLINDPDGKDPPFLLEISAQITFVLFLLFVTVILMNLLIGIAVHDIQGLKKT 920

  Fly   745 AELNGAICRTNVLSRYEQVLTGHGRAGFL---LGNHLFRSICQRLMNIYPNYLSLRQ----ISVL 802
            |.|:..:.:|.::|..|..|..    |:|   |.|.|:          |...:|.:.    :||.
Mosquito   921 AGLSKLVRQTKLISYIESALFN----GWLPNWLRNLLY----------YTALVSPQAYRVVLSVK 971

  Fly   803 PNDGNKVLIP---MSDPFEMRTLKK----ASFQQLPLSAAV-PQKKLL 842
            |.:..:..:|   |...:|:...||    .||..|....:. |||..|
Mosquito   972 PLNPGETRLPRDIMMAAYEVAKQKKHYVRKSFSTLRRDVSYDPQKNAL 1019

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
pain	NP_611979.1	ANKYR	2..>182	CDD:440430	31/137 (23%)
		ANK repeat	82..111	CDD:293786	5/28 (18%)
		ANK repeat	113..152	CDD:293786	10/44 (23%)
		ANKYR	<243..>406	CDD:440430	36/170 (21%)
		ANK repeat	324..366	CDD:293786	9/41 (22%)
		ANK repeat	368..393	CDD:293786	4/24 (17%)
		Ion_trans	495..746	CDD:459842	63/311 (20%)
LOC1279693	XP_061516912.1	None